4 Ethoxyiodobenzene 4 Iodophenyl Ethyl Ether

4-Ethoxyiodobenzene (4-ethoxyiodobenzene) and 4-iodophenyl ethyl ether (the two are actually the same substance) have a wide range of main uses.
In the field of organic synthesis, it is often used as a key intermediate. The presence of iodine atoms and ethoxy groups in the molecule gives it unique reactivity. Iodine atoms can participate in a variety of coupling reactions, such as the Ullmann reaction, whereby carbon-carbon bonds, carbon-heteroatomic bonds, etc. can be formed to synthesize complex organic compounds, which are of great significance in drug development, materials science, etc.
In the field of medicinal chemistry, with this as the starting material, other active groups can be introduced through a series of reactions to prepare compounds with specific pharmacological activities. For example, by modifying the substituents on the benzene ring, the physical and chemical properties of the compound such as lipophilicity and electron cloud density can be adjusted, and then its interaction with biological targets can be optimized to improve the efficacy and selectivity of drugs.
In the field of materials science, it can be used to synthesize functional polymer materials. It is connected to the polymer skeleton by coupling reaction to endow the material with unique optical and electrical properties. For example, synthesizing polymers with photoelectric activity can be used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices to improve the performance and efficiency of the device.
In addition, 4-ethoxyiodobenzene also plays an important role in the preparation of fine chemical products. It can be used to prepare special structures of fragrances, dyes, etc. With its unique chemical structure, it imparts novel characteristics and quality to the products.

The physical properties of 4-ethoxyiodobenzene (4-ethoxyiodobenzene) and 4-iodophenyl ethyl ether (4-iodophenyl Ethyl Ether, the same substance as 4-ethoxy iodobenzene) are quite important for their application in various fields.
Looking at its appearance, at room temperature, 4-ethoxyiodobenzene mostly appears as a colorless to light yellow liquid, which is easy to intuitively identify. It has a certain volatility and can slowly emit a smell in the air. However, this smell is not pungent and intolerable, but has a slightly special aromatic aroma. Although it is not strong, it can be distinguished.
When it comes to the melting point, the melting point is about [X] ° C. Under this temperature condition, the substance changes from solid to liquid, showing a phase change. The boiling point is around [X] ° C. When the temperature rises to the boiling point, the liquid will violently vaporize and turn into a gaseous state. This boiling point characteristic has a significant impact on separation, purification and storage. To separate this substance, it can be achieved by distillation according to its boiling point.
4-ethoxyiodobenzene has a slightly higher density than water, about [X] g/cm ³. When mixed with water, it will sink to the bottom. This property needs to be taken into account when it comes to liquid-liquid separation operations.
In terms of solubility, it is insoluble in water, because water is a highly polar solvent, while 4-ethoxy iodobenzene has a weaker polarity, and according to the principle of "similar miscibility", the two are difficult to miscible. However, it is soluble in many organic solvents, such as ethanol, ether, chloroform, etc., and can be well dispersed in these organic solvents to form a uniform solution. This property is of great significance when used as a solvent or reactant in organic synthesis reactions, which can promote the smooth progress of the reaction.
In addition, the refractive index of 4-ethoxy iodobenzene is also one of its important physical properties, about [X]. The refractive index reflects the degree of deflection of light when propagating in the substance, and is involved in the research or application of optical materials.
The above physical properties are related to each other, and together outline the characteristics of 4-ethoxy iodobenzene, which lays the foundation for its application in many fields such as chemical industry and medicine.

The chemical properties of 4-ethoxyiodobenzene (4-ethoxyiodobenzene) and 4-iodophenyl ethyl ether (4-iodophenyl Ethyl Ether, which is different from 4-ethoxyiodobenzene for the same substance) are relatively stable.
In this compound, the benzene ring is a stable conjugated system, which endows it with a certain degree of stability. Although the iodine atom has a certain activity and can undergo reactions such as nucleophilic substitution, the reactivity is restricted to a certain extent due to the conjugation of the benzene ring. The ethoxy group is connected to the benzene ring, and the electron cloud density of the benzene ring is further enhanced through the electron-giving conjugation effect, which contributes to the stability of the whole molecule. Under normal environmental conditions, without specific reagents, catalysts and suitable reaction conditions, 4-ethoxy iodobenzene will not easily undergo chemical reactions. However, in some specific scenarios, iodine atoms may be replaced in case of strong nucleophiles; under extreme conditions such as high temperature and light, the molecular structure may undergo some changes, but overall, in conventional storage and general experimental environments, its chemical properties are relatively stable and its own structure and properties can be maintained unchanged.

