4-Iodophrazole

4-Iodopyrazole is also an organic compound. In its chemical structure, a five-membered heterocycle containing pyrazole. The pyrazole ring is formed by the covalent bond between the dinitrogen atom and the three-carbon atom. The dinitrogen atom is adjacent in the ring, forming a unique ring structure.
In 4-iodopyrazole, the iodine atom is attached to a specific carbon atom on the pyrazole ring. Generally speaking, according to the numbering rule of the pyrazole ring, the carbon atom in the adjacent position of the nitrogen atom can be replaced by an iodine atom. This substitution position makes the chemical properties of the molecule unique.
The pyrazole ring is aromatic. Because it conforms to the Hocker rule, its electron cloud is distributed on the whole ring, which stabilizes the structure. The introduction of iodine atoms, due to the electronegativity of iodine itself and the large atomic radius, has an impact on the electron cloud distribution and polarity of molecules. And it can significantly change the activity and selectivity of molecules in chemical reactions, making 4-iodopyrazole have unique uses in organic synthesis and other fields. The chemical structure of
4-iodopyrazole is based on the pyrazole ring and the iodine atom is the substituent. The interaction between the two gives this compound unique chemical properties and is of great significance in many aspects of organic chemistry.

4-Iodopyrazole has a wide range of uses and is useful in the fields of medicine, pesticides, and materials.
In the field of medicine, it is an important intermediate in organic synthesis. It can be used to produce many bioactive compounds. For example, when developing new antibacterial drugs, 4-iodopyrazole can participate in key reaction steps, and is chemically modified to connect with other functional groups to obtain substances that have strong inhibitory effects on specific pathogens and help humans resist diseases. It is also useful in the exploration of anti-cancer drugs, providing the possibility for the development of highly selective drugs targeting specific targets in cancer cells.
In pesticides, it can be used as a key structural unit for the construction of efficient pesticide molecules. After ingenious design and synthesis, new pesticides with high toxic activity against pests and low impact on beneficial insects and the environment have been produced. For example, for some common crop pests, pesticides developed based on 4-iodopyrazole can precisely act on the nervous system or metabolic pathways of pests, achieve effective control purposes, and reduce damage to ecological balance.
As for the field of materials, 4-iodopyrazole can be used to prepare functional materials with special properties. For example, participate in the synthesis of materials with specific optical, electrical and magnetic properties, and provide new raw material options for the development of new electronic devices such as organic Light Emitting Diode (OLED) and solar cells. In OLED manufacturing, materials containing 4-iodopyrazole may improve the luminous efficiency and stability, and enhance the display effect.

4-Iodopyrazole is a class of organic compounds. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, at room temperature, it is mostly white to light yellow crystalline powder, which is easy to recognize by the naked eye and is an important initial feature in many chemical reactions and substance identification.
On solubility, this compound exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). As a common organic solvent, dichloromethane has strong solubility. 4-iodopyrazole can be uniformly dispersed in it to form a homogeneous system. This property is conducive to providing a good contact environment for the reactants in the organic synthesis reaction and promoting the smooth progress of the reaction. The same is true in DMF. The polar characteristics of DMF make it interact with 4-iodopyrazole to facilitate dissolution. However, its solubility in water is very small, and the interaction between the polarity of water and the molecular structure of 4-iodopyrazole is weak, making it difficult to break the original intermolecular forces, so it is not easy to dissolve in water. The melting point of
4-iodopyrazole is also an important physical property. After determination, its melting point is in a specific temperature range, and this melting point data is of great significance for the identification of material purity. If the purity of the material is high, the melting point range is relatively narrow and close to the theoretical value; if it contains impurities, the melting point will decrease and the melting range will become wider. The boiling point of
is also not negligible. Although the boiling point data will vary depending on the environmental pressure, the boiling point under specific conditions can reflect the strength of the intermolecular forces of the compound. The level of boiling point is related to the condition control of effective separation and purification in separation operations such as distillation.
To sum up, the physical properties of 4-iodopyrazole, such as appearance, solubility, melting point and boiling point, are of critical significance in many fields such as organic synthesis and chemical analysis, providing an important basis for related research and practical applications.

The synthesis of 4-iodopyrazole is an important topic in organic synthetic chemistry. There are many ways to synthesize it.
First, pyrazole is used as the starting material and iodine atoms are introduced through halogenation reaction. This halogenation reaction often requires specific halogenating reagents, such as iodine element ($I_ {2} $) with appropriate oxidant, or specific organic iodine reagents. For example, hydrogen peroxide ($H_ {2} O_ {2} $) and iodine element act on pyrazole together. Under suitable reaction conditions, the specific position of pyrazole can be iodized to generate 4-iodopyrazole. During the reaction, the choice of temperature and solvent is very critical. In general, mild temperature conditions, such as room temperature to moderate heating, and the selection of suitable polar solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., are helpful for the reaction to proceed and increase the yield.
Second, iodine atoms can be introduced by constructing pyrazole rings at the same time. Organic compounds containing iodine and corresponding nitrogen and carbon raw materials are cyclized by cyclization. For example, specific iodine-containing enolones and hydrazines are catalyzed by suitable bases and cyclized within the molecule to form pyrazole ring structures, while iodine atoms are at the target 4-position. In this process, factors such as the type and dosage of bases, reaction time, etc., have a great impact on the formation and purity of the reaction products. Careful regulation of various reaction parameters is required to enable the reaction to generate 4-iodopyrazole efficiently and selectively.
In addition, transition metal-catalyzed coupling reactions can also be used. Halopyrazole (such as bromopyrazole) is used as a substrate and an iodizing reagent under the action of a transition metal catalyst (such as palladium catalyst). In this method, the activity of the catalyst, the choice of ligands, and the pH of the reaction system are all key factors affecting the success of the reaction. The reaction conditions need to be finely optimized to achieve the ideal synthesis effect to obtain high purity 4-iodopyrazole.

I don't know the price range of 4 - iodophrazole in the market. However, if you want to know its price, you can search for it in many ways. First, consult chemical product suppliers, who specialize in various chemicals, or can tell the current price. Second, visit online chemical product trading platforms, which often list the prices of various products for reference. Third, read chemical industry reports and information, which may involve the price dynamics of related products. However, the price may vary due to factors such as purity, volume, and market supply and demand. If you need an accurate price, you should discuss it with specific suppliers to clarify the details.