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What is the chemical structure of 4- (2-chloro-5-iodobenzyl) phenol?
4- (2-tritium-5-chloropyridyl) quinoline has been investigated in the field of chemical chemistry. Its properties involve the delicate combination of polymers.
The (2-tritium-5-chloropyridyl) part, the six-element of pyridine contains nitrogen and is aromatic. Tritium, the isotope of tritium, is located in the second position of pyridine, or it affects the sub-cloud separation and chemical activity of pyridine. The chlorine atom of the fifth position, which also absorbs the sub-group, can reduce the sub-cloud density of pyridine, and change the inverse properties of the whole group.
As for the quinoline part, it is formed by fusing benzene-pyridine, which also has a high degree of aromatic properties. The nitrogen atom of quinoline can be used as the center of properties, and the reaction of polymorphism.
In 4- (2-tritium-5-chloropyridyl) quinoline, (2-tritium-5-chloropyridyl) quinoline, or from the chemical phase. This connection method has a crucial impact on the molecular stability, physical properties, and chemical properties of the whole molecule.
Therefore, the chemical reaction of 4- (2-tritium-5-chloropyridyl) quinoline is composed of pyridyl, quinoline and specific substituents, and each part interacts with each other, which gives this compound its unique chemical properties. It is useful for research in the fields of synthesis, physicochemistry, etc., or for research.
What are the main uses of 4- (2-chloro-5-iodobenzyl) phenol?
In "Tiangong Kaiwu", it is said that Pi is the seedling of tin, and lead is often found in its place of growth. 4 - (2 - calcined - 5 - Pi - base) realgar, this substance has special uses in ancient times.
First, in the field of alchemy, the ancients were keen to pursue the art of immortality. During the process of alchemy, such substances containing realgar may be regarded as important materials. Because the ancients believed that after special refining, it can make it have magical effects, and help alchemists refine the elixir of longevity.
Second, in terms of medicine, although arsenic is highly toxic, traditional Chinese medicine adheres to the concept of dialectical treatment. Under specific conditions, after special processing, a very small amount of this substance may be used as medicine. If some sores are swollen and poisonous, rational use may play a role in fighting poison with poison and help patients relieve pain.
Third, in traditional pigment production, the unique color of 4- (2-calcined-5-based) realgar may make it one of the pigment raw materials. Ancient painting, ceramic painting and other art forms have diverse requirements for color. After processing, these substances may provide unique colors for artistic creation and add charm to artworks.
Fourth, in the field of agricultural pest control, the ancients found in long-term practice that toxic substances such as arsenic can be used properly to expel pests and protect crops. If it is sprinkled around the farmland to achieve a certain pest control effect and ensure crop yield.
What are the physical properties of 4- (2-chloro-5-iodobenzyl) phenol?
4- (2-argon-5-boron-based) quinoline is an organic compound. Its physical properties are as follows:
In appearance and properties, it usually takes a solid form, but the specific appearance will vary depending on the purity and crystal form. The pure substance may be white to light yellow crystalline powder, and the color may be deepened when impurities are present.
In terms of melting point, different substituents and structures will cause differences in melting point. Generally speaking, the melting point of such compounds containing heterocycles and specific substituents is mostly in the range of tens to hundreds of degrees Celsius. Due to the interaction between molecules such as van der Waals force and hydrogen bonds, a certain amount of energy is required to overcome, so that the melting point of lattice disintegration is higher. At the boiling point, the boiling point is also affected by the structure and substituents. Due to the relatively large molecular mass and the complex intermolecular forces, the boiling point is often higher, usually at several hundred degrees Celsius. When heated, it takes a lot of energy to overcome the intermolecular forces and convert them into gaseous states, so the boiling point is high.
In terms of solubility, in organic solvents, due to the structure containing hydrophobic aromatic rings and heterocyclic parts, it has certain solubility in common organic solvents such as dichloromethane, chloroform, and toluene. These organic solvents can form van der Waals forces or weak interactions with the molecules of the compound to help them dissolve. In water, due to the strong polarity of water molecules, the interaction force with the hydrophobic part of the compound is weak, and only some of these compounds containing polar groups are slightly soluble or insoluble.
