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What are the chemical properties of 4-iodo-pyridin-3-ylamine?
4-Iodo-pyridin-3-ylamine is one of the organic compounds. Its chemical properties are particularly important and are often used in the field of organic synthesis.
Looking at its structure, it contains a pyridine ring and an amino group and an iodine atom. The amino group is basic, because the nitrogen atom has a lone pair of electrons, it can accept protons. Therefore, in an acidic environment, it can combine with protons to form ions with positive charge.
The iodine atom has a high activity. In many reactions, it can be used as a leaving group. For example, in nucleophilic substitution reactions, iodine atoms are easily replaced by other nucleophiles. Because the carbon-iodine bond energy is relatively low, it is easier to break.
The pyridine ring is aromatic, but its electron cloud distribution is slightly different from that of the benzene ring. The nitrogen atom of the pyridine ring has high electronegativity, which reduces the electron cloud density on the ring, especially in the adjacent and para-positions of the nitrogen atom. This property affects the activity and positional selectivity of the electrophilic substitution reaction of the compound. Usually, the electrophilic substitution reaction is more likely to occur in the pyridine ring intersite.
Furthermore, the chemical properties of 4-iodo-pyridin-3-ylamine are also influenced by the intracolecular conjugation effect and induction effect. The amino group forms a conjugate system with the pyridine ring, which has the effect of adjusting the electron cloud distribution and then affecting the reactivity. At the same time, the induction effect of iodine atom cannot be ignored, and its electron-withdrawing effect also changes the electron cloud density of the pyridine ring.
In organic synthesis, it can construct various complex organic molecular structures by reacting with amino and iodine atoms, and is an important raw material for organic synthesis chemistry.
What are the main uses of 4-iodo-pyridin-3-ylamine?
4-Iodo-pyridin-3-ylamine, Chinese name 4-iodine-3-aminopyridine, this substance has a wide range of uses. In the field of medicinal chemistry, it is an important intermediate in organic synthesis. In the process of many drug development, it can be used as a base to build special structures and give drugs specific biological activities.
For example, in the development of antimalarial drugs, 4-iodine-3-aminopyridine can be obtained through a series of reactions and access to specific groups to obtain compounds with targeted inhibitory effects on Plasmodium. Due to the special electronic effects and spatial structure of the pyridine ring, iodine atom and amino group, it can accurately fit specific targets in the body of Plasmodium, block key physiological processes, and inhibit the growth and reproduction of Plasmodium.
In the field of materials science, 4-iodine-3-aminopyridine is also wonderfully useful. Using it as a raw material through polymerization reaction, materials with special photoelectric properties can be synthesized. The conjugated structure of the pyridine ring and the modification of iodine atom and amino group make the obtained material excellent in light absorption and charge transport. It is expected to be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve their photoelectric conversion efficiency and stability.
In the field of pesticides, new pesticides can be developed based on 4-iodine-3-aminopyridine. With its structural characteristics, pesticide products with high toxic activity to specific pests, environmental friendliness and good biocompatibility are developed. By modifying the pyridine ring substituent, its affinity and biological activity to different pest targets are regulated to achieve precise control, reduce the amount of pesticides used, and reduce the pressure on the ecological environment.
What are 4-iodo-pyridin-3-ylamine synthesis methods?
4-Iodo-pyridin-3-ylamine is an organic compound. The methods for synthesizing this compound are common and have several ends.
First, it can be started from a pyridine derivative. First, a suitable pyridine raw material is used. After halogenation, iodine atoms are introduced into the fourth position of the pyridine ring. In the halogenation reaction, reagents such as N-iodosuccinimide (NIS) can be selected. Under appropriate reaction conditions, such as in an organic solvent, the temperature and reaction time are controlled to selectively connect the iodine atoms to the specific position of the pyridine ring. Subsequently, an amino group is introduced into the third position of the pyridine ring through an amination reaction. The amination process can use suitable amination reagents, such as ammonia derivatives, to react under the catalysis of bases to achieve the introduction of 3-position amino groups, so as to synthesize the target compound 4-iodo-pyridin-3-ylamine.
