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What are the chemical properties of 4-chloro-6-iodo-7h-pyrrolo [2,3-d] pyrimidine
4-Chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine is an organic compound with unique chemical properties. Its chemical properties are closely related to its structure. Both the chlorine atom and the iodine atom in the molecule are halogen atoms, and the halogen atom has a certain electronegativity, which affects the electron cloud distribution of the compound.
Let's talk about the effect of halogen atom substituents first. Chlorine and iodine atoms can use the induction effect to reduce the electron cloud density of the connected carbon atoms. In chemical reactions, this will affect the activity of molecular nucleophilic substitution reactions. Due to the decrease in electron cloud density, nucleophilic reagents are more likely to attack the carbon atom, and nucleophilic substitution reactions are more likely to
Let's talk about the influence of the heterocyclic structure of the compound. The pyrrolido [2,3-d] pyrimidine heterocyclic system is aromatic, and the electron cloud delocalization of the aromatic system increases the molecular stability. This stability affects its chemical activity. Compared with non-aromatic similar structures, the compound is more difficult to undergo reactions such as ring opening that destroy the aromatic system.
In addition, due to the presence of nitrogen atoms in the structure, it has lone pair electrons and can participate in a variety of reactions. For example, under appropriate conditions, nitrogen atoms can act as nucleophilic check points and react with electrophilic reagents to generate new derivatives.
In terms of acid-base properties, although the molecule has no obvious acidic hydrogen, the lone pair electron of the nitrogen atom makes the molecule alkaline to a certain extent, and can react with acids to form corresponding salt compounds.
In addition, the different reactivity of chlorine and iodine atoms in this compound is also interesting. Generally speaking, iodine atoms are more likely to leave than chlorine atoms in some reactions due to their large atomic radius and relatively small C-I bond energy, and selectively undergo specific substitution reactions.
In conclusion, 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine exhibits various chemical properties due to its halogen atom and heterocyclic structure, and has potential applications in the field of organic synthesis.
What are the synthesis methods of 4-chloro-6-iodo-7h-pyrrolo [2,3-d] pyrimidine
There are many ways to synthesize 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine. One is to start with a compound containing pyrrole rings and pyrimidine rings. If an appropriate pyrrole derivative is taken first, its structure needs to be partially compatible with the target product pyrrole, and it has active groups for subsequent reactions, such as halogen atoms or amino groups. At the same time, pyrimidine derivatives are selected, which also need to have a specific activity check point and can interact with pyrrole derivatives. Under suitable reaction conditions, such as in a specific organic solvent, a suitable catalyst is added, heated to a certain temperature, and through a condensation reaction, the pyrrole ring is connected to the pyrimidine ring to build the basic skeleton of the target product.
Furthermore, the method of gradually constructing the ring system can be used. The pyrimidine ring part is first synthesized, the pyrimidine starting material is selected, and the chlorine-containing pyrimidine intermediate is obtained by introducing chlorine atoms at a specific position in the pyrimidine ring through a halogenation reaction. Subsequently, by means of a suitable reaction, on the basis of the intermediate, through a cyclization reaction, a pyrrole ring is introduced, and iodine atoms are introduced at a specific position of the pyrrole ring through a halogenation reaction. This process requires precise control of the reaction conditions, such as reaction temperature, reaction time, and the proportion of reactants, etc., to ensure that iodine atoms are accurately introduced into the target position.
Another strategy is to start with simpler raw materials and gradually build the molecular structure through a multi-step reaction. First, small molecular compounds containing nitrogen, carbon, and hydrogen are prepared. After a series of reactions, such as nucleophilic substitution, cyclization, etc., pyrrole rings and pyrimidine rings are constructed in sequence, and chlorine atoms and iodine atoms are introduced at a suitable stage Although this method is complicated in steps, it can more flexibly regulate the molecular structure, which is quite advantageous in the synthesis of target products with complex substituents. During the synthesis process, the product needs to be separated, purified and structurally identified after each step of the reaction to ensure that the reaction proceeds as expected and the product purity meets the requirements of subsequent reactions. Commonly used methods of separation and purification include column chromatography, recrystallization, etc., while structure identification relies on analytical techniques such as nuclear magnetic resonance and mass spectrometry.
4-chloro-6-iodo-7h-pyrrolo [2,3-d] pyrimidine in which applications
4-Chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine is useful in various fields such as medicine and chemical industry.
