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What is the chemical structure of 4-amino-1- (2-deoxypentofuranosyl) -5-iodopyrimidin-2 (1h) -one?
This is the name of 4-amino-1- (2-deoxyfuran-pentyl) -5-iodopyrimidine-2 (1H) -one. To clarify its chemical structure, it is necessary to analyze it with chemical knowledge.
Looking at its name, "pyrimidine" is the basic structure. This is a six-membered heterocycle containing nitrogen, with a specific atomic arrangement and chemical bond. "2 (1H) -one" indicates that there is a carbonyl group at the 2nd position of the pyrimidine ring, and the hydrogen atom at the 1st position is in a specific state. " 5-Iodine "indicates that there is an iodine atom attached to the 5th position of the pyrimidine ring, and the iodine atom is covalently linked to the carbon atom on the ring.
" 1- (2-deoxyfuranopentyl) ", which means that the furanopentyl group is connected to the 1st position of the pyrimidine ring. The furanopentan sugar has a five-membered ring structure. The 2nd position of this sugar group is deoxygenated, and there is less one hydroxyl group, which is replaced by a carbon-hydrogen bond. The" 4-amino group "is connected to the 4th position of the pyrimidine ring. The amino group is composed of a nitrogen atom and two hydrogen atoms, and is connected to the ring by a
In this way, the structure of this compound is composed of a pyrimidine ring as the core, which is connected with an iodine atom and an amino group, and is connected to a specific 2-deoxyfuranpentyl sugar group. Each part is bound by a specific chemical bond to form a unique chemical structure, which may have specific properties and functions in the fields of biochemical and pharmaceutical research.
What are the main uses of 4-amino-1- (2-deoxypentofuranosyl) -5-iodopyrimidin-2 (1h) -one?
4 - amino - 1 - (2 - deoxypentofuranosyl) - 5 - iodopyrimidin - 2 (1H) - one, the Chinese name is often 5 - iodine - 2 '-deoxyuridine, which has a wide range of uses.
First, in the field of medical pharmacology research, its role is significant. It is like a precise "key" and can be used as a nucleoside analogue to participate in the study of many physiological processes. It can interfere with the synthesis of DNA, because its structure is similar to that of natural nucleosides, it can be incorporated into DNA replication, thereby hindering the synthesis of normal DNA and cell proliferation. In the study of cell proliferation, tumor occurrence and development mechanisms, it is like a key "bridge", providing strong support for researchers to understand the mysteries of diseases. The proliferation of many tumor cells depends on active DNA synthesis, and this compound has become an important tool for exploring the proliferation mechanism of tumor cells, helping researchers to explore potential anti-cancer targets and treatment strategies.
Second, in the field of antiviral research, it is also an indispensable "sharp weapon". The reproduction of viruses is highly dependent on the DNA synthesis mechanism of host cells. 5-iodine-2 '-deoxyuridine can inhibit the replication of certain DNA viruses by interfering with DNA synthesis. Scientists use this to deeply explore the infection and reproduction process of viruses and try to develop new antiviral drugs. For example, for DNA viruses such as herpes virus, by studying its impact on virus replication, it shines a light on the creation of antiviral drugs.
Third, it plays an important "role" in the experimental operation of molecular biology. It can be used as a marker, with the help of radioactive iodine-labeled 5-iodine-2 '-deoxyuridine, which can track DNA synthesis and cell proliferation. It is like lighting a light for cell activity in the dark, allowing researchers to observe the growth, differentiation and other processes of cells under different conditions, and gain a deeper understanding of cell life history and regulatory mechanisms.
What is the preparation method of 4-amino-1- (2-deoxypentofuranosyl) -5-iodopyrimidin-2 (1h) -one?
4 - amino - 1 - (2 - deoxypentofuranosyl) - 5 - iodopyrimidin - 2 (1H) - one, that is, 4 - amino - 1 - (2 - deoxypentofuranosyl) - 5 - iodopyrimidine - 2 (1H) - one, the preparation method of this product, let me describe in detail.
To prepare this product, it is often the way of chemical synthesis. Initially, suitable starting materials are selected, such as pyrimidine compounds with specific structures and glycosylation reagents. The pyrimidine derivative can first interact with the glycosylation reagent under specific conditions to construct the connection between the glycosyl group and the pyrimidine. This step requires attention to the reaction conditions, such as temperature and solvent selection. Too high or too low temperature may affect the rate of the reaction and the selectivity of the product; the polarity and solubility of the solvent also have a significant impact on the reaction process.