Second, it can also be used as a strategy for the construction of nitrogen-containing heterocycles. Starting from intermediates containing partial pyridine ring structures, pyridine rings are constructed by cyclization reaction. At the same time, during or after cyclization, iodine atoms and amino groups are gradually introduced into the corresponding positions through steps such as halogenation and amination. This path requires fine design of reaction steps and conditions to ensure the smooth progress of each step of the reaction and the selectivity and yield of the product.
Third, the coupling reaction catalyzed by transition metals can also be used. First prepare suitable substrates containing iodine substituents and amino substituents, respectively, and then under the action of transition metal catalysts, such as palladium catalysts, connect the two parts through a coupling reaction to form 4-iodo-pyridin-3-ylamine. This method requires optimizing the type of catalyst, the selection of ligands, and the conditions of the reaction solvent and base to improve the reaction efficiency and product purity.
Synthesis methods of 4-iodo-pyridin-3-ylamine are various, and the most suitable synthesis route should be selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the product.
4-iodo-pyridin-3-ylamine need to pay attention to when storing and transporting
4-Iodo-pyridin-3-ylamine, Chinese name 4-iodine-3-aminopyridine, is a commonly used raw material in organic synthesis. When storing and transporting, pay attention to many matters.
When storing, the first environment is dry. Because of its certain hydrophilicity, if it is in a humid place, it is easy to absorb moisture and deteriorate, resulting in a decrease in purity, which affects subsequent use. Therefore, when choosing a dry and ventilated warehouse, and the humidity of the warehouse should be controlled within a specific range.
Temperature is also critical. Avoid high temperature to prevent it from decomposing or triggering other chemical reactions. In general, a low temperature environment is conducive to storage, usually 2-8 ° C, which can ensure its chemical stability and prolong the storage period.
Furthermore, this material may have certain toxicity and irritation, and it must be isolated from food, medicine, etc. during storage to prevent contamination. And should be kept away from fire and heat sources, because it may be flammable, it may be dangerous in case of open flames and hot topics.
When transporting, the packaging must be solid. To prevent the container from being damaged during bumps and collisions, resulting in material leakage. The packaging material should have good corrosion resistance and do not chemically react with 4-iodo-pyridin-3-ylamine.
The transportation process needs to maintain a stable environment to avoid large fluctuations in temperature and humidity. Transportation personnel should also be familiar with the characteristics of this object. In case of emergencies such as leakage, they can properly handle it according to the established emergency plan to ensure safety.
What is the market price of 4-iodo-pyridin-3-ylamine?
The market price of 4-iodo-pyridin-3-ylamine, or 4-iodine-3-aminopyridine, fluctuates due to a number of factors.
This chemical reagent is very useful in organic synthesis, and is often used in the fields of medicine, pesticides and materials science. The change in market price bears the brunt of the preparation cost. To prepare 4-iodine-3-aminopyridine, the cost of raw materials is the key factor. The price of raw materials such as iodide and pyridine derivatives varies with market supply and demand. If raw materials are scarce or demand increases sharply, prices will rise, causing the cost of 4-iodine-3-aminopyridine to rise, and the price will also rise.
Furthermore, the complexity of the preparation process has a deep impact on costs and prices. If complex multi-step reactions, harsh reaction conditions, or the use of special catalysts and equipment are required, costs will increase, and product prices will also increase accordingly.
Market supply and demand relationships are also important factors in determining prices. In the field of pharmaceutical research and development, if the demand for 4-iodine-3-aminopyridine for drug development for specific diseases increases sharply, and the supply is temporarily difficult to keep up, the price will rise. On the contrary, if the market demand is weak and the supply is excessive, the price may decline.
In addition, the economies of scale and market competition of manufacturers will also have an impact on prices. Large-scale manufacturers can reduce unit production costs by virtue of economies of scale, and seize share at better prices in market competition. When market competition is fierce, manufacturers may also adjust their price strategies in order to compete for the market.
Generally speaking, in the chemical reagent market, the price of 4-iodine-3-aminopyridine ranges from a few yuan per gram to a few tens of yuan. However, this is only a rough range, and the actual price needs to be determined with reference to factors such as specific suppliers, product purity and purchase quantity. When purchasing, it is advisable to compare the quotations of different suppliers and comprehensively consider product quality and price in order to obtain the most cost-effective products.