As a leading 4-Amino-5-Iodo-7-(2-Deoxy--D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-amino-5-iodo-7- (2-deoxy--d-ribofuranosyl) -7h-pyrrolo [2,3-d] pyrimidine?
4 - amino - 5 - iodo - 7 - (2 - d eoxy - β - D - ribofuranosyl) - 7H - pyrrolo [2,3 - d] pyrimidine is a complex organic compound with a unique and delicate chemical structure.
The core of this compound is the pyrrolido [2,3 - d] pyrimidine parent nucleus, which is formed by fusing the pyrrole ring and the pyrimidine ring. It seems that the two rings are closely interdependent, forming the framework of the whole and laying the basic structure of the compound. Above the parent nucleus, there is an amino substitution at the 4 position, and the amino group is like a flexible "branch", adding activity and reaction check point. The 5-position iodine atom is substituted, and the iodine atom has a large atomic radius and electronegativity, which has a profound impact on the distribution and spatial structure of the compound electron cloud, changing its polarity, lipophilicity and other properties.
And the 7-position is connected to 2-deoxy - β - D-furan, and 2-deoxy - β - D-furan is like a delicate "accessory", which is connected to the parent nucleus through glycosidic bonds. Its furan ribose structure is a five-membered ring with a unique three-dimensional configuration. The β-configuration determines the connection direction between the sugar group and the parent nucleus. The 2-deoxy feature makes the sugar ring less than one hydroxyl group, which affects the stability and reactivity of the compound.
Overall, 4 - amino - 5 - iodo - 7- (2 - d eoxy - β - D - ribofuranosyl) - 7H - pyrrolo [2,3 - d] pyrimidine chemical structure sets a variety of groups in one, the parts of the interaction, endowing the compound with special physical, chemical and biological activities, in organic synthesis, pharmaceutical chemistry and other fields or potential application value.
What are the main physical properties of 4-amino-5-iodo-7- (2-deoxy--d-ribofuranosyl) -7h-pyrrolo [2,3-d] pyrimidine?
4 - amino - 5 - iodo - 7 - (2 - d eoxy - β - D - ribofuranosyl) -7H - pyrrolo [2,3 - d] pyrimidine is an organic compound commonly known as 5 - iodo - 2 '-deoxycytidine. This substance has many important physical properties, which are detailed as follows:
- ** Properties **: Under normal conditions, it is mostly white to off-white crystalline powder. This appearance characteristic is not only easy to distinguish, but also reflects the molecular arrangement and aggregation state, which affects its stability and reactivity in different environments.
- ** Melting point **: Melting point is about 195-199 ℃. As an important physical constant of a substance, the melting point is determined by its intermolecular forces. In this temperature range, the molecule is energized enough to overcome the lattice energy, causing the substance to change from solid to liquid state. This property is of great significance for its purification and identification.
- ** Solubility **: The compound is slightly soluble in water and has a certain solubility in organic solvents such as methanol and ethanol. Solubility is related to molecular polarity. Its molecular structure contains polar groups and non-polar parts, so its solubility varies in different polar solvents. This property is crucial for dosage form selection and drug delivery system design in drug development.
- ** Stability **: Under conventional storage conditions, the compound is relatively stable if it is protected from moisture, light and temperature is suitable. However, when exposed to strong oxidizing agents, strong acids and strong bases, chemical reactions are prone to cause structural changes. Because its structure contains active parts such as amino groups and iodine atoms, it is easy to participate in various chemical reactions, and its stability affects its storage and application.
In what fields is 4-amino-5-iodo-7- (2-deoxy--d-ribofuranosyl) -7h-pyrrolo [2,3-d] pyrimidine used?
4 - amino - 5 - iodo - 7- (2 - d eoxy - β - D - ribofuranosyl) -7H - pyrrolo [2,3 - d] pyrimidine, commonly known as iodine in Chinese, is an important nucleoside analogue. It has significant applications in the field of medicine, antiviral research and cancer treatment.
In the field of medicine, iodine glycosides mainly demonstrate antiviral efficacy. It can play a role in specific viral infections, especially herpes virus. Diseases caused by herpes viruses, such as cold sores and genital herpes, seriously affect people's health and quality of life. Iodine glycosides can be incorporated into the DNA synthesis process of viruses by virtue of their own structural characteristics, thereby interfering with the replication of viruses, effectively inhibiting the proliferation of viruses, relieving symptoms of patients, and promoting the improvement of the disease.
In the field of antiviral research, iodine glycosides are an important research tool. By exploring the mechanism of action of iodine glycosides on different viruses, researchers can gain a deeper understanding of the life cycle of viruses, DNA synthesis pathways, and the interaction between viruses and host cells. These research results not only help to develop more efficient antiviral drugs, but also lay a key theoretical foundation for understanding the pathogenesis mechanism of viruses.
In the field of cancer treatment, iodine glycosides have also emerged. The growth and proliferation of some tumor cells depend on active DNA synthesis. Iodine can interfere with the DNA synthesis process, so it has an inhibitory effect on the growth of some tumor cells. Although its effect on cancer treatment alone may be limited, when used in combination with other chemotherapy drugs, it may exhibit synergy effect, improve the effect of cancer treatment, and bring more treatment options and hope to cancer patients.
