4-Bromo-1-Iodobenzene

Fengxi Chemical

Specifications

HS Code	428905
Chemical Formula	C6H4BrI
Molar Mass	282.905 g/mol
Appearance	Colorless to light yellow liquid
Density	2.269 g/cm³
Boiling Point	248 - 250 °C
Melting Point	26 - 28 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ether, chloroform
Flash Point	110 °C
Odor	Characteristic odor
Stability	Stable under normal conditions, but light - sensitive

As an accredited 4-Bromo-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4 - bromo - 1 - iodobenzene packaged in a sealed glass bottle.
Storage	4 - bromo - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. As it is a potentially hazardous chemical, store it separately from oxidizing agents, acids, and bases to avoid reactions. Also, ensure proper labeling for easy identification and handling.
Shipping	4 - bromo - 1 - iodobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under cool, dry conditions, adhering to strict chemical shipping regulations to prevent leakage and ensure safety during transit.

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General Information

Historical Development

4 - Bromo - 1 - Iodobenzene is also an organic compound. It has gradually emerged in the field of chemistry. In the past, organic synthesis was not as developed as it is today, and chemists often encountered difficulties in trying to produce such halogenated aromatics.
At the beginning, the synthesis method was crude and simple, and the yield was quite low. As the years passed, the chemical technology advanced, and new synthesis paths gradually emerged. Chemists worked hard to explore the conditions of the reaction and the ratio of raw materials.
Since organic chemistry has flourished, the research on 4 - Bromo - 1 - Iodobenzene has also deepened. It is used in many aspects such as drug synthesis and materials science. Looking at its historical evolution, it has been unfamiliar and difficult to make at the beginning, but now it is more convenient to obtain. It is due to the hard work and unremitting efforts of chemists for generations that this achievement has been achieved, adding a touch of brilliance to the long river of chemistry.

Product Overview

4 - Bromo - 1 - Iodobenzene Product Description
There is a product today, named 4 - Bromo - 1 - Iodobenzene. Its shape is often solid, and the color is almost light to light.. The manufacture of this product is above benzene, with iodine atom at 1 position, bromine atom at 4 position, chemical formula C H BrI, molecular weight.
In terms of its properties, 4 - Bromo - 1 - Iodobenzene has a certain chemical activity. The presence of bromine iodine atoms makes it easy to In the arylation reaction, it can be filled with aryl for supply, and other active substances can be used to create new carbon-carbon or carbon-carbon atoms. And due to the different activities of bromine and iodine atoms, it can be used to synthesize the required compounds. It has an important value for the synthesis domain.

Physical & Chemical Properties

4 - Bromo - 1 - Iodobenzene is also an organic compound. Its physical and chemical properties are worth exploring. Looking at its shape, it is a colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is moderate, about a certain temperature range, due to intermolecular forces. As for solubility, it is soluble in organic solvents such as ethanol and ether, but insoluble in water, due to the difference between its molecular polarity and that of water molecules. Its chemical properties are active, and bromine and iodine atoms give it the activity of nucleophilic substitution reactions. Under appropriate conditions, it can react with many nucleophilic reagents to form new compounds. This property makes it widely used in the field of organic synthesis. It is an important intermediate for the preparation of complex organic molecules, assisting chemists in constructing diverse molecular structures and exploring the mysteries of the chemical world.

Technical Specifications & Labeling

Nowadays, there is a chemical substance called 4 - Bromo - 1 - Iodobenzene, which has attracted much attention in our chemical research. Its process specifications and identification (commodity parameters) are extremely important.
In terms of its process specifications, the synthesis method needs to be accurate. The ratio of raw materials and reaction conditions need to be carefully controlled. If the reaction temperature should be stable in a certain range, the amount of catalyst must also be appropriate to make the reaction efficient and the product pure.
As for the identification (commodity parameters), the color state of the appearance, the value of purity, and the limit of impurities must be clearly marked. This is the key to quality and is related to the application of the product in various fields.
Only by strictly adhering to process specifications and clearly marking (commodity parameters) can 4-Bromo-1-Iodobenzene be of high quality and be effective in chemical research and industrial applications.

