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What is the chemical structure of 4-iodo-1-methylpyridin-2 (1h) -one?
4-Iodo-1-methylpyridin-2 (1H) -one is an organic compound with a unique chemical structure. This compound contains a pyridine ring, which is a six-membered nitrogen-containing heterocycle and has aromatic properties.
is connected to a carbonyl group (C = O) at the second position of the pyridine ring, and the oxygen atom in the carbonyl group is connected to the carbon atom at the second position of the pyridine ring by a double bond. At the same time, the carbonyl oxygen atom also forms a 1H-structure with the hydrogen atom on the ring, that is, the hydrogen atom coexists with the carbonyl group at a specific position at the second position.
The nitrogen atom at the 1st position of the pyridine ring is connected to the methyl group (-CH 🥰). The methyl group is composed of one carbon atom and three hydrogen atoms, and is connected to the nitrogen atom through covalent bonds.
The 4th position of the pyridine ring is connected to the iodine atom (-I). As a halogen element, the iodine atom has a large atomic radius and rich electron cloud. In this way, 4-iodo-1-methylpyridin-2 (1H) -one presents unique physical and chemical properties due to the spatial arrangement of atoms and groups and electronic effects, and may have potential applications in organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 4-iodo-1-methylpyridin-2 (1h) -one?
4-Iodo-1-methylpyridin-2 (1H) -one is an organic compound with specific physical properties. It is a solid and relatively stable at room temperature. When it encounters strong oxidizing agents, strong acids or strong bases, or under high temperature conditions, it may react chemically.
Looking at its solubility, this compound has a certain solubility in organic solvents such as dichloromethane, chloroform, and acetone, because these organic solvents can form intermolecular forces with the compound to help it disperse and dissolve. However, its solubility in water is low. Due to the large difference between molecular polarity and water molecules, it cannot form an effective interaction with water.
When it comes to the melting point, the compound has a high melting point and requires a specific high temperature to melt into a liquid state. Due to the existence of various forces between molecules, such as van der Waals forces, hydrogen bonds, etc., the molecules are closely connected, and more energy is required to overcome these forces, causing the melting point to rise. The boiling point is also higher due to similar intermolecular forces. To make it change from liquid to gaseous state, sufficient energy needs to be supplied.
Its density may be different from that of water. If it is larger than water, it will float in water or sink. If it is smaller than water, it will float up, depending on its molecular mass and molecular accumulation mode.
In addition, 4-iodo-1-methylpyridin-2 (1H) -one will affect its storage and use conditions for light and heat stability. Strong light, high temperature or accelerated decomposition or deterioration, so storage should be placed in a cool, dark place to ensure the stability of its chemical structure and properties.
What are the common synthesis methods for 4-iodo-1-methylpyridin-2 (1h) -one?
4-Iodo-1-methylpyridin-2 (1H) -one is an organic compound, and its synthesis method is much more elegant in today's organic synthesis techniques.
One of the common methods is to use pyridine-2 (1H) -one as the starting material. Pyridine-2 (1H) -one is first subjected to N-methylation reaction, and suitable methylation reagents can be selected, such as iodomethane ($CH_ {3} I $). In a suitable solvent, such as N, N-dimethylformamide (DMF), add an appropriate amount of base, such as potassium carbonate ($K_ {2} CO_ {3} $), the base can assist the methylation reaction, capture the hydrogen on the nitrogen atom of pyridine-2 (1H) -one, make it a nucleophilic reagent, and undergo nucleophilic substitution reaction with iodomethane to generate 1-methylpyridine-2 (1H) -one.
Next, the iodization reaction of 1-methylpyridine-2 (1H) -one is carried out. Iodine ($I_ {2} $) and an appropriate oxidant, such as hydrogen peroxide ($H_ {2} O_ {2} $), can be used in the iodizing reagent. Under suitable reaction conditions, such as mild temperature and suitable solvent system, hydrogen peroxide can oxidize iodine to active iodine cation ($I ^{+}$), It attacks the 4-position of 1-methylpyridine-2 (1H) -one, and undergoes electrophilic substitution to obtain 4-iodo-1-methylpyridin-2 (1H) -one.
Or there is another method, using a pyridine derivative containing a suitable substituent as the starting material, through a multi-step reaction, the substituent is adjusted to achieve the purpose of synthesizing 4-iodo-1-methylpyridin-2 (1H) -one. However, all synthesis methods need to consider the reaction conditions, yield, selectivity and difficulty of post-treatment, in order to choose the best way to obtain efficient and pure products.
What are the applications of 4-iodo-1-methylpyridin-2 (1h) -one?
4-Iodo-1-methylpyridin-2 (1H) -one is an organic compound, which has applications in medicinal chemistry, materials science and other fields.
In the field of medicinal chemistry, its structure contains iodine atoms and pyridinone structures, showing unique biological activities. Iodine atoms can enhance the lipophilicity of molecules, promote their penetration through cell membranes, and improve bioavailability. Pyridinone structures are commonly found in a variety of drug molecules and have diverse biological activities. Therefore, this compound can be used as a pharmaceutical intermediate for the synthesis of active drugs with antibacterial, anti-inflammatory, and anti-tumor properties. For example, this compound can be chemically modified to develop new drugs for specific diseases, providing a key starting material for the development of new drugs.
In the field of materials science, 4-iodo-1-methylpyridin-2 (1H) -one can be used to prepare functional materials. Its unique molecular structure imparts special electrical, optical or magnetic properties to the material. For example, in the preparation of organic semiconductor materials, the introduction of this compound can regulate the energy level structure of the material, optimize the carrier transport performance, and improve the application performance of the material in devices such as organic light emitting diodes (OLEDs) and organic field effect transistors (OFETs). Furthermore, when preparing materials with special adsorption or separation properties, the compound can also play a role, and its interaction with specific substances can achieve efficient adsorption or separation of specific components.
What is the market outlook for 4-iodo-1-methylpyridin-2 (1h) -one?
4-Iodo-1-methylpyridin-2 (1H) -one is one of the organic compounds. In the current market, its prospects are complex and changeable.
From the perspective of scientific research, its prospects are quite bright. In the field of organic synthesis, chemists continue to increase their research interest in nitrogen-containing heterocyclic compounds. The unique structure of this compound makes it a key intermediate for the construction of more complex molecular structures. For example, in pharmaceutical chemistry, the development of many new drugs relies on such compounds containing iodine and nitrogen heterocyclic structures. By modifying their structures, they can explore drug molecules with higher biological activity and specificity. Therefore, as researchers continue to explore new chemical reactions and synthesis strategies, the demand for 4-iodo-1-methylpyridin-2 (1H) -one may grow steadily.
However, from the perspective of industrial production, there are many challenges. The synthesis process involves complex reaction steps and expensive raw materials, and the production cost remains high. And in large-scale production, precise control of reaction conditions and efficient separation and purification of products are difficult problems. If such problems cannot be effectively solved, large-scale industrial production will be difficult to achieve, and market supply will be limited.
Furthermore, the market competition situation also affects its prospects. If other alternatives with similar structures and lower costs emerge, the market share of 4-iodo-1-methylpyridin-2 (1H) -one may be eroded. However, if breakthroughs can be made in the synthesis process, costs can be reduced, and its unique structural advantages can establish an irreplaceable position in specific application fields, it is also expected to occupy a place in the market.