4-hydroxy-3-iodobenzaldehyde

4-Hydroxy-3-iodobenzaldehyde has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate. In the field of materials science, 4-hydroxy-3-iodobenzaldehyde can also be used to construct complex drug molecular structures through various chemical reactions. For example, when developing compounds with specific biological activities, aldehyde groups can be condensed and combined with amino-containing compounds to form Schiff base structures. Many of these structures exhibit antibacterial, antiviral and other pharmacological activities in drugs.
In the field of materials science, 4-hydroxy-3-iodobenzaldehyde is also useful. With its structural properties, it can participate in the material synthesis process and endow the material with special properties. For example, when synthesizing some functional polymer materials, it is introduced into the polymer chain, the hydroxyl group can enhance the hydrophilicity of the material, and the iodine atom can affect the electronic cloud distribution of the material, thereby changing the optical or electrical properties of the material to meet the needs of different fields such as photoelectric materials and sensor materials.
In addition, in organic synthetic chemistry, it is an important starting material. It can be derived from a series of organic reactions, such as halogenation reactions, oxidation-reduction reactions, etc., providing a rich material basis for the development of organic synthetic chemistry, and promoting the progress of organic synthesis methodologies and the creation of new compounds.

The synthesis method of 4-hydroxy-3-iodobenzaldehyde has been investigated by many predecessors, and is described in detail below.
First, 4-hydroxy benzaldehyde is used as the starting material and can be obtained by iodization reaction. Usually in a suitable reaction solvent, such as glacial acetic acid, an appropriate amount of iodine source is added. The common one is the combination of iodine elemental and hydrogen peroxide. Under a certain temperature and catalyst action, iodine atoms can selectively replace the 3-position hydrogen atom on the benzene ring, and then generate the target product 4-hydroxy-3-iodobenzaldehyde. This reaction condition is relatively mild and the yield is considerable, so it is widely used.
Second, the phenolic compound is used as the starting material to construct the structure of benzaldehyde through a series of reactions and introduce iodine atoms. First, the phenols are properly protected, and then the aldehyde group is introduced through the electrophilic substitution reaction. In this step, the Wilsmeier-Hack reaction can be used to successfully introduce the aldehyde group with N, N-dimethylformamide and phosphorus oxychloride as reagents at a suitable temperature. Then through the iodization step, the suitable iodizing reagent is selected to realize the substitution of the 3-position iodine atom under specific conditions, and the final product is 4-hydroxy-3-iodobenzaldehyde. Although this method is slightly complicated, it is more flexible in the selection of raw materials and can be adjusted according to actual needs and raw material availability.
Third, there are also those who use halobenzene as the starting material. Hydroxyl groups are first introduced through nucleophilic substitution reaction, then aldehyde groups are introduced under suitable conditions, and finally iodine atoms are introduced at the 3-position. This process requires precise control of the reaction conditions, the interaction between each step of the reaction, and a deep understanding of the reaction mechanism is required to obtain the ideal yield and purity.
The above synthesis methods have their own advantages and disadvantages. In practical application, factors such as raw material cost, reaction conditions, yield and product purity need to be comprehensively considered, and the advantages should be selected.

4-Hydroxy-3-iodobenzaldehyde is one of the organic compounds. Its physical properties are worth exploring.
First of all, its appearance, under normal conditions, is mostly solid, and the color may be white to light yellow powder. It is delicate in appearance. This is due to the orderly arrangement of molecular structures and the interaction.
As for the melting point, it is about within a specific temperature range. The existence of the melting point is due to the fact that the intermolecular force reaches a critical value. When heated, the molecules can break free from the lattice and change from solid to liquid. This property is crucial for material identification and purity judgment.
In terms of solubility, 4-hydroxy-3-iodobenzaldehyde has a certain solubility in organic solvents, such as ethanol, ether, etc. Because the compound molecule has a specific polarity, it can form interactions such as hydrogen bonds and van der Waals forces with organic solvent molecules, so it can be dispersed. However, in water, the solubility is poor, and its molecular hydrophobicity partially affects the affinity with water molecules. Only hydroxyl groups can interact with water a little, and it is difficult to dissolve in large quantities.
Volatility is also one of its physical properties. Because of its relatively strong intermolecular force and weak volatility, it rarely evaporates to the gas phase at room temperature, which helps the stability of storage and use.
In addition, the density of this compound is also a certain value, which reflects the degree of tight packing of its molecules. Compared with similar compounds, it can provide clues for the study of the relationship between its structure and properties. These physical properties are determined by its unique molecular structure and are of key guiding significance for its synthesis, separation and application.

