4 Amino 3 Iodoanisole

4-Amino-3-iodoanisole, Chinese name 4-amino-3-iodoanisole, is an organic compound that has important uses in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate for synthesizing drugs. The presence of anisole structure and amino and iodine atoms endows the compound with unique chemical activity and spatial structure, and can be chemically modified to construct a variety of bioactive molecules. For example, when developing antibacterial and antiviral drugs, its structural properties can be used to design molecules that interact with specific targets of pathogens for therapeutic purposes.
Second, in the field of materials science, it also has applications. With its special structure, it can participate in the preparation of materials with special optoelectronic properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, this compound structural unit can be introduced, or the material energy level structure can be adjusted to improve the luminous efficiency and color purity, thereby improving the display performance of OLED.
Third, in the field of organic synthetic chemistry, 4-amino-3-iodoanisole is an important synthetic building block, which can construct more complex organic molecular structures through various chemical reactions, such as coupling reactions, substitution reactions, etc. Chemists can precisely design and synthesize organic compounds with specific functions and structures by using the activities of amino and iodine atoms according to their needs, providing an important material basis for the development of organic synthetic chemistry.

The synthesis method of 4-amino-3-iodoanisole, let me tell you.
First, it can be prepared by reduction of 3-iodine-4-nitroanisole. First take an appropriate amount of 3-iodine-4-nitroanisole and place it in a suitable reaction vessel. Metal zinc powder and dilute hydrochloric acid are used as reducing agents. This is a commonly used method. Slowly add dilute hydrochloric acid to the zinc powder mixture containing 3-iodine-4-nitroanisole, and control the reaction temperature to a mild range, about room temperature, to prevent side reactions from breeding. During the reaction, the phenomenon is closely observed. After the reaction is completed, the product can be purified by conventional separation means, such as extraction, distillation, etc., to obtain 4-amino-3-iodoanisole.
Second, 4-methoxyaniline is used as the starting material. Protect its amino group first to prevent the overreaction of the amino group in the subsequent reaction. Often protect the amino group with acetyl group, take 4-methoxyaniline, and react with an appropriate amount of acetic anhydride under the catalysis of pyridine to obtain N-acetyl-4-methoxyaniline. Then, the product is reacted with iodine and a suitable oxidant, such as hydrogen peroxide, under mild conditions to achieve iodization and generate N-acetyl-4-methoxy-3-iodoaniline. Finally, hydrolysis in a dilute acid solution, deacetyl protection, and separation and purification steps can also obtain 4-amino-3-iodoanisole.
Furthermore, the aryl diazonium salt route can also be considered. 4-methoxy-3-aminobenzoic acid reacts with sodium nitrite under acidic conditions to obtain diazonium salts. Subsequently, potassium iodide is added, and a Sandmeier reaction occurs. The diazo group is replaced by an iodine atom to obtain 4-methoxy-3-iodobenzoic acid. Then the carboxyl group is converted into a methoxy group by an appropriate method, such as first converting the carboxyl group into an acid chloride, and then reacting with sodium methoxide, and finally the target product 4-amino-3-iodoanisole can be obtained. Careful control of conditions is required at each step of this process to improve yield and purity.

4-Amino-3-iodoanisole is one of the organic compounds. Its physical properties, first of all, in terms of appearance, at room temperature, are mostly white to light yellow crystalline powders. This state is easy to observe, and its quality is fine to the naked eye.
As for the melting point, it is about a specific temperature range, which is one of the important indicators for identifying the compound. Due to the different melting points of different compounds, the melting point of 4-amino-3-iodoanisole is just like its unique imprint. The melting point of 4-amino-3-iodoanisole is often accurately determined by a melting point meter in the laboratory. By observing the critical temperature at which the substance gradually melts from a solid state to a liquid state, its melting point is determined.
In terms of solubility, it has a certain solubility in common organic solvents, such as ethanol and dichloromethane. Ethanol is a common organic solvent, and the molecule has polarity. The structure of 4-amino-3-iodoanisole makes it form a certain force with ethanol molecules, so it can be soluble in it. In water, its solubility is relatively limited, because the polarity of water and the structure of the compound have a weak effect.
In addition, its density is also an important physical property. The determination of density is related to many practical applications. In the system of synthetic reactions, density affects the mixing ratio and distribution of substances, which in turn affects the reaction process.
Because of its special functional groups such as iodine, amino group and methoxy group, its physical properties are unique. The introduction of iodine atoms increases the relative mass and steric resistance of molecules, which affects the properties of melting point and density. Amino groups have certain alkalinity and can react with acids, which also indirectly affects their physical performance in different environments. The existence of methoxy groups also changes the electron cloud distribution and polarity of molecules, thus affecting the solubility and other properties.
The physical properties of 4-amino-3-iodoanisole are determined by their molecular structure, and the properties are interrelated. They are of great significance in many fields such as organic synthesis and drug development, laying the foundation for subsequent research and application.

4-Amino-3-iodoanisole is on the market, and its price range is difficult to determine. The price of this substance often changes for many reasons.
First, the price of raw materials is very related. If the price of the raw material used in the synthesis of this 4-amino-3-iodoanisole is high, the price of 4-amino-3-iodoanisole will increase. If the raw material is not easy to obtain, or its supply is scarce, the price can be increased.
Second, the method of preparation also has an impact. If the preparation process is complicated, requires many steps, and each step requires precise operation, and the equipment used also needs to be sophisticated, the preparation cost will increase greatly, and the price in the market will also be high. And if there is a new way to simplify the process and reduce the cost, the price may be reduced.
Third, the supply and demand of the market is a key factor. If there are many people looking for 4-amino-3-iodoanisole, but the supply is limited, the so-called supply is in short supply, the price will rise. On the contrary, if the market is flooded with this product, the demand is meager, and the supply exceeds the demand, the price will tend to drop.
Fourth, the price varies depending on the manufacturer. Due to the benefits of scale, the cost of large producers may be reduced, and the price may be competitive. For small producers, or due to low production and high cost, the price may be higher.
In summary, the market price of 4-amino-3-iodoanisole ranges from a few yuan to a few tens of yuan per gram, but this is only a rough estimate. The actual price should be determined in detail according to real-time market conditions and the above reasons.

4-Amino-3-iodoanisole is one of the organic compounds. Its storage conditions are crucial, which is related to the stability and quality of this substance.
The cover should be stored in a cool place because it has certain chemical activity. If placed in a high temperature, it may cause molecular movement to intensify, triggering chemical reactions and damaging its structure and properties. In a cool place, the temperature is low and molecular activity is weak, which can keep it stable.
And it must be placed in a dry place. If this compound encounters water vapor or reacts with water, it will deteriorate. Water may break chemical bonds and change the composition, so it is important to avoid water and moisture.
Furthermore, it should be stored in a closed container. Oxygen, carbon dioxide and other gases in the air may interact with 4-amino-3-iodoanisole. Oxygen can cause oxidation, and carbon dioxide or participate in chemical reactions are not conducive to its preservation. A closed container can prevent the intrusion of external gases and maintain its chemical purity.
In addition, the storage place should be away from fire sources and strong oxidants. This compound may be flammable and will burn in case of fire, causing danger. Strong oxidants can also react violently with it, causing explosions and other disasters. Therefore, the choice of storage environment should not be careless, and all factors should be taken into account to ensure the quality and safety of 4-amino-3-iodoanisole.