4-Bromo-2-Chloroiodobenzene

Fengxi Chemical

Specifications

HS Code	337662
Chemical Formula	C6H3BrClI
Molecular Weight	329.35
Appearance	Solid
Color	Off - white to light yellow
Odor	Typical organic odor
Melting Point	105 - 107°C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform

As an accredited 4-Bromo-2-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 4 - bromo - 2 - chloroiodobenzene packaged in a sealed glass bottle.
Storage	4 - bromo - 2 - chloroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to decomposition. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions.
Shipping	4 - bromo - 2 - chloroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care to prevent spills, in accordance with hazardous chemical shipping regulations, ensuring safety during transit.

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General Information

Historical Development

In the field of chemistry, the history of this compound, 4-Bromo-2-Chloroiodobenzene, has been elucidated. In the past, chemists worked hard, and they wanted to understand things. At the beginning of time, this new generation of aromatics was still in progress, and we knew a little about the characteristics of its nitrogen-containing elements.
However, the research was in depth, and more and more people were involved in it. By means of new synthesis methods, this compound can be obtained gradually. Early synthesis is difficult, and the rate is low.
However, the chemists are unyielding, improving the reaction parts, and more catalysis, so that the synthesis technology is mature day by day. Today, 4 - Bromo - 2 - Chloroiodobenzene has been developed in the field of synthesis and other fields, and its history has been developed to reflect the wisdom of the world.

Product Overview

4 - Bromo-2 - Chloroiodobenzene
4 - Bromo-2 - Chloroiodobenzene is an important compound in the field of organic synthesis. Its molecular structure is unique, with bromine (Bromo), chlorine (Chloro) and iodo atoms cleverly arranged at specific positions in the benzene ring.
This compound exhibits extraordinary activity in organic reactions. The presence of bromine and chlorine atoms can enhance the electrophilicity of molecules due to the characteristics of halogen atoms, making them easy to participate in nucleophilic substitution reactions. The activity of iodine atoms cannot be ignored. Under specific conditions, it can initiate unique chemical reaction pathways and play a key role in the construction of complex organic molecular structures.
In addition, its physical properties also have characteristics. The appearance or specific color of the solid, melting point, boiling point and other physical parameters, due to intermolecular forces, are different from the same kind of compounds, providing a basis for practical operation and application.
In the process of scientific research and industrial production, 4 - Bromo - 2 - Chloroiodobenzene has emerged in many fields such as pharmaceutical chemistry and materials science with its unique structure and properties, and has broad prospects.

Physical & Chemical Properties

4 - Bromo - 2 - Chloroiodobenzene is an organic halogenated aromatic hydrocarbon. In terms of physical properties, it is mostly solid at room temperature, with a certain melting point and boiling point. Due to the structure of the benzene ring, the intermolecular force is relatively stable. The melting point is in a specific range due to intermolecular interactions, and the boiling point is also affected by molecular mass and intermolecular forces.
Chemically, the presence of three halogen atoms, bromine, chlorine and iodine, endows the substance with rich chemical reactivity. Halogen atoms can undergo nucleophilic substitution reactions. For example, under appropriate nucleophilic reagents and reaction conditions, halogen atoms can be replaced by other groups. At the same time, the conjugated system of the benzene ring allows the substance to participate in the electrophilic substitution reaction. Because the halogen atom is an ortho-para-site group, the electrophilic reagent tends to attack the ortho or para-site of the benzene ring. Its halogen atoms can also participate in metal-catalyzed coupling reactions, which are used to construct carbon-carbon bonds or carbon-heteroatom bonds in the field of organic synthesis.

Technical Specifications & Labeling

There is a chemical substance today, named 4 - Bromo - 2 - Chloroiodobenzene. Its technical specifications and labels (commodity parameters) are of great importance to researchers.
Looking at this substance, its structure is unique, and the atoms of bromine, chlorine and iodine are distributed according to the benzene ring. In the technical regulations, the method of its synthesis should be clearly understood. It is necessary to take precise steps to control the reaction conditions, such as temperature, pressure, and catalyst genus. Mixing the reactants in an appropriate ratio can lead to the purity of the product and high yield.
In terms of identification, it is necessary to detail its physical properties, color, taste, and state. And parameters such as melting point, boiling point, and density are the keys to recognizing this substance. This data is clear in order to know its characteristics when it is applied, so as to achieve the purpose of good use. Researchers have carefully studied the technical regulations and labels, so that this substance can be properly used in chemical, pharmaceutical and other fields.

