4-iodopiperidine-1-carboxylic Acid Tert-butyl Ester

4-Iodopiperidine-1-tert-butyl carboxylate, this substance has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to create various drugs. Its structural properties enable it to participate in a variety of chemical reactions, laying the foundation for the synthesis of compounds with specific biological activities.
When developing new analgesics, with its unique structure, specific groups can be introduced to change the interaction between drug molecules and targets, improve the analgesic effect, and reduce side effects. In the development of anti-tumor drugs, it can also be used as an important starting material to build complex molecular structures through a series of reactions, which is expected to obtain high-efficiency and low-toxicity anti-cancer drugs.
In the field of organic synthesis, tert-butyl 4-iodopiperidine-1-carboxylate provides the possibility for the synthesis of complex nitrogen-containing heterocyclic compounds. Due to the difference in activity between iodine atoms and tert-butoxycarbonyl, various reactions can be selectively carried out, such as palladium-catalyzed coupling reactions, to achieve the construction of carbon-carbon and carbon-heteroatom bonds, enriching the molecular diversity of organic compounds.
Furthermore, in the field of materials science, it can be introduced into polymer structures through chemical reactions, giving materials special properties, such as improving the solubility and thermal stability of materials, and broadening the application range of materials.
In conclusion, 4-iodopiperidine-1-tert-butyl carboxylate has shown important uses in many fields such as medicine, organic synthesis, and materials science due to its unique chemical structure, providing powerful tools and foundations for research and development in various fields.

There are many methods for the synthesis of 4-iodopiperidine-1-tert-butyl carboxylate, and the list of important ones is selected.
One can be started from tert-butyl piperidine-1-carboxylate. First, use an appropriate halogenating reagent, such as an iodine substitution reagent, to interact with it under suitable reaction conditions. The reaction environment needs to be carefully regulated, such as the reaction temperature and the choice of solvent. Aprotic solvents, such as dichloromethane, are often selected to create an environment conducive to the reaction. The temperature may be controlled from low temperature to room temperature, depending on the activity of the reagent and the reaction process. The exact dosage of the halogenated reagent also needs to be considered. Generally, a little excess can promote the reaction to move in the direction of generating the target product, so 4-iodopiperidine-1-tert-butyl carboxylate can be obtained.
Second, starting from the starting material containing iodine, piperidine rings are constructed through a series of reactions and tert-butoxycarbonyl is introduced. For example, iodoolefin and nitrogen-containing nucleophiles are first cyclized under the catalysis of a metal catalyst to construct a piperidine ring structure. Then, tert-butoxycarbonyl is introduced. In this step, tert-butoxycarbonylation reagents, such as di-tert-butyl dicarbonate, can be used to react in the presence of organic bases. Organic bases such as triethylamine The reaction conditions, such as temperature and reaction time, need to be carefully explored to improve the yield and purity of the product.
Furthermore, a protective group strategy may be used. The active check point on the piperidine ring is first protected, then iodine is substituted, and finally deprotected and tert-butoxycarbonyl is introduced. The choice of protective group should be easy to introduce, easy to remove and does not affect other reaction check points. The whole process, each step of the reaction needs to be carefully designed and operated to achieve the purpose of efficient synthesis of 4-iodopiperidine-1-tert-butyl carboxylate.

