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What are the main uses of 5 - amino - 2,4,6 - triiodoisophthalic Acids
5-Amino-2,4,6-triiodoisophthalic acid, which has a wide range of uses.
In the field of medicine, it can be used as an important raw material for contrast agents. Contrast agents can help doctors clearly develop the internal structure of the human body during imaging examinations, so as to accurately diagnose diseases. Because of the iodine element, 5-amino-2,4,6-triiodoisophthalic acid can effectively enhance the contrast of tissues and organs in X-ray, CT and other examinations, so that lesions are invisible.
In the field of materials science, it also has a unique role. It can participate in the synthesis of polymer materials through specific chemical reactions. The polymer materials modified by it may have significant improvements in optical properties and thermal stability. For example, new optical materials synthesized by this method may have better light transmittance and refractive index, which has great potential in the field of optical instrument manufacturing.
At the level of scientific research and exploration, 5-amino-2,4,6-triiodoisophthalic acid is often used as an intermediate in organic synthesis. Scientists can prepare a series of organic compounds with special structures and properties through chemical structure modification and derivatization reactions, providing rich material basis and diverse possibilities for the research and development of new drugs and the creation of new functional materials.
What are the physical properties of 5 - amino - 2, 4, 6 - triiodoisophthalic Acid
5-Amino-2,4,6-triiodoisophthalic acid, this is an organic compound. Its physical properties are unique, and it has important research value and application potential.
In terms of appearance, under normal temperature and pressure, 5-amino-2,4,6-triiodoisophthalic acid is often in a white to pale yellow crystalline powder state. This form makes it easy to handle and measure in many chemical operations and applications.
Melting point is one of the key physical properties of substances. The melting point of 5-amino-2,4,6-triiodoisophthalic acid is quite high, usually above 300 ° C. The high melting point indicates that the intermolecular force is strong, the structure is stable, and the phase state transition occurs in the high temperature environment, which has a significant impact on the chemical reaction or material preparation requiring high temperature treatment.
In terms of solubility, 5-amino-2,4,6-triiodoisophthalic acid has little solubility in water. Due to the large hydrophobic iodine atom and relatively rigid benzene ring structure in the molecule, it is difficult for water molecules to interact effectively with it and disperse it. However, it is soluble in some polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. In these organic solvents, 5-amino-2,4,6-triiodoisophthalic acid can be uniformly dispersed in molecular state, which is conducive to participating in various homogeneous chemical reactions, or as a solution for material coating, film preparation and other processes.
The density of 5-amino-2,4,6-triiodoisophthalic acid is relatively large, which is closely related to the large mass of iodine atoms in the molecule. Greater density will affect the bulk density and physical properties of products in material synthesis. In the field of drug development, it may have potential effects on drug distribution and metabolism in vivo.
In addition, the compound has good stability in the solid state, and can maintain the chemical structure and physical properties unchanged for a long time under conventional storage conditions. However, in extreme chemical environments such as strong oxidants, strong acids, and strong bases, chemical reactions may occur, causing structural changes.
5 - amino - 2,4,6 - triiodoisophthalic Acid
5-Amino-2,4,6-triiodoisophthalic acid, this is an organic compound. Its chemical properties are unique and acidic. Because of its carboxyl group, it can release protons under suitable conditions, neutralize and react with bases to form corresponding salts.
There are many iodine atoms in this compound, which makes it have a high density. The presence of iodine enhances the intermolecular force and affects its physical properties such as melting point and boiling point. The presence of its amino group gives the molecule a certain alkalinity and can react with acids to form salts.
In the field of organic synthesis, 5-amino-2,4,6-triiodoisophthalic acid can be used as a key intermediate. Both carboxyl and amino groups are reactive and can participate in a variety of organic reactions, such as esterification reactions, amidation reactions, etc., to construct more complex organic molecular structures.
At the same time, because it contains multiple iodine atoms, it may play a unique role in some reactions or material preparation that require the introduction of heavy atoms. And the symmetry and substituent distribution of molecules also affect their chemical properties and reaction selectivity, and may have potential applications in pharmaceutical chemistry, materials science and other fields.
What is the synthesis method of 5 - amino - 2, 4, 6 - triiodoisophthalic Acid
The method for preparing 5-amino-2,4,6-triiodoisophthalic acid can follow the following steps.
The first step is to use isophthalic acid as the starting material. The isophthalic acid is nitrified with a mixture of concentrated nitric acid and concentrated sulfuric acid in a suitable reaction vessel. This reaction requires strict temperature control to prevent side reactions from breeding. Generally, the reaction temperature should be maintained in a certain range, such as 60-80 degrees Celsius. After this nitration reaction, a nitro group is introduced on the isophthalic acid to form 5-nitro-isophthalic acid. The key to this step lies in the precise preparation of the mixed acid ratio, as well as the strict control of the reaction temperature and time, in order to ensure a high yield and purity.
In the next step, the obtained 5-nitro-isophthalic acid is reduced. The nitro group is reduced to an amino group with a suitable reducing agent, such as the combination of iron and hydrochloric acid, or catalytic hydrogenation, etc., to obtain 5-amino-isophthalic acid. If the iron and hydrochloric acid system is used, the reaction needs to be carried out under mild conditions, and attention should be paid to the stirring and aeration of the reaction process to facilitate the smooth progress of the reaction. Catalytic hydrogenation requires the selection of suitable catalysts, such as palladium carbon, and the control of hydrogen pressure and reaction temperature.
The final step is to iodize 5-amino-isophthalic acid with an iodine source. The commonly used iodine source can be an iodine elemental substance, which is reacted in a specific solvent in the presence of an appropriate oxidant, such as hydrogen peroxide or periodic acid. This iodization reaction requires attention to the choice of solvent to ensure the solubility of the reactants and the selectivity of the reaction. At the same time, the amount and speed of oxidant addition are also very important. Beware of excessive iodization. After this iodization reaction, 5-amino-2,4,6-triiodoisophthalic acid can be obtained. After each step of the reaction, purification steps such as filtration, washing, and recrystallization are required to improve the purity of the product. Thus, following these steps, 5-amino-2,4,6-triiodoisophthalic acid can be prepared.
What is the price range of 5 - amino - 2,4,6 - triiodoisophthalic Acid in the market?
5-Amino-2,4,6-triiodoisophthalic acid, this substance is on the market, and its price range is difficult to determine. Its price often changes due to various reasons, such as supply and demand trends, cost of production, quality, competition in the market, etc.
If its past market is studied, in the market of chemical raw materials, its price fluctuates in a large range. In the past, due to the rarity of iodine sources, its production required a large amount of iodine, resulting in high costs and high prices. However, with the progress of the process, new methods of production gradually emerge, and the cost may drop, and the price may also fall.
In general chemical raw materials trading places, those with good quality may have reached a price of several hundred gold per kilogram in the past. In recent times, if the market supply is sufficient and the demand is not full, the price may drop to about 100 gold per kilogram. However, this is only an approximate number, and the actual price varies according to the different markets and changes in time. If in the field of special needs, there is a high demand for quality, and the price is different, or far more than the usual price. To know the exact price, you should consult the business of chemical raw materials and refer to the real-time market information.