4 Iodo 1h Indazole

4-Iodo (1H) indazole is an organic compound with unique and interesting chemical properties.
In this compound, the iodine atom is connected to (1H) indazole. The iodine atom has a large atomic radius and high electronegativity, which has a significant impact on the properties of the compound. From the perspective of reactivity, the iodine atom can act as a good leaving group, making this compound capable of participating in many nucleophilic substitution reactions. For example, in the presence of appropriate nucleophiles, the iodine atom can be replaced by a nucleophilic reagent to form a new carbon-heteroatomic bond or a carbon-carbon bond, which is widely used in the field of organic synthesis.
Furthermore, the (1H) indazole part has a unique electronic structure and aromaticity. The hydrogen atom on the nitrogen atom has a certain acidity, and under alkaline conditions, it is easily captured by the base to form the corresponding negative ion. This negative ion can participate in the reaction as a nucleophile. Moreover, the aromatic conjugate system of (1H) indazole endows the compound with certain stability and affects its spectral properties. For example, in the ultraviolet-visible spectrum, specific absorption peaks appear due to the presence of the conjugate system, which can be used for qualitative and quantitative analysis of compounds.
In addition, the solubility of 4-iodo (1H) indazole is also an important property. In general, because it contains polar nitrogen atoms and relatively large organic groups, it should have a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), but relatively small solubility in water. This solubility characteristic determines its applicability in different reaction systems. In organic synthesis reactions, the selection of suitable organic solvents is of great significance for the smooth progress of the reaction.
In summary, the chemical properties of 4-iodo (1H) indazole are determined by the synergy between the iodine atom and the (1H) indazole part. These properties make it show potential application value in organic synthesis, medicinal chemistry and other fields.

4-Iodo (1h) indazole, Chinese name 4-iodo-1H-indazole, is widely used in the field of medicinal chemistry and is often used as a key intermediate to help synthesize a variety of biologically active compounds. Due to its unique structure, it contains an indazole ring and iodine atoms, which can introduce various functional groups through chemical reactions, paving the way for the creation of new drugs.
In the field of materials science, it also has outstanding performance. Due to its special structure, it can be modified to obtain functional materials with specific properties, or used in the field of optoelectronics, such as Light Organic Emitting Diode (OLED), to give materials unique optoelectronic properties and improve device performance.
Furthermore, in the field of pesticide chemistry, 4-iodo (1h) indazole can also be used as a raw material for the synthesis of highly efficient and low-toxic pesticides. With its structural characteristics, compounds with specific biological activities can be synthesized to kill pests and pathogens, and escort agricultural harvests.
In short, 4-iodo (1h) indazole has important uses in many fields such as medicine, materials, and pesticides, and is an important substance for chemical research and industrial production.

4-Iodo (1h) indazole is an important organic compound, and its synthesis method contains many delicate methods. The following is a detailed description for you.
First, indazole is used as the starting material to introduce iodine atoms through a halogenation reaction. In this process, the halogenation reagent needs to be carefully selected. Commonly used ones such as N-iodosuccinimide (NIS) can be selectively halogenated in a suitable solvent, such as dichloromethane, under mild reaction conditions. During the reaction, temperature control is crucial, and it is generally maintained at a low temperature, such as 0 ° C to room temperature, to ensure the high efficiency and selectivity of the reaction. Due to high temperature, it is easy to form polyhalogenated by-products, which increases the difficulty of product separation.
Second, iodine-containing metal-organic reagents can also be used to react with corresponding precursors. For example, using indazole derivatives to prepare lithium salts or magnesium salts first, and then react with iodine substitutes such as iodomethane or iodine ethane. This method needs to be carried out in a strict environment without water and oxygen. Due to the abnormal activity of lithium salts or magnesium salts, it is very easy to react with water or oxygen, resulting in experimental failure. The reaction solvent is mostly anhydrous ether or tetrahydrofuran to create a stable reaction environment.
Third, the coupling reaction catalyzed by transition metals is also a good strategy. For example, the coupling of halogenated aromatics and indazole derivatives catalyzed by palladium requires careful selection of palladium catalysts, such as tetra (triphenylphosphine) palladium (0), with suitable bases and ligands. The base can be potassium carbonate or sodium carbonate, depending on the specific reaction requirements. Such reactions are usually carried out at higher temperatures to promote the smooth progress of the reaction, but close monitoring is also required to prevent side reactions.
The above synthesis methods have their own advantages and disadvantages. In actual operation, when considering factors such as the availability of starting materials, the difficulty of controlling reaction conditions, and the purity requirements of the target product, comprehensive trade-offs are made, and the optimal method is selected. Only then can the purpose of high-efficiency synthesis of 4-iodo (1h) indazole be achieved.

I have not obtained the exact price range of 4-iodo (1h) indazole on the market. However, to estimate its price, many factors need to be considered. The synthesis of this compound is difficult and easy. If the synthesis requires complex steps, special materials and high-precision technology, the price must be high; the availability of raw materials should also be checked. Raw materials are rare or difficult to obtain, and costs rise and prices rise; market demand is also critical. If there are many applicants, supply will outstrip demand, and prices will rise, otherwise they will fall.
In addition, purity has a great impact, and high purity is expensive. And differences in sales regions and suppliers also lead to different prices. In busy cities or professional chemical markets, prices may vary due to competition and logistics. The size of suppliers, operating costs, etc. also affect their pricing.
With common sense, if the chemical is easy to synthesize, the raw materials are common, and the demand is normal, the price per gram may be between tens and hundreds of yuan. If the synthesis is difficult, the raw materials are rare and the demand is strong, the price per gram may exceed 1,000 yuan. However, this is all speculation. To know the exact price, it is advisable to consult the chemical raw material supplier, chemical reagent seller, or check it on the professional chemical trading platform to obtain the accurate price range.

4-Iodo (1h) indazole is an organic compound whose storage conditions are crucial to its stability and quality. This compound should be stored in a cool, dry and well-ventilated place. Because a cool environment can reduce the risk of decomposition or deterioration due to excessive temperature, a dry state can avoid moisture and prevent adverse reactions with water vapor. Well-ventilated can disperse harmful gases that may be generated in time and maintain the safety of the storage environment.
Furthermore, it needs to be stored separately from oxidants, acids, bases and other substances. Due to the active chemical properties of these substances, contact with 4-iodo (1h) indazole can easily cause chemical reactions, causing its structure to change and losing its original characteristics and uses. When storing, also ensure that the container is well sealed. The sealed container can prevent the intrusion of external air, water vapor and impurities, and maintain the purity of the compound.
In addition, the storage area should be equipped with suitable containment materials to prevent leakage accidents. If leakage unfortunately occurs, it can be quickly collected and processed with containment materials to avoid its spread and cause greater harm. And obvious warning signs should be set up at the storage place to remind relevant personnel to pay attention to the danger of this compound and storage precautions, and operate with caution to prevent accidents. Only in this way can the 4-iodo (1h) indazole be properly preserved so that it can play its due role when used.