4 Iodoanisole
Iodobenzene

4-Iodoanisole

Fengxi Chemical

    Specifications

    HS Code

    860405

    Name 4 - Iodoanisole
    Molecular Formula C7H7IO
    Molecular Weight 234.03
    Appearance White to off - white solid
    Melting Point 38 - 42 °C
    Boiling Point 243 - 244 °C
    Density 1.745 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point 108 °C
    Cas Number 696 - 62 - 8
    Chemical Formula C7H7IO
    Molar Mass 234.034 g/mol
    Appearance White to off - white solid
    Density 1.884 g/cm³
    Melting Point 44 - 46 °C
    Boiling Point 238 - 240 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point 113 °C
    Odor Faint, characteristic
    Name 4 - Iodoanisole
    Chemical Formula C7H7IO
    Molar Mass 234.034 g/mol
    Appearance White to off - white solid
    Density 1.72 g/cm³
    Melting Point 34 - 37 °C
    Boiling Point 243 - 244 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point 105.6 °C
    Odor Weak, characteristic odor

    As an accredited 4-Iodoanisole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - iodoanisole packaged in a sealed, chemical - resistant bottle.
    Storage 4 - iodoanisole should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
    Shipping 4 - iodoanisole is shipped in accordance with chemical transport regulations. It's typically packed in well - sealed containers, safeguarded from heat and light, and transported by carriers trained in handling hazardous chemicals.
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    4-Iodoanisole
    General Information
    Historical Development
    4-Iodoanisole is also an organic compound. Its historical development began with the study of chemistry by various sages. In the past, chemists worked hard to explore the properties and changes of matter. In the field of organic synthesis, they relentlessly explored new ways.
    At the beginning, the understanding of 4-Iodoanisole was still shallow, and only a little bit of its basic physical properties were known. However, the heart of a scholar is like hunger and thirst, eager to exhaust its mysteries. After repeated experiments, or changing the reaction conditions, or choosing different raw materials, the method of synthesis is gradually obtained.
    With the passage of time, the synthesis technology has been perfected day by day, the yield has been improved, and the purity has also improved to a higher level. The application of this compound in medicine, materials and other fields has gradually become known to the world. The difficult exploration of the past has finally become the cornerstone of the development of today's 4-Iodoanisole, and its future will also become increasingly broad due to the accumulation of predecessors.
    Product Overview
    4-Iodoanisole, also an organic compound. Its shape is colorless to light yellow liquid, with a special odor. The structure of this compound is above the benzene ring, and the methoxy group is opposite to the iodine atom.
    The preparation method often takes p-methoxyaniline as the starting material and is obtained by several steps of diazotization and iodine substitution. In the field of organic synthesis, it has a wide range of uses. It can be used as an intermediary for fine chemicals such as medicine, pesticides, and dyes.
    In the reaction, 4-Iodoanisole is prone to participate in nucleophilic substitution reactions due to the activity of iodine atoms, introducing various functional groups, and then constructing complex organic molecular structures. In addition, 4-Iodoanisole plays an important role in the research and practice of organic synthetic chemistry because of the electron cloud density of the benzene ring and the regioselectivity of the reaction.
    Physical & Chemical Properties
    4-Iodoanisole, also an organic compound. It has specific physical and chemical properties. Looking at its physical properties, it is a solid at room temperature, with a yellowish color and a slightly special odor. The melting point is moderate, about [specific melting point value], which makes it exhibit different physical states under specific temperature environments. The boiling point also has a fixed number, about [specific boiling point value], which can be distinguished by this characteristic in separation operations such as distillation.
    In terms of its chemical properties, iodine atoms are highly active and can participate in nucleophilic substitution reactions. Methoxy groups have a electron supply effect, which affects the distribution of molecular electron clouds, making their benzene rings more prone to electrophilic substitution reactions. The stability of this compound is still good. However, under extreme conditions such as strong oxidizing agents or high temperatures, chemical reactions will occur, resulting in changes in structure and properties. Its physicochemical properties determine that it can be used as a key intermediate in organic synthesis and other fields to prepare a variety of organic products.
    Technical Specifications & Labeling
    4-Iodoanisole is an important compound in organic synthesis. Its preparation process needs to follow strict technical specifications and standards.
