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What are the chemical properties of 4-amino-5-iodo-2 (1h) -pyrimidinone?
4-Amino-5-iodo-2 (1H) -pyrimidinone is an organic compound. It has unique chemical properties and is related to many chemical reactions and uses.
In terms of physical properties, this substance may be a solid under normal conditions. Due to the presence of polar groups, it may have a certain solubility in appropriate polar solvents. Its melting point, boiling point and other properties are determined by factors such as intermolecular forces, hydrogen bonds and relative molecular mass. Amino and carbonyl groups exist in the molecule, which can form intramolecular or intermolecular hydrogen bonds, which affect its melting point, boiling point and solubility.
From the perspective of chemical properties, amino groups are alkaline and can react with acids to form salts. Under appropriate conditions, the amino group can participate in the nucleophilic substitution reaction and be replaced by other groups. The 5-position iodine atom has high activity and can participate in nucleophilic substitution, coupling and other reactions. For example, under the catalysis of palladium, it can undergo Suzuki coupling reaction with organic boric acid to form carbon-carbon bonds and generate compounds with diverse structures, which is of great significance in the field of drug synthesis and materials science. The 2-position carbonyl group can perform nucleophilic addition reactions, such as reacting with alcohols to form acetals or ketals, or reacting with amines to form imines and other derivatives.
In addition, the conjugated structure of the compound endows it with certain optical properties, or has specific absorption and emission spectra, which may have potential applications in the study of optical materials. Because pyrimidine ring is the basic building block of many bioactive molecules, this compound has attracted attention in the field of medicinal chemistry, or has biological activities such as antibacterial and antiviral, providing opportunities for the development of new drugs.
What are the common synthesis methods of 4-amino-5-iodo-2 (1h) -pyrimidinone?
4-Amino-5-iodine-2 (1H) -pyrimidinone is an important compound in organic synthesis. The common synthesis methods mainly include the following:
First, pyrimidine compounds are used as starting materials. Take a suitable pyrimidine derivative and introduce the amino group and iodine atom at a specific position under specific reaction conditions. For example, the amino group is introduced at a suitable check point on the pyrimidine ring first. This step can be achieved by nucleophilic substitution reaction, in which an amino-containing reagent reacts with the pyrimidine derivative. Under suitable base catalysis and temperature conditions, the amino group successfully replaces the corresponding group. Then, in another suitable step, iodine atoms are introduced at a predetermined position with an iodine substitution reagent through halogenation reaction, such as substitution reaction between iodine and pyrimidine derivatives under the action of specific solvents and catalysts, so as to obtain the target product.
Second, the strategy of gradually constructing pyrimidine rings is adopted. First, the basic framework of pyrimidine rings is preliminarily constructed by condensation reaction using related compounds such as nitrogen and carbonyl. For example, compounds containing amino groups and carbonyl groups are catalyzed by acids or bases to form the prototype of pyrimidine rings through condensation reactions. After that, the position on the ring is modified in sequence, and the amino group is first introduced, and suitable amination reagents and reaction conditions can be selected; then iodine atoms are introduced, and iodine atoms are introduced at the target position precisely according to the reactivity and positioning rules by the iodine substitution reaction, and finally 4-amino-5-iodine-2 (1H) -pyrimidinone is obtained.
Third, the reaction catalyzed by transition metals is catalyzed. Transition metal catalysts, such as palladium, copper and other metal catalysts, are used to catalyze the reaction of related substrates. Iodine-containing substrates and pyrimidine-containing structural fragments can be selected. Under the action of transition metal catalysts, the connection between iodine atoms and specific positions on the pyrimidine ring can be achieved through coupling reactions, etc., and the introduction steps of amino groups are optimized and adjusted. Through suitable reaction sequence and condition control, 4-amino-5-iodine-2 (1H) -pyrimidinone can be efficiently synthesized. This method is increasingly used in organic synthesis due to the high activity and selectivity of transition metal catalysts.
These common synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected according to the availability of raw materials, the difficulty of reaction conditions, and the cost.
What are the applications of 4-amino-5-iodo-2 (1h) -pyrimidinone?
4-Amino-5-iodo-2 (1H) -pyrimidinone is an organic compound that has applications in many fields.
