4-Iodo-1H-Pyrazole

4-Iodo-1H-pyrazole (4-iodo-1H-pyrazole) is an organic compound with unique chemical properties and is widely used in many fields.
This compound is weakly acidic, due to the N-H bond on the 1H-pyrazole ring, affected by the ring electron cloud, the hydrogen atom is slightly active, and can leave the proton under the action of an appropriate base to form a corresponding conjugated base. However, compared with common inorganic acids or some organic acids, its acidity is very weak.
The iodine atom of 4-iodo-1H-pyrazole has high activity. Iodine atoms are prone to nucleophilic substitution reactions due to electronegativity and atomic radius factors. When there are suitable nucleophiles, iodine atoms can be attacked and replaced by nucleophiles to form new compounds. For example, when reacted with sodium alcohol, iodine atoms can be replaced by alkoxy groups to obtain pyrazole derivatives containing different substituents.
In addition, its pyrazole ring also has certain reactivity. The π electron cloud distribution on the pyrazole ring makes it possible to participate in a variety of electrophilic substitution reactions. For example, under appropriate conditions, it can react with electrophilic reagents and introduce substituents at specific positions in the pyrazole ring, which is of great significance for the synthesis of pyrazole compounds with diverse structures. In organic synthesis, 4-iodo-1H-pyrazole is often used as a key intermediate. By reacting its iodine atom and pyrazole ring, compounds with different properties such as biological activity and photoelectric properties can be prepared, which play an important role in the fields of medicinal chemistry and materials science.

4-Iodine-1H-pyrazole is an important organic compound with a wide range of common uses. In the field of organic synthesis, this compound is often used as a key intermediate. Because its structure contains iodine atoms and pyrazole rings, it has unique reactivity, and can construct more complex organic molecular structures through various reactions such as nucleophilic substitution and coupling. For example, in the Suzuki reaction, the iodine atom of 4-iodine-1H-pyrazole can be coupled with organoboron reagents to form carbon-carbon bonds, providing an effective way for the synthesis of aromatic compounds with specific structures.
In the field of medicinal chemistry, 4-iodine-1H-pyrazole is also very important. Pyrazole ring, as a common structural unit of drug molecules, has good biological activity and pharmacokinetic properties. 4-iodine-1H-pyrazole can be structurally modified and modified to introduce different substituents, thereby regulating its interaction with biological targets, laying the foundation for the development of new drugs. Studies have shown that some compounds containing 4-iodine-1H-pyrazole structure exhibit certain inhibitory or regulatory activity on specific disease-related targets, and are expected to become potential drug lead compounds.
In materials science, 4-iodine-1H-pyrazole also has potential applications. With its reactivity, it can be introduced into polymer materials or functional material structures to endow materials with unique optical, electrical or thermal properties. For example, in the synthesis of some optoelectronic materials, the introduction of 4-iodine-1H-pyrazole structural units may improve the charge transport properties and luminous efficiency of materials, providing new strategies for the preparation of high-performance optoelectronic materials.
In summary, the unique structure and reactivity of 4-iodine-1H-pyrazoline have important uses in many fields such as organic synthesis, medicinal chemistry and materials science, providing rich possibilities and research directions for the development of related fields.

