3 Nitro 4 Iodoanisole

3-Nitro-4-iodoanisole, this is an organic compound. Its main uses cover the following numbers.
In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains nitro, iodine atoms and methoxy groups, each has unique reactivity, and can be derived from many chemical reactions. For example, nitro groups can be converted into amino groups through reduction reactions, iodine atoms are prone to nucleophilic substitution reactions, and methoxy groups can also participate in specific reactions, so that more complex organic molecular structures can be constructed for the creation of fine chemicals such as drugs, pesticides and materials.
In the field of medicinal chemistry, its use is quite important. With a specific chemical structure, it may be able to interact with targets in vivo, laying the foundation for the development of new drugs. Through structural modification and modification, explore the biological activity of the obtained derivatives, or hope to find lead compounds with the potential to treat specific diseases, and then carry out in-depth drug research and development work.
There are also potential uses in materials science. After a specific chemical reaction, it can be introduced into the structure of polymer materials or functional materials, which can endow materials with unique electrical, optical or thermal properties, so as to prepare new materials suitable for electronic devices, optical materials and other fields. In conclusion, 3-nitro-4-iodoanisole has important uses in the fields of organic synthesis, medicinal chemistry, and materials science due to its unique chemical structure, providing key starting materials and intermediates for the creation of many chemicals and materials.

There are several common methods for the synthesis of 3-nitro-4-iodoanisole.
First, anisole is used as the starting material. The nitration reaction of anisole is carried out first. This is the use of a mixed acid system of nitric acid and sulfuric acid. At a suitable temperature, the nitro group is introduced into the benzene ring of anisole. The positioning of the nitro group is affected by the methoxy group, which mainly produces a mixture of o-nitro and p-nitroanisole. Subsequently, the use of suitable separation methods, such as distillation, recrystallization, etc., to obtain p-nitroanisole. Then the iodization reaction of p-nitroanisole and iodine usually requires the presence of a catalyst, such as copper salt, to achieve the replacement of hydrogen atoms on the benzene ring with iodine atoms, and finally generate 3-nitro-4-iodoanisole.
Second, it can be started from 4-iodoanisole. Place 4-iodoanisole under nitrification conditions, such as using a mixture of nitric acid and sulfuric acid, control the reaction conditions, and selectively introduce the nitro group into the ortho-position of the iodine atom to obtain the target product 3-nitro-4-iodoanisole. The key to this path lies in the precise control of the nitrification reaction conditions to ensure that the nitro group is introduced at the desired position and avoid too many side reactions.
Third, it is also possible to use 3-nitroanisole as the raw material. 3-Nitro-4-iodoanisole can be obtained by iodizing the phenyl ring of 3-nitroanisole in a suitable reaction system with a suitable iodizing reagent, such as iodine elemental substance and a suitable oxidizing agent. This process takes into account the activity of the iodizing reagent, the reaction solvent and the reaction temperature to improve the selectivity and yield of the reaction.

3-Nitro-4-iodoanisole is one of the organic compounds. Its physical properties are particularly important and are described below.
First of all, its appearance is usually a solid state, which is caused by intermolecular forces. It is condensed and formed at room temperature and pressure. Its color is usually light yellow, like the first color of autumn wood leaves. The formation of this color is due to the absorption and reflection characteristics of nitro and iodine atoms in the molecular structure.
As for the melting point, it is about a specific numerical range, which is determined by the strength of the interaction between molecules. There are van der Waals forces, dipole-dipole interactions, etc. between molecules. When the temperature rises to a certain level, these forces are overcome, and the molecules begin to move freely, and the substance then changes from solid to liquid.
Boiling point is also an important physical property. Under a specific pressure, when the temperature reaches the boiling point, 3-nitro-4-iodoanisole changes from liquid to gaseous state. During this process, the molecule obtains enough energy to break free from the shackles of the liquid phase. The level of boiling point is closely related to the size, shape and intermolecular forces of the molecule.
In terms of solubility, organic solvents such as ethanol and ether exhibit certain solubility. Due to the fact that organic solvents and 3-nitro-4-iodoanisole molecules can form similar interactions, such as van der Waals force, hydrogen bonds, etc., following the principle of "similar miscibility". However, in water, its solubility is poor, because the hydrogen bond network between water molecules is incompatible with the molecular structure of the compound, it is difficult to form an effective interaction.
Density is also one of the physical properties of the compound. Its density indicates the mass of the substance in a unit volume, and this value is related to the mass of the molecule and the close arrangement between the molecules. By accurate measurement, the exact value of its density can be known, which is of great significance for the quantitative study of substances and in practical applications. The physical properties, appearance, melting point, boiling point, solubility and density of 3-nitro-4-iodoanisole are all determined by its molecular structure, and each property is interrelated, playing a key role in the research and application of organic chemistry.

