4-hydroxy-2-iodobenzaldehyde

4-Hydroxy-2-iodobenzaldehyde, this is an organic compound. It has many unique chemical properties.
First, it contains an aldehyde group (-CHO), and the aldehyde group is active. Oxidation reactions can occur. In case of weak oxidants, such as Torun reagent (silver ammonia solution), silver mirror reactions can occur. The aldehyde group is oxidized to a carboxyl group to form 4-hydroxy-2-iodobenzoic acid. In case of strong oxidants, such as potassium permanganate, it can also be oxidized, and the degree of oxidation is deeper.
In addition, aldehyde groups can participate in the reduction reaction, using hydrogen as the reducing agent. Under the action of a suitable catalyst, aldehyde groups can be reduced to alcohol hydroxyl groups to generate 4-hydroxy-2-iodobenzyl alcohol.
And because it contains phenolic hydroxyl groups (-OH is directly connected to the benzene ring), the phenolic hydroxyl groups are acidic and can react with bases, such as reacting with sodium hydroxide to generate corresponding sodium phenol salts. The phenolic hydroxyl groups can also activate the benzene ring, making the benzene ring more prone to substitution reactions. On the benzene ring, the adjacent and para-site electron clouds of hydroxyl groups have high densities and are vulnerable to attack by electrophilic reagents. In this compound, the 2-position has been occupied by the iodine atom, so the electrophilic substitution reaction is more likely to occur in the para-position of the hydroxyl group.
In addition, the iodine atom is attached to the benzene ring, although it reduces the electron cloud density of the benzene ring, under certain conditions, some related reactions can also occur, such as iodine atoms can be replaced under the action of appropriate nucleophiles.
In summary, 4-hydroxy-2-iodobenzaldehyde exhibits rich and diverse chemical properties due to the characteristics of the functional groups it contains, and has important applications in the field of organic synthesis.

The synthesis method of 4-hydroxy-2-iodobenzaldehyde has been investigated by chemists throughout the ages, and the details are as follows.
First, 4-hydroxy benzaldehyde is used as the starting material. First, dissolve 4-hydroxy benzaldehyde in a suitable organic solvent, such as glacial acetic acid, and slowly add an iodizing agent, such as N-iodosuccinimide (NIS), at low temperature. This reaction must be strictly controlled at temperature, and side reactions can easily occur due to high temperature. NIS gradually releases iodine cation in the system, which undergoes electrophilic substitution with the ortho-position on the 4-hydroxybenzaldehyde benzene ring to generate 4-hydroxy-2-iodobenzaldehyde. After the reaction is completed, regular post-treatment, such as extraction, washing, drying, column chromatography separation, etc., can obtain a pure product.
Second, start from 2-iodine-4-methoxyanisole. First, the methoxy group is reduced to a hydroxyl group with a suitable reducing agent, such as sodium borohydride-aluminum trichloride system, and the reaction is carried out in an anhydrous organic solvent. This process should pay attention to the amount of reducing agent and reaction time to prevent excessive reduction. Subsequently, by demethylation reaction, hydrobromic acid-acetic acid system can be used to convert 2-iodine-4-methoxyanisole into 4-hydroxy-2-iodobenzaldehyde. After the reaction, the target product can be obtained through neutralization, extraction, distillation and other operations.
Third, resorcinol is used as the starting material. First, one of the hydroxy groups of resorcinol is protected, such as benzyl protection. After that, iodine atoms are introduced through halogenation reaction, and suitable halogenating agents and reaction conditions are selected to locate the iodine atoms at a specific position. Next, the protecting group is removed, and then the aldehyde group is introduced by formylation reaction such as Duff reaction (hexamethylenetetramine and acetic anhydride system), and finally 4-hydroxy-2-iodobenzaldehyde is obtained. This method is a little complicated, but the raw materials are easy to obtain and have certain practical value.

