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What are the main uses of 4-fluoro-5-iodo-1h-indazole?
4-Fluoro-5-iodine-1H-indazole is one of the organic compounds. Its main use covers the field of organic synthesis, and it is mostly used as a key intermediate.
In the field of medicinal chemistry, it can be used as a lead compound to help the development of new drugs. Indazole compounds have a variety of biological activities, such as anti-tumor, anti-inflammatory, anti-viral and other effects. The specific substituents of 4-fluoro-5-iodine-1H-indazole may adjust the electron cloud distribution and spatial configuration of molecules, thereby affecting their interaction with biological targets to achieve ideal pharmacological activity.
In the field of materials science, it may be an important building block for the construction of special functional materials. After rational design and synthesis, with its structural properties, materials with unique optical and electrical properties can be prepared, such as organic Light Emitting Diode materials, semiconductor materials, etc.
In addition, in pesticide chemistry, it may also show potential value. Or it can be modified to create new and efficient pesticides for the prevention and control of pests and diseases and the growth of crops. In short, 4-fluoro-5-iodine-1H-indazole has broad application prospects in many scientific fields due to its unique structure, and is an important research object for scientific research and industrial production.
What are 4-fluoro-5-iodo-1h-indazole synthesis methods?
The synthesis of 4-fluoro-5-iodine-1H-indazole is an important topic in organic synthetic chemistry. There are several common methods for synthesizing this compound.
First, start with an appropriate nitrogen-containing heterocyclic precursor. For example, a certain type of indazole derivative can be selected to introduce fluorine and iodine atoms through a halogenation reaction. First, introduce fluorine atoms at a specific position in the indazole ring with a suitable fluorination reagent, such as Selectfluor, under appropriate reaction conditions. This step requires precise regulation of reaction temperature, time and reagent dosage to prevent side reactions from occurring. Subsequently, iodine atoms are introduced at another suitable check point by using iodine substitutes, such as iodine elemental agents combined with appropriate oxidizing agents. In this process, the choice of solvents is very critical, such as N, N-dimethylformamide (DMF), dichloromethane, etc. Different solvents affect the reaction rate and selectivity.
Second, you can start with the construction of the indazole ring. Compounds containing potential indazole ring structure fragments are prepared first, and the ring system is gradually built through multi-step reactions. At the same time, the reaction sequence is cleverly designed, and fluorine and iodine atoms are selectively introduced during or after the construction of the ring. For example, using a nitrogen-containing and carbon-containing fragment as the starting material, the indazole ring skeleton is formed through condensation, cyclization and other reactions, and then fluorine and iodine atoms are introduced according to the above halogenation method. This strategy requires in-depth understanding of the reaction mechanism, careful planning of each step of the reaction to ensure the yield and selectivity of each step.
Furthermore, the reaction catalyzed by transition metals can also provide an effective way for synthesis. Transition metals such as palladium and copper are used as catalysts to realize the selective coupling of halogen atoms and indazole rings. For example, under palladium catalysis, fluorine-containing or iodine-containing halogenated aromatics are coupled to indazole derivatives. This method requires screening suitable ligands to enhance the activity and selectivity of the catalyst, and optimizing the reaction conditions, such as the type and dosage of bases, reaction temperature, etc., so as to efficiently synthesize the target compound 4-fluoro-5-iodine-1H-indazole.
What are the physical properties of 4-fluoro-5-iodo-1h-indazole?
4-Fluoro-5-iodine-1H-indazole is one of the organic compounds. Its physical properties are quite important, and it is related to many uses and characteristics of this substance.
Looking at its properties, under normal temperature and pressure, 4-fluoro-5-iodine-1H-indazole is often in a solid state. The shape of this state makes it different from gaseous or liquid substances in many operations and applications. Its solid shape makes it easy to store and transport, and provides convenience in the logistics of industrial production and scientific research experiments.
When it comes to melting point, this substance has a specific melting point value. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. The melting point of 4-fluoro-5-iodine-1H-indazole determines the temperature at which its phase state changes. Knowing the melting point is of great significance for purification, crystallization and other process operations. By controlling the temperature to approach or reach the melting point, the state of the substance can be changed, and then impurities can be separated to obtain a pure product.
Solubility is also a key physical property. 4-fluoro-5-iodine-1H-indazole has different solubility in different solvents. It may have a certain solubility in organic solvents, such as some alcohols and ether solvents. This property is widely used in chemical synthesis. When synthesizing the reaction, choose a suitable solvent to fully dissolve and mix the reactants to promote the smooth progress of the reaction. If the solvent is not selected properly, it is difficult for the reactants to contact the reaction, resulting in low reaction efficiency or even failure to occur.
