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What is the chemical structure of 4-chloro-5-iodo-7h-pyrrol [2,3] pyrimidine?
The chemical structure of 4-chloro-5-iodo-7H-pyrrolo [2,3-d] pyrimidine is particularly interesting. This is a nitrogen-containing heterocyclic compound, which has both chlorine and iodine atoms substituted at specific positions.
Looking at its structure, it is based on the skeleton of pyrrolidone pyrimidine. Pyrrole ring is a five-membered heterocyclic ring containing one nitrogen atom and is aromatic; pyrimidine ring is a six-membered heterocyclic ring containing two nitrogen atoms and is also aromatic. The fused two form a unique skeleton, giving this compound a specific electron cloud distribution and chemical activity.
In this structure, the 4-position chlorine atom is substituted. The chlorine atom is quite electronegative and has an electron-absorbing induction effect, which can affect the electron cloud density of the surrounding atoms, thereby changing the polarity and chemical reactivity of the molecule. While the 5-position iodine atom is substituted, although the iodine atom is not as electronegative as chlorine, its atomic radius is large, and the spatial effect is significant, which also affects the spatial structure and reactivity of the molecule.
The 7-position of this compound is a hydrogen atom. This hydrogen atom can participate in weak interactions such as hydrogen bond formation, and may play a key role in the construction of intermolecular forces and the formation of crystal structures. On the whole, the chemical structure of 4-chloro-5-iodo-7H-pyrrolo [2,3-d] pyrimidine has potential application value and research significance in organic synthesis and medicinal chemistry due to its special heterocyclic framework and substituent distribution.
4-chloro-5-iodo-7h-pyrrol [2,3] What are the main uses of pyrimidine?
4-Chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate and participates in the synthesis of many drugs. The structure of genopyrimidine and pyrrole is common in many biologically active molecules. It can be modified by 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine to introduce different functional groups to synthesize anti-tumor drugs. In the research and development of many anti-tumor drugs, the compound is an important starting material for the development of such drugs because its structure can bind to specific targets of tumor cells and interfere with the growth and proliferation of tumor cells.
It also has important uses in pesticide chemistry. It can be chemically modified to synthesize pesticides such as insecticides and fungicides. Because its structure can specifically act on specific biomacromolecules in pests or pathogens, inhibiting related physiological processes, such as interfering with pathogen respiration or pest nervous system conduction, it can effectively prevent and control crop diseases and pests, and ensure crop yield and quality.
In addition, it has emerged in the field of materials science. With the development of organic optoelectronic materials, nitrogen-containing heterocyclic compounds have attracted attention due to their unique electronic properties. 4-Chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine, as a nitrogen-containing heterocyclic compound, can be used to prepare organic Light Emitting Diode (OLED) materials or organic solar cell materials. By adjusting the molecular structure and modification, the photoelectric conversion efficiency and stability of the material can be optimized.
What are the synthesis methods of 4-chloro-5-iodo-7h-pyrrol [2,3] pyrimidine?
The synthesis methods of 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine are ancient and diverse, all of which depend on the ingenuity and practice of chemical craftsmen.
First, chlorine and iodine atoms can be introduced by halogenation from raw materials containing pyrrole and pyrimidine structures. First, take a suitable pyrrolido-pyrimidine substrate, add an appropriate amount of halogenating reagents in a suitable reaction vessel, such as halogenating agents containing chlorine and iodine. The reaction environment is very critical, and the temperature needs to be precisely regulated, either in a low temperature cold bath or in a heated reflux state, depending on the characteristics of the substrate and the activity of the halogenating agent. At the same time, the choice of solvent is also the key. Choose a polar or non-polar solvent to facilitate the halogenation reaction, so that the chlorine and iodine atoms are in place to form the target product.
Second, it can also be done by the strategy of gradually building the ring system. First prepare the intermediate containing part of the structure, and build the prototype of the pyrrole ring or pyrimidine ring through the common reactions of organic synthesis, such as condensation and cyclization. Subsequently, in the subsequent reaction, chlorine and iodine atoms are precisely introduced, and the final construction of the ring system is completed. This process requires fine control of the conditions of each step of the reaction, and the purification and identification of intermediates are also indispensable to ensure that each step of the reaction evolves in the expected direction, resulting in 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine.
