As a leading 4-Iodo-1-Methyl-1H-Pyrazole-5-Carboxylic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-iodo-1-methyl-1h-pyrazole-5-carboxylic Acid?
4-Iodo-1-methyl-1H-pyrazole-5-carboxylic Acid has a unique chemical structure. The compound is composed of a pyrazole ring as the base, which is a five-membered heterocycle containing two adjacent nitrogen atoms. In the first position of the pyrazole ring, a methyl group is connected. This methyl group is a simple hydrocarbon group composed of only one carbon atom and three hydrogen atoms. It is connected to the pyrazole ring, giving the molecule a specific spatial structure and electronic effect. At the 4th position of the pyrazole ring, an iodine atom is attached. The iodine atom is a halogen element with a large atomic radius and strong electronegativity, which significantly affects the physical and chemical properties of the molecule, such as enhancing the polarity of the molecule. At the 5th position of the pyrazole ring, there is a carboxyl group, which is a functional group formed by connecting a carbonyl group with a hydroxyl group. This functional group imparts acidic properties to the molecule, allowing it to participate in many chemical reactions, such as acid-base neutralization and esterification. Overall, the chemical structure of 4-iodo-1-methyl-1H-pyrazole-5-carboxylic Acid has unique chemical activities and physical properties due to the combination of various groups, which may have potential application value in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 4-iodo-1-methyl-1h-pyrazole-5-carboxylic Acid?
4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid, this substance has a wide range of uses and is used in the fields of medicine, chemical industry and materials.
In the field of medicine, it is a key class of organic synthesis intermediates. With its unique chemical structure, it can participate in the construction of many drug molecules. For example, when developing new antibacterial drugs, chemists can use its structural properties to connect other active groups to create compounds with high inhibitory activity against specific pathogens. Due to the presence of pyrazole rings and iodine atoms, the binding mode of drugs and targets can be optimized, enhancing the antibacterial effect. In the research and development of anti-tumor drugs, it can also be used to build molecular frameworks with unique pharmacological activities, contributing to the solution to cancer problems.
In the chemical industry, it plays an important role in the synthesis of fine chemicals. It can be used to synthesize dyes with special properties. Because its structure can endow dyes with unique light absorption and emission characteristics, the synthesized dyes show excellent color fastness and vividness in the dyeing process, meeting the needs of high-quality dyes in textile, printing and dyeing industries. In fragrance synthesis, it may also be used as a key raw material to endow fragrances with unique aroma characteristics and expand the variety of fragrances.
In the field of materials, 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acids can be used to prepare functional materials. For example, in the field of organic optoelectronic materials, its introduction into polymer structures can regulate the electrical and optical properties of materials, and it is expected to be applied to organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve the performance and efficiency of devices. In the preparation of sensor materials, its selective interaction with specific substances can be used to develop sensors with high sensitivity and selectivity to specific ions or molecules for environmental monitoring, biological detection and other fields.
What are the synthetic methods of 4-iodo-1-methyl-1h-pyrazole-5-carboxylic Acid?
The method of synthesizing 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid has been explored by many scholars in the past, and the method of Chen number is below.
First, use 1-methyl-1H-pyrazole-5-carboxylic acid as the starting material. First dissolve it in a suitable solvent, such as dichloromethane or N, N-dimethylformamide (DMF), stir well. Then slowly add an iodine-substituted reagent, such as N-iodosuccinimide (NIS), and add an appropriate amount of catalyst, such as sulfuric acid or p-toluenesulfonic acid, to promote the reaction. The reaction temperature should be controlled between room temperature and 50 ℃, and the reaction process takes about several hours to ten hours. The reaction process can be closely monitored and tracked by thin-layer chromatography (TLC). After the reaction is completed, the product can be purified by conventional separation methods, such as column chromatography or recrystallization, to obtain 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid.
Second, 1-methyl-1H-pyrazole is used as the starting material. Carboxylation reaction is carried out first. Carbon dioxide can be selected with a suitable base, such as sodium hydride or potassium tert-butyl alcohol, and reacted in an anhydrous solvent at low temperature to obtain 1-methyl-1H-pyrazole-5-carboxylic acid. The subsequent iodine substitution step is similar to the above first method. The obtained 1-methyl-1H-pyrazole-5-carboxylic acid is operated according to the iodine substitution conditions of the first method. After iodine substitution, separation and purification, the target product can also be obtained.
