4 Iodo 4 Bromobiphenyl

4-Iodo-4 '-bromobiphenyl, Chinese name 4-iodo-4' -bromobiphenyl, the main use of this substance, is mostly in the field of chemical synthesis and scientific research.
In chemical synthesis, it is often used in the field of chemical synthesis. Because its molecules contain iodine and bromine atoms, the two active phases can lead to multi-chemical reactions, which can lead to the construction of complex molecules. For example, in catalytic cross-coupling, iodine atoms or bromine atoms can be combined with other gold compounds to generate carbon. This reaction is very important in the synthesis of chemical compounds with specific properties and functions, such as the synthesis of novel semi-chemical materials, compounds, etc.
In scientific research, 4-iodine-4 '-bromobenzene is also important. In the field of materials science, researchers have used it to synthesize materials with special optical and chemical properties to explore the power of new optical devices, such as optical diodes (OLEDs), solar cells, etc. In the field of physics and chemistry, it is used to synthesize biologically active compounds for use in chemical and chemical research, and to help new research.
Therefore, 4-iodine-4' -bromobenzene plays an indispensable role in many aspects of chemical synthesis and scientific research, promoting the development of the field.

To make 4-iodo-4 '-bromobiphenyl, there are three methods.
First, start with biphenyl, and go through the sequence of bromination and iodization. First, make biphenyl and bromine under the catalysis of iron or iron salt, in the heated state, electrophilic substitution to obtain 4-bromobiphenyl. In this step, bromine electrophilic attacks the biphenyl ring. Due to the uneven electron cloud density of the benzene ring, the 4-position is more active, and the bromine atom is easy to occupy. Later, 4-bromobiphenyl and iodine reagents, such as iodosuccinimide (NIS), in an appropriate solvent, such as dichloromethane, add an initiator, light or heat, so that iodization occurs, and the target is obtained.
Second, 4-bromo-4 '-aminobiphenyl is prepared by diazotization and iodine substitution. First, 4-bromo-4' -aminobiphenyl is diazotized with sodium nitrite in hydrochloric acid medium at low temperature to obtain diazonium salts. This diazonium salt is extremely active, and then interacts with potassium iodide or sodium iodide solution. The diazoyl group is replaced by iodine atoms to form 4-iodo-4 '-bromobiphenyl.
Third, 4-bromophenylboronic acid is coupled with 4-iodobromobenzene through Suzuki. In the presence of a base, such as potassium carbonate, a palladium complex as a catalyst, such as tetra (triphenylphosphine) palladium (0), is heated in a suitable solvent, such as a mixed solvent of dioxane and water. In this reaction, the boron group of 4-bromophenylboronic acid and the halogen atom of 4-iodobromobenzene are coupled to form a carbon-carbon bond under palladium catalysis to obtain 4-iodo-4 '-bromobiphenyl. Each method has its own advantages and disadvantages, and it needs to be selected according to the actual situation, such as the availability of raw materials, cost, yield, etc.

4-Iodo-4 '-bromobiphenyl is an organic compound. Its physical properties are particularly important and are of key significance in chemical research and industrial applications.
First of all, its appearance is often in the state of white to light yellow crystalline powder, which is convenient for preliminary identification. Looking at its color and morphology can help chemists preliminarily judge its purity and state in experiments or production processes.
Second-round melting point, 4-iodo-4' -bromobiphenyl has a high melting point and usually melts within a specific temperature range. The high melting point is due to the intermolecular force, and its molecular structure makes the intermolecular attractive force strong. It requires more energy to disintegrate its lattice structure and convert it from solid to liquid. This property is crucial in the separation and purification process. Chemists can judge its purity by melting point measurement. The higher the purity, the closer the melting point is to the theoretical value.
Furthermore, the solubility of 4-iodo-4 '-bromobiphenyl is also worthy of attention. It has a certain solubility in common organic solvents such as chloroform and dichloromethane, but has little solubility in water. This difference in solubility is related to molecular polarity. The molecular polarity of this compound is relatively weak, and it has more affinity with non-polar or weakly polar organic solvents, while it interacts weakly with water with strong polarity. This property can be used in organic synthesis to select suitable solvents to promote the reaction or separate the product.
In addition, the density of the compound is also one of its physical properties. Although the specific value varies slightly depending on conditions, its density is indispensable for accurate measurement and reaction system design. When preparing a solution at a specific concentration or performing a liquid-liquid reaction, density data can help to accurately measure the substance and ensure the accuracy and repeatability of the experiment.
The physical properties of 4-iodo-4 '-bromobiphenyl, such as appearance, melting point, solubility and density, have a profound impact on its chemical behavior and practical application. Chemists need to consider it carefully in order to make good use of it in research and production.

4-Iodo-4 '-bromobiphenyl is an organic compound derived from biphenyl. It has iodine atoms and bromine atoms at the 4th and 4th' positions of biphenyl, respectively. This compound has the following chemical properties:
- ** nucleophilic substitution reaction **: In this molecule, both iodine atoms and bromine atoms are active substitution check points. Because iodine atoms and bromine atoms have certain electronegativity, the carbon atoms connected to them can be partially positively charged and vulnerable to attack by nucleophilic reagents. If sodium oxide is used as a nucleophilic reagent, under suitable conditions, alkoxy negative ions can attack carbon atoms attached to iodine or bromine, and nucleophilic substitution reactions occur to generate ether derivatives.
- ** Metal-catalyzed coupling reaction **: 4-iodo-4 '-bromobiphenyl can participate in metal-catalyzed coupling reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc. In Suzuki coupling reaction, palladium is used as a catalyst to react with compounds containing borate esters to form new carbon-carbon bonds, thereby constructing biphenyl derivatives with more complex structures. This is an important means in organic synthesis, which can be used to prepare organic materials with specific structures and functions, pharmaceutical intermediates, etc.
- ** Redox properties **: Although the redox activity of the compound itself is not high, it can participate in redox reactions under specific conditions and suitable reagents. For example, under the action of strong oxidants, carbon atoms even iodine or bromine may be oxidized, resulting in valence changes, which in turn lead to changes in molecular structure.
- ** Chemical properties related to physical properties **: 4 -iodo-4 '-bromobiphenyl is a solid with a certain melting point and boiling point. From a chemical point of view, in its solid structure, there are interactions such as van der Waals forces between molecules. These interactions affect its solubility in different solvents, which is related to many chemical reactions. For example, in a reaction in solution, its solubility determines the contact opportunity and reaction rate of the reactants.
With these chemical properties, this compound has been widely used in organic synthesis, materials science and other fields, and can be used to synthesize new functional materials, drug molecules, etc., providing an important material basis and synthesis starting point for the development of related fields.

Today there is 4-iodo-4 '-bromobiphenyl, what is the market price? This is a commonly used product in fine chemicals, but its price varies depending on quality, quantity and market conditions. Looking at the market conditions in the past, if the quantity is small, it is used for experiments, and the purity is high, the price per gram may be around tens of yuan to hundreds of yuan. If the quantity is quite large, it is necessary for industrial production. Because it can be prepared on a large scale, the cost is slightly reduced, and the price per gram may be between a few and ten yuan.
However, the market of chemical industry is changing. The price of raw materials, the method of preparation, and the situation of supply and demand can all make the price rise and fall. Or due to the scarcity of raw materials and difficult preparation, the price will rise; or due to the advanced process, the production capacity has increased greatly, and the price may also drop. To know the exact price, you must ask the chemical supplier and check the current market situation carefully before you can get the actual price.