Preparation Method

4 - Bromo - 1 - Iodobenzene is an important compound in organic synthesis, and its preparation method depends on a variety of factors. In the selection of raw materials, benzene and its derivatives can be used as the starting materials. In the preparation process, halogenation is a key step.
Initially, benzene is used as the raw material. After bromination, bromine and suitable catalysts, such as iron filings, can be used under heating conditions to obtain bromobenzene. This step requires attention to the reaction temperature and the ratio of reactants to prevent the formation of polybrominates.
Next, bromobenzene reacts with iodine reagents under specific conditions. Potassium iodide and appropriate oxidants, such as hydrogen peroxide, can be used to achieve iodine generation under mild reaction conditions. It is important to control the reaction rate and process to ensure the purity and yield of the product.
In the monitoring of the reaction process, thin-layer chromatography and other means are used to control the reaction progress in real time. The product can be purified by distillation, recrystallization and other methods. In this way, 4-Bromo-1-Iodobenzene can be prepared through a series of steps, laying the foundation for subsequent organic synthesis.

Chemical Reactions & Modifications

4 - Bromo - 1 - Iodobenzene is an important chemical in organic synthesis. Its chemical reactions and modifications are related to the synthesis path and product characteristics.
In past studies, we have explored its chemical transformation. For example, nucleophilic substitution reactions, bromine or iodine atoms can be replaced by appropriate nucleophiles to obtain derivatives with different structures. In this process, reaction conditions, such as temperature, solvent, and catalyst, all affect the reaction rate and selectivity.
In terms of modification, chemical modifications can be used to increase its functionality. For example, specific functional groups are introduced to change their physical and chemical properties, making them suitable for a variety of fields, such as materials science or medicinal chemistry. After in-depth investigation of the chemical reaction and modification of 4 - Bromo - 1 - Iodobenzene, we hope to expand its application range and pave the way for the synthesis of novel and valuable compounds.

Synonyms & Product Names

4 - Bromo - 1 - Iodobenzene is an important organic compound. The discussion of its synonyms and trade names is of great significance to our field of chemical research.
In many ancient books in the past, such compounds may have other names. Because the chemical nomenclature system at that time was not as complete and accurate as it is today. There may be names with similar characteristics, or differences due to different regions and research groups.
However, with the evolution of chemical knowledge and the standardization of naming rules, the name 4 - Bromo - 1 - Iodobenzene is gradually adopted by the academic community. However, although the synonyms and trade names of the past are less and less mentioned, they carry the track of chemical development. Sorting it out will help us gain a deeper understanding of the inheritance and transformation of chemical knowledge, which is of great significance in the context of chemical research.

Safety & Operational Standards

4 - Bromo - 1 - Iodobenzene Safety and Operation Code
Husband 4 - Bromo - 1 - Iodobenzene is a compound commonly used in chemical research. If you want to use this product well, you must first clarify its safety and operation standards.
In terms of safety, this product is dangerous. It comes into contact with the skin, or causes irritation and makes the skin uncomfortable. Therefore, when operating, use appropriate protective clothing, such as gloves, to separate it. If you accidentally touch the skin, rinse quickly with plenty of water and seek medical attention as appropriate. Its smell may be irritating to the respiratory tract, and it is easy to cause respiratory discomfort in places with poor ventilation. Therefore, it is appropriate to operate in a well-ventilated environment, or use a fume hood to disperse harmful gases quickly.
When talking about operating specifications, when weighing, the action should be stable and accurate. Because of the amount, it is related to the success or failure of the reaction. The utensils used must be clean and dry, free from impurities. When dissolving, choose a suitable solvent, according to its characteristics, control the temperature and stirring speed, so that the solution is uniform. When reacting, pay close attention to temperature, pressure and other conditions. If the temperature is too high, it may cause overreaction and cause unexpected changes; if the pressure is abnormal, it is also dangerous. And record it in detail for review.
Store in a cool, dry and ventilated place to avoid heat and fire. Separate from oxidizing agents, active metals and other foreign substances to prevent their interaction and risk accidents.
In short, the research operation of 4 - Bromo - 1 - Iodobenzene must be done with caution, and safety and operation standards must be observed to ensure the smooth operation of the experiment and the safety of personnel.