In summary, 4-amino-5-iodo-7- (2-d eoxy - β - D-ribofuranosyl) -7H-pyrrolo [2,3-d] pyrimidine has significant application value in many fields such as medicine, antiviral research and cancer treatment, and is of great significance to promote the development of related fields.
What is the preparation method of 4-amino-5-iodo-7- (2-deoxy--d-ribofuranosyl) -7h-pyrrolo [2,3-d] pyrimidine?
4 - amino - 5 - iodo - 7 - (2 - d eoxy - β - D - ribofuranosyl) - 7H - pyrrolo [2,3 - d] pyrimidine, often known as 4 - amino - 5 - iodine - 7 - (2 - deoxy - β - D - ribofuranosyl) - 7H - pyrrolido [2,3 - d] pyrimidine, this is an important nucleoside compound, widely used in the field of pharmaceutical chemistry. The preparation method is as follows:
The starting material is usually selected as a pyrimidine or pyrrole derivative with a specific structure. For example, starting with a pyrimidine derivative containing a suitable substituent, the protective group is modified at a specific position to prevent unnecessary side reactions during the reaction. This is a common strategy in organic synthesis. Subsequently, the pyrimidine derivative containing the protective group is mixed with the iodine substitution reagent under suitable solvents and reaction conditions. In this step, the selection of the iodine substitution reagent is crucial, such as the combination of iodine with an appropriate oxidizing agent, or a specific organic iodine reagent. The solvent is mostly an inert organic solvent such as dichloromethane and tetrahydrofuran, which can dissolve the reactants without interfering with the reaction process. The reaction temperature and time also need to be precisely controlled. Generally, it starts at low temperature, and then gradually heats up to a moderate temperature to achieve precise substitution of 5-position iodine atoms to obtain 5-iodine pyrimidine derivatives.
Next, carry out ribosylation reaction. Select suitable 2-deoxy - β - D-furan ribose derivatives and treat them with activators to make them more reactive. Common activators such as phosphorus oxychloride, p-toluenesulfonyl chloride, etc. The activated ribose derivatives react with the aforementioned 5-iodine pyrimidine derivatives under alkali catalysis. The type and dosage of bases have a great impact on the reaction, and commonly used bases such as potassium carbonate, sodium hydride, etc. The reaction is carried out in a specific solvent, such as acetonitrile, N, N-dimethylformamide, for the purpose of connecting to the ribose group at the 7-position.
After the reaction is completed, the product needs to be deprotected. According to the type of protecting group, select the appropriate deprotection conditions. If it is an ester protecting group, it can be hydrolyzed under basic conditions; if it is a silicon ether protecting group, it can be removed by fluoride ion reagent. After this series of reactions and separation and purification steps, such as column chromatography, recrystallization, etc., a high purity 4-amino-5-iodo-7- (2-d eoxy - β - D-ribofuranosyl) -7H-pyrrolo [2,3-d] pyrimidine can be obtained. The whole preparation process requires fine operation and strict control of the reaction conditions to obtain the product with ideal yield and purity.
What is the market outlook for 4-amino-5-iodo-7- (2-deoxy--d-ribofuranosyl) -7h-pyrrolo [2,3-d] pyrimidine?
4 - amino - 5 - iodo - 7 - (2 - d eoxy - β - D - ribofuranosyl) - 7H - pyrrolo [2,3 - d] pyrimidine is a compound with great potential. Looking at its market prospects, it is like a treasure waiting to be discovered, hidden in the secluded place of business and scientific research, waiting for the wise to explore.
This compound is emerging in the field of pharmaceutical research and development. In today's world, various diseases are raging, and the demand for medicine is urgent. Its unique structure may open up a new path for the creation of anti-cancer and antiviral drugs. Cancer is like a tiger, eating human life, and the need for antivirus is also urgent. If researchers can use it as a foundation and study it carefully, they may be able to make a miraculous medicine and save people from illness. This is also the way to go in the light of the pharmaceutical market.
In the field of scientific research and exploration, it is also a popular choice. Its molecular structure is exquisite, like a piece of a mysterious puzzle, attracting researchers to study it. Exploring its interaction with biomolecules, or exploring the secrets, or revealing a corner of the mystery of life. If the binding mode with specific proteins is analyzed, or the details of cell physiology and pathology can be understood, it will add to the building of life science. Its scientific research value is immeasurable, so the market's investment in its research resources will also rise.
Although the market is moving forward, it is not a smooth river. The difficulty of synthesis is like a mountain. To prepare a large number of products, the process needs to be tempered in every way, and the cost needs to be carefully controlled. And market competition is like a battlefield, and similar research results may come one after another. However, opportunities and challenges coexist. If we can break the barrier of synthesis and seize the market opportunity, its prospects will be like a glow, shining brightly in the pharmaceutical and scientific research markets, adding luster to human well-being.