4-iodo-2,6-diphenylpyridine

4-Iodo-2,6-diphenylpyridine is also an organic compound. Its main uses are in various fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the unique combination of iodine atoms with pyridine rings and phenyl groups in its structure, it is given significant reactivity. Iodine atoms can be linked to other organic fragments through many organic reactions, such as coupling reactions. For example, in the Suzuki coupling reaction, the iodine atom of 4-iodo-2,6-diphenylpyridine can react with boron-containing reagents to form carbon-carbon bonds, which are crucial in the synthesis of more complex organic molecular structures. This is of key significance in the fields of medicinal chemistry and materials science.
In the field of materials science, it has also attracted much attention. The rigid structure of the pyridine ring and phenyl group makes 4-iodo-2,6-diphenylpyridine promising for the preparation of materials with specific optoelectronic properties. It can participate in the construction of conjugated systems, which in turn affect the electronic transport properties and optical properties of materials. For example, in the development of organic Light Emitting Diode (OLED) materials, compounds based on this may be able to adjust the color and efficiency of light emission, providing the possibility of preparing high-performance OLED materials.
In the field of medicinal chemistry, the structure of this compound can be used as the skeleton for the design of drug molecules. Pyridine rings and phenyl groups are commonly found in many bioactive molecules. By modifying them and introducing different functional groups, the interaction between molecules and biological targets can be adjusted, laying the foundation for the development of new drugs. Or it can be used to design small molecule inhibitors for specific disease-related targets and explore potential therapeutic drugs.

4-Iodine-2,6-diphenylpyridine is also an organic compound. The method of synthesis is as follows:
One method can be started from a pyridine compound. First take a suitable pyridine derivative and introduce an iodine atom at the 4th position by a halogenation reaction. The halogenation method is often used in combination with an iodine-containing reagent, such as an iodine elemental substance, and an appropriate oxidant. Under suitable solvents and reaction conditions, the iodine atom selectively replaces the hydrogen atom at the 4th position of the pyridine ring.
Then, the benzene-based 2,6 position is introduced by an aromatization reaction. The commonly used method is a palladium-catalyzed coupling reaction, such as the Suzuki coupling reaction. Taking halogenated benzene or phenylboronic acid derivatives, using palladium compounds as catalysts, assisted by ligands, in the presence of bases, heating reactions in organic solvents can connect phenyl groups to the 2,6 positions of the pyridine ring to obtain 4-iodine-2,6-diphenylpyridine.
The second method can also construct pyridine rings from benzene compounds. First, benzene derivatives are used to construct iodine-containing pyridine ring precursors through multi-step reactions, such as benzaldehyde derivatives and nitrogen-containing reagents through condensation, cyclization, etc. to form pyridine ring structures, and iodine atoms and phenyl groups are introduced in suitable steps. After the pyridine ring is formed by the cyclization reaction, the iodine atom is at the 4th position and the phenyl group is at the 2,6 position through appropriate modification and adjustment, and the final product is obtained.
When synthesizing this compound, attention should be paid to the control of reaction conditions, such as temperature, pH, reaction time, etc., which have a significant impact on the yield and selectivity of the reaction. The purity of the reagents used and the activity of the catalyst are also related to the success or failure of the synthesis.

