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What is the chemical structure of 4-chloro-3-iodo-1h-pyrazolo [4,3-c] pyridine?
The 4-chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is an organic compound. Its chemical structure is unique and derived from the skeleton of pyrazolo-pyridine.
Looking at its name, "4-chloro" shows that the chlorine atom (Cl) is connected to the No. 4 position of the pyrazolo-pyridine skeleton; "3-iodo", the iodine atom (I) is in the No. 3 position; "1H-pyrazolo [4,3-c] pyridine", which is the parent structure, that is, the skeleton of 1H-pyrazolo [4,3-c] pyridine. The pyrazolopyridine skeleton is formed by fusing a pyrazole ring with a pyridine ring, and the two share two atoms to form a unique fused ring system. In 1H-pyrazolo [4,3-c] pyridine, 1H indicates that there is a hydrogen atom at position 1 of the pyrazole ring.
In general, the chemical structure of 4-chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is that chlorine atoms are introduced at position 4 of 1H-pyrazolo [4,3-c] pyridine, and iodine atoms are introduced at position 3. This unique structure endows the compound with specific physical and chemical properties, which may have potential application value in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 4-chloro-3-iodo-1h-pyrazolo [4,3-c] pyridine?
4-Chloro-3-iodine-1H-pyrazolo [4,3-c] pyridine is an organic compound with important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate. Due to the structure of pyrazolopyridine, which has attracted much attention in drug development, the compound has a specific atomic substitution mode, which can give it unique biological activity. For example, by modifying and optimizing its structure, new drugs targeting specific disease targets can be designed and synthesized. For example, in the development of anti-tumor drugs, researchers hope to use this structure to achieve precise regulation of signaling pathways related to tumor cell growth and proliferation, bringing new opportunities for cancer treatment.
This compound is also useful in materials science. Due to the unique electronic properties imparted by its molecular structure, it may be used to prepare organic optoelectronic materials. In the construction of organic Light Emitting Diodes (OLEDs) and organic solar cells, such compounds containing specific heterocycles and halogen atoms can effectively regulate the electron transport and luminescence properties of materials, improve the efficiency and stability of devices, and promote the development of new optoelectronic devices.
In addition, in the field of organic synthetic chemistry, it can participate in the construction of many complex organic molecules as an important synthetic building block. Chemists can use the activity of their chlorine atoms and iodine atoms to introduce different functional groups or connect other organic fragments through various organic reactions, such as nucleophilic substitution reactions, metal-catalyzed coupling reactions, etc., to expand the structural diversity of compounds and lay the foundation for the synthesis of organic molecules with special functions or structures.
What are the synthesis methods 4-chloro-3-iodo-1h-pyrazolo [4,3-c] pyridine?
The synthesis method of 4-chloro-3-iodine-1H-pyrazolo [4,3-c] pyridine has been known in ancient times and has various routes. It is described in detail as follows.
First, the compound containing the pyridine structure is used as the starting material. Before introducing a halogen group at a specific position on the pyridine ring, the method of nucleophilic substitution can be borrowed. Under specific reaction conditions, a suitable halogen reagent is used to replace the corresponding hydrogen atom on the pyridine ring. To construct the pyrazole ring structure, this step often requires specific nitrogen-containing reagents and catalysts. For example, by reacting a hydrazine-containing compound with a carbonyl-containing compound, through cyclization and condensation, a pyrazole ring is formed, and it is connected to the pyridine ring in a specific way to obtain the target product.
Second, use pyrazole as the starting material. First modify the pyrazole ring, introduce a specific substituent, adjust its electron cloud density and reactivity. Then react with a suitable pyridine-containing fragment to construct a pyridine structural part. This process requires fine regulation of reaction conditions, such as temperature, solvent, catalyst type and dosage. In a suitable solvent, a suitable base is used as the catalyst to promote the reaction, so that the pyrazole ring and the pyridine fragment are cyclized to form the target product.
Third, the coupling reaction catalyzed by transition metals can be considered. Select suitable halogenated pyridine derivatives and halides or borates containing pyrazole fragments, and the coupling reaction occurs under the catalysis of transition metal catalysts such as palladium and nickel. This method requires strict reaction conditions and strictly controls the anhydrous and anaerobic environment of the reaction system, and the choice and dosage of catalysts have a great influence on the yield and selectivity of the reaction. By precisely controlling the reaction parameters, the reaction proceeds in the direction of generating 4-chloro-3-iodine-1H-pyrazolo [4,3-c] pyridine.
All these synthetic methods have their own advantages and disadvantages. In practical application, the choice should be weighed according to factors such as the availability of raw materials, the difficulty of controlling reaction conditions, and the purity and yield requirements of the target product.
What are the physicochemical properties of 4-chloro-3-iodo-1h-pyrazolo [4,3-c] pyridine?
4-Chloro-3-iodine-1H-pyrazolo [4,3-c] pyridine, this is an organic compound with unique physical and chemical properties.
In terms of its properties, it may be solid at room temperature, because most of these nitrogen-containing heterocyclic compounds are solid. As for the melting boiling point, due to various interactions within the molecule, such as π-π stacking between heterocyclic structures, and the van der Waals force caused by chlorine and iodine atoms, its melting point is relatively high.
In terms of solubility, because it contains polar nitrogen atoms and non-polar hydrocarbon parts, it may have a certain solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF). However, in water, the hydrophobic structure accounts for a large proportion, and the solubility may be limited.
Chemically, chlorine and iodine atoms are active check points. Chlorine atoms can undergo nucleophilic substitution reactions. When encountering nucleophilic reagents such as sodium alcohol and amine, chlorine atoms can be replaced to form new C-O or C-N bonds. Although the activity of iodine atom is slightly lower than that of chlorine atom, under appropriate conditions, such as in the cross-coupling reaction catalyzed by palladium, it can be coupled with reagents containing boron and tin to realize the construction of carbon-carbon bonds, and introduce new carbon chains or functional groups for organic synthesis. The heterocyclic structure of pyrazopyridine also has a certain alkalinity, which can react with acids to form salts. This property may affect its stability and reactivity in different acid-base environments. At the same time, the hydrogen atoms on the heterocyclic ring may deprotonate under the action of strong bases, which may lead to subsequent nucleophilic reactions.
What is the price range of 4-chloro-3-iodo-1h-pyrazolo [4,3-c] pyridine in the market?
The exact price of 4-chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine in Wuwei City. This compound may be a rare organic synthesis intermediate, and its price often varies depending on purity, source, supply and demand.
If it is a high-purity scientific research reagent sold by a well-known reagent, and the preparation requires complicated steps and the raw materials are rare, the price will be high. Or the spectrum can reach hundreds or even thousands of yuan per gram. The more difficult the preparation process of fine chemicals and scientific research reagents, the higher the cost, and the higher the price.
However, if it is industrially mass-produced, and the production technology is mature and the raw materials are easily available, the price per gram may be reduced to tens of yuan due to the scale effect. The price of chemicals in the market often fluctuates with changes in supply and demand. If there are many people who want this product, but there are few people who produce it, the price will rise; on the contrary, if the supply exceeds the demand, the price may be depressed.
It is also sold in the market, and the price varies due to different packaging, transportation, and sales regions. In remote places, the price may be higher than that of the capital city of Dayi due to logistics costs. Therefore, if you want to know the exact price, you must carefully consider each situation and consult the reagent supplier and the chemical raw material market before you can get a more realistic price range.