In the field of medicinal chemistry, it is an important synthetic block. Due to the structure of pyrimidinone, which is commonly found in many bioactive molecules, 4-amino-5-iodo-2 (1H) -pyrimidinone can be chemically modified to prepare compounds with specific biological activities. For example, in the development of some anti-cancer drugs, its structure can be modified so that the obtained new compounds can specifically act on cancer cell targets and interfere with cancer cell growth and proliferation. At the same time, in the synthesis of antibacterial drugs, it can be introduced into specific structures to enhance the inhibitory effect of drugs on bacterial physiological processes and achieve antibacterial efficacy.
In the field of materials science, it also has potential applications. Because it contains specific functional groups, it can participate in the surface modification reaction of materials. For example, in the preparation of some functional films, the introduction of 4-amino-5-iodo-2 (1H) -pyrimidinone into the film structure can change the chemical and physical properties of the film surface, such as improving the hydrophilicity of the film or giving it specific optical properties. In addition, in the process of preparing new organic semiconductor materials, it may be used as a structural unit to regulate the electrical properties of materials, providing new possibilities for the development of organic electronic devices.
In the field of pesticide chemistry, this compound can be used to create new types of pesticides. By modifying its structure, highly selective and environmentally friendly insecticides can be developed. Or by changing its ability to bind to target proteins in pests, high-efficiency insecticides can be achieved, while reducing the negative impact on non-target organisms and the environment. It can also provide new ideas for herbicide research and development, and design new herbicides that target specific weeds and do not affect crop growth.
What is the market price of 4-amino-5-iodo-2 (1h) -pyrimidinone?
4-Amino-5-iodo-2 (1h) -pyrimidinone, an organic compound, is widely used in chemical, pharmaceutical and other fields. However, its market price is difficult to generalize, and many factors will affect it.
First, the cost of raw materials is the key factor. The difficulty of obtaining and fluctuating the price of the raw materials required to synthesize this compound are closely related to the price of the final product. If the raw materials are scarce or difficult to extract, the price will be high, which will cause the cost of the compound to rise, and the market price will also rise.
Second, the complexity of the production process has a great impact. If the production process requires multi-step reactions, harsh reaction conditions or special catalysts, it will undoubtedly increase the production cost, and the price will also increase. Although advanced and efficient processes can reduce costs, the upfront R & D investment is expensive, which will also be reflected in the price.
Third, the market supply and demand relationship plays a significant role. If the market demand for this compound is strong and the supply is limited, the price will naturally increase; conversely, if the supply exceeds the demand, the price will face downward pressure. If the pharmaceutical industry has a large increase in demand for drugs containing this ingredient, it will push its price up; if the emergence of new production enterprises increases the supply, the price may decrease.
Fourth, the purity and quality of the product have a great impact on the price. High-purity products are mostly used in high-demand fields such as pharmaceutical research and development, and the price is much higher than that of low-purity products. Products with strict quality inspection and few impurities are more difficult to produce and have higher prices.
Due to the complexity and variability of the above factors, it is difficult to give the exact market price. In the market, the price may vary greatly due to different suppliers, product quality and purchase quantity. Buyers need to conduct multiple surveys and discuss with suppliers in detail to obtain more accurate price information.
What are the safety and toxicity of 4-amino-5-iodo-2 (1h) -pyrimidinone?
4-Amino-5-iodo-2 (1H) -pyrimidinone is an organic compound. In terms of its safety and toxicity, many aspects need to be considered.
From the perspective of chemical structure, this compound contains iodine and amino groups. Although iodine atoms play an important role in some biological processes, the characteristics of organic iodides may cause them to exhibit special chemical activities. Amino groups can participate in many chemical reactions or interact with molecules in living organisms.
In terms of toxicity, there is currently no detailed and exact toxicity data. However, compounds with similar structures, including halogen atoms and heterocyclic structures, may have potential toxicity. For example, some iodine-containing heterocyclic compounds may interfere with the metabolic process of organisms. Or affect the activity of enzymes, because they can bind to the activity check point of enzymes and cause changes in enzyme function.
In terms of safety, necessary protective measures should be taken when handling this compound. Because its chemical properties are not completely clear, in the laboratory environment, appropriate protective equipment should be worn, such as gloves, goggles and laboratory clothes, to prevent it from coming into contact with the skin and eyes. If inhaled or ingested, it may cause unknown health problems. Caution should also be used when storing. According to its chemical properties, it should be placed under suitable conditions to prevent it from deteriorating or reacting with other substances.
In summary, the safety and toxicity of 4-amino-5-iodo-2 (1H) -pyrimidinone are uncertain due to limited research data. When handling and using, exercise caution and follow chemical safety practices to ensure the safety of personnel and the environment.
