4-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine

4-Iodo-7H-pyrrolo [2,3-d] pyrimidine is one of the organic compounds. Looking at its name, it can be seen that this compound contains iodine (iodo) atoms and has the basic structure of 7H-pyrrolo [2,3-d] pyrimidine.
7H-pyrrolo [2,3-d] pyrimidine This part has pyrimidine as the parent nucleus. Pyrimidine, a six-membered nitrogen-containing heterocycle, has two nitrogen atoms in the ring. The structure of pyrrolo [2,3-d], the pyrrole ring is fused with the pyrimidine ring in a specific way. The pyrrole ring is a five-membered nitrogen-containing heterocycle with one nitrogen atom. After fusing the two, a unique fused ring system is formed.
At the 7th position of 7H-pyrrolo [2,3-d] pyrimidine, the hydrogen atom at the 4th position is replaced by the iodine atom in 4-iodo-7H-pyrrolo [2,3-d] pyrimidine. The iodine atom is relatively large, and its introduction will significantly affect the physical and chemical properties of the compound. For example, due to the electronegativity of the iodine atom and the atomic radius, or the polarity and steric resistance of the molecule, it is further reflected in the properties of chemical reaction activity, solubility, melting point and boiling point.
The chemical structure of this compound is unique. It is fused by a pyrimidine ring and a pyrrole ring, and there is an iodine atom substitution at a specific position. Its structure determines that it may have potential applications in organic synthesis, pharmaceutical chemistry and other fields. In organic synthesis, it can be used as a key intermediate to build more complex molecular structures; in pharmaceutical chemistry, or due to its unique structure and properties, it exhibits specific biological activities, providing opportunities for the development of new drugs.

4-Iodo-7H-pyrrolo [2,3-d] pyrimidine, which is an organic compound. Its main use is related to the field of medicinal chemistry and organic synthesis.
In medicinal chemistry, such nitrogen-containing heterocyclic compounds are often key intermediates in drug development. Due to their unique structure, they can interact with specific targets in organisms and have potential biological activity. For example, anti-cancer drugs can be developed by modifying and modifying their structures. Some studies have shown that the structure can effectively inhibit the proliferation of cancer cells after appropriate modification, bringing hope for the creation of new anti-cancer drugs.
In the field of organic synthesis, 4-iodo-7H-pyrrolo [2,3-d] pyrimidine is an important synthetic building block. Iodine atoms have high activity and can participate in a variety of organic reactions, such as Suzuki coupling reaction, Heck reaction, etc. With the help of these reactions, different functional groups or structural fragments can be introduced to construct complex and diverse organic compounds, providing powerful means for the synthesis of new materials and total synthesis of natural products.
Therefore, 4-iodo-7H-pyrrolo [2,3-d] pyrimidine is of great significance in the fields of medicine and organic synthesis, and plays an extraordinary role in promoting the development of related fields.

4-Iodo-7H-pyrrolo [2,3-d] pyrimidine is an important organic compound, and its synthesis method has attracted much attention in the field of organic synthesis. The following are some common synthesis methods for you.
The first method using nitrogen-containing heterocyclic compounds as starting materials. Appropriate pyridine or pyrimidine derivatives can be selected, and iodine atoms are introduced at specific positions by halogenation reaction. If a pyridine derivative with a suitable substituent is selected, under suitable reaction conditions, it is treated with an iodine reagent to replace the hydrogen atom at a specific position with an iodine atom, and then the structure of pyrrolido-pyrimidine is constructed by cyclization reaction. This process requires fine regulation of reaction conditions, such as temperature, solvent, catalyst, etc., to ensure the selectivity and yield of the reaction.
Furthermore, the condensation reaction of pyrrole derivatives and pyrimidine derivatives as raw materials is also an effective way. Appropriate functional modification of pyrrole and pyrimidine derivatives is first carried out, and then under the action of condensing agents, condensation reactions occur to form the core skeleton of the target product. In this process, the structure of the raw materials needs to be reasonably designed to promote the smooth progress of the condensation reaction and avoid unnecessary side reactions.
In addition, the synthesis strategy of transition metal catalysis is also popular. Using transition metals such as palladium and copper as catalysts, with their unique catalytic activities, iodine-containing reagents are coupled to nitrogen-containing heterocyclic substrates to form the structure of the target compound. Such methods often have the characteristics of high efficiency and good selectivity, but the requirements for reaction conditions and catalysts are high.
Another strategy is to use cyclization-iodization tandem reaction. First, the basic skeleton of pyrropyrimidine is formed by the cyclization reaction in the molecule under suitable reaction conditions. Then, in the same reaction system, an iodine source is introduced for iodization reaction, and 4-iodo-7H-pyrrolo [2,3-d] pyrimidine is constructed in one step. This strategy can simplify the reaction steps and improve the atomic economy of the reaction, but the control of the reaction conditions is more stringent.
There are many methods for synthesizing 4-iodo-7H-pyrrolo [2,3-d] pyrimidine, each with its own advantages and disadvantages. In actual synthesis, appropriate synthesis methods need to be carefully selected according to many factors such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the target product to achieve efficient, economical and environmentally friendly synthesis goals.