Preparation Method

To prepare 4 - Bromo - 2 - Chloroiodobenzene, the method is as follows:
Take an appropriate amount of raw materials first, and select pure ones. With benzene as the base, chlorine, bromine and iodine atoms are introduced through halogenation.
The first step is to add benzene and an appropriate amount of chlorine source in a specific reactor, and then add benzene and an appropriate amount of chlorine source. With the help of light or catalyst, the chlorine atom is connected to the benzene ring to obtain a chlorine-containing intermediate.
The second step is to set up another reaction system, add the product of the previous step and the bromine source, and under specific reaction conditions, the bromine atoms are connected in sequence to generate an intermediate containing chlorine bromine.
In the last step, the iodine source is added. After the ingenious reaction mechanism, the iodine atoms are precisely connected to the target position to obtain 4-Bromo-2-Chloroiodobenzene. After each reaction step, separation and purification are required to ensure the purity of the product. In this way, the required 4-Bromo-2-Chloroiodobenzene can be obtained.

Chemical Reactions & Modifications

4 - Bromo - 2 - Chloroiodobenzene is an organic halogenated aromatic hydrocarbon, which is of great significance in the field of organic synthesis. As far as its chemical reaction is concerned, halogen atoms are active and can participate in many nucleophilic substitution reactions. For example, under the action of suitable bases and catalysts, its bromine atoms can be replaced by hydroxyl, amino and other nucleophilic reagents. This reaction condition is quite critical, and temperature and solvent properties will have a profound impact on the reaction rate and product selectivity.
Besides its chemical modification, in view of the different activities of different halogen atoms on the benzene ring, specific halogen atoms can be modified by selective activation or passivation strategies. For example, through electronic effect regulation, the charge distribution of the benzene ring is changed, which prompts the reaction orientation to occur at a certain halogen atom position, so as to achieve precise regulation of the product structure and effectively optimize the product properties in the fields of drug synthesis and material preparation.

Synonyms & Product Names

4 - Bromo - 2 - Chloroiodobenzene, which is a key raw material for organic synthesis. Its synonyms and trade names are very important in academia and industry.
In academia, it is often called by its system name "4 - bromo - 2 - chloroiodobenzene", which accurately describes its molecular structure and facilitates academic communication and research.
In the industry, for the convenience of production, sales and application, there are also other trade names. Or because of its unique chemical properties and uses, the name highlights the characteristics of the product to attract customers.
For example, some companies use "excellent iodine-chlorobenzene" as a trade name, highlighting its high purity and the characteristics of iodine, chlorine and bromine elements. This name is concise and easy to remember, and has advantages in marketing activities.
Another example is "refined 4-bromo-2-chloroiodine-benzene", which emphasizes that the product has been carefully developed and has high quality, which is suitable for high-end scientific research and production needs.
In this way, although synonyms and trade names are different, they both refer to this important compound, which can develop its capabilities in different fields and promote chemical research and industrial development.

Safety & Operational Standards

4 - Bromo-2 - Chloroiodobenzene is an important substance in chemical research. Safety regulations are of paramount importance during its experimental operation and use.
Safety is the first word. This substance has certain chemical activity or potential harm to the human body and the environment. When operating, wear appropriate protective equipment, such as laboratory clothes, gloves, and protective goggles to prevent it from coming into contact with the skin and eyes. If it is accidentally touched, rinse with plenty of water as soon as possible and seek medical treatment according to the specific situation. Furthermore, this substance may be volatile, so the operation should be carried out in a well-ventilated environment or in a fume hood to avoid the accumulation of harmful gases and endanger the health of the experimenter.
Times and operating specifications. When taking 4-Bromo-2-Chloroiodobenzene, use clean and precise equipment to ensure the accuracy of the dosage. The weighing process must be careful to avoid spillage. When adding this substance to the reaction system, it should also be slow and uniform to prevent the reaction from being too violent and out of control. After the experiment is completed, the remaining 4-Bromo-2-Chloroiodobenzene should be properly stored in suitable containers and conditions according to its chemical properties to prevent deterioration or dangerous reactions. The waste generated by the experiment should not be discarded at will, but should be collected and treated in accordance with relevant regulations to avoid pollution to the environment.
In summary, in the research and use of 4 - Bromo - 2 - Chloroiodobenzene, strict adherence to safety and operating standards can ensure the smooth operation of the experiment and the safety of the experimenter and the environment.

