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What are the chemical properties of 4-iodobenzylamine Hydrochloride?
4-Iodobenzylamine hydrochloride is an organic compound. Its physical properties are as follows: mostly white to light yellow crystalline powder at room temperature, with certain hygroscopicity, in air or gradually deliquescent. Due to its ionic structure, it is easily soluble in water, and it also has good solubility in polar organic solvents such as methanol and ethanol. However, in non-polar organic solvents such as n-hexane and benzene, the solubility is poor.
In terms of its chemical properties, the amino group of the benzylamine part of this compound is alkaline and can form salts with acids. The amino group can participate in many reactions, such as reacting with acyl halide and acid anhydride to form amides; reacting with aldose and ketone to form Schiff base, etc. The iodine atom on the benzene ring is active and can undergo nucleophilic substitution reaction. Under suitable conditions, the iodine atom can be replaced by other nucleophilic reagents such as hydroxyl, amino, alkoxy, etc., which provides the possibility to construct a variety of compound structures. 4-Iodobenzylamine hydrochloride is widely used in the field of organic synthesis due to its structural characteristics, and can be used as an intermediate for the preparation of drugs, dyes and other functional organic materials.
What are the common uses of 4-iodobenzylamine Hydrochloride?
4-Iodobenzylamine hydrochloride is a commonly used reagent in organic chemistry and has a wide range of uses in many organic synthesis reactions. Its common usage routes are as follows:
First, it can be used as a key intermediate in the field of drug synthesis. In the process of drug development, many compounds with specific physiological activities need to be prepared by complex organic synthesis steps. 4-Iodobenzylamine hydrochloride can participate in a variety of reactions due to the presence of iodine atoms and amino groups in its structure. For example, iodine atoms can undergo nucleophilic substitution reactions and combine with other compounds containing specific functional groups to construct a drug molecular skeleton with a unique structure. Like the synthesis of some anti-tumor drugs and nervous system drugs, this reagent may be used to introduce specific structural fragments to impart the desired activity and pharmacological properties of the drug.
Second, in the field of materials science, this reagent is also useful. With the development of materials science, the demand for organic materials with special properties is increasing. 4-Iodobenzylamine hydrochloride can participate in the polymerization reaction and react with other monomers to form polymer materials with special properties. For example, by rationally designing the reaction conditions and combining monomers, materials with specific photoelectric properties can be prepared, which can be used in Light Organic Emitting Diode (OLED), solar cells and other fields. Due to the properties of amino and iodine atoms in the structure, it can affect the electron cloud distribution and molecular interactions of polymers, thereby regulating the photoelectric properties of materials.
Furthermore, in the study of organic synthetic chemistry, it is often used as a model compound for the exploration of reaction mechanisms. Researchers can gain a deeper understanding of the fracture and formation of chemical bonds during the reaction process by studying the various reactions they participate in, providing a theoretical basis for the development of more efficient and green organic synthesis methods. For example, when studying the coupling reaction catalyzed by transition metals, using 4-iodobenzylamine hydrochloride as the substrate, the reaction process and product generation were observed by changing the reaction conditions and catalyst types, etc., so as to clarify the specific mechanism of the catalytic reaction, optimize the reaction conditions, and improve the selectivity and yield of the reaction.
What is the synthesis method of 4-iodobenzylamine Hydrochloride?
To prepare 4-iodobenzylamine hydrochloride, you can follow the following ancient method. First take 4-iodobenzyl bromide, which is the starting material of the reaction. Place it in a suitable reaction vessel with ulotropine, and dissolve it with an appropriate amount of solvent, such as alcohol in common use, such as ethanol, to help the two fully mix and contact. At an appropriate temperature, heat and stir to make it react. This step of the reaction is to use ulotropine and 4-iodobenzyl bromide to undergo nucleophilic substitution to form the corresponding quaternary ammonium salt intermediate.
After the reaction is completed, the resulting quaternary ammonium salt intermediate is treated with dilute acid, such as hydrochloric acid, to neutralize and further transform. This process requires attention to the concentration and dosage of acid. If the acidity is too high or the dosage is too high, it may cause side reactions; if it is insufficient, the reaction is difficult to complete. After this treatment, the crude product of 4-iodobenzylamine hydrochloride can be obtained.
However, the crude product is impure and needs to be refined. The method of recrystallization can be used to select an appropriate solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, filter it while hot to remove insoluble impurities, and then cool it slowly, so that 4-iodobenzylamine hydrochloride can crystallize and precipitate, and then filter and dry to obtain a pure 4-iodobenzylamine hydrochloride product. During the operation, factors such as temperature, solvent ratio, and reaction time need to be carefully controlled to achieve good yield and purity.
4-Iodobenzylamine Hydrochloride What to pay attention to when storing
4-Iodobenzylamine hydrochloride is a chemical substance. When storing, many matters need to be paid attention to.
The first choice of environment. This substance should be stored in a cool and dry place, away from heat and fire sources. Due to high temperature, it may change its chemical properties, and even cause decomposition and deterioration; humid environment can easily make it absorb moisture, affecting purity and stability.
Furthermore, sealed storage is essential. It needs to be contained in an airtight container to prevent contact with air. Oxygen, water vapor and other components in the air may react with the substance, which will damage the quality. In case of oxygen, or oxidation, change its chemical structure.
Also avoid light. 4-Iodobenzylamine hydrochloride is sensitive to light. Long-term light exposure may cause luminescent chemical reactions, causing it to fail or form impurities. Therefore, it should be stored in dark containers such as brown bottles.
At the same time, isolation from other chemicals should not be ignored. Because of its unique chemical properties, or dangerous reactions with other substances. Such as strong oxidants, strong acids, strong bases, etc., should be placed separately to prevent accidents.
In addition, the storage place should be clearly marked, indicating the name of the substance, nature, danger warning and other information, easy access and management, and can let contacts know the latent risk, take protective measures. In this way, the stability and safety of 4-iodobenzylamine hydrochloride are guaranteed during storage.
What is the market price range for 4-iodobenzylamine Hydrochloride?
The market price range of 4-iodobenzylamine hydrochloride is difficult to say exactly. The market situation is changeable, and its price often varies due to multiple factors.
The first to bear the brunt is the production process and cost. If the preparation process of this product is exquisite and efficient, the raw materials are easy to obtain, and the cost is low, the price may tend to be easy. On the contrary, if the process is complicated, the raw materials are scarce and difficult, and the cost is high, the price will be high.
Furthermore, the state of market supply and demand is also the key. For example, at a certain time and place, the demand for 4-iodobenzylamine hydrochloride surges, but the supply is limited, and the price will rise; if the supply is abundant and the demand is weak, the price will tend to decline.
And different suppliers will also make the price different. Large merchants may sell at a relatively affordable price due to economies of scale and controllable costs; while small merchants may price slightly higher due to operating costs.
It also depends on the price. In places with convenient transportation and industrial agglomeration, the price may be relatively reasonable due to logistics and collaboration; in remote places, due to factors such as transportation costs, the price may be slightly higher.
Based on past market conditions, the price per gram may fluctuate between a few yuan and tens of yuan. However, this is only a rough estimate, not a definite number. To obtain an accurate market price, please consult the supplier in detail or refer to the data of recent market transactions to obtain a more accurate price.