4 Iodo 2 Methyl 1h Imidazole

4-Bromo-2-methyl-1H-imidazole is an important organic compound with critical uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate in drug synthesis. This structure has unique electronic properties and spatial configuration, which can precisely bind to specific targets in organisms. For example, some antibacterial drugs enhance the inhibition of bacterial cell wall synthesis or protein synthesis by introducing 4-bromo-2-methyl-1H-imidazole structure, thereby enhancing antibacterial activity. At the same time, in the development of anti-tumor drugs, this structure has also received extensive attention, which may inhibit the proliferation and metastasis of tumor cells by regulating specific signaling pathways.
In the field of materials science, 4-bromo-2-methyl-1H-imidazole can participate in the preparation of functional materials. It can be used as a ligand to coordinate with metal ions to construct metal-organic framework materials (MOFs) with special optical, electrical or magnetic properties. Such MOFs materials exhibit excellent performance in gas adsorption and separation, catalytic reactions, etc. For example, in the field of gas adsorption, it has high selectivity and high adsorption capacity for specific gas molecules, which can be applied to industrial waste gas treatment and air purification.
In the field of organic synthesis chemistry, 4-bromo-2-methyl-1H-imidazole is an important building block for the construction of complex organic molecules. Due to the activity of bromine atom and imidazole ring, different functional groups can be introduced through various chemical reactions, such as nucleophilic substitution reaction, coupling reaction, etc., to achieve molecular structure diversification modification, providing an effective way for the synthesis of organic compounds with specific functions.
In summary, 4-bromo-2-methyl-1H-imidazole plays a key role in the fields of drugs, materials and organic synthesis due to its unique structure and reactivity, and is of great significance to promote the development of related fields.

4-Question-2-Methyl ether-1H-furan The physical properties of capsular ether and 1H-furan have their own properties.
Methyl ether is a colorless flammable gas at room temperature and pressure, with a weak aroma unique to ethers. Its boiling point is quite low, about -24.9 ° C, due to the weak van der Waals force between molecules. The melting point is -141.5 ° C, the relative density (water = 1) is about 0.66, which is lighter than water and can float on water. Its vapor pressure is high, it is volatile, and it diffuses rapidly in the air. Methyl ether is slightly soluble in water, but it can be miscible with organic solvents such as ethanol, ether, and acetone. This is because methyl ether is a polar molecule, and intermolecular forces can be formed between it and organic solvents. And the chemical properties of methyl ether are relatively stable, but under specific conditions, such as high temperature and the presence of catalysts, reactions can occur.
As for 1H-furan, it is a colorless and volatile liquid at room temperature, with an odor similar to chloroform. The boiling point is 31.36 ° C, which is also low. The intermolecular force is also dominated by van der Waals force, but its boiling point is slightly higher than that of methyl ether due to its molecular structure. The melting point is -85.6 ° C, and the relative density (water = 1) is about 0.96, which is slightly lighter than that of water. 1H-furan is soluble in organic solvents such as ethanol, ether, acetone, etc., and has a low solubility in water. Its chemical properties are more active. Due to the conjugated structure of furan rings and the special distribution of electron clouds, it is prone to electrophilic substitution reactions, such as halogenation, nitrification, etc., and can also participate in Diels-Alder reactions.
In summary, methyl ether and 1H-furan have different physical properties such as physical state, melting point, density, solubility and chemical activity, which are due to differences in material structure.

4-Bromo-2-methyl-1H-indole, this is an organic compound. Its chemical properties are quite unique and it is widely used in the field of organic synthesis.
In this compound, the presence of bromine atoms and methyl groups greatly affects its reactivity and chemical properties. Bromine atoms have strong electronegativity, which can change the electron cloud density distribution of the indole ring. On the one hand, it can reduce the electron cloud density of the indole ring through induction effect, which in turn affects the activity and check point of electrophilic substitution reactions on the ring. For example, in the electrophilic substitution reaction, the electron cloud density of the adjacent and para-position of the bromine atom is relatively high, and the electrophilic reagent is more likely to attack these positions. Compared with the indole without the bromine atom substitution, the reaction check point and activity are different. The presence of
methyl is also not to be underestimated. Methyl is a donator group, and through the superconjugation effect, electrons can be supplied to the indole ring, which increases the electron cloud density of the ring. In this way, the interaction of the donator of methyl and the electron absorption of the bromine atom are checked and balanced, so that the reactivity of 4-bromo-2-methyl-1H-indole is in a unique state. In some reactions, the synergistic effect of the two makes the compound exhibit different reaction characteristics from indole derivatives with only a single substituent.
In addition, the indole ring of 4-bromo-2-methyl-1H-indole itself is aromatic, which gives it certain stability, but also allows it to participate in many aromatic ring-based reactions, such as the Foucault reaction. The hydrogen atom on the nitrogen atom of the indole ring is also acidic due to the influence of the ring system electron effect, and can participate in some acid-base related reactions. In conclusion, the chemical properties of 4-bromo-2-methyl-1H-indole are complex and unique, and it plays an important role in the research and application of organic synthetic chemistry.