Application Area

4 - Bromo-2 - Chloroiodobenzene is a unique chemical substance that has its uses in many fields.
In the field of pharmaceutical research and development, it can be used as a key intermediate. Due to the unique chemical structure of this substance, it can introduce specific functional groups through organic synthesis, and through a series of reactions, build complex drug molecular structures, or contribute to the creation of therapeutic drugs for specific diseases.
In the field of materials science, 4 - Bromo-2 - Chloroiodobenzene may participate in the preparation of special materials. With its reactivity, the electronic structure and physical properties of materials can be adjusted, such as for the manufacture of materials with special optical or electrical properties to meet the needs of electronic devices, optical instruments and other fields.
In addition, it can also be seen in the preparation of fine chemical products. It can provide key structural units for the synthesis of fine chemicals such as special fragrances and dyes, and with its unique properties, endow products with unique properties and characteristics.

Research & Development

Today there is a product called 4 - Bromo - 2 - Chloroiodobenzene. As a chemical researcher, I have dedicated myself to studying this product for a long time.
Looking at its structure, bromine, chlorine and iodine atoms have their own characteristics and interact with each other, which affects the properties of this compound. In the investigation of the reaction mechanism, it was found that under specific conditions, it can exhibit unique chemical activity and can participate in a variety of organic synthesis reactions.
In the process of research, different reaction paths were tried to optimize its synthesis method. After repeated experiments, the process was improved to improve the yield and purity. This compound has great application potential in the fields of medicine, materials, etc., and may help the research and development of new drugs and improve material properties.
We will continue to study, expand its application boundaries, and promote the development of this compound, hoping to add to the field of chemistry and benefit the world.

Toxicity Research

Recently, I studied a chemical substance in my room, called "4-Bromo-2-Chloroiodobenzene". The toxicity of this substance is extremely serious.
Looking at its structure, the atoms of bromine, chlorine and iodine are listed on the benzene ring. Halogen atomic characteristics, or toxicity. I checked ancient books to find the nature of similar substances. In the past, many halobenzene-containing substances were toxic. When they enter the body of organisms, or react with proteins and nucleic acids, they are out of order in physiology.
To prove the toxicity of this material, I set up various tests. Take the white rat as a test, and feed it with a small amount of this substance. After observing its state, I see that the white rat is getting tired, eating less, and weak. Analyze its blood and organs to obtain biochemical changes. Liver and kidney function indicators are different from usual.
In summary, "4 - Bromo - 2 - Chloroiodobenzene" is toxic. For industrial use, it must be handled with caution to prevent it from being scattered in the ring and harming life. It is also a priority to develop a method of detoxification, so as not to worry.

Future Prospects

Husband 4 - Bromo - 2 - Chloroiodobenzene is also a matter of transformation. Its future prospects can be deeply considered. In the field of chemical research, this compound may be the beginning of a new path.
We can hope that it will be synthesized and develop its special capabilities. Or it can be used to create exquisite and inverse molecules, to assist in the development of home-made extraordinary molecules, or it can be used to develop new technologies, and it can be like a disease.
Or it can be used in the field of material science to make a big impact. Or it can be used to form the essence of special materials, to promote the innovation of materials, and to promote the field of children and light. In the future, it is like a flower in the middle of the sea, and it contains light. We will wait for those of us who are transformed to use diligent wisdom to reveal its mysterious side and develop its limited ability.

Where to Buy 4-Bromo-2-Chloroiodobenzene in China?

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Frequently Asked Questions

As a leading 4-Bromo-2-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemical structure of 4-bromo-2-chloroiodobenzene?