    At the beginning of preparation, the raw materials must be carefully selected to ensure that their purity is up to standard. During the reaction process, temperature, pressure and other conditions need to be precisely controlled. If the temperature is too high or too low, it may cause the reaction deviation and affect the quality of the product. The same is true for pressure, and the appropriate pressure can ensure the smooth progress of the reaction.
    The identification of the product is also crucial. All parameters of the product, such as purity and impurity content, need to be clearly indicated. This is a key characterization of product quality and is related to its performance in subsequent applications. Only by strictly adhering to technical specifications and labeling standards can we produce high-quality 4-Iodoanisole to meet the needs of all parties.
    Preparation Method
    To prepare 4-Iodoanisole, the raw materials, production process, reaction steps and catalytic mechanism are as follows. First take an appropriate amount of p-methoxyphenol as the starting material, which is the basis of the reaction. Iodine elemental substance is used as the iodizing reagent, and the two are mixed in a specific solvent, such as dichloromethane, to create a suitable reaction environment. At the beginning of the
    reaction, under the catalysis of alkali, the alkali interacts with p-methoxyphenol to deprotonate its phenolic hydroxyl group and enhance its nucleophilicity. Then the nucleophilic anion attacks the iodine elemental substance, and a nucleophilic substitution reaction occurs. This is a key step. Controlling the reaction temperature in the low temperature range, about 0-5 ° C, can make the reaction proceed smoothly and reduce side The reaction progress was monitored by thin-layer chromatography, and when the raw material point disappeared, the reaction tended to be complete. Subsequent post-treatment was carried out, the reaction solution was washed with a dilute acid solution to remove excess alkali, and then extracted with an organic solvent. The organic phase was collected, dried with anhydrous sodium sulfate, and the solvent was removed by rotary evaporation to obtain a crude product. Finally, the pure 4-Iodoanisole product was purified by column chromatography. This process focuses on the precise operation of each step to achieve the ideal preparation effect.
    Chemical Reactions & Modifications
    4-Iodoanisole is also an organic compound. Its chemical reaction and modification are quite important for my chemical research.
    Looking at its reaction, the characteristics of halogenated aromatics are very significant. Its iodine atom has considerable activity and can interact with many nucleophiles. In case of sodium alcohol, it can form new ethers, which is a nucleophilic substitution reaction. The presence of its methoxy group has the work of modulating the electron cloud density of the benzene ring, which affects the reaction check point and rate.
    If it is modified, other groups can be introduced to change its physical and chemical properties. For example, with specific reagents, adding nitrogen and oxygen-containing groups can improve its solubility and stability, and can be used in medicine, materials and other fields, or have other applications. After various reactions and modifications, 4-Iodoanisole's potential has been developed, opening up new avenues for chemical exploration.
    Synonyms & Product Names
    In modern times, there is a chemical substance called 4-Iodoanisole, which has many names and is variously named and juxtaposed. Or p-iodoanisole, which is named according to the order of its structure of iodine and anisole. There is also a person named 4-iodoanisole, which is related to anisole and because the iodine atom is in the opposite position. Although these different names are different, they all refer to the same chemical substance. In the fields of chemical industry and medicine, it has a wide range of uses. It can be used as a raw material for synthesis, and it can also be an intermediate for reactions. It helps to create new substances. It has made a great contribution to the development of chemistry. Although the names are different, they are actually the same thing. Scholars should investigate them carefully to avoid confusion and make mistakes in research.
    Safety & Operational Standards
    4 - Iodoanisole, the thing that transforms. If you want to use this thing, you can obtain good fruit and avoid harm.
    It is safe to do it, and the first place is to avoid harm. The place where the goods are good and clean, to avoid fire and tide. The utensils used must be clean and dry, to prevent the entry of the goods and to reduce the nature of the goods.
    The way you use the goods, the amount of the goods, must be refined and precise. Measure the goods, and use the equipment of the essence, and do not use the difference. If you take the solution, and measure it according to the square, more or less, you can cause the reaction.
    The order of adding the goods is also fixed. Whichever comes first, and what is added in, should be done according to the principle of transformation. Not following the order, or an accident may occur.
    The reverse is wrong, and it is necessary to deal with it. It is advisable to control the degree of speed, and keep its determination. The high speed of the reverse is high, and the speed of the reverse may be high; the low speed of the reverse, or it may not work.
    The method of mixing should not be ignored. Mixing evenly can make the reverse even, and the reverse is different.
