4-Hydroxyiodobenzene

Fengxi Chemical

Specifications

HS Code	596529
Name	4 - Hydroxyiodobenzene
Molecular Formula	C6H5IO
Molar Mass	220.01 g/mol
Appearance	Off - white to light brown solid
Odor	Odorless (usually)
Melting Point	142 - 144 °C
Boiling Point	303.4 °C at 760 mmHg
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Pka	Around 9.8 (phenolic - OH)

As an accredited 4-Hydroxyiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 g of 4 - hydroxyiodobenzene packaged in a sealed, chemical - resistant container.
Storage	4 - hydroxyiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent thermal decomposition or combustion. It should be kept in a tightly sealed container to avoid moisture absorption and contact with air, which could potentially lead to oxidation. Store it separately from incompatible substances, like strong oxidizing agents, to ensure safety.
Shipping	4 - hydroxyiodobenzene should be shipped in well - sealed, corrosion - resistant containers. Ensure compliance with hazardous chemical shipping regulations, with proper labeling indicating its nature to prevent any risks during transit.

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General Information

Historical Development

4 - Hydroxyiodobenzene is also an organic compound. Its initial exploration began before the number of times. At that time, chemists devoted themselves to the analysis and creation of new substances.
At the beginning, the understanding of its structure and properties was still unknown. However, with the passage of time, the refinement of experiments, and the innovation of instruments, researchers gradually understand its molecular structure and its reaction characteristics.
Early preparation, the process is complicated and the yield is meager. Chemists think hard and improve the process. After countless attempts, new synthesis methods were developed, which improved the yield and reduced the cost.
In the past, this compound was mostly used in small-scale experiments. Following the rise of science and technology, it has emerged in the fields of medicine and materials, showing extraordinary potential. Today, the development of 4-Hydroxyiodobenzene is moving towards a broader world with bright prospects.

Product Overview

4 - Hydroxyiodobenzene is a key compound in organic synthesis. Its properties are white to light yellow crystalline powder with specific physical and chemical properties. In the field of organic synthesis, it is often used as an important intermediate.
The preparation of this compound requires specific chemical reaction steps. For example, it can be obtained from a starting material through several steps of conversion under suitable reaction conditions. The reaction process requires precise control of temperature, reaction time and other factors to ensure the purity and yield of the product.
In practical applications, 4-Hydroxyiodobenzene can participate in many organic reactions, such as coupling reactions, to build complex organic molecular structures, showing potential application value in many fields such as medicinal chemistry and materials science, and providing an important material basis for the development of related fields.

Physical & Chemical Properties

4 - Hydroxyiodobenzene is also an organic compound. Its physical and chemical properties are worth studying. Looking at its shape, at room temperature, it may be solid, white or nearly colorless. Its melting and boiling point, depending on the force between molecules, has a certain value, which is related to its application time.
In terms of its solubility, it may have different manifestations in organic solvents, depending on the polarity of the solvent. Chemically, hydroxyl and iodine atoms give it reactivity. Hydroxyl groups can be involved in reactions such as esterification, while iodine atoms participate in nucleophilic substitution. Its electron cloud distribution is unique, resulting in different reaction activities. The physical and chemical properties of this compound are the cornerstone for in-depth investigation of its synthesis and application, and are of great significance in the field of organic synthesis.

Technical Specifications & Labeling

4 - Hydroxyiodobenzene is an organic compound. It is crucial to the technical specifications and labeling (commodity parameters) of this product. In its technical specifications, the purity must reach a very high standard, and the impurity content must be strictly controlled. The appearance should be a specific color state to meet the established requirements.
In terms of labeling, commodity parameters should be clearly marked with key information such as chemical structure and molecular weight. The chemical structure accurately presents the molecular composition, and molecular weight is an important physical parameter. The applicable field should also be indicated, such as what kind of fine chemical synthesis can play a role.
To produce this product, it is necessary to strictly abide by the technical specifications and labeling guidelines to ensure high quality and correct information, so that it can be used stably in the chemical industry and promote the development of related industries.