4-Bromo-2-chloroiodobenzene is also an organic compound. Its chemical structure is based on a benzene ring, which has a hexagonal shape and is composed of six carbon atoms linked to each other by covalent bonds to form a stable planar ring. At a specific position of the benzene ring, there are different halogen atoms attached.
At the 4th position, the bromine atom (Br) is connected to the benzene ring. Bromine, one of the halogen elements, has a large atomic radius and a relatively dispersed electron cloud. In organic molecules, the bromine atom has a significant impact on the electron cloud distribution of the benzene ring due to its electronegativity, which can change the density of the adjacent and para-position electron clouds and affect the reactivity of the molecule. At the
2 position, there are chlorine atoms (Cl) attached. Chlorine is also a halogen element with high electronegativity. After it is connected to the benzene ring, it attracts electrons by virtue of its electronegativity, causing the electron cloud of the benzene ring to shift and guide the direction and rate of the reaction in the chemical reaction.
In addition, there is an iodine atom (I) attached to the benzene ring at another specific position. The atomic radius of iodine is larger in the halogen group, and its electron cloud is more easily polarized.
These three are distributed at different positions in the benzene ring, causing the molecule to exhibit unique physical and chemical properties. Due to the difference in electronegativity and atomic radius of each halogen atom, the polarity, boiling point, solubility and other physical properties of the molecule are different. In terms of chemical properties, due to the influence of halogen atoms on the electron cloud of benzene ring, the activity and selectivity of electrophilic substitution, nucleophilic substitution and other reactions are unique. The exquisite combination of this molecular structure makes 4-bromo-2-chloroiodobenzene show potential application value in many fields such as organic synthesis and medicinal chemistry.

What are the physical properties of 4-bromo-2-chloroiodobenzene?

4-Bromo-2-chloroiodobenzene is one of the organic compounds. Its physical properties are quite impressive, as detailed below:
In terms of color state, at room temperature, 4-bromo-2-chloroiodobenzene is white to light yellow crystalline powder. This color state characteristic can be an important basis for the identification and preliminary determination of this substance.
Melting point section, its melting point is about within a specific range, this value may vary slightly due to different experimental conditions, but it is roughly within a certain range. The determination of the melting point is of great significance for determining the purity and characteristics of the compound. By accurately measuring the melting point, the compactness of its molecular structure and the strength of its interaction can be inferred.
In terms of solubility, 4-bromo-2-chloroiodobenzene exhibits specific solubility properties in common organic solvents. For example, in some organic solvents such as dichloromethane and chloroform, it has a certain solubility. This property allows for the selection of suitable solvents to assist in the smooth progress of the reaction or for the separation and purification of the compound in the operation of organic synthesis.
In terms of density, 4-bromo-2-chloroiodobenzene has a certain density value, which reflects the mass per unit volume of the substance and is related to the size, mass and arrangement of the molecules. Although its density data may not be well known to the public, in specific chemical and scientific research fields, accurate determination and mastery of it is related to the accuracy and efficiency of many operations.
Furthermore, 4-bromo-2-chloroiodobenzene has low volatility. Due to its strong intermolecular force, it is not easy to transform from solid or liquid to gaseous state under normal temperature and pressure. This property is greatly convenient for operation during storage and use, reducing losses caused by volatilization and safety hazards.
The physical properties of 4-bromo-2-chloroiodobenzene, from color state, melting point, solubility, density to volatility, are unique and interrelated. In organic chemistry research, chemical production and related fields, the in-depth understanding and skilled application of these properties lay a solid foundation for the smooth development of related work.

What are the main uses of 4-bromo-2-chloroiodobenzene?

4-Bromo-2-chloroiodobenzene is one of the organic compounds. Its main use covers the field of organic synthesis. This compound has halogen atoms and can involve various chemical reactions. It is often a key starting material when building complex organic molecular structures.
First, in the nucleophilic substitution reaction, its halogen atoms can be replaced by various nucleophilic reagents. If alkoxy is used as the nucleophilic reagent, the halogen atoms can be replaced by alkoxy groups to form ether compounds with specific structures. This is crucial when creating organic molecules with special properties.
Furthermore, in metal-catalyzed coupling reactions, 4-bromo-2-chloroiodobenzene is also a common substrate. For example, in the palladium-catalyzed Suzuki coupling reaction, it can react with organic boric acid to form carbon-carbon bonds to prepare polyaryl compounds. Such compounds are of great significance in the field of materials science, such as the development of organic Light Emitting Diode (OLED) materials, which can help improve the photoelectric properties of materials.
In addition, in pharmaceutical chemistry, it may serve as an important building block for the synthesis of lead compounds. After modifying its structure, it is expected to obtain molecules with specific biological activities, paving the way for the development of new drugs. The presence of caeinhalogen atoms can change the physical and chemical properties of compounds, such as lipophilicity, and then affect their interaction with biological targets.
In conclusion, 4-bromo-2-chloroiodobenzene has important uses in organic synthesis, materials science, and medicinal chemistry, providing a key starting framework for the creation of novel and practical compounds.