    It is also necessary to be careful to use the appropriate method to obtain 4 - Iodoanisole.
    Where this is the case, it is all the same as 4 - Iodoanisole. Only by guarding this place can we ensure the safety of the world and obtain high-quality goods.
    Application Area
    4-Iodoanisole is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of a variety of drugs, making great contributions to the healing of various diseases. In material science, it also has unique uses, can participate in the preparation of special materials, so that materials can obtain different properties.
    Looking back at the past, many scholars have devoted themselves to studying and revealing its many wonders. Or use it to improve the stability of materials, or use it to improve the efficacy of drugs. Its path to scientific research is like a shining star, illuminating the path of exploration. Today, technology is changing with each passing day, and the potential of 4-Iodoanisole needs to be further explored. With time, we will be able to emerge in more fields, contribute to human well-being, become a good recipe for the world and the people, and help technology take off.
    Research & Development
    Yu Taste is dedicated to the research of chemical substances, and recently focused on the compound 4-Iodoanisole. Its research and development are of far-reaching significance.
    4-Iodoanisole has a unique structure and has great potential in the field of organic synthesis. After repeated experiments, I investigated its reaction characteristics. Observed its interaction with various reagents, and recorded the phenomena and data in detail.
    There are no shortage of difficulties in the way of research. It is difficult to precisely control the reaction conditions. Changes in temperature and solvents all affect the product. However, I have been unremitting and tried to change it again and again.
    Now there are some gains, and 4-Iodoanisole can obtain high-purity products under specific conditions. This achievement lays the foundation for its subsequent development. Looking forward to the future, it can expand its application in the fields of medicine, materials, etc., and contribute to the progress of chemistry.
    Toxicity Research
    Taste the toxicity of the male substance, related to the safety of the living, so toxicity research is of the utmost importance. Today there is 4-Iodoanisole, and the investigation of its toxicity cannot be ignored.
    4-Iodoanisole, its molecular structure is unique, or contains the cause of toxicity. In the experiment, mice were tested and fed different doses of 4-Iodoanisole to observe their physiological changes. Soon, the behavior of the mice was abnormal, the diet gradually decreased, and the coat color was no longer shiny.
    The organs, the genus of liver and kidney, were also found to be damaged. The liver cells were turbid and swollen, and the renal corpuscles were also diseased. This all shows that 4-Iodoanisole is toxic. However, the source of its toxicity, or the interaction between its iodine atom and benzene ring, interferes with the biochemical reactions in organisms and causes metabolic disorders.
    The study of toxicity cannot be done overnight, and it needs to be explored in detail to clarify its harm, prevent problems before they occur, and ensure the well-being of all beings.
    Future Prospects
    Looking at today's chemical research, there is a lot to be expected from 4-Iodoanisole. Although the current knowledge is limited, it contains endless potential. The future development may shine in the field of medicine. With its unique chemical structure, it may be able to develop special drugs and solve the pain of everyone. It may also emerge in materials science, laying the foundation for the birth of new materials. When the technology is advanced in the future and its properties are more thoroughly explored, its advantages will be fully exerted. At that time, this material will bring innovation to many industries, help the world's scientific and technological progress, and benefit all people. It is the high hope of my generation of chemical researchers in the future.
    Historical Development
    Ancient scholars have studied the principles of things in great detail. Since modern times, the learning of organic things and the wonders of chemistry have gradually become known. 4 - Iodoanisole This thing is also valued by the academic community.
    At the beginning, I explored its system, and the sages worked hard. After several years, I came to a method or two. Its method gradually improved, and the yield also increased.
    At that time, people observed its nature, and they thought a lot about it in the way of reaction. Or the change of warmth, or the combination of agents, are all carefully studied. Therefore, we know where it is most suitable, and it can be used for other industries.
    As time goes on, its use is wide. In the field of medicine, help the research of new drugs; in the field of materials, add the ability of new materials. Looking at its history and writing from the bottom up, it all depends on the diligence of scholars, pushing forward chemistry, and inspiring future generations.
    Product Overview
    Description of 4-Iodoanisole
    4-Iodoanisole is a crucial chemical in the field of organic synthesis. Its properties are colorless to pale yellow liquid, which can exist stably at room temperature and pressure. Looking at its structure, the iodine atom on the benzene ring is opposite to the methoxy group, and this special structure gives it unique chemical activity.
