4 Iodo 1 Methylpyrazole

4-Iodine-1-methylpyrazole is one of the organic compounds. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. Because of its unique structure, it can undergo a variety of chemical reactions to construct complex drug molecular structures and help develop new drugs, which is of great significance in the treatment of diseases.
In the field of materials science, it also has its uses. Or it can participate in the preparation of materials with special properties, such as those with specific photoelectric properties. Due to the chemical activity of the compound, it can react with other substances, giving the material unique properties, which may have potential applications in fields such as optoelectronic devices.
Furthermore, in the field of organic synthetic chemistry, 4-iodine-1-methylpyrazole is an important raw material, which can synthesize various organic compounds through different reaction paths. Chemists can ingeniously design reactions according to the structure of the desired target product, and use the characteristics of the compound to achieve the precise construction of organic molecules, which promotes the development of organic synthetic chemistry.

4-Iodo-1-methylpyrazole is an organic compound with unique physical properties. It is mostly solid at room temperature, and has a compact structure due to intermolecular forces. The melting and boiling points are affected by intermolecular interactions, and the melting and boiling points of iodine atoms and methyl groups affect their melting and boiling points.
Looking at its solubility, the compound has good solubility in organic solvents such as ethanol and dichloromethane due to nitrogen heterocycles and iodine, methyl and other groups. Due to the principle of similar miscibility, organic solvents can form intermolecular forces with the compound to help it disperse and dissolve. However, its solubility in water is poor, because the proportion of non-polar parts is large, and the polarity difference with water is obvious, making it difficult to form effective interactions.
Its density is higher than that of common organic solvents, and the relative atomic weight of iodine atoms is large, which increases the molecular weight and causes its density to be higher.
4-iodo-1-methylpyrazole is usually white to pale yellow solid in appearance. The color is derived from the absorption and reflection of light by the molecular structure. The specific structure absorbs specific wavelengths of light and presents this color range.
In addition, the stability of the compound is also worthy of attention. It is relatively stable under conventional conditions, but in case of high temperature, strong oxidizing agent or reducing agent, nitrogen heterocyclic, iodine atom and methyl group in its structure may participate in the reaction, and changes such as substitution and redox may occur, which affects its properties and structure.

To prepare 4-iodine-1-methylpyrazole, the following method can be followed.
Take 1-methylpyrazole as the starting material first, which is the key raw material. Place 1-methylpyrazole in an appropriate reaction vessel and introduce an iodine source under mild conditions. The commonly selected iodine source can be iodine elemental substance (I ²), or other iodine-containing compounds, such as potassium iodate (KIO
If iodine elemental substance is used as the iodine source, a suitable catalyst is required to assist the reaction. Common catalysts include copper salts, such as cuprous iodide (CuI), which can promote the smooth addition of iodine atoms to a specific position of 1-methylpyrazole. In the reaction system, a suitable solvent is also required to facilitate the uniform mixing of the reactants so that the reaction can be fully carried out. Common organic solvents, such as N, N-dimethylformamide (DMF), have good solubility to 1-methylpyrazole and iodine elemental substances, and their properties are stable and do not interfere with the main reaction.
When reacting, strictly control the temperature, reaction time and other conditions. Usually, this reaction is carried out under moderate heating conditions, and the temperature is between 50 and 80 degrees Celsius. If the temperature is too low, the reaction rate will be slow; if the temperature is too high, side reactions may occur. The reaction time depends on the specific situation, ranging from a few hours to more than ten hours. The reaction process needs to be monitored by thin layer chromatography (TLC) and other means. When the raw material point almost disappears and the product point is the main one, the reaction can be regarded as basically completed.
After the reaction is completed, the product needs to be separated and purified. First, most of the solvent is removed by vacuum distillation. Subsequently, by means of column chromatography, a suitable silica gel column is selected, and the elution is carried out with an eluent mixed with petroleum ether and ethyl acetate in a certain proportion to obtain a pure 4-iodine-1-methylpyrazole product. Thus, through this series of steps, the target product 4-iodine-1-methylpyrazole can be obtained.

In today's world, the market is changeable, and the price of things is also changeable. 4-Iodo-1-methylpyrazole is a chemical product, and its price is difficult to determine.
Looking at the business conditions of the past, the price of such chemicals has always been controlled by various factors. First, the abundance of raw materials has a lot to do with the price. If the raw materials are widely available and cheap, the production of 4-Iodo-1-methylpyrazole is also easy, and the price may be flat; conversely, if the raw materials are rare, the price will rise.
Second, the production technology also has an impact. The new technology may increase its yield and reduce its cost, resulting in a price drop; while the old technology has not been changed, the production is limited and the cost is high, and the price is difficult to suppress.
Third, the market's demand for this product is also the main reason. If various industries have strong demand for this product, but the supply is insufficient, the price will be high; if you want less supply and more, the price will be lower.
From today's commercial market, the price of 4-iodo-1-methylpyrazole ranges from tens to hundreds of yuan per gram. However, this is only an approximate number, and the actual price should be based on the current market conditions, the amount purchased and the rules of the seller. If you want to know the exact price, you must carefully study the rewards of the merchants in the city before you can obtain it.

4-Iodo-1-methylpyrazole is an organic compound, and its storage conditions are crucial, which is related to the stability and safety of the substance. According to the method of "Tiangong Kaiwu", it should be regarded as an ancient method.
This compound needs to be stored in a cool, dry and well-ventilated place. Those who are cool should avoid the harm of high temperature. High temperature can easily cause the molecular movement of the compound to intensify, or trigger reactions such as decomposition and polymerization, which will damage its chemical structure and properties. Therefore, it is advisable to choose a place with constant and low temperature, such as a cellar or a cool warehouse, to prevent heat from disturbing its properties.
Dry conditions are also indispensable. Moisture is easy to interact with compounds, or cause adverse reactions such as hydrolysis. Because some iodine atoms in 4-iodo-1-methylpyrazole are sensitive to water, they will change in contact with water. Therefore, the storage place should be dehumidified with a desiccant, or a moisture-proof facility should be built to keep the environment dry.
Good ventilation is also key. If the storage space is closed, the volatile gas of the compound may accumulate, which will not only cause the air quality to decline, but also cause danger due to high concentration, such as explosion, poisoning, etc. Good ventilation can make the volatile gas dissipate in time, and keep the storage environment safe.
Furthermore, 4-iodo-1-methylpyrazole should be stored separately from oxidants, acids and other substances. Because of its specific chemical activity, it comes into contact with oxidants, or causes severe oxidation reactions; coexists with acids, or has chemical reactions, endangering its stability and safety. It must be separated and stored to prevent interaction.
Storage containers also need to be carefully selected. Corrosion-resistant materials, such as glass or specific plastic containers, should be used. Glass containers are chemically stable and not easy to react with compounds; specific plastic containers are chemically resistant, which can protect compounds from being affected by the container material. And the container must be well sealed to prevent compound leakage and external substances from invading.