As a leading 4-Chloro-5-Iodo-1H-Pyrrolo [2,3-D] Pyrimidine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4-chloro-5-iodo-1h-pyrrolo [2,3-d] Pyrimidine?
4-Chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine is a kind of organic compound. Looking at its physical properties, the properties of this substance are often solid, but the specific color state may vary depending on the preparation method and purity, and it may be a white to light yellow solid powder.
Regarding its melting point, in the identification and characterization of organic compounds, the melting point is a key physical parameter. Unfortunately, the exact melting point of this compound has not been recorded in detail in the literature, but it can be inferred that its melting point should be within a certain range due to the interaction between atoms and intermolecular forces within the molecule. In its molecular structure, the presence of chlorine and iodine atoms can affect the intermolecular van der Waals force, resulting in a change in melting point.
In terms of solubility, it is very important for the dissolution of common organic solvents. Generally speaking, the compound may have some solubility in halogenated hydrocarbon organic solvents such as dichloromethane and chloroform. This is because the polarity of halogenated hydrocarbons and the polarity of the compound molecule are similar. According to the principle of "similar compatibility", the two are better miscible. In water, because its molecular polarity is relatively weak and there is no large number of groups that can form hydrogen bonds with water, its solubility in water is very small.
Furthermore, its density is also one end of the physical properties. Although the exact density value is difficult to find, it is inferred from its molecular composition and structure that its density may be higher than that of common hydrocarbon compounds due to the large relative atomic weight of chlorine and iodine atoms, which increases the molecular weight.
The physical properties of this compound are of great significance in the fields of organic synthesis and medicinal chemistry. Clarifying its properties, melting point, solubility and density can provide a key basis for the optimization of its synthesis process, the operation of separation and purification, and even the design of dosage forms in the process of drug development.
What are the chemical properties of 4-chloro-5-iodo-1h-pyrrolo [2,3-d] Pyrimidine
4-Chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine is one of the organic compounds. Its chemical properties are unique and are described in detail by you.
In this compound, the presence of chlorine and iodine atoms has a great influence on its chemical properties. The chlorine atom has electron-absorbing properties, which can change the density distribution of the molecular electron cloud and reduce the electron cloud density of the connected carbon atom, making the carbon atom more vulnerable to attack by nucleophiles. Similarly, although the iodine atom is slightly less electronegative than the chlorine atom, it also has a certain electron-absorbing effect. The synergistic effect of the two significantly affects the reactivity of the molecule.
In the nucleophilic substitution reaction, due to the electron-absorbing induction effect of chlorine and iodine atoms, the polarity of the carbon-halogen bond connected to the heterocycle in the molecule is enhanced, and the halogen atom is more likely to leave, so the compound is more prone to nucleophilic substitution reaction. The nucleophilic reagent can attack the carbon atom connected to the halogen atom and replace the halogen atom to form a new compound.
Furthermore, it contains a heterocyclic structure of pyrrolido-pyrimidine, which imparts a certain aromaticity to the molecule. The aromaticity makes the molecule have special stability. In chemical reactions, the heterocyclic part is relatively stable, and reactions such as ring opening and However, the nitrogen atom on the heterocycle has a lone pair of electrons, which can participate in chemical reactions, such as binding with protons and showing certain alkalinity, or participating in electrophilic substitution reactions as a nucleophilic check point.
And because of its particularity of structure, in the field of organic synthesis, 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine can often be used as a key intermediate. Chemists can use the reactivity of their halogen atoms to introduce different functional groups through a series of chemical reactions to construct more complex organic molecular structures to meet the needs of pharmaceutical chemistry, materials science and other fields.
4-chloro-5-iodo-1h-pyrrolo [2,3-d] What is the main use of Pyrimidine?
4-Chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine is an organic compound. This compound plays an important role in the field of organic synthesis and is mostly used as a key intermediate to help build many complex organic molecules.
First, in the field of medicinal chemistry, it is an important starting material for the development of new drugs. By modifying and modifying its structure, compounds with specific biological activities can be obtained to fight various diseases. For example, the creation of some anti-cancer drugs is based on 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine, and different substituents are introduced to optimize the interaction between compounds and specific targets, enhance drug efficacy, and reduce toxic and side effects.
