4 Iodopyridin 2 1h One

4-Iodopyridin-2 (1H) -one, one of the organic compounds. Its chemical structure includes a pyridine ring, which is a six-membered nitrogen-containing heterocycle and has aromatic properties. In the second position of the pyridine ring, there is a carbonyl group (C = O) connected, and the oxygen atom of this carbonyl group is in an interposition relationship with the nitrogen atom on the ring, forming the structural unit of pyridinone, which endows the compound with certain chemical activity and electronic properties. In the fourth position of the pyridine ring, an iodine atom is connected. Iodine atoms have a large atomic radius and electronegativity, which have a significant impact on the physical and chemical properties of molecules. It can enhance the polarity of molecules, affect the intermolecular forces, and then change the physical properties of compounds such as boiling point and melting point. In chemical reactions, the iodine atom can be used as a leaving group to participate in nucleophilic substitution and other reactions, introducing new functional groups to the compound and expanding its chemical synthesis pathway. The uniqueness of this structure makes 4-iodopyridin-2 (1H) -one very interesting in the fields of organic synthetic chemistry, medicinal chemistry, etc., or can be used as a key intermediate for the synthesis of drug molecules with specific biological activities, or to participate in the construction of the structural framework of complex organic compounds, promoting the development of related fields.

4-Iodopyridine-2 (1H) -ketone is a kind of organic compound. Its physical properties are very important, related to its application and characteristics.
First of all, its appearance is often in the form of a solid powder that is off-white to light yellow. This color and morphology are important for identification and preliminary judgment. Its color is yellowish, or due to the arrangement of atoms in the molecular structure and the distribution of electron clouds, light interacts with it to show this color. The powder form is conducive to storage, transportation and subsequent processing. Due to its large surface area, it can participate in the reaction more efficiently.
Furthermore, when it comes to the melting point, the melting point of this compound is in a specific range. The determination of melting point is a key means to identify its purity and characteristics. Accurate melting point data reflect the strength of intermolecular forces. Molecules are maintained by interactions such as van der Waals forces and hydrogen bonds. The melting point depends on the magnitude of these forces. The melting point of 4-iodopyridine-2 (1H) -one reveals the stability and compactness of its molecular structure.
Solubility is also an important physical property. In common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., there is a certain solubility. This solubility is derived from the polarity of the molecule. In its molecular structure, the electronegativity of the iodine atom is large, so that the molecule presents a certain polarity, and the polar organic solvent can be dissolved with each other through intermolecular forces. In solvents with strong polarity such as water, the solubility is relatively limited, because the overall polarity is not enough to overcome the hydrogen bond network between water molecules.
In addition, its density is also a characteristic. Density reflects the mass of a substance per unit volume and is related to the mass of the molecule and the way of intermolecular accumulation. The density of 4-iodopyridine-2 (1H) -one is of great significance for its application in specific processes, such as separation and mixing.
In summary, the physical properties of 4-iodopyridine-2 (1H) -one, including appearance, melting point, solubility, and density, are interrelated, which together determine its application potential and operational characteristics in many fields such as organic synthesis and drug development.

4-Iodopyridin-2 (1H) -one (4-iodine-2-pyridone) is often used as a reactant in many reactions in organic synthesis.
In halogenation reactions, its iodine atom is highly active and can participate in nucleophilic substitution. For example, when it meets a nucleophilic reagent, the iodine atom can be replaced by other groups, thus forming a new carbon-heteroatom bond. This process is like a craftsman replacing parts with exquisite skills to shape a new structure. For example, when reacting with alcohols under suitable conditions, the iodine atom may be replaced by an alkoxy group to form ether derivatives, which provides a path for the preparation of nitrogen-containing ether compounds with specific structures.
In the reaction of constructing complex cyclic structures, 4-iodine-2-pyridinone also plays an important role. Due to its unique electronic properties and spatial structure, the pyridinone skeleton can be used as a key structural unit to weave complex cyclic compounds with specific biological activities or physical properties through intramolecular cyclic reactions. This is like building a delicate interlocking mechanism, each ring is precisely connected due to the characteristics of 4-iodine-2-pyridinone.
In transition metal-catalyzed coupling reactions, 4-iodine-2-pyridinone is a frequent visitor. Its iodine atoms can be coupled with compounds containing alkenyl and aryl groups under the connection of transition metal catalysts to expand the conjugate system of molecules or build a multi-element aromatic heterocyclic structure. This process is just like under the guidance of metal catalysts, allowing different molecular fragments to be precisely spliced like a puzzle to create novel organic molecules, providing key intermediates for drug development, materials science and other fields.

