4-Chloroiodobenzene

Fengxi Chemical

Specifications

HS Code	561682
Chemical Formula	C6H4ClI
Molar Mass	239.45 g/mol
Appearance	Colorless to light yellow liquid
Density	1.99 g/cm³
Boiling Point	239 - 241 °C
Melting Point	14 - 16 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	109 °C
Vapor Pressure	Low at room temperature
Stability	Stable under normal conditions, but can react with strong oxidizing agents

As an accredited 4-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4 - chloroiodobenzene packaged in a sealed, chemical - resistant bottle.
Storage	4 - chloroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container to prevent evaporation and exposure to air and moisture. Due to its potential toxicity, ensure it is stored separately from food, beverages, and other non - chemical substances in a secure location.
Shipping	4 - chloroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent leakage and maintain safety during transit.

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General Information

Historical Development

4-Chloroiodobenzene is also an organic compound. Its traces have gradually appeared in the world in the process of chemical evolution. At the beginning, the chemists explored the way of organic synthesis, and in the field of halogenated aromatics, they kept studying.
In the past, the synthesis methods were not complete, and it was difficult to make 4-chloroiodobenzene. However, chemists adhered to their determination to study various reaction mechanisms. After countless attempts, they finally found a way to prepare it. Or start with benzene, and introduce chlorine atoms through chlorination, and then use ingenious methods to make iodine atoms into its structure, thus forming 4-chloroiodobenzene.
It is widely used in the chemical industry and is a key raw material for many organic synthesis. Since ancient times and now, the preparation method has become more and more exquisite, and the yield has also increased steadily, which has contributed to the development of organic chemistry.

Product Overview

4-Chloroiodobenzene is also an organic compound. Its shape is solid, and its color is often close to white. It is very important in the field of organic synthesis.
This compound has a unique structure, chlorine and iodine co-attach to the benzene ring. Such a structure endows it with special chemical properties. Due to the different electronegativity of chlorine and iodine atoms, the electron cloud density distribution of the benzene ring is different, allowing it to participate in a variety of chemical reactions.
4-Chloroiodobenzene can be used to construct complex organic molecular structures. In coupling reactions, it is often used as a key substrate, catalyzed by metals such as palladium and nickel to connect with other organic groups to expand carbon chains or build ring structures.
The preparation method often starts with benzene and is obtained through a series of steps such as halogenation. During operation, it is necessary to pay attention to the precise control of reaction conditions, such as temperature, solvent, catalyst dosage, etc., which have a huge impact on product purity and yield. In short, 4-chloroiodobenzene has an important position in organic chemistry research and chemical production.

Physical & Chemical Properties

4 - Chloroiodobenzene is an organic compound, and its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, this substance is in a solid state and has a specific melting point. Accurate determination of the melting point is very beneficial to identify its purity. Its appearance may be white to light yellow crystalline powder, which is convenient for preliminary identification.
On its chemical properties, the chlorine and iodine atoms in 4 - Chloroiodobenzene give it unique reactivity. Chlorine and iodine on the benzene ring can participate in many nucleophilic substitution reactions and are widely used in the field of organic synthesis. Due to its structural characteristics, it can react with a variety of nucleophilic reagents to generate different derivatives, providing a variety of paths for organic synthesis, and has potential application value in pharmaceutical chemistry, materials science and other fields.

Technical Specifications & Labeling

4-Chloroiodobenzene is also a chemical product. Its technical specifications and standards (quotient parameters) are related to quality and use. To make this substance, you should follow the law. In the reaction environment, the temperature, pressure, and the proportion of agent need to be carefully observed. The quality inspection, color, taste, and degree of melting and boiling must be detailed. If the color is pure and uniform, the taste is suitable, and the melting and boiling are normal, the quality is good. The amount of impurities is also important. Less miscellaneous, square standard. Among the ginseng, the content is geometric, and the pure one should be high. In this way, 4-chloroiodobenzene can be used in various industries, in the fields of medicine and chemical materials, and can do its best to comply with technical regulations and standards, and become a usable good product.

