4 5 Iodo 1h Imidazole

4- (5-Iodine-1H-imidazole-1-yl) benzoic acid, which has a wide range of uses. In the field of medicine, it is often used as a key intermediate to create a variety of specific drugs. Because of its unique structure, it can precisely combine with specific biological targets, and then play a role in treating diseases. For example, in the development of anti-tumor drugs, it can participate in the construction of targeted molecular structures, help drugs act more efficiently on tumor cells, inhibit tumor growth and spread, and provide strong support for overcoming cancer problems.
In the field of materials science, it also plays an important role. It can be used as a functional monomer and integrated into the synthesis process of polymer materials. Through ingenious design and reaction, materials are endowed with special properties such as optics and electricity. For example, polymer materials with special photoelectric response can be prepared and applied to optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc., to improve the performance and efficiency of these devices and promote innovation and development in the field of materials science.
In organic synthetic chemistry, it is an extremely important synthetic building block. With its active chemical properties, it can participate in a series of organic reactions, such as nucleophilic substitution, coupling reactions, etc. Through ingenious reaction design and combination, complex and diverse organic compounds can be constructed, which allows organic synthetic chemists to explore the structure and properties of new compounds, open up a broader space, and promote the continuous progress of organic synthetic chemistry.

4- (5-Iodine-1H-imidazole-4-yl) benzoic acid, this is an organic compound. Its physical properties are as follows:
- ** Appearance properties **: Usually white to light yellow crystalline powder, this form is more common in many organic compounds, because its molecules are arranged in an orderly manner, forming a stable crystalline structure at room temperature and pressure.
- ** Melting point **: About 280-285 ° C, the high melting point indicates that the intermolecular force is strong, and more energy is required to break the lattice and realize the transition from solid to liquid. This property can be used to identify the purity of substances. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
- ** Solubility **: Slightly soluble in water, because although there are carboxyl groups in the molecule that can form hydrogen bonds with water, the presence of iodine atoms and imidazole rings enhances the hydrophobicity of the molecule, and the overall water solubility is poor. However, it is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. The polarity of these organic solvents matches the compound molecules and can be dissolved through intermolecular interactions.
- ** Stability **: It is relatively stable under normal conditions, but should avoid contact with strong oxidants, strong bases and other substances. Because carboxyl groups can neutralize with bases, imidazole rings and iodine atoms may also participate in chemical reactions under specific conditions, affecting their structure and properties. Extreme conditions such as light and high temperature may also promote decomposition or other chemical reactions, so it needs to be stored in a cool, dry and dark place.

The synthesis method of 4- (5-iodine-1H-imidazole-4-yl) benzoic acid covers several routes. First, it can be started by imidazole derivatives, and by halogenation reaction, iodine atoms are introduced into a specific position of the imidazole ring, and then they are properly coupled with carboxyl-containing aromatic compounds to form the target product. In this process, the halogenation step needs to select suitable halogenation reagents and reaction conditions to ensure that the iodine atoms are precisely connected to the 5-position. The coupling reaction needs to consider the type and dosage of catalysts, bases, and the characteristics of the reaction solvent to achieve efficient and highly selective synthesis.
Second, imidazole precursors containing carboxyl groups can be constructed first, and then iodine atoms can be introduced into the 5-position of the imidazole ring through functional group transformation. During this period, the synthesis of precursors is related to the selection of starting materials and the design of a series of reaction steps. The iodine substitution reaction also needs to be carefully regulated to avoid the occurrence of side reactions, so as to improve the purity and yield of the product.
Furthermore, other related heterocyclic compounds are used as starting materials, and the structure of the target molecule is gradually constructed through multi-step reactions. This strategy requires detailed study of the mechanism and conditions of each step of the reaction, and fine control of the reaction process in order to achieve the effective synthesis of 4- (5-iodine-1H-imidazole-4-yl) benzoic acid. All methods have their own advantages and disadvantages. In actual operation, when considering the availability of raw materials, the difficulty of reaction conditions, cost-effectiveness and many other factors, the optimal synthesis path is selected.

I look at your question, but I am inquiring about the price range of 4- (5-iodo-1H-imidazole) in the market. However, the price of this item often changes due to multiple reasons, and it is difficult to determine.
First, the quality is high or low, which is related to the price. If it has high purity and few impurities, such as flawless jade, the price will be high; if it contains a lot of miscellaneous and impure quality, it will be like stone mixed jade, and the price will be low.
Second, the amount of purchase is small, which is also the price. If the purchase quantity is huge, such as Jianghai Na River, merchants often give discounts to promote block trade; if the purchase quantity is small, such as a drop in the water, the unit price or high.
Third, the source is different, and the price is different. It is produced by a small factory, although the cost is low, the quality may be difficult to guarantee, and the price is also low.
Fourth, the supply and demand of the market situation has a great impact. There are many people who ask for it, and there are few who supply it. If the goods are rare and expensive, the price will rise; if the supply exceeds the demand, such as the flood, the price will automatically decline.
The price of 4- (5-iodo-1H-imidazole) on the market today ranges from tens of yuan per gram to hundreds of yuan or more. It is difficult to accurately describe its range. To know the exact price, you need to consult pharmaceutical merchants, chemical manufacturers, etc., and carefully observe the market before you can get the truth.

4 - (5-Iodine-1H-imidazole) This product, when storing and transporting, many points need to be paid attention to.
Bear the brunt, the storage place must be dry and cool. Because the humid gas is easy to cause it to deteriorate, and the temperature is too high, or its chemical properties are unstable, and even change. Therefore, choose a dry and cool place to keep its quality as before.
Furthermore, it is necessary to prevent it from contacting with oxidizing substances. Oxidizing substances, or chemically react with 4- (5-iodine-1H-imidazole), damage its purity and change its properties. When storing, when separated from oxidizing substances, do not make contact.
When transporting, the packaging must be solid and reliable. Due to the bumpy road, if the packaging is not solid, it is easy to cause damage to the container, resulting in leakage of 4- (5-iodine-1H-imidazole). After leakage, not only the material is lost, but also it may pose a threat to the surrounding environment and personnel safety.
In addition, the transportation temperature also needs to be strictly controlled. According to its chemical characteristics, set the appropriate temperature range, not too high or too low. Improper temperature, or change the shape and properties of 4- (5-iodine-1H-imidazole), affecting its subsequent use.
And during transportation, avoid violent vibration and collision. Strong vibration, collision, or damage to the internal structure of the substance, which in turn affects its chemical properties and quality.
In short, the storage and transportation of 4- (5-iodine-1H-imidazole), when careful, pay attention to the above things to ensure its safety and quality.