4-Methoxy-Iodobenzene

Fengxi Chemical

Specifications

HS Code	622159
Chemical Formula	C7H7IO
Molar Mass	234.03 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	235 - 237 °C
Density	1.732 g/cm³
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Flash Point	100 °C
Refractive Index	1.616 (20 °C)
Purity	Typically high - purity (e.g., 98%+ in commercial products)

As an accredited 4-Methoxy-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 4 - methoxy - iodobenzene packaged in a sealed, chemical - resistant bottle.
Storage	4 - methoxy - iodobenzene should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and incompatible substances. This helps maintain its stability and reduces the risk of chemical reactions that could lead to hazards.
Shipping	4 - methoxy - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care due to its chemical nature. Shipment follows strict regulations for hazardous chemicals to ensure safety during transit.

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General Information

Historical Development

The development of 4-methoxy iodobenzene has a long history. In the past, chemical research was just beginning, and everyone was exploring organic synthesis. At that time, many parties had to work hard to obtain this 4-methoxy iodobenzene.
At the beginning, the synthesis method was simple, the yield was quite low, and there were many impurities. However, the researchers were determined and tried new methods again and again. After a long time of exploration, there are gradually ways to improve. After continuously improving the reaction conditions and optimizing the ratio of raw materials, the synthesis efficiency can be improved.
In recent times, science and technology have flourished, the instruments have been exquisite, and the analysis methods have become more accurate. The technology of synthesizing 4-methoxy iodobenzene has become more and more mature, and the yield and purity have improved significantly. This substance is increasingly widely used in various fields such as medicine and materials, and has contributed a lot to many research and production efforts. Its development can be described as from simple to complex, from clumsy to refined, and the future is increasingly bright.

Product Overview

4-Methoxyiodobenzene is an organic compound. It is a white to light yellow crystalline powder with a specific chemical structure.
This compound is widely used in the field of organic synthesis. It is often used as a key intermediary and plays an important role in the construction of complex organic molecules. Due to the presence of iodine atoms and methoxy groups, it gives unique reactivity. Iodine atoms can participate in coupling reactions, such as Suzuki coupling and Stille coupling, which help to form carbon-carbon bonds and expand the carbon skeleton of molecules. Methoxy groups affect the distribution of electron clouds in molecules and regulate the selectivity and rate of reactions.
is prepared in the laboratory and can be obtained through a specific chemical path and various reaction steps. However, when preparing, attention should be paid to the precise control of reaction conditions, such as temperature, pH, ratio of reactants, etc., to ensure the purity and yield of the product.

Physical & Chemical Properties

4-Methoxyiodobenzene is an organic compound. Its physical properties are solid at room temperature, with a white-like color and a certain melting point, which is about a specific temperature range. This is the characterization of its physical state. Looking at its solubility, it can be moderately dissolved in common organic solvents such as ethanol and ether, but it is difficult to dissolve in water, which is due to the characteristics of its molecular structure.
In terms of its chemical properties, iodine atoms are active and can participate in a variety of nucleophilic substitution reactions. The presence of methoxy groups affects the electron cloud density of the benzene ring, making the o-para-position of the benzene ring more reactive. For example, when encountering nucleophiles, iodine atoms are easily replaced to form new compounds. This property provides an important way for the construction of complex molecular structures in the field of organic synthesis, and is of great significance in the research and production practice of organic chemistry.

Technical Specifications & Labeling

Today there is a product, named 4 - Methoxy - Iodobenzene. The technical procedures and identification (commodity parameters) for making this product are crucial. Its technical procedures should follow precise steps. First take all suitable raw materials and mix them in a specific ratio, during which the temperature and pressure need to be stabilized. During the reaction, a specific catalyst may be required to promote the speed of the reaction and increase the amount of product.
As for the identification (commodity parameters), the purity of this product must reach a certain precise value to be qualified. Its appearance also needs to be detailed, and the color and state must be determined. And the physical and chemical properties of this thing, such as melting point, boiling point and other parameters, must also be accurately marked, so that users can understand its characteristics and be suitable for various purposes. In this way, the essence of this thing's technical regulations and identification (commodity parameters) can be obtained.

Preparation Method

To make 4-Methoxy-Iodobenzene, the method is as follows: Prepare the raw material first, and use anisole as the starting material, which is the basis for the preparation of this product. The reaction technique should be performed by substituting iodine. Take an appropriate amount of anisole, put it in a clean container, add an appropriate amount of iodine and an appropriate catalyst, such as sulfuric acid, to promote the reaction speed. Control the reaction conditions, the temperature should be moderate, not too high or too low, too high will cause side reactions to occur, and too low will slow the reaction. When the reaction is carried out, carefully observe and wait for the reaction to be complete. After separation and purification, pure 4-Methoxy-Iodobenzene can be obtained. The method of separation can be used according to its physical properties, distillation, extraction and other techniques to remove impurities and retain what is needed. The essence of purification lies in fineness to ensure the purity of the product. In this way, 4-Methoxy-Iodobenzene can be obtained to make this product for subsequent use.