Second, in the field of materials science, it also shows potential value. After a reasonable molecular design and synthesis strategy, it can be integrated into polymer materials or functional materials, giving the material unique optical and electrical properties. For example, it is expected to prepare materials with special photoelectric conversion properties, which can be used in solar cells and other fields to improve energy conversion efficiency.
Furthermore, in the study of organic synthesis methodologies, 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine is often used as a model substrate to explore novel chemical reaction pathways and catalytic systems. Chemists have developed more efficient and green synthesis methods by studying the reactions using it as a raw material, promoting the development of organic synthesis chemistry.
What is the synthesis method of 4-chloro-5-iodo-1h-pyrrolo [2,3-d] Pyrimidine
The synthesis of 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine is an important topic in organic synthetic chemistry. To prepare this compound, the following methods can be followed.
First method, pyrrole and pyrimidine containing specific substituents are used as starting materials. First, pyrrole derivatives are condensed with pyrimidine derivatives with specific structures under suitable conditions. This reaction requires the selection of appropriate catalysts, such as some Lewis acids, at mild temperatures and in an inert gas-protected atmosphere, through nucleophilic substitution or electrophilic substitution, the basic structure of the target molecule is gradually constructed. During this process, the proportion of reactants must be carefully adjusted to ensure that the reaction advances in the direction of generating the target product. The
sub-method uses halogenation as the key step. Select the appropriate parent structure of pyrrolidine, and first perform a chlorination reaction at its specific position. This process requires the selection of specific halogenating reagents, such as inorganic or organic reagents containing chlorine, to achieve precise chlorine atom substitution in a suitable solvent and reaction temperature. Then, the chlorinated product is replaced by iodine. Iodine substitution reagents can be selected, and the principle of halogen atom exchange or nucleophilic substitution can be followed to introduce iodine atoms into the target position, and finally 4-chloro-5-iodine-1H-pyrrolio [2,3-d] pyrimidine can be obtained.
Another method can adopt a multi-step tandem reaction strategy. Starting from a simple starting material, through a multi-step continuous reaction, in the same reaction system, the target product is directly constructed by ingeniously designing the reaction path and the transformation of the intermediate. This process requires precise control of the reaction conditions of each step, including temperature, pH, reaction time, etc., to ensure the efficiency and selectivity of each step of the reaction, and the compatibility of each step of the reaction, so as to successfully achieve the synthesis of 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine.
4-chloro-5-iodo-1h-pyrrolo [2,3-d] In which areas is Pyrimidine used?
4-Chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine, a special organic compound, has important applications in many fields.
In the field of medicine, it may be a key intermediate for the creation of new drugs. Gain pyrrolido-pyrimidine structures often have unique biological activities in pharmaceutical chemistry and can be combined with specific biological targets. Taking the development of anti-tumor drugs as an example, such compounds may be able to inhibit the proliferation of cancer cells and induce their apoptosis by precisely acting on key proteins in specific signaling pathways of cancer cells, thereby achieving the purpose of treating tumors. Furthermore, in the field of antiviral drugs, 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine may be modified to interfere with the viral replication process, opening up new avenues for antiviral therapy.
In the field of materials science, organic materials with such structures may exhibit unique optical and electrical properties. For example, in organic Light Emitting Diode (OLED) materials, it may be possible to optimize the luminous efficiency and stability of materials through unique molecular structures and electron cloud distribution, resulting in better display screen image quality and lower energy consumption. In organic photovoltaic materials, 4-chloro-5-iodine-1H-pyrrolido [2,3-d] pyrimidine may help to improve the separation and transmission efficiency of photogenerated carriers, thereby improving the photoelectric conversion efficiency of solar cells.
In the field of pesticide research and development, this compound also has potential application value. Due to its special structure, it may have inhibitory or killing effects on some pests and pathogens. It can block its normal physiological activities by simulating the material structure required for key physiological processes in pests or pathogens, and competitively combining with the corresponding action targets to achieve the effect of preventing and controlling pests. Compared with traditional pesticides, it may be more selective and environmentally friendly.