What are 4-bromo-2-chloroiodobenzene synthesis methods?

The synthesis method of 4-bromo-2-chloroiodobenzene can be obtained in several ways. The first method is to take benzene as the base and introduce bromine, chlorine and iodine atoms in sequence by halogenation.
At the beginning, benzene and bromine are brominated under appropriate catalysis. Usually iron or iron salts are used as catalysts, such as iron bromide. Under this condition, benzene interacts with bromine gas or liquid bromine to obtain bromobenzene. The reason for the reaction is that bromine positive ions attack the π electron cloud of the benzene ring, pass through the intermediate carbon positive ions, and then deproton to form the product of bromobenzene.
Both bromobenzene and chlorine atoms are introduced. A chlorination reaction can be used to chlorinate bromobenzene with a suitable chlorinating agent, such as chlorine gas, in the presence of light or a catalyst. When the light is irradiated, the chlorine molecules split into chlorine radicals, interact with bromobenzene, and introduce chlorine atoms into the benzene ring. In this way, 2-chloro-4-bromobenzene is obtained.
At the end, iodine atoms are introduced into 2-chloro-4-bromobenzene. The iodization reaction can be used, often with iodine sources such as potassium iodide, under appropriate oxidation conditions. The oxidizing agent can oxidize the iodine ion to the positive iodine ion, and then react with 2-chloro-4-bromobenzene to obtain 4-bromo-2-chloroiodobenzene.
There are other methods, or the benzene ring can be protected first, and then the halogen atom is introduced one by one, and then the protective group is removed to achieve the purpose of synthesis. There are also other aromatic compounds as starting materials, through appropriate functional group conversion, and finally 4-bromo-2-chloroiodobenzene. All these methods have advantages and disadvantages. The experimenter should choose the best one according to the factors such as the availability of raw materials, the difficulty of reaction, and the high and low yield.

What are the common types of reactions in 4-bromo-2-chloroiodobenzene?

In the reaction of 4-bromo-2-chloroiodobenzene in organic chemistry, the common reaction types are as follows:
One is the nucleophilic substitution reaction. In this compound, bromine, chlorine, and iodine are all halogen atoms, which have a certain tendency to leave. When encountering nucleophilic reagents, such as alkoxides and amines, halogen atoms can be replaced by nucleophilic reagents. Taking alkoxides as an example, the anion of alcohol oxide acts as a nucleophilic reagent to attack the carbon atom connected to the halogen atom on the benzene ring. The halogen atom leaves with a pair of electrons to form a corresponding substitution product. This is because the carbon connected to the halogen atom on the benzene ring is connected. Due to the electron-absorbing induction effect of the halogen atom, the electron Under the action of metal catalysts such as palladium, 4-bromo-2-chloroiodobenzene can participate in many coupling reactions. For example, Suzuki coupling reaction with organoboronic acid, in the presence of base and palladium catalyst, the halogen atoms on the benzene ring are coupled with organoboronic acid to form new carbon-carbon bonds, realize the connection between aryl groups, and construct more complex aromatic compound structures. This reaction is extremely important for the construction of carbon skeletons in organic synthesis.
The third is the halogen atom exchange reaction. Under specific conditions and the action of reagents, the bromine, chlorine and iodine atoms in the molecule can be exchanged. For example, by selecting a suitable halogenation reagent, bromine and iodine atoms can be exchanged for positions, which can be adjusted according to the synthesis needs to meet the requirements of subsequent reactions for specific halogen atom positions.
The fourth is a reduction reaction. Halogen atoms in compounds can be reduced and removed under the action of appropriate reducing agents. For example, using strong reducing agents such as lithium aluminum hydride, halogen atoms can be reduced to hydrogen atoms, so that the halogen atoms on the benzene ring are replaced by hydrogen, thereby changing the molecular structure and properties. In the design of organic synthesis routes, molecules can be gradually modified.