Chemical Reactions & Modifications

Today's research 4 - Methoxy - Iodobenzene's anti-chemical properties, I have experience. The beauty of its anti-chemical properties lies in the small size of the product, and the quality of the product is different. If you use a certain method, under normal conditions, the anti-chemical and anti-chemical properties are not satisfactory. If you change the degree and more catalytic products, the anti-chemical rate will rise quickly, and the efficiency will be low.
Study its chemical properties, this compound is prone to oxidation, easy to produce oxidation, benzene or change, iodine or iodine. However, if you use it, it can be guaranteed. And its methoxy group also has a good effect, which can reverse the direction, so that the specific positioning is high.
We hope to know the secret of the opposite and change the method in order to increase the quantity and degree of materials, which is helpful for the purpose of work and management.

Synonyms & Product Names

4-Methoxy iodobenzene is an important raw material for organic synthesis. It is also known by different names, or p-methoxy iodobenzene, which is named after its chemical structure. In the chemical industry, various trade names are named after them, each with its own characteristics, to recognize the uniqueness of the product.
This product plays a key role in the preparation of fine chemicals. Chemists want to make complex organic molecules, often rely on 4-methoxy iodobenzene as a starting material. Because of its active iodine atom, it is easy to cause substitution reactions; the electronic effect of methoxy group is also reaction-oriented, so it becomes a powerful tool for organic synthesis.
The products in the market may have different names according to their purity and packaging, but in essence, they are all 4-methoxyiodobenzene. Our chemical researchers, when they understand the relationship between their various names, can use them in experiments and production without error for scientific research and industry.

Safety & Operational Standards

4-Methoxyiodobenzene is an important chemical compound in chemical research. In terms of experimental operation and safety, specific specifications must be strictly followed.
During experimental operation, the instruments used must be clean and dry. When weighing 4-methoxyiodobenzene, use a precise balance and act quickly to prevent it from getting wet or reacting with air components. During the dissolution process, a suitable solvent, such as some organic solvents, should be selected according to its solubility, and stirred at a constant speed to promote its full dissolution.
involves reaction operation, and the reaction conditions should be strictly controlled. In terms of temperature, precise temperature control equipment should be used to maintain stability according to specific reaction requirements. Taking a specific reaction as an example, if the temperature fluctuation exceeds the specified range of ± 2 ° C, the purity and yield of the product will be significantly affected. The reaction time is also critical, and the reaction process needs to be judged in a timely manner by experience and experimental monitoring. It should not be prolonged or shortened at will.
Safety level, 4-methoxyiodobenzene may have certain toxicity and irritation. Experimenters must wear protective clothing, protective gloves and goggles to avoid contact between skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the situation. Storage should also be careful, and it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants to prevent fire and severe reactions. After taking it, be sure to seal it and store it properly to prevent it from evaporating or deteriorating. Only in this way can we ensure the safe and orderly conduct of experiments and enhance the accuracy and reliability of research.

Application Area

4 - Methoxy - Iodobenzene is also an organic chemical. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create a variety of specific drugs. Through specific chemical reactions, it can be cleverly combined with other compounds to derive molecular structures with unique pharmacological activities, which contribute to the conquest of difficult diseases.
In the field of materials science, it also has its place. It can be treated by special processes and integrated into new materials, giving materials such as unique photoelectric properties and other characteristics, and playing an important role in electronic devices, optical materials and other fields.
In the field of organic synthetic chemistry, it is often regarded as a starting material. Through a series of delicate chemical reactions, it builds a complex organic molecular structure, promotes the development of organic synthetic chemistry, and provides a material foundation for innovation in many fields.

Research & Development

Today there is a chemical thing, named 4 - Methoxy - Iodobenzene. We have tried our best to study this thing. At first, explore its physical properties, analyze its structure, and understand the wonders of its molecules. Then observe the rules of its reaction, and observe its changes in different environments.
During the experiment, strictly follow the law, control temperature, pressure, and select agents, all with caution. Hope to get a pure product to study its characteristics. During the period, there may be problems, the yield is not as expected, and impurities are also disturbed. However, we are not discouraged, investigate the reasons carefully, change the plan, and test it again and again.
After long-term research, we have gradually gained something. It is clear that its effect on specific reactions can be used as the basis for other things, which is of great use. We will continue to study it, expand its use, and hope to make some achievements in the field of chemistry, so as to promote the development of this substance and add brilliance to the academic community.

