4-(Tert-Butyl)-2-Iodo-1-Nitrobenzene

4- (tert-butyl) -2-iodine-1-nitrobenzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, when creating drug molecules, this compound can introduce functional groups such as tert-butyl, iodine atom and nitro through specific chemical reactions. The steric hindrance effect of tert-butyl is significant, which can affect the spatial structure of molecules and the distribution of electron clouds, which in turn has a significant impact on the activity and selectivity of drugs. Iodine atoms can participate in a variety of nucleophilic substitution reactions, helping to build new carbon-carbon bonds or carbon-heteroatom bonds, thus providing a rich way for the structural modification of drug molecules. Nitro groups also have unique electronic effects, which can adjust the polarity and reactivity of molecules, which is very beneficial in optimizing the pharmacological properties of drugs.
Second, in the field of materials science, 4- (tert-butyl) -2-iodine-1-nitrobenzene can be used to prepare functional materials. For example, by means of chemical synthesis, it is integrated into the structure of polymers, and its functional group properties endow polymers with special properties such as photoelectric properties and thermal stability. The presence of tert-butyl may enhance the hydrophobicity of the material, while iodine atoms and nitro groups may regulate the electrical and optical properties of the material, making the material show potential application value in optoelectronic devices, sensors and other fields.
Third, in the field of fine chemicals, this compound is also an important raw material for the preparation of various fine chemicals. With its special chemical structure, a variety of compounds with specific functions can be derived through a series of chemical reactions, which are used in the production of fragrances, dyes, additives and other products.

The synthesis method of 4- (tert-butyl) -2 -iodine-1 -nitrobenzene has been explored by chemists throughout the ages. The following are several common approaches.
First, benzene derivatives containing tert-butyl are used as starting materials. The nitro group is first introduced into the benzene ring. In this step, mixed acids (concentrated sulfuric acid and concentrated nitric acid) are commonly used. At a suitable temperature, the nitro group can replace the hydrogen atom on the benzene ring. Subsequently, iodine atoms are introduced under the action of specific catalysts, such as the catalytic system composed of cuprous iodide and ligands. This process requires precise control of reaction conditions, such as temperature, proportion of reactants, and reaction time, in order to obtain a higher yield of the target product.
Second, we can start from halogenated benzene. First, tert-butyl is introduced into the benzene ring. This step can be achieved by Fu-gram alkylation reaction. Tert-butyl halide is selected to react with benzene in the presence of Lewis acid catalysts such as anhydrous aluminum trichloride. Next, nitro is introduced through nitration reaction, and then iodine atoms are introduced at specific positions in the benzene ring by iodine substitution reaction. This route requires attention to the selectivity of each step of the reaction to avoid unnecessary side reactions.
Third, nitrobenzene is also used as the starting material. Halogen atoms are first introduced into the benzene ring through halogenation reaction, and then tert-butyl is introduced through nucleophilic substitution reaction under specific conditions. This synthesis strategy requires strict reaction conditions, fine regulation is required to ensure the smooth progress of the reaction, and attention should be paid to the inhibition of side reactions, so as to efficiently synthesize 4- (tert-butyl) -2 -iodine-1 -nitrobenzene.
All synthesis methods have advantages and disadvantages. Chemists need to weigh and choose the most suitable route according to actual needs and conditions to achieve the purpose of efficient and green synthesis.

4- (tert-butyl) -2-iodine-1-nitrobenzene is one of the organic compounds. Its physical properties are worth exploring.
First of all, its phase state and color are mostly solid at room temperature and pressure, and the color is light yellow. This is because its molecular structure contains nitro groups. The presence of nitro groups often causes compounds to show such colors.
times and melting points, measured by experiments, are about in a specific temperature range. The value of this melting point is determined by the intermolecular force. The tert-butyl group in the molecule has a large steric resistance, which affects the order of the intermolecular arrangement. However, the nitro group and the iodine atom enhance the intermolecular force, and the two check and balance each other, and determine the melting point.
Furthermore, the boiling point, if you want to make it boil into a gaseous state, you need to supply energy to break through the attractive force between molecules. Because the relative mass of the molecule is large, and there are polar groups, such as nitro, the intermolecular force is strong, so the boiling point is quite high.
In terms of solubility, it has good solubility in organic solvents such as toluene and dichloromethane. Because its molecules have certain hydrophobicity, the intermolecular force with the organic solvent is enough to disperse them. In water, the solubility is poor, because water is a strong polar solvent, the intermolecular force with the compound is weak, and it is difficult to miscible.
Its density is higher than that of water, which is also due to the molecular structure and relative mass, the structure composed of many atoms, which increases the mass per unit volume.
The physical properties of this compound are closely related to its unique molecular structure. Therefore, it is of great benefit for applications in organic synthesis, separation and purification.

4- (tert-butyl) -2-iodine-1-nitrobenzene is one of the organic compounds. Its chemical properties are unique and it has a variety of interesting properties.
Firstly, the presence of nitro groups makes this compound quite oxidizing. The chemical bond between nitrogen and oxygen in the nitro group gives it the ability to attract electrons, which decreases the electron cloud density of the benzene ring and weakens the electrophilic substitution reaction activity of the benzene ring. This property makes 4- (tert-butyl) -2-iodine-1-nitrobenzene more difficult to react with electrophilic reagents than ordinary benzene derivatives.
Furthermore, the properties of the iodine atom cannot be ignored. The iodine atom has a large radius and the electron cloud is relatively dispersed, so as a leaving group, nucleophilic substitution reaction can occur under suitable conditions. This is because the nucleophilic reagent can attack the carbon atom connected to the iodine, so that the iodine leaves with a pair of electrons, and then forms a new compound.
And tert-butyl is an alkyl group, which also affects the distribution of the electron cloud of the benzene ring. Tert-butyl is an electron supply group, although its electron supply ability is relatively weak, it can increase the density of the adjacent and para-site electron clouds of the benzene ring to a certain extent. However, due to the large steric resistance, its effect on the reactivity of the benzene ring In some reactions, steric hindrance can prevent the reagent from getting close to the benzene ring, which affects the reaction progress; however, under certain circumstances, it can guide the reaction selectivity to occur at a specific location.
In addition, the interaction between each group in 4- (tert-butyl) -2-iodine-1-nitrobenzene also affects its overall chemical properties. The electronic effect of each group and the spatial effect are mutually restricted and coordinated, which determines the performance of this compound in various chemical reactions. For example, in the reduction reaction, the nitro group can be reduced to an amino group, and the presence of iodine atoms and tert-butyl groups may affect the rate and selectivity of the reduction reaction. In conclusion, the chemical properties of this compound are formed by the comprehensive action of various groups, which is of unique significance in the fields of organic synthesis.

I don't know the price range of 4- (tert-butyl) -2-iodine-1-nitrobenzene in the market. The price of this compound is determined by a variety of factors, such as purity, yield, supply and demand, and manufacturing costs.
If its purity is high and the preparation process is complicated, special raw materials and processes are required, and the price may be high. However, if the preparation method is simple, the raw materials are common, and the market demand is large, the output is high, and the price may be relatively easy.
If you want to know the price range, you can consult the chemical supplier, such as Sigma-Aldrich, Alfa Aesar, etc., whose website may have price information for this product. You can also quote from multiple suppliers on the chemical product trading platform to get an approximate price range.
Because I don't know the real-time market dynamics, I can't tell the exact price range of this compound. If you need an accurate price, please go to the relevant platform or supplier to inquire.