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What is the chemical structure of 4 '-hydroxy-3' -iodobiphenyl-4 -carbonitrile
4 '-Hydroxy-3' -iodobiphenyl-4-carbonitrile, this is a kind of organic compound. In terms of its name, it is composed of several parts to clarify its chemical structure.
"biphenyl" means biphenyl, that is, the structure in which two phenyl groups are connected, which is the basic framework of the compound. "4-carbonitrile" indicates that there is a cyano group (-CN) attached to the 4th position of the biphenyl structure. Cyanyl has certain chemical activity and is very important in organic synthesis and biological activity research.
"4 '-hydroxy" refers to the 4' position of one of the phenyl rings of biphenyl, which is connected with a hydroxyl group (-OH). Hydroxyl groups can participate in many chemical reactions, such as esterification, etherification, etc., and have an impact on the physical and chemical properties of compounds, such as solubility, acidity and alkalinity.
"3 '-iodo" means that at the 3' position of the same benzene ring, there is an iodine atom (-I) attached. The iodine atom is relatively large and has a certain electronegativity. Its introduction will change the electron cloud distribution of the molecule, which in turn affects the reactivity and physical properties of the compound, such as boiling point and melting point.
In summary, the chemical structure of 4 '-hydroxy-3' -iodobiphenyl-4-carbonitrile is based on biphenyl as the skeleton, with cyano at the 4 'position, hydroxyl at the 4' position, and iodine atom at the 3 'position. This structure endows the compound with unique chemical and physical properties, which may have potential application value in organic chemistry, medicinal chemistry and other fields.
What are the physical properties of 4 '-hydroxy-3' -iodobiphenyl-4 -carbonitrile
4- (2-hydroxy-3-iodobiphenyl-4-yl) acetonitrile, this compound has several physical properties. Its appearance is usually white to off-white solid powder with fine texture. Considering the melting point, the melting point of this substance is relatively high, about [X] ° C, which makes it change from solid to liquid at a specific temperature.
In terms of solubility, it exhibits certain solubility characteristics in organic solvents, such as moderate solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. However, its solubility in water is poor, which is mainly due to the lack of sufficient hydrophilic groups in the molecular structure of the compound, while the hydrophobic benzene ring and other structures account for a large proportion.
In addition, its stability is relatively good, and it can maintain the chemical structure unchanged for a long time under conventional temperature and humidity environments. However, if it encounters extreme chemical environments such as strong acids and bases, its structure may change, triggering chemical reactions. Its density is about [X] g/cm ³, a physical parameter that is crucial in some application scenarios involving the relationship between mass and volume. Its refractive index also has a specific value, about [X], and this property of refractive index is of great significance in optical related research and applications.
What are the main uses of 4 '-hydroxy-3' -iodobiphenyl-4 -carbonitrile?
4 '-Hydroxy-3' -iodobiphenyl-4 'carbonitrile (4' -hydroxy-3 '-iodobiphenyl-4-formonitrile) This substance has a wide range of uses and is often a key intermediate for the creation of new drugs in the field of medicinal chemistry. Its structure is unique and has specific chemical activities. It can add many functional groups through chemical reactions to obtain compounds with diverse pharmacological activities. In the process of drug development, it may be possible to target specific disease targets. By modifying the structure of the substance, new agents with good efficacy and small side effects can be developed, which may have potential applications in the development of anti-cancer, anti-inflammatory and neurological diseases.
It also has applications in the field of materials science. For example, in the preparation of organic semiconductor materials, or through rational design, it can be introduced into the material structure to improve the charge transport ability and stability of the material, and applied to organic Light Emitting Diode (OLED), organic solar cells and other optoelectronic devices to improve device performance and efficiency.
In addition, in the field of fine chemicals, it can be used as a raw material for the synthesis of high-end fine chemicals. With its unique structure, through a series of chemical reactions, fine chemicals with special functions, such as special dyes, fragrances and additives, can be synthesized to meet the needs of different industrial and consumer markets, and improve product quality and added value.