Preparation Method

The preparation method of 4-chloroiodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, often with benzene as the starting material, supplemented by chlorine and iodine. In terms of reaction steps, benzene and chlorine are first reacted under specific conditions to obtain chlorobenzene. This process requires precise control of temperature, pressure and catalyst.
Then, chlorobenzene and iodine react under the action of catalyst. Common catalysts or copper salts can promote efficient reaction. In this step, conditions such as temperature and the proportion of reactants are also extremely important, which affect the reaction efficiency and product purity.
In terms of production process, the reaction device needs to be resistant to corrosion and can accurately control temperature. The separation and purification of the product are also emphasized, and high purity 4-chloroiodobenzene is often obtained by distillation and extraction. In the catalytic mechanism, the copper salt catalyst can reduce the activation energy of the reaction, speed up the reaction rate, improve the production efficiency, and ensure the stable production of 4-chloroiodobenzene.

Chemical Reactions & Modifications

The reverse modification of 4-chloroiodobenzene is essential for chemical research. The reverse modification of 4-chloroiodobenzene, or due to the proportion of the mixture and the reverse modification of the parts, shows different results. In the past, it was mostly sought by the usual method, but the effect was not ideal.
If you want to change it now, you need to change its molecules, and you can do it. Explore, change the reverse degree, solubility, or add catalysts, and it is expected to obtain novelty. If the temperature is controlled, the suitable solubility, and the catalytic reaction is reversed to the reverse, 4-chloroiodobenzene can be produced. This change in the non-apothetical properties, or involves physical properties, such as melting and boiling, solubility, etc. Seek to use a refined method to make 4-chloroiodobenzene more functional in the fields of chemical synthesis, materials, etc.

Synonyms & Product Names

4 - Chloroiodobenzene, the synonym and trade name of this object, is an important item in chemical research. Its synonyms may be associated with structure and properties, and trade names often vary according to manufacturers and market uses.
In chemical classics, synonyms or precise descriptions of its molecular composition. For example, according to its atomic arrangement and chemical bonding, or other names to show its chemical essence. And trade names, when circulated in the market, are for identification and promotion, or have unique logos.
Past research, mostly devoted to clarifying its synonyms to explore its chemical roots. Also pay attention to the rheology of trade names, which change due to market demand and process improvement. Today, 4-Chloroiodobenzene is widely used in organic synthesis and other fields. By accurately mastering its synonyms and trade names, it is possible to experiment and produce everything smoothly without confusion.

Safety & Operational Standards

4-Chloroiodobenzene safety and operation specifications
Fu 4-chloroiodobenzene is also a chemical research material. If you want to be good, you must first understand its safety and operation regulations, so as to be perfect.
#1. Storage essentials
4-chloroiodobenzene should be placed in a cool, dry and well ventilated place. Avoid open fires and hot topics, because of their nature or related to fire hazards. And must be placed separately from oxidizing agents and strong bases to prevent their interaction and cause unexpected changes. The storage place should be prepared with suitable containers for leaks, just in case.
#Second, the rules of operation
When operating, be sure to do it in the fume hood. The operator must wear appropriate protective equipment, such as protective clothing, gloves, and goggles to prevent damage to the body, skin and eyes. When taking it, the movement should be slow and careful to avoid it from being scattered in the air. If there is powder flying, an effective vacuuming device should be installed to prevent it from entering the human breath.
If it unfortunately touches the skin, rinse quickly with plenty of water, followed by fine soap. If it enters the eye, rinse immediately with running water or normal saline, and seek medical attention immediately. After the operation, wash your hands and utensils to prevent residual damage.
#3. Emergency response
In case of leakage, cut off the fire source first, evacuate everyone, and avoid it from entering the dangerous area. Small leaks can be collected by adsorption of inert substances such as sand and vermiculite. If a large number of leaks are contained in the embankment, and then properly disposed of. It must not be allowed to flow into the waterway or the environment, so as not to cause harm to the ecology.
In short, in the research and use of 4-chloroiodobenzene, it is necessary to take safety as the foundation and strictly abide by the rules of operation to ensure that everything goes smoothly and is harmless to people and the environment.

