As a leading 4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-amino-3-iodo-1h-pyrazolo [3,4-d] pyridine?
4-Amino-3-iodo-1H-pyrazolo [3,4-d] pyridine is one of the organic compounds. Its chemical structure is unique and derived from the core skeleton of pyrazolopyridine.
In terms of its name, "4-amino" means that there is an amino group (-NH ²) attached to the 4 positions of the pyrazolopyridine skeleton. The amino group has the property of electrons, which can affect the electron cloud distribution and chemical activity of this compound. It plays a key role in many chemical reactions such as nucleophilic substitution and redox. " 3-Iodo "indicates that there are iodine atoms (-I) connected at the 3-position, and the iodine atoms are relatively large. The introduction of iodine atoms can change the spatial structure and electronic effects of molecules, and iodine atoms can participate in coupling reactions, etc., which is of great significance for the construction of more complex organic molecules. The pyrazolo [3,4-d] pyridine skeleton referred to in" 1H-pyrazolo [3,4-d] pyridine "is formed by fusing the pyrazolo ring with the pyridine ring, and the fusing of the two gives the compound unique aromaticity and stability. The electronic properties of the pyrazolo ring and the pyridine ring blend with each other, giving this skeleton special chemical and physical properties.
With this structure, 4-amino-3-iodo-1H-pyrazolo [3,4-d] pyridine may have potential applications in medicinal chemistry, materials science and other fields. In medicinal chemistry, its special structure can interact with bioactive molecules to develop new drugs; in materials science, or due to its unique electronic structure and stability, it has emerged in organic semiconductor materials.
What are the main physical properties of 4-amino-3-iodo-1h-pyrazolo [3,4-d] pyridine?
4-Amino-3-iodo-1H-pyrazolo [3,4-d] pyridine is an organic compound. Its main physical properties are as follows:
In appearance, it is often in a solid state, mostly powdered or crystalline. Due to the interaction between molecules, such as hydrogen bonds and van der Waals forces, the molecules are arranged in an orderly manner, and then a solid state structure is formed.
In terms of melting point, the compound has a specific melting point. The value of the melting point depends on the strength of the intermolecular force. The interaction between the amino groups, iodine atoms and the structural units of pyrazolopyridine in the molecule jointly determines the melting point. The exact melting point needs to be determined experimentally, but it can be inferred that it is in a certain temperature range. Due to the inclusion of heteroatoms and conjugated systems, the intermolecular force is enhanced, so the melting point may not be low.
In terms of solubility, the solubility in water is poor. Although there are amino groups in the molecule that can form hydrogen bonds with water, the overall molecular conjugate system is large, and the iodine atom is a hydrophobic group, resulting in stronger hydrophobicity than hydrophilicity. However, it may have good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. Dichloromethane can provide a certain non-polar environment and interact with the non-polar part of the molecule; the polarity of DMF matches the polar groups in the molecule, which can promote the dissolution of the compound through solvation.
In addition, the compound can react with acids because it contains amino groups, which can also affect its physical properties. For example, under different pH environments, its existence form or changes, which in turn affects solubility and other properties. At the same time, iodine atoms and conjugate structures endow it with certain photophysical properties, and under specific conditions, it may be able to absorb or emit light of specific wavelengths.
What are the common synthesis methods 4-amino-3-iodo-1h-pyrazolo [3,4-d] pyridine
The common synthesis methods of 4-amino-3-iodine-1H-pyrazolo [3,4-d] pyridine are described in ancient texts in about 500 words.
To obtain 4-amino-3-iodine-1H-pyrazolo [3,4-d] pyridine, there are three common synthesis methods. First, it starts with a nitrogen-containing heterocycle and is prepared by multi-step reaction. First, a suitable pyridine derivative is taken, and a halogen atom, such as an iodine atom, is introduced at a specific position by halogenation. Then, an amination reagent is used to replace the amino group in the appropriate position to obtain the target. This process requires fine regulation of reaction conditions. Temperature, pH, and reaction time are all critical. If there is a slight difference in pooling, the product may be impure or the yield may be low.
