4 Iodoacetophenone

4-Iodoacetophenone, or 4-iodoacetophenone, has a wide range of main uses. In the field of organic synthesis, it is often used as a key intermediate.
Cover because of its structure, iodine atoms and acetophenone groups have unique chemical activities. Iodine atoms can participate in many nucleophilic substitution reactions, through which chemists can introduce various functional groups. For example, in palladium-catalyzed cross-coupling reactions, 4-iodoacetophenone can react with carbon-containing nucleophiles to form carbon-carbon bonds, and then synthesize more complex organic molecules, which is of great significance in medicinal chemistry and materials science.
In the field of drug development, 4-iodoacetophenone also plays an important role. By ingeniously modifying its structure, compounds with specific biological activities can be obtained. Medicinal chemists often use this as a starting material to design and synthesize new drug molecules through multi-step reactions to explore their potential for disease treatment.
In addition, in the field of materials science, polymers or functional materials based on the synthesis of 4-iodoacetophenone may exhibit special physical and chemical properties. For example, it can be used to prepare materials with specific optical and electrical properties, and can be used in optoelectronic devices.
In summary, 4-iodoacetophenone has important uses in many fields such as organic synthesis, drug development, and materials science due to its unique chemical structure, providing a key starting material and synthesis intermediate for many scientific research and industrial applications.

4-Iodoacetophenone, that is, 4-iodoacetophenone. There are several common methods for synthesis.
First, acetophenone is used as the starting material and can be obtained by halogenation reaction. Put acetophenone in a suitable reaction vessel, add an appropriate amount of halogenating reagents, such as iodine and an appropriate catalyst. Common catalysts include iron powder, ferric trichloride, etc. Under a certain temperature and reaction time, the hydrogen atom on the benzene ring of acetophenone can be replaced by the iodine atom to generate 4-iodoacetophenone. When reacting, it is necessary to pay close attention to the control of temperature, because the temperature is too high, or the formation of polyhalogenated by-products; if the temperature is too low, the reaction rate will be slow and the yield will be low.
Second, it can be started from 4-acetylbenzoic acid. First, 4-acetylbenzoic acid undergoes an appropriate reduction reaction to convert its carboxyl group into other easy-to-leave groups, such as alcohol hydroxyl groups, and strong reducing agents such as lithium aluminum hydride can be used. After that, it undergoes a substitution reaction with the iodizing reagent to introduce iodine atoms, and finally through appropriate treatment, 4-iodoacetophenone is obtained. In this process, the conditions of the reduction reaction and the substitution reaction need to be precisely regulated to ensure the smooth progress of each step of the reaction and a high yield.
Third, the Fu-gram acylation reaction of benzene and acetyl chloride is first carried out to generate acetophenone, and then the halogenation reaction is carried out as described above to introduce iodine atoms. For the Fu-gram acylation reaction, a suitable Lewis acid catalyst, such as anhydrous aluminum trichloride, is selected, and the reaction system needs to be kept anhydrous and oxygen-free to prevent catalyst failure and side reactions. Subsequent halogenation conditions also need to be carefully considered in order to synthesize high-purity 4-iodoacetophenone.

4-Iodoacetophenone is an organic compound. It has unique physical properties and is widely used in the field of chemistry.
Looking at its properties, it usually shows a white to light yellow crystalline powder state, which is easy to identify and operate. Its melting point range is about 57-60 ° C, and the characteristics of the melting point are of great significance in the identification and purity judgment of the compound. When the temperature rises to the melting point, 4-iodoacetophenone gradually melts from a solid state to a liquid state. This transformation follows the laws of physics and can be determined by accurate temperature measurement.
As for the boiling point, it is about 280 ° C. The boiling point reflects the energy required for the compound to convert from a liquid state to a gas state under a specific pressure. This value provides a key reference for its application under different reaction conditions, because the high temperature environment or its gasification process affects the process and result of the reaction.
The density of 4-iodoacetophenone is about 1.896 g/cm ³. Density is an inherent property of the substance, which is related to its distribution and behavior in solution or mixed system. In some experiments and production processes involving phase separation or solution preparation, density considerations are indispensable.
In terms of solubility, it is slightly soluble in water, but soluble in most organic solvents, such as ethanol, ether, chloroform, etc. This solubility property allows 4-iodoacetophenone to participate in various chemical reactions in the medium of different organic solvents, greatly expanding its application range. In the field of organic synthesis, its solubility can be used to select suitable solvents to optimize reaction conditions and promote efficient reaction.
In addition, 4-iodoacetophenone has a certain degree of volatility. Although the volatility is not strong, it should also be paid attention to in poorly ventilated environments. Because it is an organic compound and flammable, it is necessary to follow safety regulations when storing and using it, and keep it away from ignition sources and high temperatures to ensure safe operation. Its many physical properties are interrelated, which together determine the role and use of 4-iodoacetophenone in chemical research and industrial production.

4-Iodoacetophenone is an organic compound, and all matters need to be paid attention to during storage and transportation.
First, store, this substance should be placed in a cool, dry and well-ventilated place. Because it is quite sensitive to light, it should be stored in a shaded container to prevent it from decomposing or deteriorating due to light. Temperature is also critical. Excessive temperature may accelerate its chemical reaction and cause quality damage, so it should be controlled in an appropriate low temperature range. At the same time, it should be stored separately from oxidizing agents, acids, bases, etc., because 4-iodoacetophenone or reacts violently with it, which may cause safety risks. And the storage area should be equipped with suitable containment materials to prevent accidental leakage from being dealt with in time.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. The transportation process must be shock-proof, moisture-proof, and sun-proof to prevent material leakage due to package damage. Transportation vehicles should be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment, and transportation personnel should also be familiar with the nature of 4-iodoacetophenone and emergency treatment methods. During transportation, the relevant regulations on the transportation of hazardous chemicals should also be strictly followed, and they should be driven according to the designated route, away from densely populated areas and fire sources.
After all, whether it is storing or transporting 4-iodoacetophenone, it is necessary to be careful and strictly follow relevant norms and requirements to ensure personnel safety, environmental safety and material quality.

4-Iodoacetophenone is an organic compound, Chinese name 4-iodoacetophenone. Its market price often fluctuates due to many factors such as purity, supply, purchase volume and market supply and demand, so it is difficult to give an exact price.
If you buy a small amount of high purity (such as more than 98%) 4-iodoacetophenone from a chemical reagent supplier, the price per gram may range from tens of yuan to 100 yuan according to the commonly used specifications in the laboratory, such as 5g or 10g packaging. This is because the preparation of reagent-grade products requires a strict purification process, which is costly.
If it is industrial grade, the purity is slightly lower, and the purchase volume is large, such as kilogram grade or above. Due to the scale effect, the price per gram may be greatly reduced to a few yuan to a dozen yuan. During large-scale production, factors such as raw material procurement cost and production efficiency reduce the unit cost.
However, the market is changing rapidly. If the price of raw material iodine or related chemical raw materials fluctuates sharply recently, the price of 4-iodoacetophenone will also change accordingly. And different regions will have different selling prices due to differences in transportation costs and market competition. To know the exact market price, you need to inquire from relevant chemical product suppliers and distributors in real time, or refer to the quotation information of the chemical product trading platform.