In the field of medicine, it is often the key raw material for the creation of new anti-cancer drugs. These compounds have unique structures and can precisely act on specific targets of cancer cells, so as to inhibit the proliferation of cancer cells and induce apoptosis of cancer cells. For example, for cancer caused by certain gene mutations, drugs containing 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine structural units may block the signal transduction pathway of cancer cells, thereby effectively curbing the progression of cancer.
In the chemical industry, it can be used as an important intermediate for the synthesis of high-end functional materials. Because of its special chemical activity, it can participate in a variety of organic synthesis reactions to construct macromolecular materials with unique properties. Such materials may have excellent optical and electrical properties, and can be used in the fabrication of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve the performance and efficiency of devices.
Furthermore, in the research and development of pesticides, 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine also has potential value. With appropriate modification and modification, new pesticides with high efficiency, low toxicity and environmental friendliness may be created, showing excellent control effects on specific pests or pathogens and contributing to the sustainable development of agriculture.
4-chloro-6-iodo-7h-pyrrolo [2,3-d] pyrimidine market outlook
4-Chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine is an organic compound. Looking at its market prospects, many factors are intertwined.
From the field of medicine, such nitrogen-containing heterocyclic compounds often have unique biological activities, or can be used as key intermediates in drug development. Today, there is a strong demand for the treatment of many diseases such as cancer and neurological diseases, and the search for novel structures and bioactive molecules in pharmaceutical research and development has never stopped. If this compound is confirmed to have significant effects on specific disease targets, it will definitely attract the attention of pharmaceutical companies and have broad prospects in the field of drug synthesis.
In terms of pesticides, its structure may give unique insecticidal, bactericidal or herbicidal properties. With the growing demand for high-efficiency, low-toxicity and environmentally friendly pesticides in agriculture, if this compound can meet the above requirements after testing, it is expected to occupy a place in the pesticide market.
Furthermore, scientific research and exploration are endless. The field of organic synthetic chemistry continues to pursue novel reaction paths and compound structures. The unique structure of this compound may inspire researchers to explore novel synthesis methods and reaction mechanisms, bring scientific research value to it, and further expand its application potential in academic and industrial research and development.
However, its market prospects are also facing challenges. Synthesis costs may become key. If the synthesis steps are complicated and the raw materials are scarce and expensive, large-scale production and application will be limited. And the biological activity of the compound needs to be further studied and verified, and the biosafety assessment is also indispensable. Only by meeting the relevant regulatory standards can it enter the market smoothly.
In summary, 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine has potential opportunities in the fields of medicine, pesticides and scientific research, but it needs to overcome the difficulties of synthesis cost and biosafety assessment in order to fully demonstrate its market value.
What are the manufacturers of 4-chloro-6-iodo-7h-pyrrolo [2,3-d] pyrimidine
4-Chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine is an organic compound, which is widely used in the fields of medicinal chemistry and organic synthesis. As for its manufacturers, after much investigation, the list is as follows:
Overseas, there is Sigma-Aldrich Company. This is a leader in the supply of chemical reagents and scientific research products, with a long reputation and a good reputation. Its products have a wide range of products, high purity, and have extremely professional technical support and perfect after-sales service. Many scientific research institutions and enterprises often use this company as the preferred supplier.
There is also TCI (Tokyo Chemical Industry Co., Ltd.), which is also an important supplier of such compounds. The company focuses on the field of fine chemicals, with high-quality products and continuous innovation. It has developed many novel and high-quality products, which have a good reputation in the international market.
In China, there is Buringway Technology Co., Ltd. The company has long been committed to providing customers with high-quality chemical products and services, covering a wide range of products, including 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine. Its supply system is complete and can meet the diverse needs of different customers.
There is also Shanghai search banner biochemical technology joint stock company, which is also a well-known enterprise supplying this compound. Search banner focuses on the field of scientific research reagents and has a wide range of products. It can supply high-quality 4-chloro-6-iodine-7H-pyrrolido [2,3-d] pyrimidine in a timely manner for various scientific research projects and production activities.
The manufacturers mentioned above may have different product supply conditions due to market changes, production adjustments, etc. If there is a procurement demand, please consult in detail through the official website, telephone and other channels to obtain the latest and accurate product information and procurement details.