Preparation Method

4-Hydroxyiodobenzene is an important compound in organic synthesis, and its preparation method is quite critical.
Preparation of raw materials, phenol and iodine can be used as starting materials. The preparation process is as follows: first dissolve phenol in an appropriate amount of organic solvent, such as dichloromethane, to provide a suitable environment for the reaction. Next, under low temperature and stirring conditions, slowly add iodine elemental substance, and add an appropriate amount of catalyst, such as concentrated sulfuric acid, to promote the reaction.
Reaction steps: The electron cloud density of the hydroxyl group ortho-site of phenol is high, and the iodine elemental substance forms an electrophilic reagent under the action of the catalyst, attacks the phenol ortho-site, and undergoes an electrophilic substitution reaction to generate 4-Hydroxyiodo
Catalytic mechanism: Concentrated sulfuric acid acts as a catalyst to enhance the electrophilicity of iodine, reduce the activation energy of the reaction, accelerate the reaction rate, and enable the reaction to proceed efficiently under milder conditions, thus realizing the preparation of 4-Hydroxyiodobenzene.

Chemical Reactions & Modifications

The chemical substances that have been studied in recent years should be processed and modified in 4-Hydroxyiodobenzene, and there is much thought. The ancient method of the transformation of this substance mostly follows the conventional path, but the yield and purity are often not perfect.
I tried to think about it, but if I want to change its corresponding state, I need to change the conditions. The traditional response, the choice of temperature and solvent, are all regular. I tried to control it at different temperatures, and it is easy to use different solvents, and watch how it should change. At the beginning, the response was not good, and the product was mixed and impure. After careful consideration, the quality of the response, or the choice of catalysts. I tried all kinds of catalysts over and over again, in order to promote the smoothness of the response and increase the purity of the product.
After repeated tests, we finally got some results. With a new type of catalyst, temperature control at an appropriate value, and a suitable solvent, the yield of 4-Hydroxyiodobenzene has increased by several percent, and the purity has also been greatly improved. This research has made me clear that in the process of chemical application and modification, we should not be bound by the old method, and we should use innovative thinking to seek better results.

Synonyms & Product Names

4 - Hydroxyiodobenzene is also a chemical substance. The name of the same product is important in chemical research.
Take the name of the same product, or the name of iodophenol. As far as benzene is concerned, the iodine atoms of the alkyl group stand together, hence the name. As for the name of the product, it may vary depending on the home and the purpose.
In the field of chemical production, the name is one of the most important. There may be differences between the name of the same product and the name of the product, but they all refer to this thing. Researchers need to distinguish them to avoid confusion and lead to research. In order to explore the nature and purpose of this thing, we should also pay attention to the use of the name, so as to be able to clearly improve the quality and promote the research.

Safety & Operational Standards

4 - Code of Safety and Operation of Hydroxyiodobenzene
F 4 - Hydroxyiodobenzene is also a chemical research object. To ensure safety and follow the rules of operation, this is the most important thing.
For storage, it is necessary to choose a cool, dry and well-ventilated place. The cover may be sensitive to temperature and humidity, excessive temperature and humidity may cause deterioration, and even risk. It must be isolated from oxidants, acids, etc., to prevent unexpected chemical reactions. Store in a sealed device to avoid excessive contact with air and cause changes in composition.
As for operation, be sure to wear appropriate protective equipment. Protective clothing is on the body, which can prevent it from contaminating the skin; goggles are on the eyes, which can prevent it from splashing in; masks are on the mouth, which can prevent it from entering the lungs. In the place of operation, ventilation must be smooth, so that harmful gas can quickly disperse and do not gather in the room.
When taking it, the method should be stable and accurate. Take it with a clean device, and the amount should not be increased or decreased according to the needs of the experiment. If it is accidentally spilled, clean it up quickly in an appropriate way. If it is covered with an adsorbed substance, then carefully collect it, and then dispose of it according to regulations. Do not discard it elsewhere at will.
During the reaction, closely observe its situation. Temperature and pressure must be controlled within a certain area. If there is any abnormal phenomenon, such as color change, odor abnormality, temperature rise, etc., the operation should be stopped immediately and the cause should be investigated before proceeding.
In short, the safety and operation of 4-Hydroxyiodobenzene, all details must be taken with care. A slight omission may lead to disaster. Only by following the rules can we ensure the smooth operation of the experiment and the safety of personnel.