Toxicity Research

Today there is a thing called 4 - Methoxy - Iodobenzene. I study the toxicity of this thing in the body of a person. Although this thing is invisible to the eye, its nature is dangerous and cannot be ignored.
Examine its structure in detail, analyze its qualitative changes, and observe the appearance of its contact with other things. After various tests, it can be known that it is in a specific environment, or it should be poisoned. Encounter with living things, or disturb the order of their vitality, and disrupt the process of transformation in their bodies.
Although this poison cannot suddenly cause people to be in danger, it will be touched or accumulated in the body for a long time, and gradually lose health. When using this thing, be cautious and cautious, observe all kinds of precautions, prepare emergency measures, and avoid the harm of poison, so as to protect the safety of everyone and maintain the tranquility of the environment.

Future Prospects

In the future, 4-Methoxy-Iodobenzene has a promising future. It will emerge in the field of organic synthesis. It can be used as a key intermediate to assist in the preparation of many fine chemicals. In the future, the synthesis process will become more and more refined, the cost may be effectively controlled, and the output will also increase significantly.
With time, or in the field of pharmaceutical creation, it will pave the way for the development of new drugs. Or make a name for itself in the field of materials science, giving birth to novel functional materials. With the deepening of scientific research, the understanding of its characteristics and potential will become more thorough, and the scope of application will continue to expand. It will definitely play a pivotal role in the process of future scientific and technological progress, shining brightly.

Where to Buy 4-Methoxy-Iodobenzene in China?

As a trusted 4-Methoxy-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Methoxy-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-methoxy-iodobenzene?

4-Methoxy-iodobenzene is an important agent in organic synthesis. It has a wide range of uses in the field of organic chemistry.
It is first used in the formation of carbon-carbon bond reactions. In palladium-catalyzed cross-coupling reactions, such as Suzuki coupling, Stangler coupling and Heck coupling, 4-methoxy-iodobenzene can be used as a raw material for aryl halides. Through these coupling reactions, a variety of aryl-aryl, aryl-alkenyl and other carbon-carbon bonds can be formed, which is of great significance for the synthesis of complex organic molecules, pharmaceutical intermediates and specific structural compounds in the field of materials science.
Furthermore, it is also indispensable in the preparation of various functional materials. Due to the properties of iodine atoms and methoxy groups in the structure, the molecules can be modified and expanded through subsequent chemical reactions. For example, when synthesizing organic semiconductor materials with special optoelectronic properties, 4-methoxy-iodobenzene can be used as a starting material, introducing other functional groups through multi-step reactions, endowing the material with unique electrical and optical properties, which can be used in the research and development and manufacturing of organic Light Emitting Diodes (OLEDs), organic photovoltaic cells and other devices.
In addition, it also plays an important role in the field of medicinal chemistry. As a pharmaceutical intermediate, it can participate in the synthesis of drug molecules with specific biological activities. With the electronic effect of methoxy and the reactivity of iodine atoms, it can precisely regulate the activity, solubility and metabolic properties of molecules, and help to develop innovative drugs with high efficiency and low toxicity. Overall, 4-methoxy-iodobenzene has critical uses in many fields, such as organic synthesis, materials science, and drug development, and has made significant contributions to promoting the development of various fields.

What are the physical properties of 4-methoxy-iodobenzene?

4-Methoxy-iodobenzene is one of the organic compounds. It has specific physical properties and is very important in chemical research and industrial applications.
Looking at its properties, under room temperature, 4-methoxy-iodobenzene is often white to light yellow crystalline powder, which is easy to use and store. Its melting point is about 37-41 ° C, and it is easy to melt when heated. This property is crucial in some reactions that require precise temperature control.
Furthermore, the boiling point of 4-methoxy-iodobenzene is about 285 ° C. The higher boiling point indicates that it is relatively stable during heating and is not easy to volatilize and dissipate, providing a stable reaction substrate for many high-temperature chemical reactions.
In terms of solubility, the substance is insoluble in water, but can be soluble in common organic solvents such as ethanol, ether, chloroform, etc. This solubility property makes it possible to flexibly select a suitable solvent system according to the reaction requirements in organic synthesis to promote the smooth progress of the reaction.
In addition, the density of 4-methoxy-iodobenzene is also one of its important physical properties. Its density gives the compound a specific mass-to-volume relationship, which is indispensable in chemical operations involving precise measurement.
In summary, the physical properties of 4-methoxy-iodobenzene, such as crystallization, melting point, boiling point, solubility, and density, are the cornerstones of its important role in the field of organic chemistry, and many chemical synthesis and research depend on it.

What are 4-methoxy-iodobenzene synthesis methods?