To prepare 4-ethoxyiodobenzene (4-iodophenyl ethyl ether), which is 4-iodophenyl ethyl ether (4-iodophenyl ethyl ether), the following ancient methods can be used.
The method of nucleophilic substitution is first proposed. Using 4-iodophenol and haloethane as raw materials, this reaction can be carried out in an alkaline environment. Take an appropriate amount of 4-iodophenol and place it in the reaction vessel, and then add alkaline substances such as potassium carbonate slowly. Using alcohols as solvents, such as ethanol, can help dissolve and promote the reaction. After stirring well, add haloethane dropwise. Depending on the activity of haloethane, if it is bromoethane or iodoethane, the activity is higher, and the reaction conditions can be slightly milder; if it is chloroethane, the activity is slightly lower, and the reaction time needs to be properly heated and prolonged. Under heating and stirring, the phenolic hydroxyl oxygen atom of 4-iodophenol acts as a nucleophilic reagent to attack the α-carbon atom of haloethane, and the halogen ion leaves, and 4-ethoxyiodobenzene is obtained. After the reaction is completed, the pure product can be obtained by conventional separation and purification methods, such as extraction, distillation, column chromatography, etc.
Furthermore, it can be prepared by the electrophilic substitution reaction of phenyl ring. First, benzene is used as the starting material and ethoxylated to obtain eth The mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as the nitrifying reagent to nitrate ethyl ether, and the nitro group is introduced at the para-position of the benzene ring. After the reduction step, the nitro group is reduced to the amino group by the reduction system such as iron powder and hydrochloric acid to obtain p-ethoxyaniline. The diazonium salt solution composed of sodium nitrite and hydrochloric acid reacts with p-ethoxyaniline at low temperature to form a diazonium salt. Subsequently, the potassium iodide solution is added, the diazonium group is replaced by the iodine atom, and the final 4-ethoxyiodobenzene is obtained. This route step is slightly complicated, but the raw material is easy to obtain, and the reaction conditions of each step are relatively mature.
Another cross-coupling reaction catalyzed by p 4-Iodohalobenzene and sodium ethanol are used as raw materials to react in the presence of palladium catalysts and ligands. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands such as tri-tert-butylphosphine, etc. The reaction is carried out in an appropriate organic solvent such as N, N-dimethylformamide (DMF). Under heating and inert gas protection, halogen atoms are cross-coupled with the ethoxy group of sodium ethanol to form the target product 4-ethoxyiodobenzene. This method is efficient and selective, but the cost of catalysts and ligands is high, and the requirements for reaction equipment and operation are also stricter.

I think what you are asking is the price range of 4-ethoxyiodobenzene (4-ethoxyliodobenzene) and 4-iodophenyl Ethyl Ether (4-iodophenyl ethyl ether) in the market. However, the price of the two in the market often changes due to many reasons, and it is difficult to determine a certain number.
First, the price of raw materials often changes due to time, geographical location, and supply and demand. If the raw materials required for its preparation are rare, or there are disasters or wars in the place of origin, which make the raw materials difficult to harvest, the price must be high. Such as ancient treasures, because it is not easy to produce, the price is high and rare.
Second, the method of preparation also affects its price. If the preparation process is complicated, requires multiple processes, takes a long time, consumables are many, and labor is huge, then the price will be high. The exquisite craftsmanship of ancient times is time-consuming and laborious, and the finished product is precious.
Third, the supply and demand of the city is also the main reason. If there are many applicants for this product, but there are few suppliers, the price will rise; if the supply exceeds the demand, the price will drop. Just like the reason that the valley is low in a good year, and the valley is expensive in a bad year.
Today, 4-ethoxyiodobenzene and 4-iodophenyl ethyl ether are in the market, and their prices range from tens to hundreds of yuan per gram. However, this is only an approximate number, and the actual price should be subject to the quotation of each supplier and the real-time market conditions. To know the exact price, you need to check the dynamics of the market in detail and consult the merchants before you can get it.