Application Area

4 - Hydroxyiodobenzene is also a wonder of chemical engineering. Its application in the field of research and development can be used to help create special effects and solve diseases. In the field of materials, it can be used to synthesize special materials, to give materials special properties, such as better performance or quality, for high-tech products. It also plays an important role in the field of synthesis, serving as a starting material, building a framework of molecules, and exploring new ways of synthesis, promoting the steps of chemical engineering, benefiting people's lives in many aspects.

Research & Development

Taste the industry of chemical industry, with each passing day, new things emerge one after another. Today there is 4-Hydroxyiodobenzene, which is quite crucial in our research.
Begin to study this thing in detail. Its shape, its quality, and its transformation are all investigated in detail. After repeated experiments, I understand the rules of its reaction and the laws of its change.
Then seek its development. Want to use it widely, explore its potential in the fields of medicine and materials. Although there are many difficulties on the way, we will persevere. With the rigor of ancient methods, in line with today's new technologies, strive to break through.
Looking at the present, although I have already gained something, the road ahead is still far away. We must persevere and make continuous progress, hoping to make great achievements in the research and development of this thing, and do our best for the prosperity of the chemical industry.

Toxicity Research

Today, there is a thing named 4 - Hydroxyiodobenzene, and we want to study its toxicity. The chemical nature of this thing is related to people's health and health, and it cannot be ignored.
At first, look at its structure, think about its chemical reaction state, or combine with other things, or change itself, all of which can cause toxic changes. Then test it on the thing, and observe its impact on the living thing. Take a small animal as a test, and observe its state after eating, touching, and sucking. See its hair or messy, slow action, or even life-threatening.
And explore its situation in the environment, when it encounters water, soil, and air, how it changes. Lest it be scattered in all directions, harming living beings. After this study, it can be seen that the toxicity of 4-Hydroxyiodobenzene is essential for future prevention, control, preparation, and protection of all living beings.

Future Prospects

Although the product of 4 - Hydroxyiodobenzene has been achieved in the present, its future prospects still have a vast environment to be explored by us.
This substance can be used in the field of chemical industry, or it can use its characteristics to improve the existing process, making the process more essential and more productive. In medicine, its unique structure may pave the way for the development of new agents and cure more diseases.
Furthermore, in the field of materials science, 4 - Hydroxyiodobenzene may participate in the creation of new materials, giving materials specific properties, such as better conductivity and stability.
We scientific researchers should be diligent and explore the unknown, hoping to make 4-Hydroxyiodobenzene shine in various fields in the future, for the well-being of the world, to develop the grand future, and to live up to the mission of scientific research.

Where to Buy 4-Hydroxyiodobenzene in China?

As a trusted 4-Hydroxyiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Hydroxyiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-hydroxyiodobenzene?