4-Iodo-7H-pyrrolo [2,3-d] pyrimidine is an organic compound with unique physical properties that has attracted much attention in the fields of organic synthesis and medicinal chemistry.
Looking at its appearance, under room temperature and pressure, 4-iodo-7H-pyrrolo [2,3-d] pyrimidine is usually in a solid state, either powdery or crystalline, depending on the synthesis method and purity. The color of this compound may be white to light yellow, and if it contains impurities, the color may change.
The melting point is discussed, and its melting point is within a certain range due to the interaction between atoms in the molecular structure. Accurate melting point data need to be determined by experiments, but in general, such compounds containing heterocycles and iodine atoms have higher melting points due to strong intermolecular forces.
In terms of solubility, 4-iodo-7H-pyrrolo [2,3-d] pyrimidine has better solubility in organic solvents than in water. Its molecular structure has a certain hydrophobicity, so it may have better solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), while water is a polar solvent, and the intermolecular force of the compound is weak, resulting in its low solubility in water.
As for the density, although there is no exact general value, according to its molecular composition and atomic weight, it can be inferred that its density is higher than that of common organic solvents. Due to the large atomic weight of iodine atoms, it contributes significantly to the overall density.
The stability of 4-iodo-7H-pyrrolo [2,3-d] pyrimidine is also an important physical property. Under normal conditions, the compound is relatively stable. When exposed to high temperatures, strong oxidants or specific chemical reaction conditions, the molecular structure may change. For example, in high temperature environments, chemical bonds within molecules may break due to high energy, triggering decomposition reactions; in strong oxidants, nitrogen-containing heterocycles and iodine atoms may be oxidized, changing chemical properties.

4-Iodine-7H-pyrrolido [2,3-d] pyrimidine, an organic compound, has attracted much attention in the fields of medicinal chemistry and organic synthesis. Looking at its market prospects, it can be said that it has both opportunities and challenges.
From the perspective of pharmaceutical research and development, many new anti-cancer drugs and antiviral agents are often created with such nitrogen-containing heterocyclic compounds as key intermediates. Due to its unique chemical structure, it can be tightly bound to specific biological targets and exhibit significant biological activity. For example, some studies have revealed that compounds containing pyrrolido-pyrimidine structures have inhibitory effects on the proliferation of certain cancer cells and are expected to be developed as new anti-cancer drugs. The introduction of iodine atoms into the structure of this compound may optimize its electronic properties and spatial configuration, enhance its affinity with biological targets, and enhance its pharmacological activity. Therefore, under the upsurge of innovative drug development, the demand for 4-iodine-7H-pyrrolido [2,3-d] pyrimidine in the field of medicine may be on the rise.
The field of organic synthesis is also an important stage for it. Chemists can modify and derive the compound through various chemical reactions. As a synthetic building block, it can build more complex organic molecular structures. With the advancement of organic synthesis technology, the demand for high-purity, specific-structure 4-iodine-7H-pyrrolido [2,3-d] pyrimidine may gradually increase. In order to expand their product lines and develop novel organic materials, scientific research institutions and chemical companies will also increase their investment in procurement and research of such characteristic compounds.
However, although the market prospect is broad, there are also challenges. First, the optimization of the synthesis process is crucial. The current methods or procedures for synthesizing the compound are cumbersome, the yield is not high, and the cost is high, which limits large-scale production and application. If more efficient and green synthesis paths can be developed to reduce production costs, market competitiveness can be enhanced. Second, the impact of regulations and policies cannot be underestimated. In the field of medicine, the safety and effectiveness of drugs are strictly regulated, and new drugs developed with this compound as an intermediate need to go through a long and strict approval process. This process is time-consuming and laborious, and tests the financial and technical strength of enterprises.
4-iodine-7H-pyrrolido [2,3-d] pyrimidine market has a bright future. To fully tap its potential, researchers and the business community need to work together to overcome the problems of synthesis technology and comply with regulatory requirements in order to emerge in the market and promote the progress and development of related fields.