Furthermore, the method of catalytic synthesis is also a good strategy. The use of specific catalysts can accelerate the reaction process and improve the selectivity and yield of the product. Add suitable metal catalysts or organic catalysts to the reaction system to use their unique catalytic activity to guide the reaction. Factors such as the amount of catalyst, reaction time, and pH of the reaction system need to be carefully considered and optimized to achieve the purpose of efficient synthesis.
All these synthesis methods require chemists to maintain a rigorous attitude, study the reaction mechanism in detail, and operate cautiously in order to make the synthesis of 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine smooth, which will contribute to the development of chemical research and related fields.
4-chloro-5-iodo-7h-pyrrol [2,3] What are the physical properties of pyrimidine?
4-Chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine, this is an organic compound. Looking at its structure, it is formed by the fusing of pyrrole and pyrimidine, and there are chlorine and iodine atoms connected at specific positions. Its physical properties are quite critical, and it is related to the application of this compound in various scenarios.
First, the melting point has a specific melting point due to factors such as intermolecular forces and structural regularity. With strong intermolecular forces and high structural regularity, more energy is required to destroy the lattice, and the melting point is high. However, the specific melting point value is difficult to determine due to the lack of accurate experimental data.
times and boiling points are closely related to molecular weight and intermolecular forces. The molecular weight of this compound is large, and there are intermolecular forces such as van der Waals forces, which require more energy to vaporize, so the boiling point also has a certain value. However, the exact boiling point is difficult to determine due to no experimental determination.
Furthermore, the solubility, in view of the electronegativity of chlorine and iodine atoms in the molecule, as well as the structure of pyrrole and pyrimidine rings, may have a certain solubility in organic solvents. Chlorine and iodine atoms are lipophilic, and pyrrole and pyrimidine rings are also hydrophobic, so they may be soluble in organic solvents such as dichloromethane and chloroform. However, in water, due to the strong overall hydrophobicity of the molecule, the solubility may not be good.
And density, which is determined by its molecular composition and packing mode. The relative atomic weight of chlorine and iodine atoms in the molecule is relatively large, resulting in an increase in molecular weight. If the molecules are packed tightly, the density may be relatively high, but the specific density value needs to be accurately determined experimentally.
The physical properties of 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine have a profound impact on its application in organic synthesis, drug development and other fields. For example, in organic synthesis, the melting point and boiling point are related to the choice of reaction conditions, and the solubility affects the choice of reaction solvents. In drug development, properties such as solubility and density may affect the absorption and distribution of drugs and other pharmacokinetic processes. Although many specific physical properties need to be accurately determined experimentally, structural analysis can provide important guidelines for their research and application.
4-chloro-5-iodo-7h-pyrrol [2,3] What are the chemical properties of pyrimidine?
4-Chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine has many unique chemical properties. In its structure, the presence of chlorine and iodine atoms greatly affects its chemical activity. Chlorine atoms have certain electronegativity, which can change the distribution of molecular electron clouds, making the carbon atoms connected to them partially positive, making them vulnerable to nucleophiles. For example, in the case of nucleophiles containing hydroxyl and amino groups, a substitution reaction can occur, and hydroxyl or amino groups replace chlorine atoms to form new derivatives.
Furthermore, although iodine atoms are relatively large and highly polarized, they can also affect molecular reactivity. Due to the relatively low bond energy of iodine-carbon, under certain conditions, iodine atoms are easy to leave, triggering various reactions. For example, in some metal catalytic reactions, iodine atoms can be used as leaving groups to enable molecules to participate in coupling reactions and build more complex organic structures.
In terms of acidity and alkalinity, this compound has a certain alkalinity due to its nitrogen atom. The lone pair of electrons on the nitrogen atom can accept protons, and in an acidic environment, it can combine with protons to form cations. However, its alkalinity is affected by the electronic effects of surrounding atoms and groups. The conjugated structure of the pyrrolycopyrimidine system also disperses the electron cloud density on the nitrogen atom, resulting in relatively weak alkalinity.
In addition, the solubility of this compound in organic solvents is quite important. Generally speaking, due to its halogen atom and aromatic ring structure such as chlorine and iodine, it should have a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). However, the specific solubility is still closely related to solvent polarity and intermolecular interactions.
In short, 4-chloro-5-iodine-7H-pyrrolido [2,3-d] pyrimidine exhibits various chemical properties due to its unique structure, which lays an important foundation for research and application in the fields of organic synthesis and medicinal chemistry.