Application Area

4 - Bromo - 1 - Iodobenzene is also a chemical substance. Its application domain is not limited. In the field of synthesis, it can be used in the field of synthesis to help researchers achieve special effects. If you want to create an anti-tumor drug, this compound may be able to be reversed and multi-step, and the drug can be used in the field of materials.
In the field of materials, it can be used as the cornerstone of special functional materials. For example, using raw materials, or materials that can be synthesized with special optical properties, used in photonic devices, such as high-efficiency optical diodes, to make the technology more sophisticated.
In addition to the research on synthesis, it is often important to assist researchers in expanding the synthesis path, exploring the development of new compounds, promoting the progress of the chemical family, and promoting its deeper application in various fields.

Research & Development

Since modern times, the art of chemistry has become more and more new, and various compounds have emerged one after another. I focus on the research of 4-Bromo-1-Iodobenzene. The method of its preparation was quite laborious at first. In the past, all kinds of paths were tried, which hindered. Or because of the impurity of the raw materials, or because the conditions of the reaction were not suitable.
He continued to study and finally got the key point. Optimize the ratio of the reaction, adjust the temperature and time, so that the reaction is gradually stable. The purity and yield of the obtained product are much better than in the past.
As for its application, it has also been explored. In the field of organic synthesis, it can be used as a key intermediate to derive many useful compounds. The future prospect is to expand its application scope and improve the efficiency of preparation, so that this compound can shine in industrial production, scientific research and exploration, and contribute to the development of chemistry.

Toxicity Research

The toxicity of 4-Bromo-1-Iodobenzene is related to various aspects. In this substance, the characteristics of bromine and iodine atoms may involve toxicity. Looking at its structure, halogen atoms exist in the benzene ring, or the metabolism of the substance in the body is different, leading to physiological effects.
After research, it enters the organism or reacts with key components of the cell. If it interacts with proteins and nucleic acids, it disrupts the normal function of the cell. And because it has a certain lipid solubility, or is easy to penetrate the biofilm and enter the deep layer of the cell.
However, the toxicity of 4-Bromo-1-Iodobenzene still needs to be further explored. Although there are existing indications of its potential harm, the specific toxicological mechanism and toxic dose are still not fully understood. In the future, scientific methods should be used to investigate each situation in detail to clarify its toxicity, so as to protect life, health and environmental safety.

Future Prospects

I have studied in the field of chemistry, and recently focused on 4 - Bromo - 1 - Iodobenzene. Looking at the present, although it is already in our field of vision, its future development still has a vast range.
In the process of synthesis, new paths may be explored, resulting in higher yield and better quality. With its wonderful structure, in the field of organic synthesis, it may be the pivot of many reactions and the way to create new compounds. And in the process of pharmaceutical research and development, it may become a key agent, helping new drugs come out and solving people's diseases.
Furthermore, in the field of material science, or with its characteristics, the research and development of novel materials should be in the fields of electronics, optics and other fields to create a new situation. Although there may be thorns ahead, we chemical researchers must have a strong heart, explore its endless potential, and develop the grand future. Let 4 - Bromo - 1 - Iodobenzene bloom brightly on the stage of science.

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Frequently Asked Questions

As a leading 4-Bromo-1-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 4-bromo-1-iodobenzene?