4-Iodine-pyridine-2 (1H) -one is an important intermediate in organic synthesis. The synthesis methods are various, and I will describe them today.
One is to use pyridine-2-one as the starting material. First dissolve pyridine-2-one in a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc. Then add an iodine source, such as iodine elemental substance, supplemented by suitable oxidants, such as hydrogen peroxide, sodium periodate, etc. At an appropriate temperature, or at room temperature, or by heating and refluxing, the iodine atom is introduced into the 4-position of pyridine-2-one through oxidation and iodization reaction, and the target product 4-iodine-2 (1H) -one can be obtained.
The second is to use halogenated pyridine derivatives as raw materials. If there is 4-halogenated pyridine-2-one (the halogen atom can be chlorine, bromine, etc.), a halogen exchange reaction can be used. Take this halogenated pyridine-2-one, place it in a suitable solvent, such as acetone, acetonitrile, etc., add iodizing reagents, such as potassium iodide, sodium iodide, etc., and then add an appropriate amount of catalyst, such as cuprous iodide, etc. After heating and stirring, the halogen atom is replaced by the iodine atom, so as to obtain 4-iodopyridine-2 (1H) -one.
Third, pyridine is used as the starting material. Pyridine is first acylated, an acyl group is introduced, and the corresponding acyl pyridine derivative is formed. Then, through a series of reactions such as oxidation and halogenation, the required functional groups are gradually constructed The pyridine ring is oxidized to oxidize nitrogen atoms into pyridine-N-oxide, then halogenated under suitable conditions, and halogen atoms are introduced. Finally, the halogen atoms are replaced by iodine atoms through substitution reaction, and the carbonyl group is formed at the 2-position, and 4-iodopyridine-2 (1H) -one is finally obtained.
Synthesis methods have advantages and disadvantages. The method of using pyridine-2-one as raw material is relatively simple, but the selection and dosage of oxidizing agent need to be carefully controlled to prevent excessive oxidation. For halogenated pyridine derivatives as raw materials, the halogen exchange reaction conditions are relatively mild, but the preparation of raw materials may require other methods. The method of using pyridine as the starting material, although the steps are complicated, the raw material is easy to obtain, and if the reaction conditions of each step can be optimized, it is also a feasible path. When synthesizing, it is necessary to weigh and choose according to the availability of raw materials, the difficulty of reaction, the high cost and other factors.

4-Iodopyridine-2 (1H) -one is widely used in the field of medicine. This compound has a unique chemical structure and is often a key intermediate in drug development.
The cover can cause a variety of chemical reactions due to the characteristics of iodine atom and pyridone structure, which helps to construct complex drug molecular structures. First, in the creation of antibacterial drugs, 4-iodopyridine-2 (1H) -one can be used as a starting material, and new compounds with antibacterial activity can be obtained through series transformation. Second, in the exploration of anti-cancer drugs, based on this, modified and modified, or can synthesize drugs that target cancer cells, and interact with specific targets of cancer cells through its structure to inhibit the proliferation of cancer cells.
Furthermore, in the field of neurological drug development, 4-iodopyridine-2 (1H) -one is also possible. After appropriate chemical modification, compounds that can modulate neurotransmitters may be generated for the treatment of neurological diseases such as Parkinson's disease, Alzheimer's disease, etc.
And it is also an important object in the study of synthetic methods of pharmaceutical chemistry. Chemists can explore novel synthesis pathways by studying their reactivity and mechanism, improve the efficiency and selectivity of drug synthesis, and provide more possibilities for pharmaceutical innovation. They can also assist in the creation of new drugs to solve patients' pain and promote the development and progress of medicine.