4-Iodine-2,6-diphenylpyridine is one of the organic compounds. Its physical properties are particularly important, and it is related to many uses and reactions of this compound.
First of all, its appearance is often solid, which is caused by intermolecular forces. The combination of iodine atoms and diphenylpyridine structures in the molecule increases the attractive force between molecules, and then stabilizes into a solid state at room temperature and pressure. Looking at its color, it is generally almost white to light yellow. The formation of this color is due to the characteristics of molecular structure on light absorption and reflection.
As for the melting point, 4-iodine-2,6-diphenylpyridine has a specific melting point value. The melting point is the critical temperature at which a substance changes from solid to liquid. The melting point of this compound depends on the strength of intermolecular forces, including van der Waals forces, hydrogen bonds, etc. In its structure, the presence of iodine atoms enhances intermolecular forces, resulting in an increase in melting point. Accurate determination of melting point is extremely beneficial for identification and purity judgment. The melting point of pure 4-iodine-2,6-diphenylpyridine is fixed. If it contains impurities, the melting point may drop and the melting range becomes wider.
Solubility is also an important physical property. In organic solvents, such as common toluene, dichloromethane, etc., 4-iodine-2,6-diphenylpyridine exhibits certain solubility. This is because the organic solvent and the compound molecules can form similar intermolecular forces, which is in line with the principle of "similar miscibility". In water, because the molecule is non-polar or weakly polar, the force difference between the molecule and the water molecule is large, so the solubility is very small.
In addition, the density of 4-iodine-2,6-diphenylpyridine is also an inherent physical property. Density reflects the mass of a substance per unit volume and is affected by the molecular structure and packing method. Understanding its density is crucial for material measurement and mixing ratio control in chemical production and experimental operations. In conclusion, the physical properties of 4-iodine-2,6-diphenylpyridine, such as its appearance, melting point, solubility, and density, are essential for its application and research in organic synthesis, materials science, and other fields.

4-Iodo-2,6-diphenylpyridine is an organic compound, and its chemical stability needs to be viewed from many aspects.
This compound contains a pyridine ring, and the pyridine ring has certain aromaticity. Because the intra-ring π electron cloud conforms to the 4n + 2 rule, it endows it with a relatively stable structure. Electrons in the aromatic system are delocalized, which reduces the molecular energy and improves the stability.
Iodine atoms are attached to the pyridine ring. Although iodine has a large electronegativity, due to its large atomic radius and weak conjugation effect with the pyridine ring, it has limited effect on the distribution of the pyridine ring electron cloud. Under normal conditions, the C-I bond is relatively stable and is not easy to break spontaneously. However, under specific reaction conditions such as nucleophilic substitution, iodine atoms can participate in the reaction as leaving groups.
Two phenyl groups are attached to the 2,6 positions of the pyridine ring. The phenyl group also has an aromatic structure and forms a conjugate system with the pyridine ring. This conjugation further increases the conjugation range of the molecule, making the electron delocalization more significant, reducing the molecular energy and enhancing the stability. The steric hindrance effect of phenyl groups cannot be ignored. Due to its large volume, it will affect the spatial environment around the molecule, preventing some reagents from approaching the reaction check point, protecting the molecule to a certain extent and improving the stability.
However, the stability is not absolute. Under extreme conditions such as high temperature, strong acid-base or strong oxidant, the chemical structure of 4-iodo-2,6-diphenylpyridine will be affected. High temperature may intensify the vibration of chemical bonds in the molecule, increase the energy to a certain extent, and break the chemical bonds, triggering decomposition or rearrangement reactions. In strong acid-base environments, pyridine ring nitrogen atoms can protonate or react with bases, changing the distribution of molecular electron clouds, thereby affecting their stability and reactivity. Strong oxidants may attack electron-rich regions in molecules, such as conjugated systems, resulting in structural destruction.
In general, 4-iodo-2,6-diphenylpyridine has good chemical stability under normal and mild conditions due to its aromatic conjugate structure and steric hindrance effect. However, under extreme conditions, its stability will be challenged, and various chemical reactions may occur to change the molecular structure.

4-Iodo-2,6-diphenylpyridine is an organic compound. The market price varies depending on the purity, supply, and purchase quantity.
In terms of purity, high purity is the higher the price. For chemical experiments, high purity is often required, and few impurities do not disturb the reaction. This price is high. General industrial grade, with slightly lower purity, the price may be appropriate.
Supply source also affects the price. Well-known large-scale factory production, strict quality control, excellent raw material selection, good craftsmanship, and high price is reasonable; small factories or low price, natural quality or unstable.
Purchase quantity is also critical. Buy in large quantities, suppliers may give discounts, and the unit price will drop; buy in small quantities, and the unit price will be high.
According to past transactions and market conditions, laboratories use high purity (≥ 98%), small packages (such as 5 grams), or around tens to hundreds of yuan per gram; industrial-grade large-scale purchases (hundreds of kilograms), per kilogram or hundreds of yuan.
To confirm the price, you can consult chemical merchants and chemical e-commerce platforms, and compare multiple quotations to get an accurate price.