4 5 Diiodo 1h Imidazole

4,5-Dibromo-1H-indole is an important intermediate in organic synthesis. It has a wide range of uses and is often a key raw material for the synthesis of many drugs in the field of medicinal chemistry. Many biologically active compounds rely on this intermediate for their synthesis pathways. For example, in the preparation of some antidepressant drugs, 4,5-dibromo-1H-indole is involved. Through a series of chemical reactions, the core structure of the drug is constructed, which gives the drug specific pharmacological activity to help relieve depression symptoms in patients.
In the field of materials science, it also has important functions. It can be used as a starting point for the synthesis of specific functional materials. For example, the synthesis of organic materials with special optoelectronic properties may be applied to organic Light Emitting Diode (OLED) technology. The structural characteristics of 4,5-dibromo-1H-indole make it chemically modified to exhibit unique photoelectric response, improve the luminous efficiency and stability of OLED devices, and then promote the development of display technology.
In addition, in the field of pesticide chemistry, it is also an important component in the synthesis of new pesticides. Through rational molecular design and synthesis strategies, pesticide molecules based on 4,5-dibromo-1H-indole may have the characteristics of high efficiency, low toxicity and environmental friendliness, which can effectively control crop diseases and pests, ensure the harvest of agricultural production, and reduce the negative impact on the environment. In short, 4,5-dibromo-1H-indole plays an indispensable role in many fields and is of great significance to promote scientific and technological progress and industrial development in various fields.

4,5-Dibromo-1H-imidazole is an organic compound with unique physical properties, which is described in detail in ancient Chinese.
Its state is usually solid, and it may appear as a white to light yellow powder. This color state varies slightly depending on the preparation method and purity. Its melting point has a fixed number, which is about a specific temperature range, which is an important indicator of its purity and characteristics. To measure its melting point, use a subtle method to place a small amount of sample in a special appliance, gradually heat up, and observe the change of its state in detail. When the sample is slowly melting from the solid state, the temperature at this moment is the melting point. This temperature is crucial for its identification and quality determination.
4,5-dibromo-1H-imidazole has different solubility in different solvents. In organic solvents such as ethanol, dichloromethane, etc., it has a certain solubility. In ethanol, after stirring and shaking, it is partially soluble and forms a homogeneous liquid phase. Due to the force between the molecule and the ethanol molecule, the two interact to disperse the imidazole molecule in the ethanol system. However, in water, the solubility is very small. Due to the large difference between the molecular structure and the polarity of water, it is difficult for water molecules to interact effectively with imidazole molecules, making it difficult to dissolve in water.
The density of this compound is also an inherent property. Although accurate instruments and operations are required for determination, its density value can help to distinguish the difference from other substances. When measuring the density, carefully measure a certain volume of the sample, weigh it on a precise balance, and calculate it according to the density formula. The value of density reflects the degree of compactness of its molecular accumulation, and is also related to the interaction between molecules.
4,5-dibromo-1H-imidazole vapor pressure is extremely low, and under normal conditions, the tendency to volatilize is small. Due to the strong intermolecular force, molecules want to escape from the solid or liquid surface into a gaseous state, and need to overcome large resistance, so the vapor pressure is not high. This characteristic is of great significance during storage and use, because it is not easy to volatilize, and there is no need to worry too much about its loss due to volatilization or safety issues during storage.

The chemical properties of 4,5-dibromo-1H-indole are quite stable. In this compound, bromine atoms interact with indole rings, giving it unique properties. Bromine atoms have strong electronegativity, which can affect the electron cloud distribution of indole rings. However, in its structure, the conjugate system of indole rings is huge, forming a stable π-electron delocalization system, which contributes greatly to molecular stability.
From the perspective of reactivity, 4,5-dibromo-1H-indole is difficult to spontaneously react under normal conditions. Due to the stability of indole rings, specific conditions and reagents are required to initiate the reaction. In case of nucleophilic reagents, although bromine atoms can be used as leaving groups, the reaction conditions are quite harsh, and appropriate solvents, temperatures and catalysts are required.
Furthermore, its stability is also reflected in the tolerance to external factors such as light and heat. Usually under light, the structure of the compound does not change significantly, and the thermal stability is also good. In a moderate temperature range, it will not easily decompose or rearrange the structure. Even at slightly higher temperatures, it will take a certain amount of time for noticeable changes to occur.
In summary, 4,5-dibromo-1H-indole has relatively stable chemical properties due to the conjugate structure of indole ring and the interaction between bromine atom and ring, and can maintain its own structure and properties under many common environments and general reaction conditions.

The synthesis method of 4,5-dibromo-1H-pyrrole is often found in various books. The methods vary, and each has its own strengths. Choose to describe it.
One is the halogenation method. Based on pyrrole, it meets bromine in a suitable reaction medium. This reaction requires careful control of the temperature and the amount of bromine. If the temperature is too high and the amount of bromine is too high, it is easy to cause excessive halogenation and generate polybrominated pyrrole; if the temperature is too low and the bromine is insufficient, the reaction will be slow and the yield will be difficult to be high. Usually an inert solvent such as carbon tetrachloride is used as a medium, under low temperature such as ice bath conditions, bromine is slowly added dropwise, stirred to make it fully react, and then the target product 4,5-dibromo-1H-pyrrole can be obtained by separation and purification.
The second is a derivative containing pyrrole structure as a starting material. After a specific chemical reaction, bromine atoms are introduced. For example, select a suitable pyrrole derivative and activate it first, so that the activity of hydrogen atoms on the pyrrole ring is enhanced, and it is easier to replace with bromine sources. Catalysts such as Lewis acid can be used to accelerate the reaction process. After the reaction, the product is refined by extraction, distillation, recrystallization and other means according to the physical and chemical properties of the product and impurities.
The third is to construct a pyrrole ring through a multi-step reaction and introduce bromine atoms at the same time. First, a simple organic compound is used as the raw material, and the pyrrole skeleton is constructed through condensation, cyclization and other reactions. During the construction process, the reaction steps are cleverly designed to introduce bromine atoms to the target position. Although this method is complicated, the structure and purity of the product are more precisely controlled, which can effectively avoid the occurrence of side reactions. It is necessary to pay attention to the conditions of each step of the reaction, such as the proportion of reactants, reaction temperature, reaction time and catalyst selection, which are all related to the quality and yield of the final product.
All kinds of synthesis methods have their own uses. When considering factors such as the availability of raw materials, cost, yield and product purity, the choice should be made carefully according to actual needs.

The price of 4,5-dibromo-1H-indole in the market often varies depending on quality, source, supply and demand. The price may be slightly higher for those with high quality; when mass production is sufficient, the price may be slightly lower.
Looking at the pharmaceutical market and chemical raw materials, the price of this product is roughly in the range of tens to hundreds of dollars per gram. If the purchase quantity is small, and the high purity product is required, the price per gram may be nearly a hundred dollars, or even more; if it is for industrial use, the quantity is required and the purity is slightly wider, and if purchased in bulk, the price per gram may be tens of dollars.
However, the market situation is impermanent, and the price also fluctuates. In the event of scarcity of raw materials, or changes in production, the supply is less and the demand is more, the price will rise; if the production capacity increases sharply, the supply exceeds the demand, and the price may trend downward. To know the real-time price, consult the relevant merchants and chemical trading platforms to determine the exact number.