4-Hydroxyiodobenzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis.
4-Hydroxyiodobenzene has a unique chemical structure. The hydroxyl and iodine atoms are combined on the benzene ring, which gives it special reactivity. Chemists often use it to construct more complex organic molecules through a variety of chemical reactions, such as coupling reactions. In the Suzuki coupling reaction, 4-Hydroxyiodobenzene can interact with boron-containing compounds, catalyzed by a palladium catalyst, to generate carbon-carbon bonds to prepare aromatic compounds with different substituents. This is crucial in many aspects of drug synthesis, materials science, etc.
In the process of drug development, 4-hydroxyiodobenzene is also useful. Using it as a starting material, through a series of chemical modifications, it can prepare biologically active molecules for drug screening and lead compound optimization. Due to the particularity of its structure, the physicochemical properties and biological activities of molecules can be adjusted by introducing different functional groups, and then potential therapeutic targets and drug action mechanisms can be explored.
And in the field of materials science, 4-hydroxyiodobenzene can also participate in the creation of functional materials. Through its polymerization with other monomers, polymer materials with specific photoelectric properties can be synthesized, such as used in organic Light Emitting Diodes (OLEDs), solar cells and other devices, to help improve the performance of materials. In short, the unique structure of 4-hydroxyiodobenzene is an indispensable material in many fields such as organic synthesis, drug development, and materials science, laying the foundation for many scientific research and practical applications.

What are the physical properties of 4-hydroxyiodobenzene?

4-Hydroxyyiodobenzene, that is, 4-hydroxyiodobenzene. The physical properties of this substance are very important, and it is related to its performance in various chemical processes and practical applications.
First of all, its appearance, 4-hydroxyiodobenzene is often white to light yellow crystalline powder. This morphological feature is easy to observe and handle. At the beginning of laboratory operation or industrial production, its purity and quality can be preliminarily judged by its appearance.
When it comes to the melting point, the melting point range of 4-hydroxyiodobenzene is roughly specific. This physical constant is of great significance for the identification of this substance. During the heating process, when a certain temperature range is reached, the substance changes from solid to liquid state. The determination of this melting point provides a key basis for confirming its identity and purity. < Br >
The other is solubility, which shows some solubility in organic solvents such as ethanol and acetone, but poor solubility in water. This difference in solubility has a significant impact on separation, purification and construction of the reaction system. Taking the organic synthesis reaction as an example, according to its solubility, a suitable solvent can be selected to promote the efficient progress of the reaction. At the same time, in the product separation stage, the difference in solubility can also be used to achieve effective separation of products and impurities.
In addition, the density of 4-hydroxyiodobenzene is also an important physical property. Although the specific value needs to be accurately determined, its density characteristics are indispensable in terms of mass and volume conversion, as well as in the study of substance distribution in heterogeneous reaction systems.
In conclusion, the physical properties of 4-hydroxyiodobenzene, such as appearance, melting point, solubility, and density, play a key role in both chemical research and practical applications, providing a foundation for in-depth exploration of its chemical behavior and expanding its application scope.

What is the chemistry of 4-hydroxyiodobenzene?

4-Hydroxyiodobenzene is also an organic compound. Its chemical properties are unique and related to many reactions and characteristics.
In terms of nucleophilic substitution reactions, iodine atoms have high activity and can be replaced by nucleophilic reagents. In case of reagents containing active nucleophilic groups, such as alkoxides, amines, etc., iodine atoms are easy to leave, and nucleophilic reagents replace them to generate corresponding substitution products. Because iodine atoms are connected to the benzene ring, affected by the electronic effect of the benzene ring, the carbon-iodine bond has a certain polarity and is easier to break.
In terms of redox properties, hydroxyl groups can participate in oxidation reactions. Under the action of appropriate oxidizing agents, hydroxyl groups can be oxidized to oxygen-containing functional groups with higher valence states such as aldehyde For example, when treated with a suitable strong oxidizing agent, the hydroxyl group may be converted into a carbonyl group, thereby changing the chemical properties and reactivity of the molecule.
Furthermore, the benzene ring in 4-hydroxyiodobenzene is aromatic and can undergo aromatic electrophilic substitution. Because the hydroxyl group is the power supply, the electron cloud density of the benzene ring can increase, and the electrophilic reagent is easy to attack the ortho and para-position. For example, when reacting with halogenating agents, nitrifiers, etc., the electrophilic substitution mostly occurs in the ortho and para-position of the hydroxyl group.
In addition, the intramolecular hydroxyl group and the iodine atom can interact with each other. The conjugation effect of the hydroxyl group may affect the reactivity of the iodine atom; conversely, the electron-absorbing induction effect of the iodine atom also plays a certain role in the acidic properties of the hydroxyl group.
In summary, 4-hydroxyiodobenzene is rich in chemical properties, and in the field of organic synthesis, it can be used to construct various complex organic molecules, providing an important foundation for the research of organic chemistry and the development of related industries.

