4 Amino 3 Iodopyridine

4-Amino-3-iodopyridine is an organic compound with a wide range of uses and is of great significance in the field of medicinal chemistry.
First, in drug development, this compound can be used as a key intermediate. Because its structure contains amino and iodine atoms, it endows unique reactivity and chemical properties. Taking the development of antibacterial drugs as an example, amino groups can interact with specific biological targets, while iodine atoms can regulate the lipophilicity and electron cloud distribution of molecules, optimize the binding ability of drugs to targets, and enhance antibacterial activity. In the creation of many new antibacterial drugs, 4-amino-3-iodopyridine is often used to build the core structure, and then subsequent modifications can improve the efficacy and selectivity of drugs.
Second, in the field of materials science, this compound has also made its mark. Due to its special structure, it can participate in the synthesis of materials with specific photoelectric properties. In the synthesis of organic Light Emitting Diode (OLED) materials, 4-amino-3-iodopyridine is used as the basic structural unit to regulate the luminous color and efficiency of the material. By rationally designing the molecular structure, using the characteristics of amino and iodine atoms, the electron transport and luminescence properties of the material can be optimized, providing the possibility for the preparation of high-performance OLED materials.
Third, in organic synthetic chemistry, 4-amino-3-iodopyridine is a commonly used synthetic block. Amino groups can undergo a variety of classical reactions, such as amidation, alkylation, etc.; iodine atoms are prone to nucleophilic substitution and coupling reactions. With the help of these reactions, chemists can use this as a starting material to construct complex and diverse organic compounds, providing an important material basis for the development of organic synthetic chemistry and helping to explore the synthesis paths and methods of new organic molecules.

To prepare 4-amino-3-iodopyridine, there are many methods, and the following are common synthesis routes.
First, 3-iodopyridine is used as the starting material. First, 3-iodopyridine is reacted with an appropriate protective group to protect a specific position on the pyridine ring to prevent subsequent reaction interference. Then, the protected 3-iodopyridine is reacted with ammonia under suitable conditions. This ammonia source can be selected from ammonia gas, ammonia water or other amino-containing reagents. During the reaction, factors such as temperature, pressure and reaction time should be paid attention to. For example, under high temperature and pressure, a metal catalyst is used to promote the nucleophilic substitution of ammonia at a specific position on the pyridine ring, and an amino group is successfully introduced. After the reaction is completed, the protective group is carefully removed to obtain 4-amino-3-iodopyridine. This process requires fine operation to avoid damaging the structure of the product.
Second, start from 4-aminopyridine. First protect the amino group of 4-aminopyridine to prevent it from overreacting in the iodization reaction. Next, select suitable iodization reagents, such as iodine elemental substance, N-iodosuccinimide (NIS), etc., and iodize the pyridine ring in the presence of appropriate solvents and catalysts. The iodization reaction conditions need to be precisely regulated to ensure that iodine atoms are mainly introduced into the 3-position. After the iodization reaction is completed, the amino protecting group is removed, and the target product 4-amino-3-iodine is obtained through separation and purification steps.
Third, using pyridine derivatives as raw materials, the target molecule is constructed through multi-step reaction. First, the pyridine derivative is functionally converted to construct a pyridine intermediate containing suitable substituents. Then, through a series of nucleophilic substitution, redox or other organic reactions, amino and iodine atoms are gradually introduced at specific positions. This route requires a deep understanding of the order and conditions of organic synthesis reactions, and careful design of each step to improve the yield and purity of the target product.
Each synthesis method has its own advantages and disadvantages. In actual operation, the best synthesis strategy should be selected according to factors such as raw material availability, cost, feasibility of reaction conditions and purity requirements of target products.

4-Amino-3-iodopyridine is an organic compound with specific physical properties. It is mostly solid at room temperature, and the melting point is relatively high because the molecule contains amino groups and pyridine rings, or can form hydrogen bonds. Although no exact melting point data has been reported, compounds with similar analogical structures may be between tens and two hundred.
This compound has limited solubility in water because the pyridine ring and the iodine atom have certain hydrophobicity, but the amino group can form hydrogen bonds with water to increase its water solubility to a certain extent. In organic solvents, such as dichloromethane, chloroform, ethanol, etc., the solubility may vary depending on the force between the solvent and the compound. In polar organic solvents ethanol, because it can form hydrogen bonds with amino groups, the solubility may be relatively good.
4-amino-3-iodopyridine has hygroscopicity, because the amino group can form hydrogen bonds with water molecules in the air, and it should be stored with moisture protection. Its appearance may be white to light yellow crystalline powder, and the color may change due to impurities or crystal forms. Due to the iodine atom, the molecular weight increases, and the density may be higher than that of ordinary pyridine compounds, but there is no exact density value. In addition, the compound has certain stability, but under extreme conditions such as strong acid, strong base or high temperature, the structure may be changed due to chemical reactions.

4-Amino-3-iodopyridine is one of the organic compounds. Its chemical properties are unique and of great research value.
In this compound, the electron cloud density distribution of the pyridine ring connected by the amino group and the iodine atom is changed due to the characteristics of the two. The amino group has the characteristics of the electron supplier, which can increase the electron cloud density of the adjacent and para-position of the pyridine ring, while the iodine atom is a halogen atom, but has a weak electron-absorbing effect. In this way, the interaction between the two affects the reactivity and selectivity of the compound.
In the electrophilic substitution reaction, due to the influence of the amino power supplier, the reaction check point tends to the amino o and para-position. For example, when the electrophilic substitution such as halogenation and nitrification occurs, the reagent is more likely to attack this position.
Its amino group is weakly basic and can react with acids to form corresponding salts. This property can be used in organic synthesis to separate and purify the compound, or under specific reaction conditions, its solubility and reactivity can be changed by salting.
Iodine atoms have certain reactivity due to relatively low C-I bond energy. Under suitable reaction conditions, iodine atoms can be replaced by nucleophiles and participate in various organic synthesis reactions, such as Ullman reaction, Suzuki reaction, etc., to construct various carbon-carbon bonds or carbon-hetero bonds, providing an important way for the synthesis of complex organic molecules. 4-Amino-3-iodopyridine is widely used in medicinal chemistry, materials science and other fields due to its unique chemical properties. It is a valuable intermediate in organic synthesis.

4-Amino-3-iodopyridine is also a thing of transformation. If you want to know the market, you can't make it easy. The situation is influenced by factors like a boat traveling on waves, fluctuating.
First, the main reason for the land. If you come from a place of wealth, the raw materials are easy to obtain, the workmanship is skilled, and the quality is cheap; if the land is remote, the raw materials are not available, and the quality is not high.
Second, the supply and demand are also low. If the world is seeking this thing, and the quantity is limited, if you want it, you will eat it, and the price will be high; on the contrary, if the supply is high and the demand is high, the price will be low, and the price will be flat.
Third, the quality of the degree is low, and the price will be high. Those with high quality are like fine gold and beautiful jade, and those with low quality are slightly like jade, which is easy to obtain, and they are also relatively cheap.
Also, the market is often different, yesterday was and now is not. If you want to know the exact size of the grid, you can only omit the approximate. However, this information also needs to be updated before you can get it.