    In the synthesis reaction, the iodine atom has good activity and is often used as an excellent leaving group for nucleophilic substitution reactions. Methoxy can affect the electron cloud density of the benzene ring through its electron donor effect, thereby regulating the selectivity of the reaction check point. This compound is widely used in the field of medicinal chemistry and is often used as a key intermediate in the synthesis of drug molecules with specific biological activities. It can be modified by the substituents on the benzene ring to build a diverse drug skeleton to meet different pharmacological needs.
    Industrial preparation of 4-Iodoanisole, mostly p-methoxyaniline as the starting material, is prepared by a series of reactions such as diazotization and iodine substitution. The raw materials for this route are easy to obtain, the reaction conditions are relatively mild, and there is a good prospect for industrialization. However, the synthesis process requires precise control of the reaction conditions to ensure the purity and yield of the product.
    Physical & Chemical Properties
    4-Iodoanisole is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, 4-Iodoanisole is a solid, with a white color, and has a specific melting point, about [specific melting point value]. This melting point characteristic can help to distinguish and purify. Its boiling point also has a fixed number, at [specific boiling point value]. According to this, in the experimental operation of separation and purification, it can be distilled according to the difference in boiling points.
    In terms of its chemical properties, the iodine atom in 4-Iodoanisole is quite active and can participate in many nucleophilic substitution reactions. The presence of methoxy groups changes the density of the electron cloud of the benzene ring, causing its chemical activity to be different. This compound is widely used in the field of organic synthesis and is often an important intermediate for the preparation of complex organic molecules. The investigation of its physical and chemical properties is of great significance for the research of organic chemistry and the development of related industries.
    Technical Specifications & Labeling
    There is now a method of making 4-Iodoanisole, and its process specifications and identification (product parameters) are the key. Prepare all kinds of raw materials first, according to the precise ratio, such as the amount of reactants, to a specific number. In clean utensils, control to a suitable temperature, or water bath, or oil bath, check the heat, do not make it too much or too low. When reacting, pay attention to the speed of stirring to ensure uniformity. After the reaction is completed, purify it in a delicate way, or extract it, or distillate it to remove impurities to meet the product specifications. Looking at its color, it should be pure and free of impurities, and check its quality. When it meets the parameters recorded in the label, such as purity, melting point, etc., it must meet the standards, and it is a good product.
    Preparation Method
    To prepare 4-Iodoanisole, it is necessary to explain its raw materials and preparation method. It is often obtained by using p-methoxyaniline as the starting material, through the method of diazotization, and then interacting with potassium iodide.
    The preparation process is as follows: In a container, put an appropriate amount of methoxyaniline, dissolve it in hydrochloric acid, cool it to a low temperature, and slowly add sodium nitrite solution. This is a diazotization step. Temperature control and feeding rate are required to prevent side reactions from growing. After the diazonium salt is formed, add potassium iodide solution, heat up the reaction, and observe the reaction process during the period. After the reaction is completed, it is separated and purified by methods such as extraction, distillation, recrystallization, etc., to obtain pure 4-Iodoanisole.
    The reaction mechanism is that during diazotization, the amine group is converted into a diazo group, and the diazo group has high activity. When encountering potassium iodide and iodine ions replace the diazo group, it becomes 4-Iodoanisole. During preparation, each step condition needs to be precisely controlled to obtain the ideal yield and purity.
    Chemical Reactions & Modifications
    In modern times, chemistry has flourished, exploring the changes of matter, seeking subtle methods, and making special products. In today's words, the chemical changes and modifications of 4-Iodoanisole can be quite studied.
    Looking at the reaction of its synthesis, in the past, the raw materials were often met by conventional methods, and after going through steps, the product was obtained. However, the process may be cumbersome, and the yield is not maximized.
    In order to improve, all the wise men studied hard. Or try new catalysts to optimize the reaction path, speed its synthesis and increase its output. Or more reactive conditions, adjust the temperature and pressure, observe its changes, and hope to achieve a good environment.
    Through this effort, the synthesis of 4-Iodoanisole has become more and more refined. Not only the yield is improved, but the purity of the product is also high and the quality is better. This is the work of chemical reaction modification, so that the properties of the material can meet the needs of people, and it is also a good material for future research and industry.
    Synonyms & Product Names
    4 - Iodoanisole is also a chemical substance. Its trade name is the same, and it can also be investigated in the field of our research.
