What is the chemical structure of 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidin-2-one?

This is an organic compound with a complex chemical structure. According to its name "4-amino-1 - [ (2r, 3s, 4r, 5r) - 3-fluoro-4-hydroxy-5 - (hydroxymethyl) oxolan-2 - yl] - 5 - iodopyrimidin-2 - one", its structure can be estimated.

"4-amino" indicates that there is an amino group attached at the 4th position of the pyrimidine ring; "1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl]" means that at the 1st position of the pyrimidine ring there is a five-membered furan sugar ring structure defined by a specific stereoconfiguration (2r, 3s, 4r, 5r). This sugar ring has a fluorine atom at the 3rd position, a hydroxyl group at the 4th position, and a hydroxymethyl group at the 5th position; "5 - iodopyrimidin - 2 - one" indicates that in the pyrimidin The fifth position of the pyrimidine ring contains an iodine atom and the second position is a carbonyl group.

In summary, the structure of this compound is composed of a pyrimidine ring containing a specific substituent and a furan sugar ring with a specific stereo configuration and substituent. Each substituent at the corresponding position endows the compound with unique chemical properties and spatial structure.

What are the physical properties of 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidin-2-one?

4 - amino - 1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl] - 5 - iodopyrimidin - 2 - one is an organic compound. The physical properties of this compound are as follows:
Its shape or white to quasi-white crystalline powder, because many nucleoside compounds with similar structures are in this shape. From the melting point point point perspective, such nucleoside derivatives often have a specific melting point range. It is inferred that the melting point of this substance may be within a certain range, but the exact value needs to be determined experimentally and accurately. In terms of solubility, in view of the hydrophilic groups such as hydroxyl and amino groups in its molecules, it may have a certain solubility in polar solvents such as water, methanol, and ethanol, among which the solubility in water may be relatively considerable due to the formation of hydrogen bonds between molecules and water molecules; in non-polar solvents such as n-hexane and toluene, the solubility may be very small, because the molecular polarity is quite different from that of non-polar solvents, following the principle of "similar miscibility".
The density of this substance is also an important physical property. Although it is difficult to predict with certainty, it can be roughly inferred from its molecular structure and atomic weight. Since the molecule contains atoms such as fluorine and iodine, the atomic weight is large, and the molecular structure is compact, and the density may be relatively high.
Its stability is better under conventional conditions, but in strong acid and alkali environments, amide bonds, glycosidic bonds, etc. in the molecule may be affected, triggering reactions such as hydrolysis; light and high temperature conditions may also cause it to decompose or change isomerization, because some chemical bonds in the molecule can be excited to break or rearrange under the action of light energy and heat energy.

What are the main uses of 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidin-2-one?

4 - amino - 1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl] - 5 - iodopyrimidin - 2 - one is an organic compound with a wide range of main uses. This compound is of great significance in the field of pharmaceutical research and development, or can be used as a key component of antiviral drugs. Due to its unique combination of groups in the structure, it may have a significant inhibitory effect on the replication mechanism of specific viruses.

It also plays a key role in the creation process of nucleoside drugs. Nucleoside analogues are often used to interfere with the synthesis and metabolism of viral nucleic acid, and the specific three-dimensional configuration of this compound and substituents such as fluorine atoms and iodine atoms may enhance its affinity with virus-related enzymes, thereby more effectively blocking the reproduction path of viruses.

Furthermore, in the exploration of cancer therapeutic drugs, it may be able to exert potential anti-cancer activity by affecting the nucleic acid metabolism process related to cell proliferation. Researchers can modify and optimize its structure to develop anti-cancer drugs with better efficacy and milder side effects. At the scientific level, it can also be used as a chemical tool to help scientists delve deeper into the biosynthetic pathways of nucleic acids and the mechanisms of action of related enzymes, contributing to basic research in life sciences.

What are the synthesis methods of 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-iodopyrimidin-2-one?

To prepare 4 - amino - 1 - [ (2r, 3s, 4r, 5r) -3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl] -5 - iodopyrimidin - 2 - one, there are many methods, as described below.

