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What is the chemical structure of 4-chloro-2-iodo-1h-pyrrolo [2,3-b] pyridine?
The 4-chloro-2-iodo-1H-pyrrolo [2,3-b] pyridine is one of the organic compounds. Its chemical structure is quite unique. The core structure of this compound is pyrrolido [2,3-b] pyridine, which is formed by fusing a pyrrole ring with a pyridine ring. On this basic structure, substituents are introduced at specific positions. An iodine atom is added at position 2, a chlorine atom is added at position 4, and a hydrogen atom is added at position 1. The dense ring structure of
pyrrolido [2,3-b] pyridine gives this compound its unique electronic properties and spatial configuration. The introduction of iodine atoms and chlorine atoms significantly affects their physical and chemical properties. Iodine atoms have a large atomic radius and a high electron cloud density, which can enhance the van der Waals force between molecules and play a role in the physical properties of compounds such as melting point and boiling point. Chlorine atoms have strong electronegativity, which can affect the polarity of molecules, thereby changing their solubility and other properties, and also affect chemical reactivity. In reactions such as nucleophilic substitution and electrophilic substitution, this two-substituent will guide and regulate the reaction check point and reaction rate due to electronic and spatial effects. The chemical structure of this compound is the basis for its unique properties and potential applications.
What are the physical properties of 4-chloro-2-iodo-1h-pyrrolo [2,3-b] pyridine?
4-Chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine has many physical properties. Its appearance is often in the form of a white to light yellow solid powder. This shape is quite common in many chemical substances, which is determined by its molecular structure and crystallization properties.
When talking about the melting point, it is about 140-145 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This value reflects the strength of the intermolecular forces of the compound. At this temperature range, the molecules acquire enough energy to overcome the attractive forces between each other, and the lattice structure disintegrates and becomes a liquid state.
Its solubility is also an important property. In organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), it exhibits good solubility. Dichloromethane has moderate polarity and volatility, and can form suitable interactions with the molecules of the compound to disperse it; DMF uses strong polarity and hydrogen bonds to help the compound dissolve. However, in water, its solubility is poor, because the polarity of water does not match the structure of the compound, and the molecule cannot overcome its own interaction and disperse between water molecules.
Furthermore, the density of the compound is about 2.04 g/cm ³. Density represents the mass of a substance per unit volume. This value shows that it is relatively heavy, which is due to the presence of relatively large atoms such as chlorine and iodine in the molecule, resulting in an increase in the mass per unit volume.
These physical properties are of great significance in the fields of chemical synthesis and drug development. For example, in the synthesis process, the reaction temperature can be controlled according to the melting point, and the appropriate reaction solvent can be selected by solubility; in drug development, solubility is related to drug absorption and bioavailability, and density affects the preparation process.
What are the main uses of 4-chloro-2-iodo-1h-pyrrolo [2,3-b] pyridine?
4-Chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine is an important compound in the field of organic chemistry. Its main uses are quite wide, and in the field of pharmaceutical chemistry, it is often a key intermediate for the creation of new drugs. Due to its unique molecular structure, it has the potential to interact with specific targets in organisms. Chemists can modify its structure to explore compounds with specific pharmacological activities, such as antibacterial, anti-tumor and other drugs.
In the field of materials science, this compound also shows extraordinary application prospects. Due to its specific electronic and optical properties, it can be used to prepare organic optoelectronic materials, such as organic Light Emitting Diodes (OLEDs), organic solar cells, etc. In such applications, the structure of 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine can effectively regulate the electron transport and luminescence properties of materials, and improve the efficiency and stability of devices.
Furthermore, in the field of organic synthetic chemistry, it serves as a key synthetic building block for the construction of more complex organic molecular structures. Based on this compound, chemists can skillfully construct diverse molecular structures through various organic reactions, such as coupling reactions, substitution reactions, etc., to expand the types and functions of organic compounds, and then promote the development of organic synthetic chemistry.
What are the synthesis methods 4-chloro-2-iodo-1h-pyrrolo [2,3-b] pyridine?
There are many ways to synthesize 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine. First, the corresponding pyridine derivative can be started and obtained by halogenation reaction. For example, take the pyridine containing the appropriate substituent first, use the chlorine source, such as thionyl chloride or chlorine gas, under suitable conditions, chlorinate the pyridine ring at a specific position, and then introduce the iodine atom. When introducing the iodine atom, an iodizing reagent, such as potassium iodide, can be used to cooperate with the appropriate oxidizing agent, or the iodine elemental substance can be reacted under the catalyst of a specific catalyst. This process requires attention to the control of the reaction conditions, such as temperature, solvent and reactant ratio, to ensure that the reaction proceeds in the desired direction.
Furthermore, it can be synthesized by the strategy of constructing pyrrolido [2,3-b] pyridine rings. The pyridine ring part is first constructed from suitable raw materials, and then cyclized to form a pyrrolido structure, and then halogenated at a specific location. For example, select an appropriate aminopyridine derivative to react with halogenated acetyl compounds, cyclize to form a pyrrolido [2,3-b] pyridine skeleton, and then introduce chlorine and iodine atoms in turn through halogenation. This process is crucial for the purification and identification of the reaction intermediate, so as not to affect the purity and yield of the final product due to impurities.
Or the coupling reaction catalyzed by transition metals can be used. Chlorine and iodine atoms are directly introduced by coupling reaction with chlorine and iodine reagents in transition metal catalysts such as palladium. This method requires careful selection of catalysts, ligands and reaction conditions in order to efficiently and selectively achieve the synthesis of target compounds, improve reaction efficiency and product purity.
4-chloro-2-iodo-1h-pyrrolo [2,3-b] What should I pay attention to when storing and transporting pyridine?
4-Chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine requires attention in many aspects during storage and transportation.
Its chemical properties are relatively active, and it must be stored in a dry and cool place. Due to water vapor in the air, it is easy to cause reactions such as hydrolysis, which will damage the quality. If the ambient humidity is too high, water molecules may interact with some groups in the compound, causing structural changes. Therefore, a well-sealed container should be used to avoid water vapor intrusion.
Furthermore, light also affects it. This compound may be sensitive to light, and under light, it may lead to luminescent chemical reactions, causing it to decompose or convert into other substances. Therefore, the storage place should be protected from light, and it can be contained in dark containers, or stored in a place without direct light.
During transportation, temperature control is critical. If the temperature is too high, or the compound may undergo thermal decomposition and other reactions. Therefore, it is necessary to reasonably control the transportation ambient temperature according to its thermal stability. If the transportation distance is long and it passes through a temperature-variable area, it is even more necessary to carefully arrange and take necessary temperature control measures.
In addition, because it has a certain chemical activity, it is also extremely important to avoid mixing with other chemical substances. Unpredictable reactions may occur between different chemical substances, resulting in dangerous conditions such as the production of toxic gases, fire or even explosion.
When loading and unloading, operators should handle it with care to avoid damage to the packaging. If the packaging is broken, the compound is exposed to the external environment, which will not only affect its own quality, but also may cause harm to the surrounding environment and personnel. In short, the storage and transportation of 4-chloro-2-iodine-1H-pyrrolido [2,3-b] pyridine requires comprehensive consideration of its chemical properties and careful operation to ensure safety and quality.
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