What are the synthesis methods of 4 '-hydroxy-3' -iodobiphenyl-4 -carbonitrile
To prepare 4- (27-hydroxy-3-iodobiphenyl-4-formonitrile), there are many methods, and the common ones are described in detail below.
One is to start with biphenyl derivatives. First, the biphenyl is interacted with a halogenating reagent under specific conditions, so that it is halogenated at a specific position, and iodine atoms are introduced to form an intermediate containing iodine biphenyl. This step requires careful selection of halogenating reagents and reaction conditions to control the substitution check point and yield of iodine atoms. Next, the intermediate is hydroxylated and hydroxyl groups are introduced. It can be achieved by means of nucleophilic substitution, metal catalysis, etc. The control of these conditions is extremely critical, which is related to the accuracy of hydroxyl group introduction and product purity. At the end, the cyanide-containing reagent is reacted with the intermediate, and the cyanyl group is introduced at another specific position of the biphenyl to obtain the final target product 4- (27-hydroxy-3-iodobiphenyl-4-formonitrile).
The second is to start with simple aromatic hydrocarbons. The structure of the biphenyl is constructed by multi-step reaction, and then iodine atoms, hydroxyl groups and cyanyl groups are introduced in sequence. First, the aromatic hydrocarbons are coupled to form a biphenyl framework, and then each functional group is introduced one by one as described above. Although this path is complicated, the starting material is easy to obtain, and the selectivity and condition control of each step of the reaction have mature experience In the preparation process of
, the control of reaction conditions is crucial, such as temperature, pressure, catalyst type and dosage, which will affect the reaction process and product quality. And after each step of reaction, separation and purification are required to remove impurities and maintain the purity of the product. Separation and purification methods include distillation, recrystallization, column chromatography, etc., which should be reasonably selected according to the properties of the product and impurities. In this way, through exquisite design and rigorous operation, the target 4- (27-hydroxy-3-iodobiphenyl-4-formonitrile) can be obtained.
4 '-Hydroxy-3' -iodobiphenyl-4 -carbonitrile What are the precautions in storage and transportation
4 '-Hydroxy-3' -iodobiphenyl-4-formonitrile is an important organic compound, and there are many key points to be paid attention to when storing and transporting it.
First, because of its specific chemical properties, it must be stored in a dry and cool place. Humid environments can easily cause moisture, which can lead to chemical reactions and damage its quality. Moisture may react with some groups of the compound to change its chemical structure and purity. Temperature is also extremely critical. Excessive temperature can accelerate the movement of its molecules, causing them to decompose or deteriorate. Therefore, in general, it is advisable to store it in a temperature-controlled environment, such as refrigeration conditions of 2-8 ° C. In this temperature range, the rate of physical and chemical changes can be effectively slowed down.
Furthermore, the storage place must be away from fire sources, heat sources and oxidants. This compound may be flammable, and it is at risk of burning in case of open flames and hot topics. Contact with oxidants can easily induce violent oxidation reactions, causing changes in its chemical properties, and even causing serious consequences such as explosion. At the same time, it should be placed separately from other chemicals to avoid unpredictable chemical reactions due to interaction.
As for transportation, it should not be taken lightly. Appropriate packaging materials need to be selected to ensure good sealing. Sealed glass bottles or plastic bottles can be used, wrapped in shock-proof and moisture-proof materials, such as foam, desiccant, etc., to prevent package damage due to vibration and collision during transportation, and to resist the intrusion of external moisture. During transportation, it is necessary to strictly control the temperature and humidity, according to their characteristics, or use cold chain transportation to maintain a stable environment. Transport personnel should also be familiar with the characteristics of the compound and know the countermeasures in emergency situations, so as to ensure that 4 '-hydroxy-3' -iodobiphenyl-4-formonitrile remains stable during storage and transportation, without quality problems or safety accidents.