After the glycosyl-pyrimidine structure is constructed, it is often necessary to modify it to introduce the desired 4-amino and 5-iodine groups. The introduction of 4-amino groups can be achieved by nucleophilic substitution or other suitable reaction mechanisms using amino-containing reagents. In this process, the reaction conditions need to be carefully adjusted to avoid side reactions, such as excessive substitution of amino groups or other check point reactions.
The introduction of 5-iodine groups is often achieved by iodizing reagents. In this step, the activity and selectivity of the reaction need to be carefully controlled to prevent deviation of iodization position or excessive iodization phenomenon.
After the reaction is completed, the product often needs to be separated and purified. Chromatography, such as silica gel chromatography column, can be used to separate the product from the impurity by the difference in the partition coefficient between different compounds in the stationary phase and the mobile phase. The method of recrystallization can also be used to achieve the purpose of purification according to the different solubility of the product and impurities in specific solvents with temperature. Through this series of operations, pure 4-amino-1- (2-deoxypentanosyl) -5-iodopyrimidine-2 (1H) -one can be obtained.
What are the physicochemical properties of 4-amino-1- (2-deoxypentofuranosyl) -5-iodopyrimidin-2 (1h) -one?
4 - amino - 1 - (2 - deoxypentofuranosyl) -5 - iodopyrimidin - 2 (1H) -one is also an organic compound. Its physical and chemical properties are quite important, let me describe them in detail for you.
Looking at its physical properties, the shape of this substance often needs to be carefully studied. It is either crystalline or powdered, which is related to its microstructure and intermolecular forces. Its color is either white like snow or slightly yellowish, which is determined by impurities and its own structure. As for the melting point, it is one of the inherent properties of the substance, which can vary slightly due to different purity. When heated to the melting point of this compound, the lattice structure disintegrates and changes from solid to liquid. This phase transition process is of great significance for its identification and purity determination.
When it comes to chemical properties, the compound is rich in many active check points. The presence of amino groups makes it alkaline, which can neutralize with acids to form corresponding salts. The furan glycosyl part has the characteristics of sugars and can participate in many glycosylation reactions, such as glycosylation reactions. The 5-position iodine atom has high activity and is prone to substitution reactions. Under appropriate conditions, the iodine atom can be replaced by other functional groups, resulting in a series of compounds with different structures, providing many possibilities for organic synthesis. The pyrimidine ketone ring is the core structure of this compound. Its conjugate system endows the molecule with certain stability, but it also affects its reactivity and exhibits unique properties in electrophilic substitution and nucleophilic substitution reactions. The solubility of this compound in different solvents is also different, which has guiding value for its separation, purification and choice of reaction conditions.
4-Amino-1- (2-deoxypentofuranosyl) -5-iodopyrimidin-2 (1h) -one What are the precautions during use?
4 - amino - 1 - (2 - deoxypentofuranosyl) - 5 - iodopyrimidin - 2 (1H) - one, this is a rather complex chemical substance, and many matters need to be paid attention to when applying.
Bear the brunt, safety is the key. Due to its chemical properties, it may be potentially toxic and irritating. When operating, be sure to wear protective equipment, such as gloves, goggles, protective clothing, etc., to prevent direct contact with the skin and eyes, avoid inhalation of its dust or volatile gases, and prevent damage to the respiratory tract and body. Operate in a well-ventilated environment, it is best to have a fume hood to discharge possible harmful gases in time.
Furthermore, precisely control the dosage. The required dosage of this substance varies greatly in different reactions or application scenarios. If the dosage is too small, the reaction may not achieve the desired effect; if the dosage is too large, it will not only cause waste, but also cause side reactions, which will affect the purity and quality of the product. Therefore, before use, it is necessary to accurately weigh or measure the required dosage according to specific experimental or production requirements, with the help of accurate measurement tools, such as balances, pipettes, etc.
Storage should not be ignored. According to its nature, it should be stored in a suitable environment. Usually it should be placed in a dry and cool place, away from fire sources and oxidants. Some light-sensitive substances should also be stored in brown bottles to prevent light from decomposing and deteriorating. Regularly check the storage conditions and the state of the substance. If there is any abnormality, deal with it in time.
In addition, the use process requires strict reaction conditions. Factors such as temperature, pH value, reaction time, etc., will have a significant impact on the reaction process and results. If the temperature is too high or too low, or the reaction rate is abnormal, it will affect the formation of products. Therefore, it is necessary to precisely regulate and monitor the reaction conditions with the help of thermometers, pH meters and other instruments to ensure that the reaction is carried out in the best state.
After use, properly dispose of the remaining substances and waste. It should not be discarded at will, and it should be sorted and collected and treated according to relevant environmental protection regulations. For waste containing this substance, a specific treatment process may be required to reduce the harm to the environment.