4-Hydroxy-3-iodobenzaldehyde is also an organic compound. When storing and transporting, many matters must be paid attention to.
First storage, this compound should be stored in a cool, dry and well-ventilated place. Because the cool environment can avoid its character variation caused by heat, drying can prevent its hydrolysis by moisture. If it is in a humid place, water molecules are prone to interact with 4-hydroxy-3-iodobenzaldehyde, causing its structure to change and damage its quality. Good ventilation can prevent the accumulation of harmful gases and keep the storage environment safe.
Furthermore, it must be strictly avoided from contact with oxidants. 4-Hydroxy-3-iodobenzaldehyde has specific chemical activity, and it is easy to cause violent chemical reactions when encountering oxidants, or risk combustion and explosion. Therefore, when storing, it must be separated from dangerous substances such as oxidants, and clearly marked to prevent mismixing.
When transporting, the packaging must be solid and reliable. Choose suitable packaging materials, which can not only resist external impact, but also ensure sealing. If using special chemical packaging bottles, add buffer materials to avoid packaging damage caused by transportation bumps, so that 4-hydroxy-3-iodobenzaldehyde leaks.
And the temperature and humidity should be controlled during transportation. According to its characteristics, maintain a suitable temperature and humidity range. If the temperature and humidity are too high or too low, it may affect its chemical stability. At the same time, transportation personnel should be familiar with its characteristics and emergency treatment methods. In case of emergencies such as leakage, they can respond quickly and properly to reduce the harm.
In short, the storage and transportation of 4-hydroxy-3-iodobenzaldehyde should carefully follow relevant norms and requirements to ensure personnel safety and compound quality.

4-Hydroxy-3-iodobenzaldehyde, a key organic compound in the field of fine chemicals, is widely used in many industries such as medicine, pesticides, and materials. However, its market price range is difficult to describe, because it is affected by many factors.
First, the cost of raw materials has a great impact. The prices of raw materials required to synthesize 4-hydroxy-3-iodobenzaldehyde, such as phenols and iodides, fluctuate frequently. If the supply of raw materials is tight, or the price rises due to the imbalance of market supply and demand, abnormal climate in the place of origin, and turbulence in the international situation, the production cost of 4-hydroxy-3-iodobenzaldehyde will also rise, which will then cause the market price to rise.
Second, the preparation process is simple and complicated. Those with advanced and mature processes have high production efficiency, good product purity, controllable cost, and competitive prices. If the process is complex, high-end equipment is required, harsh conditions are required, and there are many side reactions and low yield, the cost will increase greatly, and the market price will be expensive.
Third, the market supply and demand situation is also the key. If there is a surge in demand for pharmaceutical research and development, or the expansion of new application fields leads to strong demand, and the supply is difficult to respond in a timely manner, the price often rises; on the contrary, if the market demand is sluggish and the supply is excessive, the company may reduce the price for sales.
Fourth, the product purity requirements are different, and the price difference is obvious. High-purity products are suitable for high-end pharmaceutical research and development, and have extremely high requirements for production process and quality control, so the price is much higher than that of ordinary purity products.
Generally speaking, the average purity of 4-hydroxy-3-iodobenzaldehyde in the chemical raw material market, the price per kilogram may range from hundreds to thousands of yuan; if it is high purity and reaches the pharmaceutical grade standard, the price may rise to thousands or even tens of thousands of yuan per kilogram. However, this is only a rough guess. The actual price needs to be paid attention to the market dynamics in real time and consulted the relevant suppliers in detail to know accurately.