One can be started from a specific glycosyl derivative. First, take the sugar with a suitable configuration and modify it in several steps to introduce the desired substituent at a specific position in the sugar ring. For example, by nucleophilic substitution reaction, fluorine atoms and hydroxyl groups are introduced at the appropriate check point of the sugar ring to obtain key glycosyl intermediates. Then the intermediate is reacted with a reagent containing iodine and pyrimidinone structure, or through a series of steps such as condensation and cyclization, the glycosyl group is partially connected to the pyrimidinone to build the basic structure of the target product. However, this process requires fine regulation of the reaction conditions to ensure the correct configuration and selectivity of the reaction.

Second, the pyrimidinone matrix can also be started. The pyrimidinone ring is modified first, and iodine atoms are introduced at a suitable position, and then, by reacting with a reagent containing a suitable glycosyl fragment. This glycosyl fragment needs to be prepared in advance, and it needs to have an activity check point connected to the pyrimidinone ring through a multi-step reaction, and the configuration of the glycosyl group meets the requirements of the target When the reaction between the two, the reaction solvent, temperature, catalyst and other conditions need to be optimized to make the reaction proceed smoothly in the direction of generating the target product, so as to obtain 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5 -iodopyrimidin-2-one.

Third, a convergent synthesis strategy can be considered. Fragments containing pyrimidinone core structure and active reaction check point, and fragments containing specific sugar groups and can be reacted with, respectively. Then, the two fragments are linked under suitable conditions. The advantage of this strategy is that each fragment can independently optimize the synthesis route and improve the overall synthesis efficiency. However, the linking reaction requires quite high, and precise control is required to make the two fragments join in a predetermined way and ensure that the stereochemical configuration of the glycosyl group is not affected, so as to successfully prepare the target product.

What are the safety precautions -5-iodopyrimidin-2-one 4-amino-1- [ (2r, 3s, 4r, 5r) -3-fluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl]?

4 - amino - 1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl] - 5 - iodopyrimidin - 2 - one is a chemical, related to the safety precautions of this thing, let me elaborate.

Bear the brunt, because it is a chemical, be sure to wear appropriate protective equipment when operating. This protective equipment should contain laboratory clothes to protect the clothes from stains and chemical erosion; wearing gloves can prevent direct contact between the skin of the hands and the substance, but it is necessary to pay attention to whether the material of the gloves is suitable to prevent corrosion and failure; goggles are also indispensable, because the eyes are fragile, if the substance is accidentally splashed, it may cause serious damage.

Furthermore, the environment in which the operation is located is extremely critical. It should be carried out in a well-ventilated place, and the best choice is in a fume hood. Good ventilation can disperse possible volatile chemical gases in time, reduce their concentration in the air, and avoid the operator from inhaling harmful gases, causing respiratory damage, or even causing more serious health problems.

The storage of this chemical substance also needs to be treated with caution. When following specific storage conditions, it may need to be stored at low temperature, dry, and protected from light. Low temperature can inhibit its chemical reactivity, dry environment can prevent it from deteriorating due to moisture absorption, and dark can avoid reactions such as decomposition caused by light. When storing, make sure that the container is well sealed to prevent leakage, and store it separately from other chemicals to prevent mutual reaction.

In terms of waste disposal, it must not be discarded at will. It needs to be properly disposed of in accordance with local regulations and laboratory regulations. Or it needs to be collected centrally and treated harmlessly by professional institutions. It must not be dumped into sewers, etc., so as not to pollute the environment and endanger the ecology.

In the process of using this substance, once it comes into contact with skin or eyes, be sure to rinse it with plenty of water immediately. If you still feel unwell after rinsing, seek medical attention promptly. If inhaled, move quickly to fresh air, and if symptoms persist, seek medical attention.

Operation 4 - amino - 1 - [ (2r, 3s, 4r, 5r) - 3 - fluoro - 4 - hydroxy - 5 - (hydroxymethyl) oxolan - 2 - yl] - 5 - iodopyrimidin - 2 - one Be careful and follow safety procedures to ensure your own safety and environmental safety.