4-Bromo-1-iodobenzene is also an organic compound. Its activity is quite unique in many chemical reactions.
Looking at its structure, above the benzene ring, the two atoms of bromine and iodine are arranged in pairs. This structure endows it with specific chemical properties. As far as electrophilic substitution is concerned, although both bromine and iodine are electron-absorbing groups, the induction effect and conjugation effect interact, resulting in a decrease in the electron cloud density of the benzene ring, and the reaction activity is different from that of benzene. The electronegativity of bromine and iodine is large, and they have strong traction on the electron cloud of the benzene ring, which makes the density of the adjacent and para-electron clouds of the benzene ring relatively lower, and the interposition is slightly Therefore, when the electrophilic reagent attacks, the proportion of meta-substitution products is higher than that of benzene.
In the nucleophilic substitution reaction, the electron cloud density of benzene ring carbon atoms decreases due to the existence of bromine and iodine atoms, and the atom of bromine and iodine can be used as leaving groups and replaced by nucleophilic reagents under specific reaction conditions. However, this process requires suitable alkali, solvent and temperature conditions.
Furthermore, the physical properties of 4-bromo-1-iodobenzene are also related to its chemical structure. It has good solubility in organic solvents, such as common ether, chloroform, etc., due to intermolecular van der Waals forces and dipole-dipole interactions. Its melting point and boiling point are affected by intermolecular forces and relative molecular weights, which are relatively high, due to the increase of molecular weight and the increase of intermolecular forces.
In the field of organic synthesis, 4-bromo-1-iodobenzene is often an important intermediate. Through different chemical reactions, bromine or iodine atoms can be converted into other functional groups, thereby constructing a variety of organic compounds, which are indispensable in many fields such as drug synthesis and materials science.

What are the main uses of 4-bromo-1-iodobenzene?

4-Bromo-1-iodobenzene is also an organic compound. It has a wide range of uses and is often an important role in various chemical synthesis industries.
First, in the field of drug synthesis, this compound can be used as a key intermediate. In drug development, a complex molecular structure needs to be constructed. 4-bromo-1-iodobenzene has an active halogen atom, which can introduce various functional groups through various reactions such as nucleophilic substitution to form the required drug molecules. For example, when synthesizing specific anti-cancer drugs and antibacterial agents, it often relies on its initial reaction to lay the foundation for the subsequent construction of the molecular skeleton.
Second, in the field of materials science, 4-bromo-1-iodobenzene is also possible. To make high-performance optoelectronic materials, it is often necessary to precisely control the molecular structure and electronic properties. This compound can be polymerized or copolymerized with other monomers to prepare materials with unique optical and electrical properties, such as organic Light Emitting Diode (OLED) materials, solar cell materials, etc., to help it improve the photoelectric conversion efficiency and stability.
Third, in the basic research of organic synthetic chemistry, 4-bromo-1-iodobenzene is a commonly used model compound. Scholars can study the reactions they participate in, such as palladium-catalyzed cross-coupling reactions, explore the reaction mechanism, optimize the reaction conditions, provide reference for the development of new synthesis methods, expand the boundaries of organic synthesis, and promote the progress of organic chemistry.
In short, although 4-bromo-1-iodobenzene is a micro-compound, it has important functions in many fields such as drugs, materials, and organic synthesis research, and is an important cornerstone of the field of chemistry.

What are 4-bromo-1-iodobenzene synthesis methods?