Second, the method of cyclization is adopted. Select the appropriate bifunctional compound, and its structure needs to contain elements that can form a pyrazole-pyridine ring. Under suitable catalyst and reaction environment, intramolecular cyclization occurs. For example, compounds containing nitrogen and carbon double bonds undergo complex cyclization rearrangement under the action of metal catalysts to form a pyrazole-pyridine skeleton, and then undergo iodine and amination modifications to obtain the product. This approach requires a high understanding of the purity of the raw material and the reaction mechanism, but if properly operated, the yield and purity can be observed.
Third, with the help of solid-phase synthesis method. The starting material is fixed on the solid-phase carrier, and various reactions are carried out in sequence, such as coupling, substitution, etc. After each step of the reaction, impurities can be removed by simple washing, filtration, etc. After the series of reactions is completed, the product is cleaved from the carrier. The advantage of this method is that it is simple to operate, easy to automate, and the product separation and purification is relatively convenient, which can improve the synthesis efficiency and product purity, and is especially valuable for large-scale preparation or high-throughput synthesis.
4-amino-3-iodo-1h-pyrazolo [3,4-d] pyridine is used in which areas
4-Amino-3-iodine-1H-pyrazolo [3,4-d] pyridine, this compound has applications in medicine, materials and other fields.
In the field of medicine, it may be used as a pharmaceutical intermediate to help create new drugs. Due to its unique chemical structure, it can interact with specific biological targets and show therapeutic potential for specific diseases. For example, in the development of anti-tumor drugs, the structure of the compound can be modified to enhance its targeting and inhibitory activity against tumor cells, so as to achieve the purpose of efficient treatment of tumors. Furthermore, in the field of antiviral drugs, it is also possible to develop therapeutic drugs targeting specific viruses by virtue of their structural properties.
In the field of materials, 4-amino-3-iodine-1H-pyrazolo [3,4-d] pyridine can be used to prepare functional materials. Because its structure contains special groups, it may endow the material with unique electrical and optical properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials, introducing it into the material structure may improve the luminous efficiency and stability of the material, thereby improving the performance of OLED devices. In addition, in terms of sensor materials, the interaction characteristics with specific substances may be used to prepare sensor materials with high sensitivity to specific substances.
In conclusion, the unique structure of 4-amino-3-iodine-1H-pyrazolo [3,4-d] pyridine has broad application prospects in the fields of medicine and materials. With the deepening of research, it is expected to generate more innovative results.
What is the market outlook for 4-amino-3-iodo-1h-pyrazolo [3,4-d] pyridine?
The 4-amino-3-iodo-1H-pyrazolo [3,4-d] pyridine is also an organic compound. In today's market prospects, it is quite promising.
Looking at the field of medicine, this compound shows unique potential. Due to its nitrogen-containing heterocyclic structure, it has a variety of biological activities. Studies have shown that it may be used as a key intermediate for the synthesis of new drugs. Nowadays, there is a growing demand for novel active molecules in pharmaceutical research and development. Due to its special structure, 4-amino-3-iodo-1H-pyrazolo [3,4-d] pyridine may open up a new path for the creation of anti-malarial, anti-cancer and other drugs. With the development of precision medicine, the demand for compounds with specific structures and activities is increasing. This compound is expected to fit this trend and occupy a place in the future pharmaceutical market.
Re-examine the field of materials science. Organic electronic materials are developing rapidly, and compounds containing iodine and nitrogen heterocycles may emerge in the preparation of organic semiconductor materials due to their unique electronic properties. 4-amino-3-iodo-1H-pyrazolo [3,4-d] pyridine may be suitably modified and applied to devices such as organic Light Emitting Diode (OLED) and organic field effect transistor (OFET), injecting new force into the research and development of high-performance organic electronic devices. In addition, scientific research has not only explored new functional materials, but this compound also has broad development space in the materials market.
However, its marketing activities also face challenges. The synthesis process is complex and the cost remains high, limiting its large-scale production and application. And related research is still in the development stage, and many properties and applications need to be further explored. Only by overcoming the synthesis problems, reducing costs, and deepening the understanding of its properties and applications can 4-amino-3-iodo-1H-pyrazolo [3,4-d] pyridine shine in the market and be widely used in the fields of medicine and materials.