4 Iodo 1h Pyridin 2 One

4-Iodo-1H-pyridin-2-one, one of the organic compounds. Its chemical structure contains a pyridine ring, in which the nitrogen atom is connected to a hydrogen atom in the 1 position; the 2 position is a carbonyl group, and the oxygen atom is connected to the carbon atom in the ring by a double bond; the 4 position is connected to the iodine atom.
The pyridine ring of this compound has a six-membered ring structure, which is composed of five carbon atoms and one nitrogen atom arranged coplanar according to a specific bond angle and bond length. The electron cloud distribution of the pyridine ring is due to the higher electronegativity of the nitrogen atom than that of the carbon atom, resulting in uneven electron cloud density on the ring, which affects its chemical activity and reaction characteristics. The carbonyl group at the
2 position is a strong electron-absorbing group. The presence of this carbonyl group can further shift the electron cloud of the pyridine ring, enhance the electrophilicity at a specific position on the ring, and then affect the performance of the compound in nucleophilic substitution, addition and other reactions. And the oxygen atom of the carbonyl group can participate in the formation of hydrogen bonds due to its lone pair of electrons, which also has a significant impact on the physical properties of the compound, such as melting point, boiling point and solubility. The iodine atom at the
4 position has a large atomic radius and relatively low electronegativity. The introduction of iodine atoms not only increases the molecular mass and volume, but also changes the spatial structure of the compound. Due to the high polarizability of iodine atoms, the nucleophilicity of the compound changes. In organic synthesis, iodine atoms can often be used as leaving groups to participate in various substitution reactions, providing an important reaction check point for the construction of complex organic molecular structures.
In summary, the chemical structure of 4-iodo-1H-pyridin-2-one is formed by the interaction of pyridine ring, 2-position carbonyl and 4-position iodine atoms. This unique structure endows the compound with specific physical and chemical properties and has important research and application value in the field of organic chemistry.

4-Iodine-1H-pyridine-2-one is an organic compound with unique physical properties. This compound is mostly solid at room temperature, and its melting boiling point is of great significance for identification and purification. After verification or experiments, it can be found that the melting point is about [X] ° C, and the boiling point is about [X] ° C. This melting boiling point characteristic affects its phase state and stability under a specific temperature environment.
Looking at its solubility, 4-iodine-1H-pyridine-2-one behaves differently in different solvents. In polar organic solvents, such as methanol and ethanol, it exhibits certain solubility. Because the molecular structure contains polar groups, it interacts with polar solvent molecules through hydrogen bonds or other molecular forces to promote dissolution. However, in non-polar solvents, such as n-hexane and benzene, the solubility is poor.
The density of 4-iodine-1H-pyridine-2-one is also an important physical property. The density is about [X] g/cm ³. This value reflects the mass of the substance per unit volume. It is particularly critical when chemical production and solution preparation are related to dosage and concentration calculations.
In addition, its appearance may be white to light yellow crystalline powder, which can be used as a preliminary visual discrimination. In terms of odor, it may have a weak special odor, but the odor description is subjective and may be different for different people.
In short, the melting point, boiling point, solubility, density, appearance and odor of 4-iodine-1H-pyridine-2-one provide an important basis and basis for its application in chemical synthesis, drug development and other related fields.

4-Iodo-1H-pyridin-2-one, Chinese name 4-iodine-1H-pyridin-2-one, this substance has a wide range of uses. In the field of medicine, it plays an important intermediate role. In the synthesis of many drugs, this is used as the starting material or key structural unit, and compounds with specific pharmacological activities can be constructed through a series of chemical reactions. For example, when developing antibacterial drugs, modifying the structure of 4-iodo-1H-pyridin-2-one is expected to create new antibacterial agents, which show a unique antibacterial mechanism for specific bacteria and add new means for the treatment of bacterial infections.
In the field of organic synthesis chemistry, it is also an indispensable reagent. Due to the structural characteristics of iodine atoms and pyridinones, it can participate in a variety of organic reactions, such as nucleophilic substitution reactions and coupling reactions. In nucleophilic substitution, iodine atoms can be replaced by various nucleophilic reagents, introducing different functional groups to enrich the structure and properties of organic molecules. In coupling reactions, it can be connected with other organic fragments to build complex macromolecular structures, laying the foundation for the synthesis of organic materials with special functions.
In the field of materials science, 4-iodo-1H-pyridin-2-one can be used to prepare functional materials after appropriate chemical modification. For example, by copolymerizing with polymer monomers, polymers are endowed with special optoelectronic properties, which are used to manufacture optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve device performance and efficiency. In short, 4-iodo-1H-pyridin-2-one has important uses in many fields such as medicine, organic synthesis and materials science, providing key support for the development of related fields.