What are 4-hydroxyiodobenzene synthesis methods?

The synthesis of 4-hydroxyiodobenzene has been known since ancient times, and many books have been recorded. Today I will describe it in detail.
First, phenol is used as the starting material. Phenol reacts with iodine reagents under suitable conditions. It is often necessary to use appropriate solvents, such as organic solvents, to help it dissolve and react. During the reaction, the control of temperature is very critical. If it is too high, it is easy to cause side reactions to occur, and if it is too low, the reaction rate will be delayed. At a mild temperature, in the presence of a catalyst, iodine atoms can replace hydrogen atoms on the benzene ring to generate 4-hydroxyiodobenzene. This catalyst can be selected from specific metal salts or organic compounds, and its function is to promote the progress of the reaction and improve the selectivity of the reaction. < Br >
Second, it can be started from p-hydroxybenzoic acid. First, the p-hydroxybenzoic acid is properly converted, such as by esterification, the carboxyl group is converted into an ester group to protect the carboxyl group and avoid its interference in subsequent reactions. After that, in a specific reaction system, an iodine source is introduced. This iodine source can be obtained in various ways, such as a system composed of iodine elemental substance and an appropriate reducing agent. After a series of reactions, the iodine atom enters the 4-position of the benzene ring to form an intermediate containing iodine. Then through hydrolysis and other steps, the protective group is removed, and finally 4-hydroxyiodobenzene is obtained.
Third, other benzene derivatives are also used as starting materials. After a multi-step reaction, the hydroxyl and iodine atoms are gradually constructed at specific positions in the benzene ring. This process often involves many delicate operations such as conversion, protection and deprotection of functional groups. Each step requires careful control of the reaction conditions, including the proportion of reactants, reaction time, temperature, and reagents used, to obtain pure 4-hydroxyiodobenzene.
There are many methods for synthesizing 4-hydroxyiodobenzene, each with its own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to actual needs, such as the purity requirements of the product, cost considerations, and the feasibility of reaction conditions.

4-hydroxyiodobenzene What are the precautions during storage and transportation?

4-Hydroxyiodobenzene is also an organic compound. When storing and transporting, there are several ends to pay attention to.
First words storage. This substance has certain chemical activity and should be stored in a cool, dry and well-ventilated place. If placed in a warm, humid place, or cause it to deteriorate, it will affect its chemical properties and purity. If the cover temperature is too high, or cause a chemical reaction, causing it to decompose; if the humidity is too high, it will easily absorb moisture and damage its quality. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion, because it may be flammable or react with certain substances flammable. Furthermore, it needs to be stored separately from oxidizing agents, acids, alkalis, etc. This is because 4-hydroxyiodobenzene and various substances are prone to chemical reactions, and mixed storage may be dangerous.
Secondary transportation. It is necessary to ensure that the packaging is complete and the loading is secure during transportation. If the packaging is damaged, 4-hydroxyiodobenzene or leakage will not only damage the environment, but also endanger the safety of transporters. When loading, it should be classified according to its dangerous characteristics, and must not be mixed with contraindicated substances. During transportation, it is also necessary to pay close attention to environmental factors such as temperature and humidity, and adjust it in a timely manner to make the transportation environment suitable and avoid deterioration or danger of 4-hydroxyiodobenzene due to environmental changes. Transportation vehicles need to be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. In the event of an emergency, they can respond in a timely manner to reduce damage hazards.