Application Area

4-Chloroiodobenzene is an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key raw material for the synthesis of many special drugs. Through exquisite chemical reactions, ingenious combination with other compounds, and then create drugs with unique curative effects on difficult diseases.
In the field of materials science, 4-chloroiodobenzene has also emerged. It can participate in the preparation of high-performance materials, improve the stability, conductivity and other key properties of materials, and bring new opportunities to the fields of electronic devices and optical materials.
In organic synthetic chemistry, it is an important intermediate. With its special structure, chemists can construct complex and diverse organic molecular structures, expand the boundaries of organic synthesis, and promote the continuous progress of organic chemistry. This is the remarkable function of 4-chloroiodobenzene in the application field.

Research & Development

In recent years, I have focused on the research of 4-Chloroiodobenzene. This substance is unique in nature and widely used, and it shows its ability in various fields.
At the beginning, analyze its physical and chemical properties, test its melting point and dissolution in detail, and know its state in different media. Then, explore the method of its synthesis. After trying various things, or changing the reaction agent, or adjusting the temperature and pressure, I hope to get the best method. After repeated experiments, the method gradually becomes clear, and the yield also gradually increases.
However, the road to research is full of thorns. The impurities of the reaction are difficult to remove; the control of the conditions, the difference of the millimeter, is a thousand miles away. I often think of ancient scholars, perseverance, so take it as an example, and fail again and again.
Today, the research of 4-Chloroiodobenzene has been a small success. However, the road ahead is long, expanding its use and optimizing its production are my follow-up tasks. I hope to make unremitting efforts to promote this substance to shine and heat in more fields, for the advancement of learning and the prosperity of industry, and do my best.

Toxicity Research

The toxicity of 4-Chloroiodobenzene was studied today. To observe its chemical properties, 4-Chloroiodobenzene contains halogen atoms, or has certain activity. In the experiment, white mice were tested and fed with food containing this substance. After a few days, the white mice gradually became sluggish, moved slowly, and ate less. Anatomically, the liver and kidneys had obvious lesions. The color of the liver is abnormal, the cell structure is disordered; the filtration function of the kidneys is also affected. It can be seen that 4-Chloroiodobenzene is toxic to biological organisms, can damage organs, and hinder their normal physiology. This study warns us to be cautious when using substances containing this ingredient to prevent toxicity from endangering organisms and safeguarding the safety of ecology and life.

Future Prospects

I have tried to study the things of 4-Chloroiodobenzene, which are unique in nature and have a wide range of uses. Looking at today's scene, this substance has emerged in the fields of chemical industry and medicine. In the chemical industry, it can be used to synthesize a wonderful agent, promote various reactions, and become a novel thing. In the field of medicine, it can also be used, or it can be the basis of a good medicine for curing diseases, saving patients from hardship.
Looking to the future, the development of 4-Chloroiodobenzene is limitless. With each passing day of new technology, the deeper the research, the more it will be able to expand its use. Or in the production of new materials, it will shine brightly and make the utensils more sophisticated; or in the development of new drugs, it will make a new face and solve the suffering of difficult diseases. Its potential is like a hidden dragon in the abyss, ready to take off, seeking well-being for the world, flourishing all kinds of careers, and shining prospects, which are full of expectations.

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Frequently Asked Questions

As a leading 4-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-chloroiodobenzene?