In terms of density and relative density, the density and relative density will change according to the specific structure and composition. Generally, due to the presence of carbon, hydrogen, nitrogen, boron, argon and other atoms in the molecule, the relative density is slightly higher than that of water. Due to the atomic weight and the compactness of the molecule, the mass per unit volume is larger than that of water.
In terms of volatility, the volatility is low. Due to the strong intermolecular force, it takes high energy for molecules to escape from the liquid or solid surface to form gas-phase molecules, and they evaporate slowly at room temperature and pressure.
What is the synthesis method of 4- (2-chloro-5-iodobenzyl) phenol?
To prepare 4- (2-cyanopyridine-5-bromopyridine) benzonitrile, the synthesis method is as follows:
First, 2-cyanopyridine-5-bromopyridine is used as the starting material. This raw material can be prepared by the corresponding pyridine derivative through reaction steps such as bromination and cyanidation.
Take an appropriate amount of 2-cyanopyridine-5-bromopyridine, place it in a reactor, add a suitable organic solvent, such as N, N-dimethylformamide (DMF), to promote the dissolution of the raw material and the reaction proceeds.
Subsequently, a benzonitrile derivative with a stoichiometric ratio of 2-cyano-5-bromopyridine is added. A suitable base, such as potassium carbonate, is added to the reaction system. The function of the base is to promote the reaction and adjust the pH of the reaction system.
Under continuous stirring, slowly heat up to a specific temperature range, generally about 80-120 ° C. This temperature range can effectively promote the reaction to occur while avoiding side reactions caused by excessive temperatures. Keep the reaction at this temperature for a certain time, about 6-12 hours, so that the raw materials can fully react.
After the reaction is completed, the reaction liquid is cooled to room temperature. Next, an appropriate amount of water is added to the quenching reaction to stop the reaction process. After that, an organic solvent is used for extraction, such as dichloromethane. After multiple extractions, the organic phases are combined.
The organic phase is then washed, first with a dilute hydrochloric acid solution to remove the remaining alkaline substances in the organic phase; then washed with water to remove the remaining acid and water-soluble impurities.
The washed organic phase is dried with anhydrous sodium sulfate to remove the moisture in it. Subsequently, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Finally, the crude product is separated and purified by column chromatography. A suitable silica gel was selected as the stationary phase, and petroleum ether and ethyl acetate were mixed as the mobile phase in a certain proportion to carry out column chromatography. The eluent containing the target product was collected and concentrated to obtain a higher purity 4- (2-cyano-5-bromopyridine) benzonitrile product.
What are the precautions for using 4- (2-chloro-5-iodobenzyl) phenol?
Saltpeter and sulphur are also important items for firework. They are widely used in alchemy and firearms. However, they are strong in nature, and when they are used, there must be everything to pay attention to.
The first one should be stored with caution. Saltpeter and sulphur are both afraid of the tide, and should be placed in a dry place to avoid water and moisture, so as not to change their properties. And the two should not be mixed with other things, especially with flammable and explosive products, to prevent them from accidentally touching and causing harm.
Both, the amount must be accurate. In the art of alchemy, the amount is related to the success or failure of the elixir; in the manufacture of firearms, the proportion of the agent determines its power and stability. Less is not enough, and more is dangerous. Therefore, when handling, you must balance it with precision, and it is not bad at all.
Furthermore, when combining medicine, you should avoid open flames. Saltpeter and sulfur will ignite in case of fire, and even explode. The combination of other substances as medicine must be used in an open and non-fire place, and the operator needs to clean his hands and equipment, except for the trouble of fireworks. Mixing utensils should not be used for those that are prone to sparks to prevent accidents.
Also, the user should be familiar with their properties. Saltpeter is cold in nature and sulphur is warm in nature. If the two are combined, their properties will be strong. The user must be well aware of pharmacology and fire properties, so that he can control them at will, so as not to make mistakes. If you use it without knowing its nature, it is like a blind person who uses the blade and is in danger.
Although saltpeter and sulfur are divine weapons, when you use them, you should be careful, accurate, avoid fire, and clear, so as to keep them safe, so as to make the best use of them and benefit the world. Don't cause disasters due to carelessness, remember it.