Third, synthesized by one-pot method. The nitrogen-containing heterocyclic construction materials, methylation reagents, carboxylation reagents and iodine substitutes are reacted in the same reaction system in an appropriate order. For example, the pyrazole ring is first constructed with appropriate amines and carbonyl compounds under acid catalysis, and then the methylation reaction is carried out, followed by the introduction of carboxyl groups and iodine atoms. Although this method is a compact step, the regulation of the reaction conditions is quite critical. The dosage, reaction temperature and time of each reagent need to be carefully controlled to achieve higher yield and purity. After the reaction is completed, it is isolated and purified by extraction, column chromatography and other means to obtain 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acid.
What are the physical properties of 4-iodo-1-methyl-1h-pyrazole-5-carboxylic Acid?
4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid, this is an organic compound. Its physical properties are crucial and indispensable in chemical research and practical applications.
First, the appearance is usually white to light yellow crystalline powder. This form is easy to observe and handle, and in many experimental operations and industrial production processes, this appearance feature is easy to identify and use.
Besides the melting point, the melting point of the substance is within a specific range. The melting point is an important basis for identification and purity determination. By accurately measuring the melting point, its purity status can be known. If the purity is high, the melting point will approach the theoretical value; if it contains impurities, the melting point may decrease and the melting range may become wider.
Solubility is also a key property. In common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., there is a certain solubility. In water, the solubility is relatively limited. This solubility characteristic determines its application in different reaction systems. In organic synthesis reactions, according to the needs of the reaction, a suitable solvent can be selected to promote the reaction.
In addition, the compound has certain stability. However, under certain conditions, such as high temperature, strong acid or strong alkali environment, the structure may change. Knowing this stability allows appropriate measures to be taken during storage and use to prevent its deterioration and ensure that its chemical properties and functions are not affected.
Knowing these physical properties of 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acids is of great significance for their applications in organic synthesis, drug discovery, and other fields, enabling researchers and engineers to better design experiments and optimize production processes.
4-iodo-1-methyl-1h-pyrazole-5-carboxylic the market outlook for Acid
4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid, this is a class of organic compounds. Looking at its market prospects, it can be analyzed from various aspects.
In the field of medicine, there is a surge in the development of innovative drugs, and many compounds containing heterocyclic structures have emerged in the screening of drug activity. Pyrazole compounds are often used as key intermediates in drug development due to their unique structures and diverse biological activities. 4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acids contain iodine atoms, methyl groups and carboxyl groups, or endow them with specific biological activities, such as potential antibacterial, anti-inflammatory, anti-tumor and other activities. If the R & D team can use this as a basis to further explore its structure-activity relationship, or develop new specific drugs, it may have broad prospects in the pharmaceutical R & D raw material market.
Looking at the field of materials, with the development of science and technology, the demand for functional materials is increasing. Some organic heterocyclic compounds can exhibit unique photoelectric properties after specific modifications. 4-Iodine-1-methyl-1H-pyrazole-5-carboxylic acid may be used in the preparation of organic optoelectronic materials through rational molecular design and synthesis, such as organic Light Emitting Diode (OLED), solar cells and other fields. With the expansion of the market scale of such materials, its use as a basic raw material may usher in more market opportunities.
However, its market development also faces challenges. The process of synthesizing the compound or its storage steps are complicated and costly. To achieve large-scale industrial production and wide market application, scientific researchers and chemical companies need to work together to optimize the synthesis process and reduce production costs. Furthermore, market competition is also a factor that cannot be ignored. With the advancement of organic synthesis technology, or the emergence of alternatives with similar structures and properties, enterprises and R & D institutions are required to continuously improve product quality and performance in order to maintain market competitiveness.
Overall, although 4-iodine-1-methyl-1H-pyrazole-5-carboxylic acids face challenges, their potential application value in the fields of medicine and materials makes them have considerable market prospects. Over time, with the efforts of all parties, they may occupy an important position in the relevant market.