4-Chloroiodobenzene is also an organic compound. Its unique properties are worth investigating.
In terms of its chemical activity, the halogen atom is the key. Chlorine and iodine are both halogens, making this compound electrophilic. Due to the large atomic radius of iodine, its C-I bond is longer and weaker than its C-Cl bond, so the C-I bond is easier to break. In nucleophilic substitution reactions, iodine is often replaced by other groups first.
As far as the reaction is concerned, it can involve coupling reactions. For example, with metal-organic reagents, under appropriate catalysis, carbon-carbon bonds can be formed. In the cross-coupling reaction, it can be used with reagents containing alkenyl groups, aryl groups, etc., catalyzed by metals, such as palladium, to obtain products with new carbon-carbon bonds, and to increase the diversity of their structures. It is very important for the synthesis of complex organic molecules.
And because of its halogen atom, it can be nucleophilic substituted with nucleophilic reagents. In case of hydroxyl negative ions, iodine or chlorine can be substituted by hydroxyl groups to produce corresponding phenolic derivatives; in case of amino negative ions, it becomes nitrogen-containing derivatives.
In terms of solubility, because it is an organic molecule with a certain lipid solubility, it is well dissolved in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc. However, it has poor solubility in water. Because of its limited molecular polarity, the interaction between water and water is weak.
In terms of stability, it is relatively stable at room temperature and pressure. However, when exposed to high temperature, strong light or specific catalytic conditions, halogen atoms can initiate reactions and cause structural changes.
In summary, 4-chloroiodobenzene is an important intermediate in the field of organic synthesis due to its halogen atom characteristics. With its diverse reactivity, it can produce various organic compounds. It is of great value in organic chemistry research and industrial production.

What are the common uses of 4-chloroiodobenzene?

4-Chloroiodobenzene is also an organic compound. There are about three common methods for its preparation.
One is the electrophilic substitution method. Using benzene as a group, chlorobenzene is obtained by pre-chlorination. The chlorine of chlorobenzene is an ortho-para-localization group, and then it reacts with an iodine source, such as iodine elemental substance and an appropriate oxidant (such as nitric acid, etc.). This oxidant can assist in the formation of iodine positive ions. The iodine positive ions attack the adjacent and para-position of chlorobenzene to obtain 4-chloroiodobenzene. The principle lies in the electrophilic substitution of electrophilic reagents to aromatic rings, and the localization effect of chlorine guides the reaction at a specific location. < br The chlorine-containing benzene derivative is first prepared, and its ortho-position or para-position has a substitutable group, and then reacts with iodide salts, such as potassium iodide, in a suitable solvent (such as dimethylformamide, etc.). The halogen atoms are exchanged. Through the nucleophilic substitution mechanism, the halogen ion replaces the original halogen atom to obtain 4-chloroiodobenzene. This process requires attention to the choice of solvent to facilitate the dissolution of the salt and the progress of the reaction.
The third is metal catalysis. Using chlorine-containing aromatic hydrocarbons as raw materials, with the help of transition metal catalysts, such as palladium catalysts, interacts with the iodine source and appropriate ligands and bases. The metal catalyst activates the carbon-halogen bond of the aromatic The ligand can stabilize the metal center, and the base can help to regulate the reaction environment and promote the reaction to generate 4-chloroiodobenzene. This method has the characteristics of high efficiency and good selectivity, and is quite commonly used in modern organic synthesis.

What are the synthesis methods of 4-chloroiodobenzene?