4-Iodopiperidine-1-tert-butyl carboxylate, this is an organic compound. Its physical and chemical properties are crucial and affect many application fields.
In terms of its appearance, at room temperature, 4-iodopiperidine-1-tert-butyl carboxylate is often in the state of white to light yellow crystalline powder, with a fine appearance and uniform texture. This morphology is conducive to storage and access, and it is easy to measure accurately in various experiments and production operations.
Melting point is also an important property. Its melting point is within a specific range, and this value is of great significance for controlling the phase transition of this substance. When the temperature rises near the melting point, the substance gradually changes from solid to liquid. This property can be used as a key reference index in separation, purification and synthesis processes to help operators clarify the reaction conditions and ensure that the reaction proceeds as expected.
In terms of solubility, 4-iodopiperidine-1-tert-butyl carboxylate exhibits good solubility in organic solvents such as dichloromethane and chloroform. This property is of great significance in the field of organic synthesis. Because many organic reactions are carried out in a solution environment, good solubility allows the reactants to fully contact, accelerate the reaction rate, improve the reaction efficiency and product purity.
Stability is also a point that cannot be ignored. Under normal temperature, pressure and dry environment, 4-iodopiperidine-1-tert-butyl carboxylate has certain stability. However, it is more sensitive to light, heat and humidity. Under light, photochemical reactions may be triggered, resulting in structural changes; high temperature is easy to break chemical bonds and decompose; high humidity environment will promote its hydrolysis, affecting quality. Therefore, it needs to be stored in a cool, dry and dark place.
In addition, the chemical activity of 4-iodopiperidine-1-tert-butyl carboxylate is determined by its structure. Iodine atoms and tert-butoxycarbonyl give their unique reactivity, which can participate in a variety of reactions such as nucleophilic substitution and coupling. In the field of drug synthesis, they are often used as key intermediates to construct complex drug molecular structures and provide an important material basis for the development of new drugs.

Looking at this question, I am inquiring about the price range of 4-iodopiperidine-1-tert-butyl carboxylate in the market. However, the price of this compound often changes for many reasons.
First, the amount purchased has a great impact on the price. If the purchase quantity is very small and is only used for a little research in the laboratory, the merchant may price it higher due to cost considerations. Taking a common chemical reagent as an example, the price per gram can reach tens to more than 100 yuan for small packages such as 1 gram, or due to packaging, transportation and other costs.
Second, the supply channel is also the key. Purchased by well-known suppliers with high quality assurance, their prices may be higher due to strict product quality control, high R & D investment, etc. However, some emerging or better cost control suppliers may have slightly lower prices.
Third, the market supply and demand situation also affects its price. If there is a surge in demand for this compound at a certain time and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may decline.
Basically speaking, in the common chemical raw material market, when purchasing in small quantities, the price per gram may be between tens of yuan and two or three hundred yuan. If a large number of purchases, such as kilograms, are made, the price per gram may decrease to several tens of yuan due to the scale effect, but the specific details still need to be consulted with each supplier, depending on the current market situation.

4-Iodopiperidine-1-tert-butyl carboxylate is also an organic compound. Its storage conditions are crucial, which are related to the quality and stability of this compound.
This compound should be stored in a cool and dry place. Covering a cool environment can slow down the rate of chemical change. If it is exposed to high temperature, or the molecular activity is greatly increased, it will cause adverse reactions such as decomposition and polymerization, which will damage its inherent structure and properties. A dry place is also indispensable, because moisture may be able to chemically react with the compound, especially when it contains functional groups that are easy to interact with water, such as ester groups, which will deteriorate in contact with water or hydrolysis.
Furthermore, it should be stored in a dark place away from light. Light may be an inducing factor for chemical reactions, or cause intramolecular electron transitions, which stimulate chemical reactions, affecting the purity and activity of compounds.
When storing, also pay attention to the choice of containers. Containers with good sealing properties should be used to prevent contact with air. Oxygen in the air may be oxidizing and can oxidize some easily oxidized groups in compounds; gases such as carbon dioxide may also react with compounds.
And should be kept away from fire sources, heat sources and incompatible substances. Fire sources and heat sources will increase the temperature and increase the risk of reaction; incompatible substances may come into contact with them or react violently, causing danger.
In conclusion, to properly store 4-iodopiperidine-1-tert-butyl carboxylate, it is necessary to choose a cool, dry, dark place, and use a well-sealed container to avoid fire, heat, and incompatible materials, so as to maintain its quality and stability for subsequent use.