3-Nitro-4-iodoanisole is an organic compound. Its molecules contain methoxy (-OCH), nitro (-NO) and iodine atoms (-I). These functional groups endow the compound with unique chemical properties.
As far as nucleophilic substitution reactivity is concerned, the electron cloud density of the benzene ring can be reduced due to the strong electron absorption of the nitro group, especially the electron cloud density of the carbon atom in the adjacent and para-position with the nitro group, which is more vulnerable to attack by nucleophilic reagents. In this compound, the carbon atom connected to the iodine atom is affected by the nitro group, and the electron cloud density is reduced, so the iodine atom can be used as a leaving group, which is prone to nucleophilic substitution. For example, in the case of strong nucleophiles, such as alkoxy anions (RO) or amines (RNH2O), iodine atoms may be replaced to form new organic compounds.
Besides its reducing properties, the nitro group in the molecule can be reduced. Common reducing agents such as iron and hydrochloric acid, tin and hydrochloric acid, etc., can gradually reduce the nitro group. First, the nitro group may be reduced to the nitroso group (-NO), which is then reduced to the hydroxylamine group (-NHOH), and finally reduced to the amino group (-NH2O). If iron and hydrochloric acid are used as reducing agents, under suitable reaction conditions, the nitro group of 3-nitro-4-iodoanisole can be converted into an amino group through a series of reactions to obtain an amino-containing product. The chemical properties of this product are different from those of the original compound due to the electron-donning nature of the amino group.
In addition, 3-nitro-4-iodoanisole may participate in the aromatic electrophilic substitution reaction. Although nitro is a meta-locator and has the effect of passivating benzene ring, methoxy is an o-and para-locator and has strong electron-donating ability. Combining the effects of the two, under appropriate reaction conditions and the action of electrophilic reagents, the electrophilic substitution reaction may occur in the ortho-position of the methoxy group (affected by the steric resistance of the iodine atom, the ortho-reactivity may be slightly weaker) or the para-position. For example, when reacting with halogenated reagents, new halogen atoms can be introduced at specific positions in the benzene ring.
Because the molecule contains iodine atoms, 3-nitro-4-iodoanisole may participate in the metal-catalyzed coupling reaction. For example, under palladium catalysis, Suzuki coupling reaction can occur with boric acid or borate esters containing alkenyl groups and aryl groups to realize the construction of carbon-carbon bonds and generate organic compounds with new carbon frameworks. This is of great significance in the field of organic synthesis and can be used to construct complex

I have not seen the exact price of "3-nitro-4-iodoanisole" in the market. However, in order to estimate its price, various factors need to be considered.
First, the purity of this product is important. If the purity is extremely high, close to the purity of chemical analysis, suitable for fine experiments, its price must be high; if the purity is slightly lower, it is only used for general synthesis, and the price may be slightly reduced.
Second, the supply and demand of the market are also heavy. If there are many people seeking this product, but there are few producers, the price will rise; conversely, if the market is sufficient, there are few applicants, and the price may decline.
Furthermore, the difficulty of preparation also affects its price. If the preparation requires complicated steps, rare raw materials or special conditions, the cost is high and the price is also high; if the preparation is relatively simple, the price may be close to the people.
In addition, different merchants have different pricing strategies. Well-known big merchants, their products may have strict quality control, good additional services, or high prices; while small merchants compete for the market, or lower prices.
To sum up, the price of "3-nitro-4-iodoanisole" in the market is difficult to determine the exact range due to differences in purity, supply and demand, difficulty of preparation, and merchants. For details, you can consult chemical raw material suppliers, or check the price of chemical product trading platforms.