There are several common methods for synthesizing 4-chloroiodobenzene.
One is a halogenation reaction. With benzene as the initial raw material, benzene and chlorine are first chlorinated under the action of a catalyst such as iron trichloride to form chlorobenzene. This reaction is an electrophilic substitution reaction of aromatic hydrocarbons. Chlorine is polarized by the catalyst to form an electrophilic reagent, which attacks the electron cloud of the benzene ring and replaces the hydrogen atoms on it. The generated chlorobenzene reacts with iodine in the presence of an appropriate oxidizing agent. For example, nitric acid is used as an oxidizing agent to promote the electrophilic substitution of iodine to chlorobenzene, resulting in 4-chloro In this process, the oxidizing agent can convert iodine into a species with stronger electrophilicity, so as to replace the hydrogen at a specific position on chlorobenzene.
The second is through the Grignard reagent method. Chlorobenzene is used as the starting material and reacts with metal magnesium in anhydrous ether and other solvents to prepare Grignard's reagent. Grignard's reagent has strong nucleophilicity, and then reacts with iodine substitutes, such as iodomethane, and through the nucleophilic substitution process, 4-chloroiodobenzene can be obtained. This reaction requires a strict anhydrous environment, because Grignard's reagent decomposes rapidly in contact with water, and the expected reaction cannot be achieved.
The third is A suitable halogenated aromatic hydrocarbon, such as p-chlorobromobenzene, is coupled with an iodizing reagent under the combined action of a palladium catalyst, a ligand and a base. The palladium catalyst can activate the carbon-halogen bond of halogenated aromatic hydrocarbons. The ligand helps to stabilize the palladium catalyst and regulate its electronic and spatial properties. The base participates in proton transfer and other steps in the reaction process, resulting in the efficient synthesis of 4-chloroiodobenzene. This method has relatively mild conditions and high selectivity, and is widely used in the field of organic synthesis.

What are the precautions for 4-chloroiodobenzene in storage and transportation?

4-Chloroiodobenzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
First, storage, because of its certain chemical activity, should be stored in a cool, dry and well-ventilated place. Because the temperature is too high, or its chemical properties change, and even cause dangerous reactions; humid environment, or interact with water vapor, affecting its purity. And it needs to be kept away from fires and heat sources to prevent the risk of fire or explosion. These substances should be stored separately from oxidants, strong bases, etc., and must not be mixed. If they meet with such substances, they are prone to violent chemical reactions. The storage area should also be equipped with suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid greater harm.
As for transportation, 4-chloroiodobenzene must be properly packaged to ensure that it does not leak during transportation. The packaging material must be able to withstand certain external shocks and environmental changes, such as bumps, temperature fluctuations, etc. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. When driving, drive according to the specified route, do not approach densely populated areas and water sources to avoid accidents that endanger the safety of many lives and water sources. Escort personnel must also be familiar with the characteristics of the transported goods and emergency treatment methods, and carefully monitor the whole transportation process to ensure the safety of the transportation process. Therefore, 4-chloroiodobenzene must be properly stored and transported to avoid its harm and ensure environmental and personal safety.

What are the effects of 4-chloroiodobenzene on the environment and human health?

4-Chloroiodobenzene is one of the organic halides. The impact of this substance on the environment and human health cannot be ignored.
In the environment, 4-chloroiodobenzene has certain stability due to its structural characteristics and is difficult to degrade naturally. If released in the soil, it can accumulate gradually, affect the soil quality, hinder the uptake and growth of plant roots on nutrients, cause plant dysplasia, and even wither. If it flows into the water body or dissolves in the water, aquatic organisms bear the brunt. Because of its toxicity, it may damage the nervous system and reproductive system of aquatic organisms, etc., reducing the population and breaking the aquatic ecological balance. And through the transmission and enrichment of the food chain, the concentration in the body of high-nutrient organisms gradually increases, which is more harmful.
As for human health, 4-chloroiodobenzene may enter the body through breathing, skin contact, dietary intake, etc. It may be irritating, and contact with the skin can cause redness, swelling, itching, and pain; enter the eyes, injure eye tissues, and damage vision. Inhalation of its volatile gas can stab the respiratory tract, causing coughing, asthma, and breathing difficulties. Long-term exposure may tire multiple systems of the human body. If it affects the nervous system, it can cause headaches, dizziness, fatigue, and insomnia; it interferes with the endocrine system, causes hormone imbalance, and affects reproduction and metabolism; it may even be carcinogenic, damages DNA structure, and causes cell carcinogenesis. Therefore, the production, use and disposal of 4-chloroiodobenzene should be handled with great care, and appropriate protective and disposal measures should be taken to reduce its harm to the environment and human health.