In addition, the color and smell of 4-fluoro-5-iodine-1H-indazole are also characterized by its physical properties. Generally speaking, it may have a specific color, although it is not bright and eye-catching, it is also one of the identification characteristics. In terms of smell, it may have a slight special smell, although it is not pungent and unpleasant, it can be used as a basis for identification.
In conclusion, the physical properties of 4-fluoro-5-iodine-1H-indazole, such as morphology, melting point, solubility, color and odor, are important for the understanding and application of this substance, and have far-reaching influence in many fields such as chemical industry and medicine.
What are the chemical properties of 4-fluoro-5-iodo-1h-indazole?
4-Fluorine-5-iodine-1H-indazole, this is an organic compound. Its chemical properties are unique and related to many aspects.
Let's talk about its stability first. In this compound, fluorine and iodine atoms are attached to the indazole ring. Fluorine atoms have high electronegativity, which can absorb electrons by inducing effects and change the distribution of molecular electron clouds. Although iodine atoms are less electronegative than fluorine, their atomic radius is large, which can cause steric hindrance. The two work together to affect molecular stability. Generally speaking, due to the characteristics of fluorine and iodine atoms, this compound has certain stability under normal conditions, but may react under extreme conditions such as strong oxidants, reducing agents or high temperatures.
Let's talk about its reactivity. In the nucleophilic substitution reaction, the iodine atom can be used as the leaving group. Because the C-I bond energy is relatively low, it is easy to break, providing a check point for the attack of nucleophilic reagents. For example, in the case of reagents containing active nucleophilic groups, such as alkoxides, amines, etc., iodine atoms may be replaced to form new derivatives. Although fluorine atoms are highly electronegative, the C-F bond is relatively stable and not easy to be directly replaced by nucleophilic reagents, but they can indirectly affect the reactivity by affecting the density of the ortho-electron cloud.
In the electrophilic substitution reaction, the electron cloud density distribution of the indazole ring is affected by fluorine and iodine atoms. The electron-absorbing induction effect of fluorine atoms reduces the density of electron clouds on the ring, especially the adjacent and para-sites are greatly affected. Therefore, when electrophilic reagents attack, the meta-sites are relatively easier to react, but the specific reaction check point is also related to the activity of electrophilic reagents and reaction conditions.
In addition, this compound may also exhibit acidity and alkalinity. The nitrogen atom of 1H-indazole has a solitary pair electron, which theoretically accepts protons and shows a certain alkalinity. However, due to the electron-absorbing effect of fluorine and iodine atoms, or the reduction of the electron cloud density of nitrogen atoms, the alkalinity is weakened.
In conclusion, the chemical properties of 4-fluoro-5-iodine-1H-indazole are determined by the interaction of fluorine and iodine atoms with the indazole ring in its structure. Under different chemical reactions and conditions, there are various chemical behaviors.
What is the price range of 4-fluoro-5-iodo-1h-indazole in the market?
The price range of 4-fluoro-5-iodine-1H-indazole in the market is difficult to say exactly. The price of this compound is affected by many factors.
First, the cost of production. The difficulty of obtaining raw materials and the price of raw materials have a great impact on their cost. If the raw materials required to prepare 4-fluoro-5-iodine-1H-indazole are scarce and expensive, the price of the finished product will be high. And in the synthesis process, if complex reaction steps, special reaction conditions or expensive catalysts are required, the cost will also increase greatly, which will then push up the price.
Second, the supply and demand of the market. If many pharmaceutical companies and scientific research institutions have strong demand for 4-fluoro-5-iodine-1H-indazole and limited supply, its price will rise. On the contrary, if the demand is weak and the supply exceeds the demand, the price will decline.
Third, the difference in quality. High purity 4-fluoro-5-iodine-1H-indazole, due to the difficulty of preparation, requires high production process, and the price is often higher than that of ordinary purity.
As far as the current market situation is concerned, in the scientific research reagent market, 4-fluoro-5-iodine-1H-indazole in small packages (such as a few grams), if the purity is high, the price per gram may be in the hundreds of yuan. However, in large-scale industrial procurement scenarios, due to the huge purchase volume, the unit price may be reduced to tens of yuan per gram. However, this is only a rough guess. The actual price still needs to be consulted with the relevant suppliers, depending on the time and space of the specific transaction and trading conditions.