4-Iodo-1H-pyridin-2-one is an organic compound. There are many methods for synthesis, and the following are common ones.
First, pyridin-2-one is used as the starting material. Pyridine-2-one is first combined with a suitable base agent, such as sodium hydride, in an anhydrous organic solvent, such as anhydrous tetrahydrofuran, to generate corresponding negative ions. After that, iodine-containing reagents, such as iodomethane or iodosuccinimide, are added. This reaction process involves nucleophilic substitution, where an iodine atom replaces the hydrogen at a specific position of pyridin-2-one to obtain 4-iodo-1H-pyridin-2-one. The advantage is that the starting material is readily available and the reaction conditions are milder. However, the reaction selectivity may need to be finely regulated to prevent side reactions from occurring.
Second, it starts from 2-aminopyridine. 2-aminopyridine is reacted with diazotide and sodium nitrite and acids such as hydrochloric acid to form diazonium salts at low temperatures. After that, the diazonium salt reacts with an iodine source such as potassium iodide, and through the Sandmeyer reaction, the diazonium group is replaced by an iodine atom to obtain the target product. The advantage of this path is that the reaction steps are clear in logic and the yield is sometimes quite high. However, the diazotization reaction requires low temperature operation, and the conditions are relatively harsh, and the stability of the diazonium salt is not good, so the operation needs to be cautious.
Third, through the catalytic coupling reaction of transition metals. Halogenated pyridine-2-one is used as the substrate and the iodine source is coupled in the presence of ligands and bases under the action of transition metal catalysts such as palladium catalysts. This method has good selectivity and can efficiently construct carbon-iodine bonds. However, transition metal catalysts are expensive, and post-reaction processing may require complex steps to separate the catalysts.
When synthesizing 4-iodo-1H-pyridin-2-one, the advantages and disadvantages of each method need to be weighed according to specific needs and conditions, and the appropriate path should be selected to achieve satisfactory synthesis results.

4-Iodo-1H-pyridin-2-one is an organic compound. When storing and transporting, the following items should be noted:
First, the storage environment should be dry and cool. This compound is prone to chemical reactions such as hydrolysis in case of moisture, which will damage its purity and quality. Therefore, a dry place should be selected, and the temperature should not be too high to prevent its decomposition or deterioration due to heat. If placed in a well-ventilated and cool warehouse, keep away from heat and fire sources.
Second, the air must be isolated. The substance may react with oxygen and other components in the air. It can be stored in a sealed container, such as a sealed glass bottle or plastic bottle, to ensure that the air is difficult to contact. When transporting, it is also necessary to ensure that the packaging is tight to prevent air intrusion.
Third, avoid light. Light or the photochemical reaction of this compound will affect its stability. During storage and transportation, opaque packaging materials, such as brown bottles, should be used for storage. When transporting, it should be shaded with a shading cloth to reduce the influence of light.
Fourth, it should be isolated from other substances. 4 - iodo - 1H - pyridin - 2 - one or chemically react with certain substances, such as strong oxidants, strong acids, strong bases, etc. When storing, it should not be mixed with these substances; when transporting, it should not be transported with such chemicals in a cabin or a truck to avoid dangerous reactions.
Fifth, follow the specifications. Whether it is handling, placement during storage, or loading and unloading during transportation, it must be strictly operated according to the specifications, handled with care to prevent packaging damage. Once the packaging is damaged, the compound is exposed, which is easy to absorb moisture, oxidize and pollute the environment, and even cause safety problems.