4 Bromo 1 Iodo 2 Trifluoromethoxy Benzene

4-Bromo-1-iodine-2 - (trifluoromethoxy) benzene, an organic compound, is widely used in the field of organic synthesis.
First, it is often used in drug synthesis. When creating new drug molecules, the compound can act as a key intermediate. Because its structure contains halogen atoms (bromine and iodine) and trifluoromethoxy groups, these functional groups give it unique chemical properties. Halogen atoms can participate in many nucleophilic substitution reactions, and by reacting with other compounds containing specific functional groups, complex drug molecular structures can be constructed. The introduction of trifluoromethoxy can significantly change the physical and chemical properties of molecules, such as lipophilicity, stability, etc., which in turn affect the pharmacokinetic properties such as drug activity, absorption, distribution, metabolism and excretion.
Second, it also has important uses in the field of materials science. It can be used as a structural unit for constructing functional materials. For example, it is used to prepare organic materials with special optical and electrical properties. Due to its structural properties, the material may exhibit unique photoelectric properties, such as for the research and development of organic Light Emitting Diode (OLED) materials, photoconductor materials, etc., by participating in the reaction to construct the material structure, or to optimize the material's charge transport, luminous efficiency and other properties.
Furthermore, it is an important research object in the study of organic synthesis methodologies. Chemists use it as a substrate to explore novel reaction pathways and synthesis strategies. By studying the reaction conditions and reaction mechanisms involved in it, more efficient and green organic synthesis methods are developed, which promotes the development of organic synthesis chemistry and provides new ways and new ideas for the synthesis of more complex organic compounds.

The synthesis method of 4-bromo-1-iodine-2-trifluoromethoxy-benzene is described in detail below.
First, it can be started from a compound containing phenols. First, the phenols are reacted with trifluoromethyl halides under the action of bases to form trifluoromethoxy benzene derivatives. Bases, such as potassium carbonate and sodium carbonate, are reacted in suitable organic solvents such as N, N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO). After generating trifluoromethoxy benzene derivatives, the benzene ring is halogenated. At the time of bromination, liquid bromine can be selected, and iron powder or iron tribromide can be used as a catalyst. React in a suitable solvent, such as dichloromethane, to obtain the bromide product. Then, using iodine reagents, such as the combination of potassium iodide and hydrogen peroxide, under acidic conditions, the iodine reaction is realized to obtain 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene.
Second, the halogenated benzene derivative is used as the starting material. If the starting material is a benzene derivative containing bromine or iodine, the trifluoromethoxy group is introduced first. It can be reacted with trifluoromethyl alcohol salts in the presence of a phase transfer catalyst, such as tetrabutylammonium bromide. After that, the rest of the benzene ring is halogenated. If the starting material contains only one halogen atom, the second halogen atom is introduced first. The bromination and iodization methods are as above, and finally the trifluoromethoxy group is introduced.
Third, palladium-catalyzed cross-coupling reaction. React with trifluoromethoxy-containing phenylboronic acid derivatives with halogenated aromatics, that is, aromatics containing bromine and iodine. Palladium catalysts often use tetra (triphenylphosphine) palladium, etc., ligand can be selected from tri-tert-butylphosphine, etc., and base can be selected from cesium carbonate. 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene can also be synthesized by reacting in suitable organic solvents such as toluene and dioxane.
During the synthesis process, attention should be paid to the precise control of reaction conditions, such as temperature, reaction time, and proportion of reactants. After each step of the reaction, appropriate separation and purification methods, such as column chromatography and recrystallization, are required to improve the purity of the product and obtain the target product 4-bromo-1-iodine-2- (trifluoromethoxy) benzene.

4-Bromo-1-iodine-2- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties are unique, let me tell you in detail.
Looking at its properties, under room temperature, this substance is mostly a colorless to light yellow liquid. If it is properly refined, it may also be a white crystalline solid. The quality varies according to the preparation process and environment.
When it comes to the melting point, its melting point is about [X] ° C, and the boiling point is around [X] ° C. This melting boiling point characteristic allows this substance to maintain a relatively stable physical state within a specific temperature range. The boiling point is related to the difficulty of gasification during heating, while the melting point determines the critical temperature at which it changes from solid to liquid, both of which are of great significance in the separation, purification and application of compounds.
Again, the density is about [X] g/cm ³, which is lighter or heavier than the density of water (1 g/cm ³). This property affects its distribution in the liquid phase system and can be used as a key basis in separation operations such as extraction.
In terms of solubility, 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene is soluble in common organic solvents, such as ether, dichloromethane, chloroform, etc. However, its solubility in water is very small. Due to the strong hydrophobicity of trifluoromethoxy, bromine and iodine atoms in the molecular structure of this compound, it is difficult to form effective interactions with water molecules.
In addition, the volatility of this compound is relatively moderate, and it will evaporate slowly in an open environment. This property requires attention during storage and use. Improper storage conditions may cause it to be lost due to volatilization, or to evaporate in the air, causing environmental pollution and safety hazards.
The physical properties of this compound have a profound impact on its application in many fields such as organic synthesis, medicinal chemistry, and materials science. Only by making good use of its characteristics can it be maximized.

4-Bromo-1-iodine-2 - (trifluoromethoxy) benzene is an organic compound. Its chemical properties are interesting and it is an important object of chemical research.
Discussing the reactivity of this compound, due to the presence of bromine and iodine atoms in its structure, it can participate in the typical reaction of halogenated aromatics. Bromine and iodine atoms are active and easy to leave in nucleophilic substitution reactions, providing an opportunity for the synthesis of new compounds. For example, when they meet nucleophilic reagents such as alkoxides and amines, nucleophilic substitution can occur, resulting in the formation of corresponding ethers or amines.
Furthermore, the characteristics of trifluoromethoxy should not be underestimated. Trifluoromethoxy has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and affect the reactivity of the benzene ring. This effect not only increases the difficulty of the electrophilic substitution reaction of the benzene ring, but also reduces the electron cloud density of the ortho and para-sites more than that of the meta-sites, which in turn affects the selectivity of the reaction check point.
In terms of thermal stability, 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene is quite stable under normal conditions. In case of high temperature or specific chemical environment, the chemical bond may break and cause decomposition reaction.
In terms of solubility, since it is an organic compound, and the hydrophobic trifluoromethoxy group and halogen atoms have poor solubility in polar solvents, while in non-polar or weakly polar organic solvents, such as dichloromethane, chloroform, toluene, etc., the solubility is relatively good.
In summary, the chemical properties of 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene are determined by its structure. In the field of organic synthesis and chemistry research, with its unique properties, it plays an important role, providing possibilities for many chemical reactions and compound preparation.

The market price of 4-bromo-1-iodine-2 - (trifluoromethoxy) benzene varies depending on factors such as quality, purity, purchase quantity and suppliers, so it is difficult to determine its specific price range.
Guanfu's "Tiangong Kaiwu", although the detailed description of various process products, the chemical compounds at that time were not as common as they are today, nor did they list the price of this product. At present, this product is mostly obtained from chemical synthesis and is circulated in the chemical raw material market.
If you ask for its approximate price, the pure one is high, and the coarse one is cheap. If you buy it in small quantities, the unit price may be high; if you buy it in bulk, the price per unit is expected to drop slightly. And in different regional markets, prices also fluctuate due to differences in supply and demand. To know the exact price, you need to consult chemical raw material suppliers, chemical reagent sellers, or check in detail on the chemical trading platform to get the current exact price range.