4 Iodoisatin

The chemical structure of 4-iodoloman-1,3-dione (4-iodosatin) is unique. This compound belongs to isoindoloman-1,3-dione derivatives, and the core structure is an isoindole full ring with iodine atoms connected to the 4-carbon position.
The isoindole full ring is formed by fusing a benzene ring with a nitrogen-containing five-membered lactam ring. The benzene ring is aromatic, with six carbon atoms connected by a conjugated double bond, in a planar hexagonal structure, which endows the molecule with certain stability and special electronic effects. In the nitrogen-containing five-membered lactam ring, the nitrogen atom is connected to the carbonyl group, and the nitrogen atom has a lone pair of electrons, which can participate in a variety of chemical reactions, and the lactam structure also affects the overall properties of the molecule.
The iodine atom connected at the 4 position has a large relative atomic mass of iodine and a rich electron cloud. It can cause molecular polarity changes. Because iodine electronegativity is different from carbon, the carbon-iodine bond has polarity, which affects the intermolecular forces, such as van der Waals force and dipole-dipole interaction. At the same time, iodine atoms can be used as leaving groups to participate in nucleophilic substitution and other reactions, providing the possibility for the introduction of new functional groups into
In conclusion, the chemical structure of 4-iodoisoindoloman-1,3-dione is composed of a full ring of isoindoloman and a 4-position iodine atom, and the interaction of each part endows the compound with unique physical and chemical properties.

4-Iodoisatin-1,3-dione has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of many specific drugs. For example, some drugs with anti-tumor activity can be modified by the unique chemical structure of 4-iodoistin-1,3-dione through a series of reactions to obtain compounds with high selective inhibitory effect on cancer cells. This structure can accurately embed the specific biomolecular action check point of cancer cells, block the key pathway of cancer cell proliferation, and then inhibit tumor growth.
In the field of materials science, 4-iodoistin-1,3-dione also has extraordinary performance. It can be used to prepare organic materials with special functions, such as materials with specific photoelectric properties. The molecular structure of the iodine atom and the isoindoloman-1,3-dione skeleton cooperate to give the material unique optical and electrical properties. It can be applied to the field of organic Light Emitting Diode (OLED) to improve the luminous efficiency and stability of the device, so that the display screen presents more brilliant colors and lower energy consumption.
In chemical research, 4-iodine isoindoloman-1,3-dione is a common raw material for organic synthesis chemists. Because of its high activity of iodine atoms, it is prone to a variety of chemical reactions, such as nucleophilic substitution, coupling reactions, etc. Chemists use this to explore novel organic synthesis routes, create complex organic compounds with unique properties, and contribute to the development of organic chemistry theory and practice.

The synthesis method of 4-iodosatin has been known for a long time, and is described in detail below.
First, isoindole-1,3-dione is used as the starting material. First, isoindole-1,3-dione is dissolved in a suitable solvent, such as dichloromethane, N, N-dimethylformamide. Subsequently, iodine sources are slowly added to the system. Common iodine sources include iodine elemental, N-iodosuccinimide (NIS), etc. If iodine is used, an appropriate amount of oxidizing agent, such as hydrogen peroxide, potassium persulfate, etc., needs to be added to promote the oxidative addition reaction of iodine. During the reaction, attention should be paid to the control of temperature, which is usually carried out at low temperature to room temperature, such as 0 ° C to 25 ° C. After a certain period of time, the reaction process is monitored by thin layer chromatography (TLC). When the raw material point is almost gone, the reaction is complete. After extraction, washing, drying, column chromatography and other operations, pure 4-iodoisoindole-1,3-dione can be obtained.
Second, anthranilic acid derivatives are used as starting materials. First, the anthranilic acid derivative is reacted with appropriate acylating reagents, such as acetic anhydride, oxalyl chloride, etc., to obtain the corresponding amide compound. Next, the amide compound is cyclized and iodized in the presence of an iodine source and a catalyst. The catalyst can be selected from Lewis acids, such as aluminum trichloride, boron trifluoride ethyl ether complexes, etc. The reaction conditions also need to be carefully controlled, and the temperature and reaction time are all exquisite. After the reaction is completed, the product is purified by similar separation and purification steps, such as filtration, distillation, and recrystallization.
Third, there are those who use indole derivatives as starting materials. First, the indole derivative is oxidized at a specific position to obtain the corresponding indole oxide intermediate. Then iodine atoms are introduced into this intermediate, and the introduction method can be based on the above methods of iodine source and reaction conditions. Finally, after appropriate transformation and purification, 4-iodoisoindole-1,3-dione is obtained.
These synthesis methods have their own advantages and disadvantages. Experimenters should make careful choices according to their own conditions, the availability of raw materials, and the difficulty of reaction.

4-Iodoxisatin-1,3-dione is also an organic compound. It has specific physical properties, which are hereby described in detail by you.
Looking at its appearance, under room temperature and pressure, 4-iodoxisatin-1,3-dione is mostly white to light yellow crystalline powder. The characteristics of this color state can be used to help identify things.
When it comes to the melting point, it is about 230-234 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. When the temperature gradually rises, the lattice structure of 4-iodoisoindolmane-1,3-dione begins to change, and the intermolecular force gradually weakens, so it melts into a liquid state.
Solubility is also one of its important physical properties. It has a certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF). However, in water, the solubility is very small. Because 4-iodoisoindolmane-1,3-dione molecules have strong hydrophobicity, it is difficult to form an effective interaction with water molecules, so it is difficult to dissolve in water.
As for the density, although the value is not detailed, it can be inferred that due to the presence of iodine atoms in the molecular structure, the relative molecular weight increases, and the density is slightly higher than that of common organic compounds.
And its stability is still good at room temperature, but it is also at risk of reaction in case of hot topics, open flames or strong oxidants. This is the approximate physical properties of 4-iodoisoindolmane-1,3-dione. It is clear that its related research and application are beneficial.

4-Iodoisoindoloman-1,3-diketone (4-iodosatin) is an organic compound. It is difficult to determine the range of its price in the market. The matter of covering the price often varies with many factors.
First, the supply and demand of the market is the most important reason. If there are many people in need and few people in supply, the price will increase; if the supply exceeds the demand, the price may decrease. Second, the difficulty of preparation is also related to the price. If the preparation requires complicated methods and expensive materials, the cost will be high and the price will be expensive; if the preparation is simple and the materials used are ordinary, the price will be low. Third, the quality is high, which also affects the price. The price of high quality is often higher than that of low quality.
And the field of the market is also different. In the prosperous capital of Dayi, there are frequent transactions, or due to the convenience of logistics and information, the price may be different; in remote places, or due to the difficulty of transportation and the lack of knowledge, the price is also different.
From this perspective, if you want to know the price range of 4-iodoisoindole-1,3-dione, you can get a more accurate number when you carefully observe the supply and demand of the city, the situation of preparation, the status of quality and the region of the market. However, it is difficult to generalize the price range today.