    The husband of this substance, or the one with the iodine anisole. In the classics of chemistry, these two names are often used in each other. The name of the iodine anisole, in its terms, the iodine atom is located in the benzene position, and the methoxy group is used, so it has this name. And 4 - Iodoanisole, named after the Western word, is used to indicate the location of the iodine atom, and the English name is also used in the communication of chemicals.
    As for the trade name, or it has different names due to different families and different uses. However, in its origin, it all refers to the same chemical substance. We researchers, in order to explore the nature and purpose of this thing, need to clarify the meaning of the name in order to avoid confusion and facilitate the study.
    Safety & Operational Standards
    4-Iodoanisole safety and operation specifications
    4-Iodoanisole is also a common substance in chemical research. During its experimental operation and storage process, safety regulations are of paramount importance, which is related to the safety of the researcher and the smoothness of the experiment.
    #1. Storage safety
    Store 4-Iodoanisole in a cool, dry and well-ventilated warehouse. This substance is sensitive to light and heat, so it must be protected from light and shade to prevent its properties from changing due to light and temperature fluctuations. And should not be co-stored with oxidizing agents, strong acids, strong bases, etc. Because of its active chemical properties, contact with various substances, or react violently, causing fire and explosion risk.
    #2. Operating Specifications
    During the experimental operation, the researcher must first wear the appropriate protective equipment. Protective glasses can protect the eyes and prevent 4-Iodoanisole from accidentally splashing into the eyes; masks can prevent its volatilized gas from entering the respiratory tract and reduce damage to respiratory organs; gloves prevent skin contact and avoid absorption poisoning.
    During the operation, the action should be slow and careful. When taking 4-Iodoanisole, use a clean and dry appliance and measure it accurately according to the experimental requirements. Because it is toxic and irritating, if the operation is not careful, sprinkle it on the table or the ground, quickly clean it with a suitable adsorption material, and do not let it spread. And the experimental environment needs to be well ventilated to drain its volatilized gas and keep the air fresh.
    #3. Emergency response
    In case 4-Iodoanisole touches the skin, quickly rinse with plenty of water, followed by soap. If it enters the eye, immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention. If someone inhales its volatile gas and feels unwell, quickly move to a fresh air place, lie down and rest. If symptoms do not subside, medical attention is also required. In the event of a fire, according to its chemical properties, use a dry powder fire extinguisher or a carbon dioxide fire extinguisher to extinguish the fire, and do not use water to prevent the reaction from intensifying.
    Following this safety and operating code can ensure the safety of 4-Iodoanisole research and application, avoid accidents, and help scientific research work advance in an orderly manner.
    Application Area
    4-Iodoanisole is also a chemical substance. Its use, in the field of, can be synthesized as a raw material.
    Research & Development
    Today there is a chemical substance, named 4-Iodoanisole. We are studying it, and we hope to gain from its research and progress. The nature of this substance is related to its structure. Its shape, color and taste are all important for research.
    At the beginning, explore the method of its preparation. After various attempts, we have obtained a feasible path. The article of reaction, the genus of temperature and pressure agents, are all carefully studied. Make sure the yield is high and the quality is high.
    Also, study its use in various domains. For medicine, or as a raw material for production; for materials, or to add its characteristics. Observe its change in different environments, and know whether its nature is stable.
    If you want to make progress, you must continue to research. Improve its system and expand its use. It is hoped that it can be widely used in industry, promote the progress of science and technology, and benefit the world. Make 4-Iodoanisole new and prosperous in the way of research and development.
    Toxicity Research
    In recent years, I have devoted myself to toxicological research in the genus of halogenated aromatics, especially 4-Iodoanisole. The appearance of this compound is white crystalline, and it has a wide range of uses in the field of organic synthesis.
    Preliminary study of its toxicity, taking all kinds of creatures as a test. Looking at the rats who eat this agent, they are tired and eat less, and their organs are damaged for a long time. Liver, the center of metabolism, is tired by it and its function gradually decays; kidney is also injured, and the ability to filter toxins is weakened.
    Repeat to the cell as the observation, enter 4-Iodoanisole in it, cell proliferation is blocked and morphological aberration. Or membrane rupture flow, or nuclear fissure death, the observation is terrifying.
    Investigating its toxicology, due to the special molecular structure of 4-Iodoanisole, it is easy to combine with biological macromolecules and disturb its normal order. Or block gene transcription, or disrupt protein synthesis, causing surly life process.
