4 Iodo 1h Indazol 3 Amine

4-Iodo-1H-indazol-3-amine, an organic compound with unique chemical properties. Its structure contains an indolazole ring, with iodine atom substitution at the 4th position and an amino group at the 3rd position.
The physical properties of this compound are either solid under normal conditions. Due to the iodine atom, the intermolecular force is enhanced, and the melting point and boiling point are relatively high. Iodine atoms have large atomic radius and electronegativity, which affect molecular polarity or make the compound soluble in polar solvents.
Chemical properties, amino groups are basic and can react with acids to form salts. Due to the electron-giving effect of the amino group, the electron cloud density of the indolazole ring can increase, and it is easier to react at a specific position in the electrophilic substitution reaction of the aromatic ring. Under suitable conditions, substituents can be introduced into other positions of the indolazole ring. Iodine atoms are more active and can participate in nucleophilic substitution reactions. For example, when interacting with nucleophiles, iodine atoms are replaced to form new carbon-heteroatomic bonds, thereby forming more complex organic molecular structures. In addition, the compounds may have certain biological activities, because indolazole compounds often exhibit unique biological activities in the fields of medicine and pesticides. The specific structure of 4-iodo-1H-indazol-3-amine may endow it with affinity and effect to certain biological targets, which has potential application value in drug development.

4-Iodo-1H-indazol-3-amine, Chinese name 4-iodine-1H-indazol-3-amine, this is an organic compound with important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Drug developers can create new drug molecules with specific biological activities by modifying their chemical structures. For example, for specific disease-related targets, using 4-iodine-1H-indazole-3-amine as the starting material, through a series of chemical reactions, specific functional groups are added or transformed, or innovative drugs with good curative effect and small side effects can be developed for the treatment of cancer, inflammation and other diseases.
In the field of materials science, this compound is also useful. Due to its unique chemical structure and electronic properties, it may participate in the preparation of materials with special optical and electrical properties. For example, it can be used in the synthesis of organic optoelectronic materials and applied to organic Light Emitting Diode (OLED), solar cells and other devices, contributing to the improvement and optimization of material properties.
Furthermore, in the field of organic synthetic chemistry, 4-iodine-1H-indazole-3-amine is an important cornerstone for the construction of more complex organic molecules. Chemists can use its iodine atom and amino activity to connect it with other organic fragments through various organic reactions, such as coupling reactions, substitution reactions, etc., to construct organic compounds with diverse structures and high complexity, expanding the boundaries of organic synthetic chemistry and providing rich options for the creation of new substances.

To prepare 4-iodo-1H-indazol-3-amine, the following ancient method can be used.
First take a suitable starting material, such as o-nitroaniline as a group. Schilling o-nitroaniline reacts with a suitable halogenated hydrocarbon in a suitable solvent under the catalysis of a base, so that the halogen atom is attached to a specific position in the phenyl ring of o-nitroaniline to obtain a halogenated o-nitroaniline derivative. This step requires controlling the reaction temperature, time and material ratio to increase the purity and yield of the product.
Then the obtained halogenated o-nitroaniline derivative is carried out in the reduction system for nitro reduction. Nitro groups are often converted to amino groups by a combination of metals and acids, such as iron and hydrochloric acid, or by catalytic hydrogenation to obtain halogenated o-phenylenediamines. During this reduction process, attention should be paid to the mildness of the reaction conditions to avoid adverse effects on functional groups such as halogen atoms.
Then take halogenated o-phenylenediamine and formic acid or its derivatives, and cyclize under heating conditions. In this cyclization step, temperature regulation is crucial. If the temperature is too low, the reaction will be slow, and if it is too high, it will cause side reactions to cluster. After this cyclization, derivatives of 1H-indazol-3-amine can be obtained.
Finally, the iodization reaction of 1H-indazol-3-amine derivatives is carried out. Appropriate iodizing reagents can be selected, such as the combination of iodine element and oxidant, and the iodine atom can be introduced to the target position under suitable solvent and reaction conditions, and the final product is 4-iodo-1H-indazol-3-amine. After each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to obtain pure products, which lays a good foundation for the next reaction.

I don't know what the market price of 4-iodo-1h-indazol-3-amine is. This is a special chemical substance, and its price is affected by many factors.
One is about purity. If the purity is extremely high, it is almost flawless, and the price is high; if it contains impurities, the price is low. And the preparation of this high-purity product requires exquisite craftsmanship, high cost, and rising price.
Second, market supply and demand determine its price. If there are many people who want it, the supply is in short supply, and the merchant may raise the price; if the supply exceeds the demand, the price will drop.
Third, the preparation cost is different. The raw materials used, the reaction conditions, and the production technology all affect the cost and price. If the raw materials are rare, the preparation process is complicated, the cost is high, and the price is also high.
Fourth, the differences between manufacturers and brands also have an impact. Well-known large factories, emphasizing quality control and research and development, have excellent products, and the price may be high; small factories have low product prices, but the quality may be difficult to guarantee.
Because I do not have the exact market information, it is difficult to say the specific price. To know the price, you can consult chemical reagent suppliers, check chemical product trading platforms, or communicate with industry insiders to get a more accurate price.

4-Iodo-1H-indazol-3-amine is a chemical substance. Its storage conditions are crucial, related to the stability and quality of the substance.
This substance should be stored in a cool, dry and well-ventilated place. In a cool environment, it can avoid changes in its properties due to high temperature. High temperature often causes chemical reactions to accelerate, or cause substances to decompose and deteriorate. Therefore, the warehouse temperature should be controlled within a specific range to avoid heat damage.
Dry conditions are also indispensable. Water vapor in the air is easy to interact with substances, or cause deliquescence, changing their physical and chemical properties. It is necessary to prevent moisture in the storage place, and a desiccant can be prepared to absorb moisture in the air and keep the substance dry.
Good ventilation is also important. If the air in the storage space does not circulate, harmful substances accumulate, or cause safety hazards, it will also affect the substance itself. The circulating air can disperse the harmful gases that may be generated and maintain a suitable storage environment.
In addition, 4-iodo-1H-indazol-3-amine may be sensitive to light, so it should be stored away from light. Light irradiation or photochemical reactions damage the structure and properties of the substance. It can be stored in dark containers such as brown bottles, protected from direct sunlight and strong artificial light.
When storing, it must also be stored separately from oxidants, acids, bases and other substances. Due to their chemical properties, contact with their substances can easily cause chemical reactions, or cause serious consequences such as combustion and explosion. Each substance is stored in categories and clearly marked to facilitate management and access, and to reduce the risk of accidents. When handling, it should also be handled lightly to prevent damage to the packaging container and leakage of substances.