4 - Question - The synthesis method of 2-methyl-1H-imidazole, although it is not directly explained in Tiangong Kaiwu, it can be explored from the relevant ideas of ancient chemical processes.
Among the ancient methods, many methods of substance transformation are involved, which may provide reference for their synthesis. In ancient alchemy and metallurgical processes, the treatment of various minerals and compounds may contain similar reaction principles.
First, consider the reaction between nitrogen-containing compounds and methyl-containing raw materials. In ancient times, there were attempts to react with some organic compounds containing methyl groups with natural nitrogen-containing substances, such as nitrogen-containing substances generated after the decay of plant proteins. If specific plant rhizomes are fermented, the resulting product may contain methyl-containing components, which are co-placed in a pottery kettle with nitrogen-containing waste materials, boiled slowly over a slow fire, or formed by complex reactions. Although the exact structure of imidazole was not known at that time, it was inferred from the reaction phenomenon and product characteristics, or explored in this direction.
Second, the acid-base catalytic pathway. Although there was no modern acid-base catalytic theory in ancient times, it may have similar applications in practical operation. Plant ash (containing basic substances such as potassium carbonate) or some acidic ores are used as catalysts to promote the combination of nitrogen-containing and methyl-containing raw materials. For example, in a sealed porcelain pot, nitrogen-containing plant ashes and methyl-containing oils taken from the vicinity of oil ore seedlings are added with an appropriate amount of acid-base catalyst, and braised for a long time to observe the changes of the product, or to separate similar 4-question-2-methyl-1H-imidazole substances.
Third, learn from the fermentation process. Ancient fermentation technologies such as winemaking and vinegar brewing are mature, and it can be conceived that microbial metabolic processes can be used to achieve synthesis. With raw materials rich in nitrogen sources and methyl sources, such as some special grains and methyl-containing sugars, connected to specific microbial flora, temperature, humidity and other conditions, microorganisms generate target products during the metabolic process or through a series of enzymatic reactions. Although this synthesis path was not precisely grasped in ancient times, the embryonic form of imidazoles may exist in the complex products produced during the fermentation process.

No. 4 Question 2. There are many things to pay attention to in the storage and transportation of methane-based 1H rocket fuel.
In terms of storage, the boiling point of methane is very low, about -161.5 ° C. It needs to be stored in a low-temperature liquid form in a storage tank with excellent thermal insulation performance to effectively reduce evaporation loss. The material of the storage tank must be able to adapt to the low temperature environment to prevent brittle cracking. And the storage tank needs to be equipped with accurate liquid level and pressure monitoring devices to control the methane storage status in real time. Once the pressure rises abnormally, the safety valve must be able to open the pressure relief in time to ensure safety.
When transporting, the transportation vehicle or ship must have a reliable refrigeration and insulation system to maintain the liquid methane state. Transportation pipelines also need to be well insulated and insulated to prevent external heat from entering and causing methane vaporization. Moreover, the whole process of transportation should strictly follow relevant safety regulations, such as transportation routes should avoid densely populated areas, transportation personnel need to undergo professional training, familiar with methane characteristics and emergency response methods.
Furthermore, methane is a flammable and explosive gas. Whether it is storage or transportation sites, fireworks should be strictly prohibited, obvious fire ban signs should be set, and complete fire protection facilities and leakage detection devices should be equipped. In the event of a leak, the detection device should immediately alarm, and the on-site personnel need to take emergency measures, such as cutting off the gas source, evacuating personnel, and strengthening ventilation, to prevent explosions and fire accidents. In this way, the safety of methane-based 1H rocket fuel during storage and transportation can be ensured.