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What is the chemistry of 4-iodopyridin-3-amine?
4-Iodopyridine-3-amine, this is an organic compound. Its chemical properties are quite important and affect many chemical processes and applications.
First of all, its physical properties, at room temperature, or as a solid, as for the exact color and morphology, often vary according to purity and crystal form. Its solubility is also a key property. It may have some solubility in organic solvents such as ethanol and dichloromethane, but in water, its solubility may be limited. This solubility property has a great influence on the choice of reaction medium in chemical synthesis.
When it comes to chemical activity, the iodine atom in 4-iodopyridine-3-amine has a high activity. Iodine atoms can participate in many nucleophilic substitution reactions, because iodine atoms, as good leaving groups, are easily replaced by other nucleophiles. For example, when reacted with nucleophiles containing hydroxyl groups and amino groups, novel compounds can be formed, which is an important means to construct complex molecular structures in the field of organic synthesis.
Furthermore, its amino groups also have unique chemical properties. Amino groups are basic and can react with acids to form salts. And amino groups can participate in electrophilic substitution reactions. Under appropriate conditions, other functional groups can be introduced into the pyridine ring to enrich the structure and properties of compounds. The electron cloud distribution of the pyridine ring itself makes 4-iodopyridine-3-amine exhibit specific reactivity and selectivity. The electron cloud density distribution on the pyridine ring is uneven, resulting in different substitution reactivity at different positions, providing various possibilities for chemical synthesis.
In addition, 4-iodopyridine-3-amine also has a certain response to redox reactions. Under specific oxidation or reduction conditions, the functional groups in the molecule may undergo corresponding transformation, resulting in the derivation of products with different structures and properties. The chemical properties of this compound have wide application and research value in many fields such as medicinal chemistry and materials science.
What are the main uses of 4-iodopyridin-3-amine?
4-Iodopyridine-3-amine, this substance has important uses in chemical engineering, medicine and other fields.
In the chemical industry, it is often a key intermediate in organic synthesis. With its unique structure, it can participate in a variety of chemical reactions to build more complex organic molecular structures. For example, it can be coupled with other compounds containing specific functional groups through coupling reactions to expand carbon chains or build special cyclic structures, laying the foundation for the preparation of new materials and fine chemicals.
In the field of pharmaceutical research and development, it has a significant effect. Due to its structural characteristics of pyridine and amine groups, it is endowed with certain biological activity. Many studies have shown that compounds constructed on this basis may have potential pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. Scientists can modify and optimize their structures, introduce different substituents, change their physicochemical properties and biological activities, and screen out lead compounds with good efficacy and small side effects, and then develop new drugs.
Furthermore, in the field of materials science, 4-iodopyridine-3-amine may also have extraordinary performance. It can participate in the preparation of functional materials, such as optoelectronic materials. With its iodine atom and pyridine ring properties, it may be able to adjust the electronic transport properties and optical properties of materials, which contribute to the development of materials science. In conclusion, although 4-iodopyridine-3-amine is an organic compound, it has shown great application potential in many fields, promoting technological innovation and development in various fields.
What is 4-iodopyridin-3-amine synthesis method?
To prepare 4-iodopyridine-3-amine, the method of organic synthesis is often followed. It can be started from compounds containing pyridine structure. One method is to use 3-aminopyridine as raw material, because it already has a pyridine ring and an amino group, which is in line with the partial structure of the target product.
First protect the amino group of 3-aminopyridine to prevent it from participating in the subsequent reaction without reason and interfering with the main reaction process. Protective groups such as acetyl can be used to react with 3-aminopyridine with acetyl chloride in a suitable alkaline environment to acetylate the amino group to form N-acetyl-3-aminopyridine.
Then, the intermediate is iodized. In a suitable solvent such as dichloromethane, iodine is combined with a suitable oxidant such as hydrogen peroxide or potassium persulfate to initiate iodization. This reaction condition needs to be precisely regulated, and the temperature and the proportion of the reactants are all key, so that the iodine atom selectively replaces the hydrogen atom at the 4-position on the pyridine ring to obtain N-acetyl-4-iodine-3-aminopyridine.
