4 5 Iodo 1 H Imidazole

4- (5-iodo-1H-imidazol-1-yl) compound is a unique substance in the field of organic chemistry. The chemical properties of this compound are of great interest and are the focus of many chemistry researchers.
Viewing its structure, the 5-iodo-1H-imidazole part endows it with many special properties. The introduction of iodine atoms, due to the large relative atomic mass of iodine and the unique electron cloud distribution, causes the polarity of the molecule to change, which in turn affects its physical and chemical behavior. The electronegativity of iodine atoms allows the compound to exhibit unique activity in certain reactions, or to participate in the reaction as an electrophilic agent, interacting with electron-rich groups.
And the 1H-imidazole structural unit itself has certain basicity and coordination ability. The nitrogen atom in this imidazole ring can provide lone pairs of electrons to form coordination bonds with metal ions, which may have important applications in the field of catalysis and materials science.
Furthermore, the reactivity of this compound is also closely related to its surrounding substituents. Different substitution modes can significantly affect the distribution of electron clouds in the molecule, thereby changing its reaction check point and reactivity. For example, if there are electron-withdrawing groups around, or the electron cloud density on the imidazole ring is reduced, its basicity and nucleophilicity are affected; conversely, the electron-donating group can enhance its electron cloud density and improve its nucleophilic reaction ability.
In addition, in terms of physical properties, the melting point, boiling point, solubility and other properties of this compound are affected by the presence of iodine atoms and imidazole rings. The larger volume and mass of iodine atoms may increase the melting point; and the polar characteristics of the imidazole ring play a role in its solubility in different solvents, and may have better solubility in polar solvents.
In conclusion, the chemical properties of 4- (5-iodo-1H-imidazol-1-yl) compounds are rich and diverse, and they have potential application value in many fields such as organic synthesis, catalysis, and materials science, which are worthy of further investigation.

4- (5) -Iodine-1 (H) -imidazole is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help to form compounds with specific biological activities.
For example, when creating antibacterial drugs, 4- (5) -iodine-1 (H) -imidazole can be chemically modified to introduce suitable functional groups to obtain new drugs that have significant inhibitory or killing effects on specific bacteria. And in the field of materials science, it may also have potential use. After specific reactions, it may be able to participate in the construction of polymer materials with special properties, such as specific electrical conductivity and optical properties.
In organic synthetic chemistry, it is often an important building block for the construction of complex organic molecules. Chemists can use the activity of iodine atoms to initiate coupling reactions, etc., to skillfully splice different organic fragments to achieve the synthesis of target compounds. It is a chemical substance that cannot be ignored in scientific research and industrial production, and is of great significance for promoting progress in related fields.

The synthesis method of 4- (5-iodine-1H-imidazole-1-yl) benzoic acid is related to the technology of organic synthesis and is an important research direction in the field of chemistry.
First, it can be started from 5-iodine-1H-imidazole, and the imidazole nitrogen atom is protected to prevent it from overreacting in subsequent reactions. Appropriate protective groups, such as tert-butoxycarbonyl (Boc), are selected to form a protective imidazole derivative by reacting with imidazole. Subsequently, this derivative undergoes nucleophilic substitution reaction with carboxyl-containing halogenated aromatics. For example, in the catalytic system of p-halobenzoic acid (halogen atoms such as bromine, iodine, etc.) and protected imidazole derivatives under basic conditions and suitable catalysts, such as potassium carbonate, cuprous iodide and ligands (such as o-phenanthroline), a substitution reaction occurs to generate the target product containing the protective group. Finally, the protective group is removed. For example, under acidic conditions, the Boc protective group can be gently removed to obtain 4- (5-iodine-1H-imidazole-1-yl) benzoic acid.
Second, another strategy can be started from p-benzoic acid derivatives. First, p-benzoic acid is activated, such as conversion to acyl chloride, and thionyl chloride and other reagents are used to react with p-benzoic acid to obtain acyl chloride. At the same time, the activation of 5-iodine-1H-imidazole nucleophilic test agent can be treated with alkali to remove hydrogen from imidazole nitrogen atoms to form more nucleophilic imidazole negative ions. Then, the activated acyl chloride and the activated imidazole negative ions undergo nucleophilic addition-elimination reaction to directly generate the target product 4- (5-iodine-1H-imidazole-1-yl) benzoic acid. The steps of this method are relatively simple, but attention needs to be paid to the control of the reaction conditions to avoid side reactions, such as hydrolysis of acyl chloride.
Or, the coupling reaction path catalyzed by transition metals can also be adopted. With 5-iodine-1H-imidazole and p-halobenzoic acid derivatives as raw materials, under the action of transition metal catalysts such as palladium and nickel, with the assistance of ligands (such as three-tert-butylphosphine, etc.), and the presence of bases (such as sodium carbonate, etc.), the coupling reaction is carried out. This method has the advantages of high efficiency and good selectivity, but the catalyst cost is high, and the reaction conditions are more demanding. It is necessary to strictly control the parameters such as reaction temperature, time and catalyst dosage to achieve high yield synthesis of the target product.

I look at you and ask "4 - (5 - iodine - 1H - imidazole) " in the market price range. However, the price of this chemical substance is not static, and it often changes due to many factors.
First, purity is the key. If its purity is high, almost perfect, and there is no impurity disturbance, the price will be high. Such as fine gold and jade, pure and flawless, comparable to extraordinary products. If the purity is low, there are many impurities, and it is still pure gold and jade without careful polishing, the price will be low.
Second, the supply and demand situation is also serious. If the world needs this imidazole, the demand is greater than the supply, such as the clouds in a drought, the price will rise. On the contrary, if the supply exceeds the demand, if the accumulated salary is too much, the price will drop.
Third, the difficulty of preparation and the price of raw materials are affected. If the preparation method is complicated, rare raw materials are required, time-consuming and laborious, such as alchemy, and the materials used are harsh, the price will be high. If the preparation is easy, the raw materials are often easy to obtain, and the price will be close to the people.
As far as I know, the price of this imidazole ranges from tens to hundreds of yuan per gram. However, this is only a rough number. The actual price must be consulted with chemical reagent merchants in detail to obtain an accurate value.

4- (5) -Iodine-1 (H) -imidazole This substance needs to be detailed in terms of its safety and precautions.
First of all, safety, this substance may be potentially harmful in experimental and production applications. From the perspective of chemical properties, the introduction of iodine atoms makes its chemical activity different. It may be irritating. If it accidentally touches the skin, it may cause skin discomfort, redness in mild cases, or blisters in severe cases. If it comes into contact with the eyes, it is even more harmful, or it may damage the tissues of the eyes and affect vision. Inhaling its dust or volatile gas can also cause irritation to the respiratory tract, causing coughing, asthma, etc. Long-term exposure, or chronic damage to respiratory organs such as the lungs.
Let's talk about precautions. When operating, be sure to wear professional protective clothing and protective gloves to prevent skin contact. Eye protection is also indispensable, and protective glasses must be worn securely. The operating environment should be kept well ventilated, and it is best to operate in a fume hood, so that any harmful gases that may be generated can be dissipated in time. If there are substances spilled during the operation, do not panic. It needs to be cleaned up according to specific procedures to avoid its spread and cause greater harm. The remaining substances after taking them must not be discarded at will, and should be properly disposed of according to regulations to prevent pollution to the environment. For storage, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants, to prevent dangerous chemical reactions. In short, the use of 4- (5) -iodine-1 (H) -imidazole must be carefully and strictly followed to ensure safety.