4-Hydroxy-2-iodobenzaldehyde is an organic compound that is useful in many fields.
In the field of medicine, it may be a key intermediate for the synthesis of drugs. Because its molecular structure has a specific activity check point, it can be chemically modified to introduce various functional groups, and then construct complex drug molecular structures. Such as synthesizing compounds with specific pharmacological activities, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs, with the uniqueness of its structure, it interacts with targets in organisms to achieve the purpose of treating diseases.
In materials science, it also has applications. Can participate in the synthesis of functional materials, such as fluorescent materials. Due to its special electronic structure, it may endow materials with unique optical properties, making it useful in optical sensors and display technologies. When irradiated with specific light, it may emit light of specific wavelengths, which can be used to detect specific substances or provide unique optical effects in the display field.
Furthermore, in the field of organic synthetic chemistry, this compound is an important building block. Organic chemists can use it to undergo various chemical reactions with different reagents, such as nucleophilic substitution, condensation reactions, etc., to construct more complex organic molecular structures. By carefully designing reaction paths, a series of organic compounds with special structures and functions can be prepared, expanding the boundaries of organic synthesis and laying the foundation for the development of new materials and new drugs.
Overall, 4-hydroxy-2-iodobenzaldehyde plays an important role in many fields such as medicine, materials science, and organic synthetic chemistry, promoting the development and innovation of various fields.

4-Hydroxy-2-iodobenzaldehyde is an organic compound, and its market price is volatile and subject to many factors.
First, the cost of raw materials has a significant impact. If the starting material required to synthesize this compound is difficult to obtain, or the price rises due to the imbalance between supply and demand in the market, it will definitely lead to an increase in the cost of 4-hydroxy-2-iodobenzaldehyde, which will push up the price. For example, if the key starting material is damaged due to the origin and the output is sharply reduced, the price will rise, which will then lead to the price of this product.
Second, the preparation process is also key. If the preparation process requires special equipment, harsh reaction conditions or complex multi-step operations, the production cost will increase significantly. For example, some reactions that need to be carried out under extreme conditions such as ultra-low temperature and high vacuum are not only expensive in equipment, difficult to operate, but also high in energy consumption, which ultimately leads to high product prices.
Third, the market supply and demand relationship plays a significant role. If the demand for 4-hydroxy-2-iodobenzaldehyde in the pharmaceutical, chemical and other industries increases sharply during a certain period, but the supply is limited, the price will naturally rise; on the contrary, if the demand is low and the supply exceeds the demand, the price will fall.
Fourth, the production scale also has an impact. In large-scale production, due to the scale effect, the fixed cost per unit product is reduced, and the price may have room to decline; in small-scale production, the cost is relatively high, and the price is also high.
In addition, factors such as transportation costs and storage conditions will also play a certain role in its price. Due to the special nature of this product, or special storage conditions are required, if the storage cost is high, it will also be reflected in the price.
To sum up, in order to know the exact market price of 4-hydroxy-2-iodobenzaldehyde, it is necessary to pay attention to the raw material market dynamics and manufacturer quotations in real time, and comprehensively consider the above factors.

4-Hydroxy-2-iodobenzaldehyde is also an organic compound. The key to its storage is related to the quality and safety of this substance, which cannot be ignored.
First of all, the storage place should be a cool and dry place. Cover this object with fear of heat and moisture, and heat will easily promote its chemical change, and the tide will cause its hydrolysis and other changes. In the warehouse, it should be well ventilated to dissipate turbid gas, so as not to cause danger due to its accumulation.
In terms of storage equipment, glass or specific plastic containers should be used. Glass, chemically stable, does not react with 4-hydroxy-2-iodobenzaldehyde; specific plastics, with anti-corrosion ability, can ensure that this material does not leak and not damage. And the container must be tightly closed to prevent the entry of air and water vapor to prevent oxidation and deliquescence.
Furthermore, when storing, it must be kept away from fire sources, heat sources and strong oxidants. 4-hydroxy-2-iodobenzaldehyde in case of open flame, hot topic, fear of explosion; contact with strong oxidants, easy to cause violent chemical reaction, resulting in a critical emergency.
Also, in the storage place, obvious warning signs should be set up to indicate its risk and make everyone aware of it. The person in the warehouse must also check the storage condition frequently to see if the container is damaged and leaking, and whether the ambient temperature and humidity are suitable. If there is any abnormality, dispose of it quickly to ensure the integrity of 4-hydroxy-2-iodobenzaldehyde.