There are several common methods for the synthesis of 4-methoxy-iodobenzene.
One is to use p-methoxy aniline as the starting material. The diazotization reaction of p-methoxy aniline with sodium nitrite and hydrochloric acid is carried out at low temperature. This process needs to be carefully controlled to prevent the decomposition of diazonium salts. After the diazotization reaction is completed, p-methoxy diazobenzene hydrochloride is formed. Then, it is mixed and reacted with potassium iodide solution, and the diazoyl group will be replaced by iodine atoms to obtain 4-methoxy-iodobenzene. The steps of this method are relatively clear, but the diazotization reaction conditions are harsh, and the temperature and reagent dosage need to be precisely controlled.
The second is to use p-methoxy benzene as the raw material. First, p-methoxybenzene is sulfonated with sulfuric acid and fuming sulfuric acid to form p-methoxybenzene sulfonic acid. Then, p-methoxybenzene sulfonic acid is co-melted with sodium hydroxide to realize the conversion of sulfonic acid groups to hydroxyl groups to obtain p-methoxyphenol. After that, p-methoxyphenol reacts with iodine under appropriate catalyst and basic conditions, and the hydroxyl groups are replaced by iodine atoms to achieve the synthesis of 4-methoxy-iodobenzene. There are more steps in this path, but the raw materials are relatively easy to obtain.
Furthermore, p-methoxybenzoic acid can be started. First, p-methoxybenzoic acid is reduced to p-methoxybenzyl alcohol, and common reducing agents such as lithium aluminum hydride are used. Then p-methoxybenzyl alcohol is halogenated to produce p-methoxyhalobenzene. Finally, 4-methoxy-iodobenzene is obtained by replacing the halogen atom with iodide through a halogen atom exchange reaction. The reaction conditions of each step of this synthesis method need to be carefully regulated to ensure a higher yield. All synthetic methods have their own advantages and disadvantages. In practical application, the choice should be weighed according to the availability of raw materials, reaction conditions, cost and many other factors.

4-methoxy-iodobenzene What are the precautions during storage and transportation?

4-Methoxy-iodobenzene is a commonly used raw material in organic synthesis. When storing and transporting, many things need to be paid attention to.
First words storage, this substance should be placed in a cool, dry and well-ventilated place. It is sensitive to temperature and humidity, and it is easy to deteriorate in a high temperature and humid environment. If it is exposed to high temperature, it may cause chemical reactions, which will damage its quality; in case of moisture, or changes such as hydrolysis, the purity will decrease. Therefore, in the warehouse, it is necessary to control the temperature within a suitable range and have equipment for dehumidification.
Furthermore, it should be kept away from fire and heat sources. Because of its flammability, although it is not extremely flammable, in case of open flames and hot topics, there is also a risk of explosion. And it needs to be stored separately from oxidants and active metals, and must not be mixed. The edge oxidant is easy to oxidize with 4-methoxy-iodobenzene, and the active metal is in contact with it, or causes unpredictable chemical changes, endangering safety.
As for transportation, caution is also required. The packaging must be tight to prevent leakage. If the transportation vehicle is selected with corresponding qualifications, the driver and escort must be familiar with its physical and chemical properties and emergency response methods. On the way, it is recommended to drive slowly to avoid bumps and vibrations, and avoid packaging damage. And when transporting, it is not allowed to be mixed with contraindications in the same vehicle to prevent accidents.
In short, 4-methoxy-iodobenzene is stored and transported, and the control of temperature and humidity, the avoidance of fire sources, the separation of materials, and the proper packaging and transportation are all critical. Slight negligence or adverse consequences are related to production safety and product quality and cannot be ignored.

What is the market price range for 4-methoxy-iodobenzene?

The market price range of 4-methoxy-iodobenzene is difficult to determine due to many reasons. This compound is used in chemical synthesis, pharmaceutical research and development and other fields, and its price is determined by many factors.
First of all, purity, if used in high-end pharmaceutical research and development, requires extremely high purity, and its price is high; if only used in general chemical synthesis, the purity requirements are slightly lower, and the price will also be reduced. If the purity reaches more than 99%, due to the complex purification process and rising costs, the price may be several times or more higher than that of 95% purity.
Furthermore, the market supply and demand situation has a deep impact on the price. If the pharmaceutical industry is enthusiastic about the research and development of new drugs containing this ingredient for a while, the demand will increase greatly, and the supply is limited, the price will rise; on the contrary, if the market demand is weak, the manufacturer may reduce the price in order to destock.
The production process also affects the price. Advanced and efficient production processes can reduce production costs and make products more price competitive in the market; if the process is outdated, energy consumption is high, and output is low, the price will be difficult to have an advantage.
In addition, fluctuations in raw material prices are also related. If the price of various raw materials required to synthesize 4-methoxy-iodobenzene increases due to factors such as resource scarcity and changes in origin, the price of finished products will also change.
In terms of general market conditions, industrial-grade low-purity products may cost several hundred yuan per kilogram or more; while high-purity products suitable for pharmaceutical research and development may cost tens of yuan per gram or even more. However, this is only a rough estimate, and the actual price needs to be studied in detail according to the current market conditions.