Finally, the protective group of the amino group is removed. The product is treated with an alkaline solution such as sodium hydroxide aqueous solution, so that the acetyl group is hydrolyzed and separated, and the amino group is restored to its original state, resulting in 4-iodopyridine-3-amine. In the whole process of
synthesis, the control of reaction conditions is of paramount importance. The choice of solvent, the adjustment of temperature, and the control of reaction time are all related to the purity and yield of the product. And after each step of the reaction, appropriate separation and purification methods, such as column chromatography, recrystallization, etc., are required to remove impurities and purify to obtain pure 4-iodopyridine-3-amine.
4-iodopyridin-3-amine any precautions during storage
For 4-iodopyridine-3-amine, there are various matters to be paid attention to when storing. This compound has specific chemical properties. First, it is quite sensitive to light and air. Components in light and air, such as oxygen, can cause it to chemically react and cause it to deteriorate. Therefore, it should be stored in a place protected from light and should be stored in a sealed container to isolate air and maintain its chemical stability.
Furthermore, temperature is also a key factor. High temperature can accelerate the reaction rate, causing decomposition or other chemical changes. Therefore, it should be stored in a cool place. Generally speaking, a refrigerated environment of 2-8 ° C is appropriate, but the specific temperature depends on the experimental requirements or product instructions.
In addition, humidity cannot be ignored. Humid environment may cause it to absorb moisture, which in turn affects its quality. The storage place should be kept dry, or a desiccant should be placed in the storage container to maintain a dry atmosphere.
At the same time, it needs to be stored in isolation from other chemicals. Because of its chemical structure, it may react with certain substances, causing danger. For example, avoid co-storage with strong oxidants, strong acids, strong bases, etc., to prevent unexpected chemical reactions.
The place of storage should also be clearly marked, specifying its name, nature, hazard and emergency treatment method. In case of accidental contact, it should be handled in accordance with established emergency procedures to ensure the safety of personnel and the environment is not contaminated. In this way, the quality and safety of 4-iodopyridine-3-amine can be maximized when storing it.
What are some common derivatives of 4-iodopyridin-3-amine?
4-Iodopyridine-3-amine is an organic compound, and there are many common derivatives derived from it. The following is explained in detail.
First of all, halogenated derivatives are quite common. Since iodine atoms already exist in the molecule, iodine can be replaced with other halogen atoms, such as chlorine and bromine, through nucleophilic substitution reactions. This substitution can change the physical and chemical properties of the molecule. In organic synthesis, it can be used as an intermediate to construct more complex structures.
Furthermore, alkylated derivatives are also common types. Alkyl groups can be introduced into molecules through nucleophilic substitution or other related reactions. The introduction of alkyl groups of different carbon chain lengths can significantly affect the solubility and lipid solubility of the compound. In the field of medicinal chemistry, this modification is often used to optimize the pharmacokinetic properties of drugs.
In addition, amide derivatives cannot be ignored. The amino group of 4-iodopyridine-3-amine can react with acid chloride and acid anhydride to form amide bonds. Amide derivatives have important applications in many fields, such as materials science, bioactive molecule design, etc. Their stability and unique spatial structure endow molecules with new functions and characteristics.
Another sulfonated derivative. Amine groups can react with sulfonyl chloride to form sulfonamides. Sulfonamide compounds are widely used in the fields of medicine and pesticides, and some have biological activities such as antibacterial and weeding.
Ether derivatives can also be prepared from 4-iodopyridine-3-amine. Through appropriate reaction conditions, amino groups can be converted into ether bonds. The introduction of ether structures can change the polarity and stability of molecules, showing unique uses in organic synthesis and materials.
In short, 4-iodopyridine-3-amine can be derived from various types of compounds due to the activity of iodine atoms and amino groups in its structure. It has important value and wide application prospects in many fields such as organic synthesis, drug development, and materials science.