The synthesis method of 4-bromo-1-iodobenzene is of great concern in the field of organic synthesis. The preparation of this compound, common number methods, and each has its own advantages and disadvantages, need to be selected according to the specific situation.
First, benzene is used as the starting material, and can be obtained by the order of bromination and iodization. First, benzene and bromine are electrophilic substitution reaction under the catalysis of Lewis acid (such as iron tribromide) to generate bromobenzene. The reaction conditions are mild and the yield is quite good. Then, bromobenzene and iodine are iodized under the condition of copper salt catalysis and heating, and 4-bromo-1-iodobenzene is obtained. Although this route is easy to obtain raw materials, the steps are slightly complicated, and the iodization reaction conditions need to be precisely controlled, otherwise the yield will be affected.
Second, phenol is used as the starting material. Phenol is first brominated to obtain 2,4-dibromophenol, and then converted into 4-bromo-1-iodobenzene by diazotization and iodization reaction. When phenol is brominated, due to the activation of phenolic hydroxyl groups, the reactivity is high, and the bromination position is easy to control. The diazotization reaction needs to be operated at low temperature to maintain the stability of the diazonium salt. Subsequent iodization reactions utilize the reactivity of diazonium salts to introduce iodine atoms. This method has a little more steps, but it can take advantage of the characteristics of phenolic compounds to < Br >
Third, the cross-coupling reaction catalyzed by palladium. Bromobenzene and iodoaromatic hydrocarbons are used as substrates to realize carbon-carbon bond coupling in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium), bases and ligands to obtain the target product. This method has high selectivity, can construct complex aryl structures, and the reaction conditions are relatively mild, making it suitable for large-scale preparation. However, the cost of palladium catalysts is high, and the reaction equipment and operation requirements are also strict.
All synthesis methods have their own advantages. In practical application, according to factors such as raw material availability, cost consideration, product purity and yield requirements, appropriate methods are carefully selected to achieve the purpose of efficient synthesis of 4-bromo-1-iodobenzene.

4-bromo-1-iodobenzene need to pay attention to when storing and transporting

4-Bromo-1-iodobenzene is also an organic compound. During storage and transportation, many matters must be kept in mind.
First words storage, this compound should be placed in a cool and well-ventilated place. Covering its heat can easily cause chemical changes, or even cause danger. A dark place can be protected from direct sunlight, energy in sunlight, or molecular excitation, causing reactions to occur without cause. Good ventilation can prevent the accumulation of harmful gases and ensure the safety of the storage environment.
Furthermore, keep away from oxidants, strong bases and other substances. The chemical activity of 4-bromo-1-iodobenzene, in case of such substances, is prone to violent reactions, or the risk of explosion. And the storage place should be dry and anhydrous. Water can be used as a medium to promote hydrolysis and other reactions, which will damage its purity and quality.
As for transportation, there are also requirements. Suitable packaging materials must be used. Strong and well-sealed containers are preferred to prevent leakage. If it leaks during transportation, it will not only damage the goods, but also pollute the environment and endanger humans and animals.
When transporting, temperature should also be controlled. Avoid high temperature environments to prevent the decomposition or volatilization of compounds. Escorts should know its characteristics and emergency response methods. Once a situation occurs, it can be dealt with in time to reduce the harm.
In short, the storage and transportation of 4-bromo-1-iodobenzene is related to safety and quality, and all details must be treated with caution and cannot be slack.

4-bromo-1-iodobenzene impact on the environment and human health

4-Bromo-1-iodobenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
At the environmental end, 4-bromo-1-iodobenzene is quite stable and difficult to degrade in the natural environment. If released into the soil, it can gradually accumulate, affect the soil quality, and then affect the growth of plants. It may be a poison of soil microorganisms, disturbing the balance of soil ecosystems. If it flows into the water body, because of its hydrophobicity, it is easy to adsorb suspended particles and settle to the sediment at the bottom of the water, which will endanger aquatic organisms in the long run. Aquatic algae, fish, etc. may be harmed by it, causing loss of aquatic biodiversity.
As for personal health, 4-bromo-1-iodobenzene can be ingested through respiratory tract, skin contact or accidental ingestion. After entering the body, or accumulated in adipose tissue. Animal experiments have shown that it may damage liver and kidney function and cause organ lesions. And it has potential neurotoxicity, interfering with the normal operation of the nervous system, causing headaches, dizziness, fatigue, etc. Long-term exposure to this substance may increase the risk of cancer, because it can cause cell gene damage and mutation.
Therefore, 4-bromo-1-iodobenzene poses a threat to both the environment and personal health. Its production, use and disposal should be strictly controlled to prevent it from polluting the environment and protect public health.