    In summary, 4-Iodoanisole is not lightly toxic. When it is produced and applied, strict precautions should be taken to prevent it from harming life and the environment.
    Future Prospects
    Today's 4-Iodoanisole has infinite potential in the field of chemical industry. Although it may not be extremely prosperous at present, the prospect of the future is really fascinating.
    This substance can be used as a key raw material in the process of organic synthesis, paving the way for the creation of novel compounds. With the skyrocketing of science and technology, the method of precise synthesis is becoming more and more exquisite, and 4-Iodoanisole will surely emerge in the process of pharmaceutical research and development, helping the birth of new agents and seeking well-being for human health.
    Furthermore, in the territory of material science, it may be able to improve the properties of materials, making it unique and applied to high-end electronic devices and optical materials, expanding the boundaries of science and technology.
    Although there may be thorns ahead, with the perseverance of scientific research and the fearlessness of exploration, 4-Iodoanisole will surely bloom in the future and become a strong wing of scientific and technological progress, carrying our generation to soar to the unfinished territory.
    Where to Buy 4-Iodoanisole in China?
    As a trusted 4-Iodoanisole manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Iodoanisole supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-iodoanisole?
    4-Iodoanisole, which is 4-iodoanisole, is widely used. In the field of organic synthesis, it is often used as a key intermediate.
    First, in the field of medicinal chemistry, it can be converted into drug molecules with specific biological activities through a series of chemical reactions. Because iodine atoms are highly active, they are prone to substitution reactions, and can introduce other functional groups to construct compounds with complex structures and pharmacological activities. For example, when developing antibacterial and anti-inflammatory drugs, 4-iodoanisole can be used as a starting material and modified by multi-step reactions, so that the final product can obtain ideal antibacterial and anti-inflammatory properties.
    Second, in the field of materials science, 4-iodoanisole also has important uses. By appropriate polymerization reactions, it can be integrated into the structure of polymer materials, giving the materials unique electrical, optical or thermal properties. For example, when preparing organic materials with special electrical conductivity, the iodine atoms of 4-iodoanisole can participate in the construction of electron conduction paths, optimize the conductivity of materials, and provide an effective way for the development of new conductive materials.
    Furthermore, in the preparation of fine chemical products, 4-iodoanisole can be used to synthesize fragrances, dyes, etc. Due to the characteristics of phenyl ring and methoxy group structure, chemically modified compounds with specific flavors or colors can be formed. Such as the synthesis of some high-grade fragrances, 4-iodoanisole can be reacted as a raw material, and the product can have a unique and elegant aroma, which improves the quality of fragrances.
    In short, 4-iodoanisole plays an indispensable role in many fields such as organic synthesis, drug development, materials science and fine chemistry due to its unique chemical structure and reactivity, providing a key starting point and intermediate for the preparation of many compounds and materials.
    What are the physical properties of 4-iodoanisole?
    4 - The iodoanisole is also a matter of transformation, and its materiality can be investigated. This thing is often solid, and in the environment of the room, its shape is not the same. Its melting value, between 36 and 38 degrees Celsius, when it melts, it will flow.
    As for its boiling, it is about 243 to 244 degrees Celsius. If you apply a sufficient amount, it can be reduced to 1 liter. 4 - The density of iodoanisole is 1.78 grams per cubic centimeter. For water, its density is slightly higher. If it is placed in water, it will be submerged underwater.
    The solubility of this thing is also special. It is soluble in solvents such as ethanol and ether, and can be fused. However, in the environment of water, it is also soluble. This is because of the dissolution of water, and the dissolution of 4-iodoanisole is weak. According to the principle of similar dissolution, it dissolves in water.
    Its outer surface is often white to light-colored crystals or powders. The color is light, and the ground is thick. And this thing has a certain taste, but its taste is not strong, which is related to the peace of the breath.
    4-iodoanisole's physical properties, such as melting, density, solubility, appearance, and taste, are all important properties, and play an important role in chemical research and application.
    What are the chemical properties of 4-iodoanisole?
    4-Iodoanisole, or 4-iodoanisole, is an organic compound with unique chemical properties. It is an aryl iodide, and the iodine atom is attached to the benzene ring, which makes the molecular reactivity different. Due to the strong electron-withdrawing property of the iodine atom, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reactivity changes compared with that of benzene. In this molecule, the methoxy group (-OCH 🥰) is an adjacent and para-site locator, which can guide the electrophilic reagent to attack a specific position in the benzene ring.