The synthesis method of 4-iodine-1H-pyrazole has been known for a long time, and its methods are diverse, and now it is your way.
First, pyrazole is used as the starting material and can be obtained by halogenation reaction. In the reaction kettle, an appropriate amount of pyrazole is placed, and suitable solvents, such as dichloromethane, chloroform, etc., are added to create a reaction environment. Then, slowly add iodine sources, such as iodine elemental substance, N-iodosuccinimide (NIS), etc. When adding dropwise, pay attention to the reaction temperature, and always control it at a low temperature, such as between 0 ° C and room temperature, to avoid side reactions. After adding it dropwise, stirring for several hours, until the reaction is complete, the product can be purified by conventional separation methods, such as extraction, column chromatography, etc., to obtain 4-iodine-1H-pyrazole.
Second, the pyrazole derivative containing a specific substituent is used as the starting material. If there is a suitable substituent on the pyrazole ring, its activity can be used to introduce iodine atoms through a specific reaction path. For example, the substituent of some pyrazole derivatives can undergo nucleophilic substitution reaction with the iodine substitution reagent under the catalysis of a base. Select a suitable base, such as potassium carbonate, sodium carbonate, etc., in an organic solvent, heat and reflux to promote the reaction. After the reaction is completed, the target product can also be obtained through separation and purification.
Third, the coupling reaction catalyzed by transition metals. Pyrazole derivatives containing functional groups such as borate esters or halogenated hydrocarbons and iodine substitutes are used under suitable reaction conditions under the action of transition metal catalysts such as palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.). This reaction requires the assistance of specific ligands, and the type and dosage of reaction solvents and bases are particular. After optimizing the reaction conditions, the corresponding separation operation after the reaction can achieve the purpose of synthesizing 4-iodine-1H-pyrazole.
All kinds of synthesis methods have their own advantages and disadvantages, and they need to be carefully selected according to factors such as actual demand, availability of raw materials, and cost considerations.

Today there is a 4-iodo-1h-pyrazole, and the price in the market is what everyone is concerned about. However, it is not easy to know its exact price. The price of this product is influenced by many factors, which is like a changing situation and elusive.
The first to bear the brunt is the situation of supply and demand in the market. If there are many people who want this product, but there are few people who supply it, its price will rise, just like the reason that rare things are expensive; on the contrary, if the supply exceeds demand and floods the market, the price will definitely drop.
Furthermore, the cost of production is also the key. The price of raw materials and the simplicity of the preparation process are all closely related to the cost. The raw materials are rare and rare, and the process is complicated and difficult, so the cost will be high, and the selling price will also rise; if the raw materials are easy to obtain and the process is simple, the cost can be reduced, and the price may be lowered.
In addition, the quality also affects the price. Those with high quality are naturally favored by everyone, and their prices are also high; those with lower quality will have different prices.
In addition, the price varies depending on the region. In prosperous places, where business is prosperous and transactions are frequent, the price may vary; in remote places, inconvenient transportation, and high logistics costs, the price may also vary.
As for the specific price, it is difficult to say exactly. If you want to know the details, you need to visit the chemical materials business, or consult the people in the industry who are well versed in this, in order to obtain a more accurate figure. However, the market conditions change rapidly, and the price you get is only a temporary price, which cannot be determined for a long time.

4-Iodine-1H-pyrazole is an organic compound, and its safety and toxicity need to be carefully examined.
Let's talk about toxicity first, 4-iodine-1H-pyrazole may have certain toxicity. From the perspective of chemical structure, the presence of iodine atoms may affect its biological activity and toxicity. In some experimental situations, iodine-containing organic compounds may cause damage to the cells of organisms. It may interfere with the normal metabolic process of cells, such as affecting the activity of enzymes, and then destroy the normal biochemical reactions in cells. If this compound enters the human body, after absorption, or circulates with the blood to various tissues and organs, it can cause damage to important organs such as liver and kidney. The liver is an important detoxification organ of the human body, and the kidneys are responsible for excreting waste products. 4-Iodine-1H-pyrazole may interfere with its normal function, resulting in abnormal organ function.
As for safety, in industrial production and laboratory operations, exposure to 4-Iodine-1H-pyrazole requires strict follow of safety procedures. Because of its irritation, if it comes into contact with the skin and eyes, it can cause discomfort, redness, pain, and severe inflammation. When operating, wear appropriate protective equipment, such as gloves, goggles and protective clothing, to avoid direct contact. And it needs to be operated in a well-ventilated environment to prevent inhalation of its volatile gases. If accidentally inhaled, or irritates the respiratory tract, causing cough, asthma and other symptoms. When storing, it should also be properly placed to avoid mixing with other chemicals to prevent dangerous chemical reactions.
Overall, 4-iodine-1H-pyrazole has potential toxicity and certain safety risks. When handling and using, it is necessary to be careful and strictly follow relevant safety regulations to ensure the safety of personnel and the environment from pollution.