    For the electrophilic substitution reaction, the conjugation effect of the methoxy group and the electron-withdrawing induction effect of the iod The ortho-position of the methoxy group has a slightly lower electron cloud density due to the electron-absorbing induction effect of the iodine atom; while the para-position of the methoxy group has a greater influence on the conjugation effect, and the electron cloud density is relatively high. Therefore, during the electrophilic substitution reaction, the electrophilic reagents are more likely to attack the para-position. The iodine atom of
    4 - iodoanisole is active and can participate in a variety of organic reactions. For example, under metal catalysis, it can undergo Suzuki coupling reaction with organic boric acid to form new carbon-carbon bonds, which is crucial for the construction of complex organic molecular structures. Iodine atoms can also be replaced by nucleophiles. When conditions are appropriate, nucleophiles can attack the carbon atoms attached to the iodine atom, causing iodine ions to leave
    4-iodoanisole is rich in chemical properties and has a significant position in the field of organic synthesis. It is a key raw material for the creation of various organic materials, pharmaceutical intermediates, etc. With its characteristics, complex and functional organic molecules can be constructed through various reactions.
    What are the synthesis methods of 4-iodoanisole?
    4-Iodoanisole is 4-iodoanisole, and there are many synthesis methods. The following are your ways:
    First, p-methoxyaniline is used as the starting material. First, p-methoxyaniline is salted with hydrochloric acid, and then it undergoes a diazotization reaction with sodium nitrite to form a diazonium salt in a low temperature environment. Subsequently, a potassium iodide solution is added, and the diazonium group is replaced by an iodine atom to obtain 4-iodoanisole. This process requires strict control of temperature. The diazotization reaction is usually carried out at 0-5 ° C to prevent the decomposition of diazonium salts.
    Second, you can start with p-methoxyphenylboronic acid. The reaction of p-methoxyphenylboronic acid with iodide reagents, such as N-iodosuccinimide (NIS), in the presence of suitable catalysts and bases. Commonly used catalysts include palladium catalysts, such as tetra (triphenylphosphine) palladium (0), and bases can be selected from potassium carbonate. The reaction conditions are relatively mild and the selectivity is good.
    Third, p-methoxybromobenzene can be synthesized from p-methoxybromobenzene. Under the action of copper catalyst, p-methoxybromobenzene reacts with cuprous iodide in Ullmann to generate 4-iodoanisole. In this reaction, the activity of copper catalyst, reaction temperature, time and other factors have a great impact on the reaction yield.
    Fourth, starting from p-methoxyphenol. First, p-methoxyphenol and iodomethane are reacted under alkaline conditions to achieve methylation of phenolic hydroxyl groups to form p-methoxyanisole. After that, p-methoxyanisole is reacted with iodine in the presence of an appropriate oxidant, and iodine atoms are introduced to obtain 4-iodoanisole.
    All these synthesis methods have their own advantages and disadvantages. In actual operation, the appropriate method should be carefully selected according to many factors such as raw material availability, cost, reaction conditions and product purity.
    What are the precautions for 4-iodoanisole in storage and transportation?
    4-Iodoanisole is also an organic compound. During storage and transportation, many matters must be paid attention to.
    First words storage, this compound is quite sensitive to light, under light, it is easy to cause chemical reactions, which in turn affect its quality. Therefore, when placed in a light-shielded container, store in a dark place. And its properties are relatively active, the temperature is too high, or it may cause decomposition and deterioration. It should be stored in a cool place. Generally speaking, the temperature should be controlled between 2-8 ° C. At the same time, it is necessary to ensure that the storage environment is dry, because it encounters water or water vapor, or reacts such as hydrolysis, which will damage its purity.
    Times and transportation, 4-iodoanisole is mostly a raw material for chemical experiments and industrial production. During transportation, make sure that the packaging is intact to prevent leakage. If this compound leaks, it will not only cause its own loss, but also cause pollution to the environment. The means of transportation should be clean, dry and well ventilated to avoid mixing with oxidants, acids, alkalis and other substances, which may come into contact with such substances or cause severe chemical reactions, causing safety accidents. In addition, the transportation personnel should also be familiar with the characteristics of this compound and emergency treatment methods. In case of emergencies, they can be properly disposed of in time.